IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene CDK5R1 Ensembl ENSG00000176749 Chromosome 17 Start 27838214 End 27842383
Description Cyclin-dependent kinase 5 activator 1 Precursor (CDK5 activator 1)(Cyclin-dependent kinase 5 regulatory subunit 1)(Tau protein kinase II 23 kDa subunit)(p23)(TPKII regulatory subunit) [Contains Cyclin-dependent kinase 5 activator 1, p35(p35);Cyclin-dependent kinase 5 activator 1, p25(p25)] [Source:UniProtKB/Swiss-Prot;Acc:Q15078]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 1775
     Entrez Gene : 8851
     UCSC : uc002hhn.2
     GeneCards : 1775
     RefSeq : NM_003885
     CCDS : CCDS11273.1
     Uniprot : Q15078
     Interpro : Q15078
     OMIM : 603460
     GeneTests : CDK5R1
     CGAP : CDK5R1
     PMID : 8090221

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  36273_at  0.12  4.32e-1  5.39e-1  0.33  1.45e-1  2.24e-1
 HG_U95  799_at  0.16  1.19e-2  2.72e-2  0.21  1.94e-2  4.08e-2
 HG_U95  800_g_at  0.06  7.36e-1  8.07e-1  0.34  1.27e-1  2.00e-1
 HG_U133A  204995_at  0.84  5.28e-9  1.72e-8  5.44  1.46e-54  3.59e-54
 HG_U133A  204996_s_at  -0.06  6.31e-1  6.76e-1  0.44  5.50e-2  5.85e-2
 HG_U133_Plus2  204995_at  1.34  8.78e-17  1.46e-15  2.56  2.07e-29  8.78e-28
 HG_U133_Plus2  204996_s_at  0.04  7.70e-1  8.23e-1  0.39  3.66e-2  5.37e-2
 Stanford  20692  -0.39  3.91e-1  5.88e-1  -1.47  4.68e-3  4.07e-2
 Agilent_HS_21.6K  19969  0.06  5.90e-2  1.63e-1  0.07  3.11e-2  8.63e-2

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  204995_at  0.81  2.51e-1  8.53e-1  -0.24  5.72e-1  1.00e+0
 HG_U133A  204996_s_at  0.14  7.64e-1  9.75e-1  -0.20  4.34e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 36273_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 799_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 800_g_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 204995_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 204996_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 204995_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 204996_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 20692    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 19969    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
p35 marginal-zone lymphomas Finally, malignant B-cells from follicular and marginal zone lymphomas expressed IL-12 p35 and p40 transcripts, whereas only p35 mRNA was detected in mantle cell lymphoma. 11940489 Human
p35 mantle-cell lymphoma Finally, malignant B-cells from follicular and marginal zone lymphomas expressed IL-12 p35 and p40 transcripts, whereas only p35 mRNA was detected in mantle cell lymphoma. 11940489 Human
p23 tumor The mRNA of the translationally controlled tumor protein P23/TCTP is a highly structured RNA, which activates the dsRNA-dependent protein kinase PKR. 11991642 Human
p23 tumor Two out of five cDNA clones we obtained contained sequences derived from the mRNA of the translationally controlled tumor protein P23/TCTP, indicating that this mRNA is present in the dsRNA-rich fraction. 11991642 Human
p25 tumours RESULTS: We found significant differences (p < 0.0001) between the median (P25, P75) size of tumours in the benign group 2.0 (1.2, 3.5) and in the potentially 7.5 (4.0, 13.0) and definitely 5.0 (4.0,6.5) malignant groups. 12375611 Human
p23 prostate cancer The 8p22 through p23 region has been identified as a potential site for genes associated with prostate cancer. 12377406 Human
p23 esophageal tumors The gene LZTS1 has been mapped to the 8p22 through p23 region and identified as a potential tumor suppressor based on loss of heterozygosity studies using primary esophageal tumors. 12377406 Human
p23 tumor The gene LZTS1 has been mapped to the 8p22 through p23 region and identified as a potential tumor suppressor based on loss of heterozygosity studies using primary esophageal tumors. 12377406 Human
p35 tumor These findings demonstrate that antiapoptotic factors, such as p35, can be used in a novel manner to enhance prodrug activation gene therapy by delaying tumor cell death, thereby increasing the net production of bystander cytotoxic metabolites and, hence, 12460909 Human
