IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene CPD Ensembl ENSG00000108582 Chromosome 17 Start 25730110 End 25819825
Description Carboxypeptidase D Precursor (EC 3.4.17.22)(Metallocarboxypeptidase D)(gp180) [Source:UniProtKB/Swiss-Prot;Acc:O75976]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 2301
     Entrez Gene : 1362
     UCSC : uc002hfb.1
     GeneCards : 2301
     RefSeq : NM_001304
     CCDS : CCDS11257.1
     Uniprot : O75976
     Interpro : O75976
     OMIM : 603102
     GeneTests : CPD
     CGAP : CPD
     PMID : 9628828

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  34876_at  0.62  3.11e-4  1.12e-3  0.09  4.72e-1  5.76e-1
 HG_U133A  201940_at  0.67  8.59e-8  2.47e-7  2.75  1.09e-86  5.22e-86
 HG_U133A  201941_at  0.72  1.08e-10  4.11e-10  1.52  2.62e-68  8.22e-68
 HG_U133A  201942_s_at  1.92  1.36e-24  1.48e-23  1.95  1.82e-28  3.00e-28
 HG_U133A  201943_s_at  1.02  6.64e-14  3.30e-13  -3.82  1.56e-125  2.22e-124
 HG_U133_Plus2  201940_at  0.69  6.62e-8  3.60e-7  0.04  6.54e-1  7.03e-1
 HG_U133_Plus2  201941_at  0.69  9.71e-8  5.16e-7  -0.36  2.82e-4  5.90e-4
 HG_U133_Plus2  201942_s_at  1.21  2.69e-10  2.02e-9  0.10  5.47e-1  6.04e-1
 HG_U133_Plus2  201943_s_at  1.10  1.44e-14  1.85e-13  0.36  1.67e-3  3.10e-3
 HG_U133_Plus2  229600_s_at  0.53  1.66e-2  3.20e-2  0.54  3.23e-2  4.79e-2
 Stanford  2015  0.41  2.05e-1  3.96e-1  -0.21  4.92e-1  7.09e-1
 Stanford  3041  0.91  2.03e-2  1.02e-1  0.35  2.42e-1  4.77e-1
 Agilent_HS_21.6K  10881  0.17  1.42e-1  2.98e-1  0.07  3.22e-1  4.81e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  201940_at  -0.36  4.34e-1  9.12e-1  -0.12  7.15e-1  1.00e+0
 HG_U133A  201941_at  -0.18  6.65e-1  9.63e-1  -0.17  4.15e-1  1.00e+0
 HG_U133A  201942_s_at  -0.78  3.46e-1  8.87e-1  -0.90  8.27e-2  1.00e+0
 HG_U133A  201943_s_at  -0.23  6.45e-1  9.60e-1  -0.53  1.92e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 34876_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 201940_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 201941_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 201942_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 201943_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 201940_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 201941_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 201942_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 201943_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 229600_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 2015    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 3041    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 10881    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
cpd pituitary adenomas This study evaluated the expression patterns of CPE, CPD, and CPZ immunoreactivity in 48 pituitary adenomas. 12417617 Human
cpd adenomas Our immunohistochemistry demonstrated extensive intracytoplasmic immunoreactivity for CPE, CPD, and CPZ in adrenocorticotrophic hormone (ACTH)-producing adrenocorticotroph cells, prolactin-producing lactotroph cells, and growth hormone (GH)-producing soma 12417617 Human
cpd adenomas In contrast to the restricted expression in the normal adenohypophysis, CPD appeared to be widespread in the majority of adenomas, suggesting that CPD levels are increased in adenomas. 12417617 Human
cpd tumors In null-cell adenomas, CPE immunoreactivity was detected in the majority of tumors, but CPD and CPZ were identified only in a minority of cases. 12417617 Human
cpd adenomas In null-cell adenomas, CPE immunoreactivity was detected in the majority of tumors, but CPD and CPZ were identified only in a minority of cases. 12417617 Human
cpd human hepatoma Luciferase reporter assays with various size constructs containing the promoter region upstream of the start sites showed that it was active in three different cell lines, especially in the human hepatoma cell line HepG2 and the human monocytic cell line 12489804 Human
carboxypeptidase d lymphoma A full-length, PRL-inducible complementary DNA (cDNA) encoding a novel, nuclear-targeted carboxypeptidase D isoform (designated CPD-N) was identified in the rat PRL-dependent Nb2-11C and PRL-independent Nb2-Sp lymphoma cell lines by differential display. 11181555 Rat
cpd breast cancer Indeed, CPD expression in the PRL-responsive HepG2 hepatoma and MCF-7 breast cancer cell lines was low in control cells but was markedly stimulated by PRL after 3 h. 11181555 Human
cpd hepatoma Indeed, CPD expression in the PRL-responsive HepG2 hepatoma and MCF-7 breast cancer cell lines was low in control cells but was markedly stimulated by PRL after 3 h. 11181555 Human
cpd melanoma Northern blotting of mRNA from human tissues and cells showed high levels of CPD mRNA in placenta, pancreas and Hep G2 hepatoma cells, and smaller amounts in skeletal muscle, heart and HT-29 colon carcinoma and melanoma cell lines. 9355738 Human
cpd hepatoma Northern blotting of mRNA from human tissues and cells showed high levels of CPD mRNA in placenta, pancreas and Hep G2 hepatoma cells, and smaller amounts in skeletal muscle, heart and HT-29 colon carcinoma and melanoma cell lines. 9355738 Human
cpd colon carcinoma Northern blotting of mRNA from human tissues and cells showed high levels of CPD mRNA in placenta, pancreas and Hep G2 hepatoma cells, and smaller amounts in skeletal muscle, heart and HT-29 colon carcinoma and melanoma cell lines. 9355738 Human
cpd myeloma Several haematopoietic cell lines including human K562 myeloma, Jurkat T-lymphoma and murine CTLL-2 cytotoxic T-cells express a 160 kDa CPD-immunoreactive protein, whereas mEL4 T-lymphoma cells express the 180 kDa CPD. 15918796 Human
cpd breast cancer In contrast, MCF-7 breast cancer cells express only the 180 kDa CPD, which is mainly in the TGN. 15918796 Human

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