IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene EVI2A Ensembl ENSG00000126860 Chromosome 17 Start 26668802 End 26672843
Description Protein EVI2A Precursor (Ecotropic viral integration site 2A protein homolog)(EVI-2A) [Source:UniProtKB/Swiss-Prot;Acc:P22794]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 3499
     Entrez Gene : 2123
     UCSC : uc002hgm.2
     GeneCards : 3499
     RefSeq : NM_001003927
     CCDS : CCDS32608.1
     Uniprot : P22794
     Interpro : P22794
     OMIM : 158380
     GeneTests : EVI2A
     CGAP : EVI2A
     PMID : 2117566

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  204774_at  -0.50  4.71e-8  1.39e-7  -0.70  2.82e-16  3.89e-16
 HG_U133_Plus2  204774_at  -0.80  1.80e-9  1.21e-8  -1.60  3.55e-14  2.53e-13
 Stanford  12590  -0.96  1.02e-2  6.54e-2  -1.46  6.65e-3  5.21e-2
 Stanford  15192  -1.06  5.43e-3  4.29e-2  -1.62  4.09e-3  3.72e-2
 Agilent_HS_21.6K  15481  0.17  3.98e-2  1.23e-1  0.11  2.12e-1  3.58e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  204774_at  0.07  8.09e-1  9.83e-1  -0.19  3.66e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U133A - 204774_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 204774_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 12590    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 15192    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 15481    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
evi2a neurofibroma Since patients with the NF1 large-deletion syndrome have a significantly increased risk of neurofibroma development and mental retardation, hemizygosity for genes from the deleted region around the neurofibromin locus (CYTOR4, FLJ12735, FLJ22729, HSA27219 11468690 Human
evi-2 tumors A common site of ecotropic murine leukemia virus integration designated Evi-2 (ecotropic viral integration site-2) has been identified in BXH-2 myeloid tumors. 2851124 Mouse
evi-2 murine leukemia A common site of ecotropic murine leukemia virus integration designated Evi-2 (ecotropic viral integration site-2) has been identified in BXH-2 myeloid tumors. 2851124 Mouse
evi-2 myeloid leukemia Retroviral integration at the Evi-2 locus in BXH-2 myeloid leukemia cell lines disrupts Nf1 expression without changes in steady-state Ras-GTP levels. 7609078 Mouse
evi-2 myeloid leukemias Approximately 15% of BXH-2 myeloid leukemias harbor proviral integrations at the Evi-2 common viral integration site. 7609078 Mouse
evi-2 tumor Evi-2 is located within a large intron of the Nf1 tumor suppressor gene, raising the possibility that proviral integration at Evi-2 predisposes mice to myeloid tumor development by disrupting Nf1 expression. 7609078 Mouse
evi-2 tumor Evi-2, a common site of viral integration in BXH-2 myeloid lymphomas, is located within a large intron of the Nf1 tumor suppressor gene. 7474134 Human
evi-2 lymphomas Evi-2, a common site of viral integration in BXH-2 myeloid lymphomas, is located within a large intron of the Nf1 tumor suppressor gene. 7474134 Mouse
evi2a neurofibromatosis We have examined two closely related genes present in the first intron of the neurofibromatosis type I gene--the oligodendrocyte myelin glycoprotein (OMGP) gene and the ecotropic viral integration 2A (EVI2A) gene--in 36 patients with multiple sclerosis (M 7477728 Human
evi-2 von recklinghausen neurofibromatosis The human homolog of murine Evi-2 lies between two von Recklinghausen neurofibromatosis translocations. 2117565 Mouse
evi-2 tumors As part of our exploration of this region, we have mapped the human homolog of a murine gene (Evi-2) implicated in myeloid tumors to a location between the two translocation breakpoints on chromosome 17. 2117565 Mouse
evi2 neurofibromatosis 1 Identification and characterization of transcripts from the neurofibromatosis 1 region: the sequence and genomic structure of EVI2 and mapping of other transcripts. 2117566 Human
evi2 neurofibromatosis type 1 Mapping of the EVI2 gene between the translocation breakpoints of two patients with neurofibromatosis type 1 (NF1), combined with the likely role of its murine homolog in neoplastic disease, implicates EVI2 as a possible candidate for the NF1 gene. 2117566 Human
evi-2 myeloid leukemias Here we report on the characterization of a novel common viral integration site in BXH-2 myeloid leukemias, designated Evi-2. 2167436 Mouse
evi-2 von recklinghausen neurofibromatosis Interestingly, the human homolog of Evi-2 has recently been shown to be tightly linked to the von Recklinghausen neurofibromatosis locus, suggesting a role for Evi-2 in human disease as well. 2167436 Human
evi-2 tumors Fli-1, p53, and Evi-1 were found to be rearranged in 72%, 23%, and 18% of the tumors, respectively, whereas no DNA alteration were detected for c-myc, c-myb, Pim-1, Evi-2, and EpoR genes. 8391616 Mouse
evi-2a tumors Two translocation breakpoints that interrupt the NF1 gene in NF1 patients flank a 60-kb segment of DNA that contains the EV12A locus (previously reported as the EV12 locus), the human homolog of a mouse gene, Evi-2A, implicated in retrovirus-induced murin 1903357 Mouse
evi-2a tumors In the mouse the 5' exon of the homologous gene, Evi-2B, lies approximately 2.8 kb from the 3' end of Evi-2A, in the midst of a cluster of viral integration sites identified in retrovirus-induced myeloid tumors; thus, Evi-2B may function as an o 1903357 Mouse
evi-2 tumors We have mapped the human homologue of a murine gene (Evi-2) that is implicated in myeloid tumors, to a location between two NF1 translocation breakpoints on chromosome 17. 1903909 Mouse
evi-2 myeloid tumors A common site of ecotropic murine leukemia virus integration designated Evi-2 (ecotropic viral integration site-2) has been identified in BXH-2 myeloid tumors. 2851124 Mouse
evi-2 myeloid tumors As part of our exploration of this region, we have mapped the human homolog of a murine gene (Evi-2) implicated in myeloid tumors to a location between the two translocation breakpoints on chromosome 17. 2117565 Mouse
evi-2 myeloid tumors We have mapped the human homologue of a murine gene (Evi-2) that is implicated in myeloid tumors, to a location between two NF1 translocation breakpoints on chromosome 17. 1903909 Mouse
evi-2 myeloid tumor Evi-2 is located within a large intron of the Nf1 tumor suppressor gene, raising the possibility that proviral integration at Evi-2 predisposes mice to myeloid tumor development by disrupting Nf1 expression. 7609078 Mouse
evi-2a myeloid tumors Two translocation breakpoints that interrupt the NF1 gene in NF1 patients flank a 60-kb segment of DNA that contains the EV12A locus (previously reported as the EV12 locus), the human homolog of a mouse gene, Evi-2A, implicated in retrovirus-induced murin 1903357 Mouse
evi-2a myeloid tumors In the mouse the 5' exon of the homologous gene, Evi-2B, lies approximately 2.8 kb from the 3' end of Evi-2A, in the midst of a cluster of viral integration sites identified in retrovirus-induced myeloid tumors; thus, Evi-2B may function as an o 1903357 Human

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