p35 astrocytoma Here we demonstrate that both Cdk5 and p35 are expressed in the human astrocytoma cell line, U373. 11228158 Human
p35 human tumors Because human tumors of glial origin can express neuronal proteins, we examined whether Cdk5 and its activator protein, P35, are present in early passage human glioblastoma multiforme (GBM) cells lines and primary tumor specimens. 11296485 Human
p35 glioblastoma multiforme Because human tumors of glial origin can express neuronal proteins, we examined whether Cdk5 and its activator protein, P35, are present in early passage human glioblastoma multiforme (GBM) cells lines and primary tumor specimens. 11296485 Human
p35 tumors In contrast, IL-12 p35 and IL-12 p40 were only rarely expressed in regressing Burkitt tumors. 11358987 Human
p25 breast cancer Attachment assays performed in the presence of a synthetic peptide (p25), which interferes with the formation of uPAR-integrin complexes, reveal that uPAR is able to regulate the adhesive function of integrins in breast cancer cells. 11549590 Human
p25 tumor On dissociation of the uPAR-integrin complexes by p25, tumor cell attachment to the extracellular matrix was either decreased (vitronectin) or increased (fibronectin). 11549590 Human
p25 tumor Moreover, the tumor cells display remarkable morphological changes when cultured on fibronectin in the continuous presence of p25, leading to increased cell spreading and attachment. 11549590 Human
p25 tumor Stably transfected MDA-MB-231 cells that overexpress p25 showed a significant reduction in tumor progression in bone (P < or = 0.0001 versus mock-control). 11549590 Human
p25 tumor In line with these observations, continuous administration of p25 (25 microg/mouse/day, osmotic minipumps) for 28 days resulted in significantly reduced tumor progression of MDA-MB-231 cells in bone (P < or = 0.005) when compared to scrambled control pept 11549590 Mouse
p35 squamous-cell carcinoma p35 protein as a prognostic factor of squamous cell carcinoma of the oesophagus. 11977366 Human
p25 prostate cancer RESULTS: A BPH-associated protein, designated P25/26, was identified that showed a strong sequence similarity with superimmunoglobulin family members, overexpressed in BPH, with lower expression observed in both normal and prostate cancer tissues. 10639194 Human
p35 b16 melanoma To investigate the mechanism of the antitumor effect of locally secreted interleukin-12 (IL-12), we introduced the IL-12 p35 and p40 cDNAs into mouse B16 melanoma cells. 10754989 Human
p35 cancer We constructed an rAAV vector expressing interleukin-12 (IL-12) for cancer immunotherapy studies in a mouse model by inserting murine IL-12 (mIL-12) p35 and p40 cDNAs into the plasmid pRep4 and inserting the encephalomyocarditis virus internal ribosomal e 10770641 Human
p25 cancer Rakowicz) p120, p42, and p25, as well as HIV-1-like segments of cancer DNA (RAK gene alpha), have been found before in breast and prostate cancers. 10799446 Human
p25 prostate cancers Rakowicz) p120, p42, and p25, as well as HIV-1-like segments of cancer DNA (RAK gene alpha), have been found before in breast and prostate cancers. 10799446 Human
p25 cancer RAK antigens p120, p42, and p25 were found in 95% of ovarian, uterine, and cervical cancer cases and in 75% of vulvar cancer cases. 10799446 Human
p25 cervical cancer RAK antigens p120, p42, and p25 were found in 95% of ovarian, uterine, and cervical cancer cases and in 75% of vulvar cancer cases. 10799446 Human
p25 prostate cancer RAK antigens p120, p42, and p25 exhibit molecular and immunological similarity to the proteins encoded by HIV-1 and are expressed by 95% of breast and gynecological cancer cases in women and prostate cancer cases in men. 10891290 Human
p25 gynecological cancer RAK antigens p120, p42, and p25 exhibit molecular and immunological similarity to the proteins encoded by HIV-1 and are expressed by 95% of breast and gynecological cancer cases in women and prostate cancer cases in men. 10891290 Human
