IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene SUZ12 Ensembl ENSG00000178691 Chromosome 17 Start 27288185 End 27352162
Description Polycomb protein SUZ12 (Suppressor of zeste 12 protein homolog)(Joined to JAZF1 protein)(Chromatin precipitated E2F target 9 protein)(ChET 9 protein) [Source:UniProtKB/Swiss-Prot;Acc:Q15022]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 17101
     Entrez Gene : 23512
     UCSC : uc002hgs.2
     GeneCards : 17101
     RefSeq : NM_015355
     CCDS : CCDS11270.1
     Uniprot : Q15022
     Interpro : Q15022
     OMIM : 606245
     GeneTests : SUZ12
     CGAP : SUZ12
     PMID : 8590280

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  40957_at  0.24  4.33e-2  8.18e-2  0.49  3.85e-4  1.33e-3
 HG_U133A  212287_at  -0.01  8.67e-1  8.88e-1  -0.14  1.43e-2  1.55e-2
 HG_U133_Plus2  1566190_at  0.33  1.77e-2  3.38e-2  0.40  1.47e-2  2.33e-2
 HG_U133_Plus2  1566191_at  0.32  1.85e-1  2.59e-1  -0.28  2.48e-1  3.04e-1
 HG_U133_Plus2  212287_at  0.17  3.10e-3  7.21e-3  0.27  3.40e-4  7.03e-4

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  212287_at  -0.10  7.08e-1  9.69e-1  0.14  5.52e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 40957_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 212287_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 1566190_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 1566191_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 212287_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
jjaz1 endometrial stromal tumors Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors. 11371647 Human
jjaz1 endometrial stromal tumors Analyses of tumor RNA indicate that a JAZF1/JJAZ1 fusion is present in all types of endometrial stromal tumors; however, the fusion appears to be rarer among endometrial stromal sarcomas that would be considered high-grade according to certain classificat 11371647 Human
jjaz1 endometrial stromal sarcomas Analyses of tumor RNA indicate that a JAZF1/JJAZ1 fusion is present in all types of endometrial stromal tumors; however, the fusion appears to be rarer among endometrial stromal sarcomas that would be considered high-grade according to certain classificat 11371647 Human
jjaz1 tumor Analyses of tumor RNA indicate that a JAZF1/JJAZ1 fusion is present in all types of endometrial stromal tumors; however, the fusion appears to be rarer among endometrial stromal sarcomas that would be considered high-grade according to certain classificat 11371647 Human
jjaz1 endometrial stromal tumors Endometrial stromal tumors (ESTs), including low-grade endometrial stromal sarcomas (LGESSs) and endometrial stromal nodules (ESNs) of classic histology, exhibit characteristic morphologic features and contain the nonrandom t(7;17)(p15; q21), which result 15043312 Human
jjaz1 low-grade endometrial stromal sarcomas Endometrial stromal tumors (ESTs), including low-grade endometrial stromal sarcomas (LGESSs) and endometrial stromal nodules (ESNs) of classic histology, exhibit characteristic morphologic features and contain the nonrandom t(7;17)(p15; q21), which result 15043312 Human
jjaz1 endometrial stromal nodules Endometrial stromal tumors (ESTs), including low-grade endometrial stromal sarcomas (LGESSs) and endometrial stromal nodules (ESNs) of classic histology, exhibit characteristic morphologic features and contain the nonrandom t(7;17)(p15; q21), which result 15043312 Human
kiaa0160 neurofibroma Since patients with the NF1 large-deletion syndrome have a significantly increased risk of neurofibroma development and mental retardation, hemizygosity for genes from the deleted region around the neurofibromin locus (CYTOR4, FLJ12735, FLJ22729, HSA27219 11468690 Human
jjaz1 endometrial stromal sarcoma Cytogenetic and molecular genetic analyses of endometrial stromal sarcoma: nonrandom involvement of chromosome arms 6p and 7p and confirmation of JAZF1/JJAZ1 gene fusion in t(7;17). 12850374 Human
jjaz1 tumor The most characteristic translocation of this tumor type, t(7;17)(p15 approximately p21;q12 approximately q21), was recently shown to generate a JAZF1/JJAZ1 fusion gene. 12850374 Human
jjaz1 neurofibromatosis type 1 High frequency of mosaicism among patients with neurofibromatosis type 1 (NF1) with microdeletions caused by somatic recombination of the JJAZ1 gene. 15257518 Human
jjaz1 tumors Recently, a gene fusion on chromosome 7 that includes two zinc-finger genes (JAZF1 and JJAZ1) has been discovered in these tumors. 16049311 Human
jjaz1 endometrial stromal tumors In comparison to published data, our results identified the JAZF1/JJAZ1 gene fusion more frequently in endometrial stromal tumors than hitherto presumed. 16049311 Human
suz12 colon cancer Using oligonucleotide arrays, we first identified a cohort of genes whose expression changes upon siRNA-mediated removal of Suz12, a core component of PRC2/3, from colon cancer cells. 15231737 Human

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