IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene BLMH Ensembl ENSG00000108578 Chromosome 17 Start 25599349 End 25643204
Description Bleomycin hydrolase (BLM hydrolase)(BMH)(BH)(EC 3.4.22.40) [Source:UniProtKB/Swiss-Prot;Acc:Q13867]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 1059
     Entrez Gene : 642
     UCSC : uc002hez.1
     GeneCards : 1059
     RefSeq : NM_000386
     CCDS : CCDS32604.1
     Uniprot : Q13867
     Interpro : Q13867
     OMIM : 602403
     GeneTests : BLMH
     CGAP : BLMH
     PMID : 9407121

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  37700_at  -0.13  1.44e-1  2.23e-1  0.48  1.23e-3  3.71e-3
 HG_U95  394_at  -0.06  7.01e-1  7.78e-1  0.64  2.07e-3  5.85e-3
 HG_U133A  202179_at  -0.06  5.64e-1  6.14e-1  -1.72  4.40e-28  7.18e-28
 HG_U133_Plus2  202179_at  0.05  6.03e-1  6.81e-1  1.04  4.29e-18  4.79e-17
 Stanford  3811  0.55  9.87e-2  2.46e-1  1.12  2.26e-3  2.44e-2
 Agilent_HS_21.6K  11076  -0.18  2.18e-2  8.10e-2  0.09  4.19e-1  5.78e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  202179_at  0.57  1.59e-1  8.13e-1  0.11  6.66e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 37700_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 394_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 202179_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 202179_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 3811    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 11076    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
bleomycin hydrolase tumor It has been postulated that bleomycin hydrolase, a protease encoded by the BLH1 gene in humans, may account for tumor resistance to bleomycin. 12555812 Human
bleomycin hydrolase tumor Although its conserved cellular function is as yet unknown, human bleomycin hydrolase (hBH) has clinical significance in that it is thought to be the major cause of tumor cell resistance to bleomycin chemotherapy. 10404591 Human
bleomycin hydrolase tumors Bleomycin hydrolase (BH) is the only known eukaryotic enzyme that inactivates the widely used antineoplastic agent bleomycin (BLM) and is a primary candidate gene for protection against lethal BLM-induced pulmonary fibrosis and for BLM resistance in tumor 9331073 Human
bleomycin hydrolase neurofibromatosis type 1 Chromosomal localization of the human bleomycin hydrolase gene revealed that it maps to chromosome 17q11.2, very close to the locus of the neurofibromatosis type 1 gene. 9407121 Human
bleomycin hydrolase breast tumors Finally, Southern blot analysis of DNA from leukocytes and autologous breast tumors has shown that the bleomycin hydrolase gene is not a frequent target of amplification in human breast carcinomas. 9407121 Human
bleomycin hydrolase human breast carcinomas Finally, Southern blot analysis of DNA from leukocytes and autologous breast tumors has shown that the bleomycin hydrolase gene is not a frequent target of amplification in human breast carcinomas. 9407121 Human
bleomycin hydrolase human tumors Preliminary expression analysis of bleomycin hydrolase in different human tumors showed increased expression of the enzyme in a series of head and neck carcinomas when compared with paired adjacent normal mucosa. 8620487 Human
bleomycin hydrolase head and neck carcinomas Preliminary expression analysis of bleomycin hydrolase in different human tumors showed increased expression of the enzyme in a series of head and neck carcinomas when compared with paired adjacent normal mucosa. 8620487 Human
bleomycin hydrolase burkitt's lymphomas We also observed a variable degree of bleomycin hydrolase expression in different types of lymphoma, with low or undetectable levels in Hodgkin's disease samples and higher levels in Burkitt's lymphomas. 8620487 Human
bleomycin hydrolase tumor These results are consistent with a proposed role for human bleomycin hydrolase in resistance of some tumor to bleomycin chemotherapy. 8620487 Human
bleomycin hydrolase tumor The bleomycin-inactivating enzyme, bleomycin hydrolase, is believed to be involved in tumor resistance to the anticancer drug bleomycin. 8718865 Human
bleomycin hydrolase tumour Bleomycin hydrolase activity is low in lungs and skin, the two major sites of normal tissue toxicities, and levels of this enzyme have been elevated in some but not all tumour cell lines selected for resistance to bleomycin. 2439200 Human
bleomycin hydrolase ehrlich ascites carcinoma Potentiation of the cytotoxicity of peplomycin against Ehrlich ascites carcinoma by bleomycin hydrolase inhibitors. 2448282 Human
bleomycin hydrolase human tumors Bleomycin hydrolase activity and cytotoxicity in human tumors. 6179595 Human
bleomycin hydrolase germ-cell cancer Genetic variation in the bleomycin hydrolase gene and bleomycin-induced pulmonary toxicity in germ cell cancer patients. 15900213 Human
bleomycin-hydrolase cervical squamous carcinoma These results suggested that cervical squamous carcinoma cells and ovarian myosarcoma cells were sensitive to PEP and Bleomycin-hydrolase activity was one of factors which decided the PEP sensitivity of human cultured tumor cells. 6209350 Human
bleomycin-hydrolase tumor These results suggested that cervical squamous carcinoma cells and ovarian myosarcoma cells were sensitive to PEP and Bleomycin-hydrolase activity was one of factors which decided the PEP sensitivity of human cultured tumor cells. 6209350 Human
bleomycin-hydrolase myosarcoma These results suggested that cervical squamous carcinoma cells and ovarian myosarcoma cells were sensitive to PEP and Bleomycin-hydrolase activity was one of factors which decided the PEP sensitivity of human cultured tumor cells. 6209350 Human
bleomycin hydrolase hodgkin's disease We also observed a variable degree of bleomycin hydrolase expression in different types of lymphoma, with low or undetectable levels in Hodgkin's disease samples and higher levels in Burkitt's lymphomas. 8620487 Human
bleomycin hydrolase germ cell cancer Genetic variation in the bleomycin hydrolase gene and bleomycin-induced pulmonary toxicity in germ cell cancer patients. 15900213 Human
bleomycin hydrolase lymphoma We also observed a variable degree of bleomycin hydrolase expression in different types of lymphoma, with low or undetectable levels in Hodgkin's disease samples and higher levels in Burkitt's lymphomas. 8620487 Human
bleomycin hydrolase oncogenes Several mechanisms have been suggested to contribute to chemoresistance: 1) amplification or overexpression of the P-glycoprotein family of membrane transporters (eg, MDR1, MRP, LRP) which decrease the intracellular accumulation of chemotherapy; 2) change 9090498 Human
bleomycin hydrolase tumour Bleomycin hydrolase (BH) is a hexameric papain family cysteine protease which is involved in preparing peptides for antigen presentation and has been implicated in tumour cell resistance to bleomycin chemotherapy. 17007609 Human
bleomycin hydrolase germ-cell cancer A plausible candidate is the gene for bleomycin hydrolase (BLMH), an enzyme that inactivates bleomycin, an essential component of chemotherapy regimens for disseminated testicular germ-cell cancer (TC). 18398146 Human
blmh germ-cell cancer A plausible candidate is the gene for bleomycin hydrolase (BLMH), an enzyme that inactivates bleomycin, an essential component of chemotherapy regimens for disseminated testicular germ-cell cancer (TC). 18398146 Human
bleomycin hydrolase testicular germ cell cancer Variation in bleomycin hydrolase gene is associated with reduced survival after chemotherapy for testicular germ cell cancer. 18398146 Human

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