p23 lipoblastoma We report a case of lipoblastoma in a 6-month-old girl with a new chromosomal aberration, 46, XX, der (2) add (2) (p23) del (2) (q33), add (8) (q1?). 10982693 Human
p23 tumor A cnidarian homologue of translationally controlled tumor protein (P23/TCTP). 11180799 Human
p23 tumor A protein homologous to P23, or translationally controlled tumor protein (TCTP), was cloned in Hydra vulgaris, the most ancient type of metazoan from which P23/TCTP has been characterized to date. 11180799 Human
p35 b-cell lymphoma To investigate the mechanisms underlying the regulation of the p35 gene, we characterized murine p35 expression in the B cell lymphoma line A20 and in bone marrow-derived dendritic cells. 10201930 Mouse
p23 breast cancer Finally, ectopic expression of human p23 in MCF-7 breast cancer cells increases both hormone-dependent and hormone-independent transcriptional activation by the ER. 10207098 Human
p25 adult t-cell leukemia A B-cell line having translocations of chromosome 14 at break band q11 (the assigned locus of the alpha-chain gene of the T-cell antigen receptor) and chromosome 3 at break band p25 (the assigned locus of the c-raf-1 oncogene) was established from periphe 2895757 Human
p25 t-cell leukemia The same chromosome 14 aberration at break band q11 and chromosome 3 aberration at break band p25 were also found in fresh T-cell leukemia cells. 2895757 Human
p25 ehrlich ascites tumor Purification of the growth-related protein p25 of the Ehrlich ascites tumor and analysis of its isoforms. 3190723 Human
p25 ehrlich ascites tumor 1. Two of the three isoforms of the growth-related protein p25 of the Ehrlich ascites tumor have been purified to homogeneity by giant two-dimensional polyacrylamide gel electrophoresis. 3190723 Human
p35 murine neuroblastoma We achieved this in a poorly immunogenic murine neuroblastoma model by gene therapy with a single chain interleukin 12 (scIL-12) fusion protein that assures equal expression of its p35 and p40 subunits. 9482910 Human
p35 liver metastases Thus, NXS2 hybrid neuroblastoma cells (C1300 x dorsal root ganglion cells), which form experimental bone marrow and liver metastases in syngeneic A/J mice, were transduced with a gene encoding murine interleukin 12, monomerized by introduction of a protei 9482910 Human
p35 tumor Simultaneous infection of primary tumor cells with up to three rAAV vectors containing genes encoding the immunostimulatory proteins B7-2 (CD86), p35 subunit of IL-12, and p40 subunit of IL-12 resulted in high expression of B7-2 in more than 90% of the tu 9607416 Human
p35 melanoma We inserted the genes coding for the p35 and p40 chain of interleukin-12 (IL-12) in two independent eukaryotic expression vectors and transduced melanoma cells of 15 different primary tumor cultures with both plasmids by a ballistic gene transfer approach 9614572 Human
p23 tumors These data provide first evidence for a hypoxia-induced upregulation of the mammalian growth-related protein p23, which might be relevant for understanding of the physiology of hypoxic conditions in tumors. 9666514 Human
p25 cancer Upon deprivation, these cancer cells up-regulated P21 and Bcl-2 and/or BclX(L), lost response to withdrawal-induced up-regulation of Bax/Bad/Bak or decreased or even completely lost Bax expression and expressed some novel proteins such as P25 and P54/55 c 9699682 Human
p23 tumor On the basis of comigration with proteins in published 2-D gel electrophoresis databases and immunoblotting with a specific monoclonal antibody, we identified this protein as translationally controlled tumor protein (TCTP), also known as p23 or IgE-depend 9700033 Human
p25 prostate cancer RAK antigens p120, p42, and p25 exhibit molecular and immunological similarity to the proteins encoded by human immunodeficiency virus type 1 (HIV-1) and are expressed by 95% of breast and gynecological cancer cases in women and prostate cancer cases in m 9729531 Human
p25 gynecological cancer RAK antigens p120, p42, and p25 exhibit molecular and immunological similarity to the proteins encoded by human immunodeficiency virus type 1 (HIV-1) and are expressed by 95% of breast and gynecological cancer cases in women and prostate cancer cases in m 9729531 Human
p23 tumor Structure of the promoter and complete sequence of the gene coding for the rabbit translationally controlled tumor protein (TCTP) P23. 9799103 Human
p23 tumor We have isolated genomic recombinants containing the complete gene coding for the rabbit translationally controlled tumor protein (TCTP), also known as histamine-releasing factor (HRF) P23. 9799103 Human
p25 breast cancer Eighty-five percent of histologically normal breast tissue samples, isolated either from breast cancer patients or patients with advanced fibrocystic disease, tested RAK-negative, with the exception of low expression of p25, observed in some patients. 9029174 Human
p35 human tumor Cloning of human IL-12 p40 and p35 DNA into the Semliki Forest virus vector: expression of IL-12 in human tumor cells. 9176524 Human
p23 anaplastic large-cell lymphoma Molecular characterization of the t(2;5) (p23; q35) translocation in anaplastic large cell lymphoma (Ki-1) and Hodgkin's disease. 8562933 Human
p35 tumors Profiles of cytokine expression differed between progressive and regressive Burkitt's tumors in that regressive tumors expressed larger levels of TNF-alpha, IL-6, IFN-gamma, IP-10, Mig, and IL-12 p35, but not other chemokines/cytokines. 8958926 Human
p35 bladder cancer Detection of the p35 and p40 subunits of interleukin-12 in melanoma and bladder cancer cell lines. 8958962 Human
p23 large-cell anaplastic lymphoma Some patients with large-cell anaplastic lymphoma (Ki 1 lymphoma) have the translocation t(2;5) (p23; q35), involving a possible growth-regulating tyrosine kinase. 7815887 Human
p23 ki-1 lymphoma Some patients with large-cell anaplastic lymphoma (Ki 1 lymphoma) have the translocation t(2;5) (p23; q35), involving a possible growth-regulating tyrosine kinase. 7815887 Human
p35 human neuroblastoma Up-regulation of cDK5/p35 by oxidative stress in human neuroblastoma IMR-32 cells. 12577309 Human
p23 carcinoma We describe a 23-kDa cell surface protein (p23) which is specifically associated with CD40 on B cells and on urinary bladder transitional carcinoma cells. 8524818 Human
p35 ewing sarcoma Whereas the levels of association of p35, p37Cyclin H, and p75 with CDK7 remain unchanged between density-arrested and proliferating Ewing sarcoma EW-1 cells, the association of p95 with CDK7 was significantly decreased as cells reached confluency. 8521393 Human
p35 hairy-cell leukemia Identification of hairy cell leukemia subset defining p35 as the human homologue of Ii. 6583461 Human
p35 hairy-cell leukemia Demonstration of p35 in hairy cell leukemia of Japanese patients. 6584195 Human
p35 hairy-cell leukemia Using SDS polyacrylamide gel electrophoresis (SDS-PAGE), several coworkers isolated a unique membrane protein that they named p35 from hairy cells of white patients with hairy cell leukemia. 6584195 Human
p35 hairy-cell leukemia In the current study using a similar technique, p35 was identified in hairy cells from 2 of 4 Japanese patients with hairy cell leukemia. 6584195 Human
p35 hairy-cell leukemia The abundant expression of Ii on butyrate-treated P3HR-1 cells mimicked the high level of expression of p35 or Ii on leukemic cells of a subset of patients with hairy cell leukemia. 6434395 Human
p35 hairy-cell leukemia Spiro and coworkers found a 35000 dalton membrane protein (p35) expressed abundantly in hairy cells of a subset of white, American patients with hairy cell leukemia. 6084635 Human
p35 hairy-cell leukemia Using related analytical techniques, we have studied leukemic cells of two blood and one splenic samples from three Japanese patients with hairy cell leukemia and have demonstrated abundance of p35 in the splenic and one of the blood samples. 6084635 Human
p35 burkitt's lymphoma Control cells from one each of acute lymphoblastic leukemia and Burkitt's lymphoma were negative for abundant p35 expression after culture as well as in the fresh state. 6084635 Human
p35 acute lymphoblastic leukemia Control cells from one each of acute lymphoblastic leukemia and Burkitt's lymphoma were negative for abundant p35 expression after culture as well as in the fresh state. 6084635 Human
p35 hairy-cell leukemia One can conclude that the Japanese form of hairy cell leukemia, while varying in several distinct clinical and laboratory features from hairy cell leukemia in caucasians, is characterized also by abundant expression of p35 as seen in a subset of white pat 6084635 Human
p25 ehrlich ascites tumor The expression of the growth-related 25kDa protein (p25) of Ehrlich ascites tumor cells is increased by hyperthermic treatment (heat shock). 2403339 Human
p25 tumor 4. The synthesis of p25 and its induction by hyperthermic treatment in EAT cells depends on the stage of tumor growth from which the cells were harvested. 2403339 Human
p25 tumor The results are discussed with respect to correlations between regulation of tumor growth and the abundance of p25, its synthesis and induction during tumor growth. 2403339 Human
p35 hepatic tumor It appears that 1,25-dihydroxyvitamin D3 regulates cellular p35 content (within a specific restricted range) as a consequence of proliferative perturbation, rather than differentiated status, of cultured hepatic tumor cells. 2917007 Human
p35 friend erythroleukemia Decreased content of the 35 kDa cytoskeletal protein p35 in Friend erythroleukemia cells exposed to dimethyl sulfoxide and retinoic acid is associated with entrance into a quiescent substrate. 2477289 Human
p35 friend erythroleukemia 1. The effect of all-trans-retinoic acid (RA) on cell cycle kinetics, RNA content, and expression of the 35 kDa cytoskeletal protein p35 in exponentially-growing Friend erythroleukemia (FL) cells was compared with the prototypic differentiation-inducer di 2477289 Human
p35 mastocytoma Immunogenic tumor cell variant P35 was obtained by mutagen treatment of mouse mastocytoma P815. 8423052 Mouse
p35 tumor Immunogenic tumor cell variant P35 was obtained by mutagen treatment of mouse mastocytoma P815. 8423052 Mouse
p23 t-cell leukemia All HTLV-I and simian T cell leukemia virus type I sera tested reacted with p23. 8486936 Human
p 35 cervical cancer Proteins that are specific for cervical cancer were a protein with a relative migration rate of 0.5, obtained by disc-electrophoresis, and a small protein, p 35, obtained by SDS-PAGE. 7505134 Human
p25 human neuroblastoma In this study, we investigated APP(Thr668) phosphorylation and APP processing mediated by p35/Cdk5 and p25/Cdk5 in the human neuroblastoma cell line SH-SY5Y. 12860412 Human
p35 human neuroblastoma In this study, we investigated APP(Thr668) phosphorylation and APP processing mediated by p35/Cdk5 and p25/Cdk5 in the human neuroblastoma cell line SH-SY5Y. 12860412 Human
p35 tumor Antigen-loss P35.iscA- clones were found to be more tumorigenic than variant P35 which has a greatly reduced tumorigenic capacity compared to the original P815 tumor. 6178608 Human
p25 oligodendroglioma TPPP/p25 in brain tumours: expression in non-neoplastic oligodendrocytes but not in oligodendroglioma cells. 17136548 Human
p25 brain tumours TPPP/p25 in brain tumours: expression in non-neoplastic oligodendrocytes but not in oligodendroglioma cells. 17136548 Human
neuronal cdk5 activator rb Here we report that neuronal Cdc2-like kinase (Nclk), composed of Cdk5 and a neuronal Cdk5 activator (p25(nck5a)), can bind and phosphorylate RB. 9038171 Human
p23 ehrlich ascites tumour Synthesis of the mammalian growth-related protein P23 is rapidly induced after serum stimulation of mouse fibroblasts and Ehrlich ascites tumour cells. 7787881 Mouse
p23 transitional carcinoma We describe a 23-kDa cell surface protein (p23) which is specifically associated with CD40 on B cells and on urinary bladder transitional carcinoma cells. 8524818 Human
p23 hepatomas In rat liver, P23 expression is developmentally regulated and modulated by dietary glucose, and its mRNA is induced by starvation, in the presence of fatty-acids and in 3-MeDAB-induced hepatomas. 15558217 Human
p25 hcl The expression of Ia auxiliary proteins, p41 and p25, was also enhanced in Jijoye cells by butyrate treatment and was prominent in HCL cells. 3856614 Human
p25 hcl The class II MHC-associated Ii chain was present in all three cell types, but the Ii-derived p25 protein was not found in HCL cells. 3264359 Human
p25 rb Remarkably, the overexpression of a transgene coding for human neurofilament H, a phosphorylation sink for deregulated Cdk5 activity by p25, resulted in a reduction in levels of nuclear Cdk4 and Rb phosphorylation. 12657672 Human
p25 prostate cancer Involvement of Cdk5/p25 in digoxin-triggered prostate cancer cell apoptosis. 15123618 Human
p25 prostate cancer Because cyclin-dependent kinase (Cdk)5 and p35 cleavage (p25 formation) have been reported to be targets of intracellular Ca(2+), and subsequently correlated to apoptosis, we not only demonstrated first that Cdk5, p35, and p25 proteins were all expressed 15123618 Human
p25 carcinoma of the prostate Because cyclin-dependent kinase (Cdk)5 and p35 cleavage (p25 formation) have been reported to be targets of intracellular Ca(2+), and subsequently correlated to apoptosis, we not only demonstrated first that Cdk5, p35, and p25 proteins were all expressed 15123618 Human
p25 prostate cancer These results suggest that Cdk5/p35 and p25 are novel players in digoxin-triggered prostate cancer cell apoptosis and, therefore, become potential therapeutic targets. 15123618 Human
p35 hcl The newly established cell lines, but not long-established B lines such as Raji, demonstrated high levels of synthesis of p35, (a protein complex expressed abundantly by cells of a subset of HCL patients) and high levels of tartrate-resistant acid phospha 6316777 Human
p35 other tumor Albumin secretion was unaffected by 1,25-dihydroxyvitamin D3 exposure; in contrast, the cellular content of the proliferation-associated protein p35 was reduced by 39%, a decline similar in trend and degree to that observed in other tumor cells exposed to 2917007 Human
p35 metastatic tumor Computer assisted analysis of the resultant autoradiograms revealed that the amounts of only two proteins, p35 and p36, were consistently and significantly decreased in the metastatic tumor cells. 2026354 Human
p35 cll CLL lymphocytes contain a higher concentration of p35 li than do EBVL or Raji cells. 8400296 Human
p35 necrosis Interestingly, a necrosis inhibitor, pyrrolidine dithiocarbomate, but not the pancaspase inhibitors, carbobenzoxy-VAD-fluoromethyl ketone and p35, blocked the HSpin1-induced cell death. 12815463 Human
p35 necrosis Interestingly, death effector domain-containing proteins such as MC159, E8, K13, and cellular FLIP, but not the apoptosis inhibitors Bcl-xL, p35, and XIAP, potently suppressed programmed necrosis. 14532286 Human
p35 prostate cancer These results suggest that Cdk5/p35 and p25 are novel players in digoxin-triggered prostate cancer cell apoptosis and, therefore, become potential therapeutic targets. 15123618 Human
p35 tumors However, PGE2 produced by tumors potently inhibits the production of endogenous IL-12 at the level of protein secretion, mRNA synthesis, and transcription of the constituent p40 and p35 genes. 15123779 Human
p35 human leukemia We reported recently that cyclin-dependent kinase (Cdk)5 and p35Nck5a (p35) are expressed in human leukemia HL60 cells induced to differentiate to monocytes by an exposure to 1,25-dihydroxyvitamin D(3) (1,25D(3)), form a complex, and this complex has kina 15289351 Human
p35 human neuroblastoma Induction of cyclin-dependent kinase 5 and its activator p35 through the extracellular-signal-regulated kinase and protein kinase A pathways during retinoic-acid mediated neuronal differentiation in human neuroblastoma SK-N-BE(2)C cells. 15485494 Human
p35 human neuroblastoma In this study we newly found that RA treatment of SK-N-BE(2)C, human neuroblastoma cells, increased the expression of Cdk5 and its neuron specific activator p35 through the extracellular-signal-regulated kinase1/2 (ERK1/2) and cAMP-dependent protein kinas 15485494 Human
p35nck5a human leukemia We reported recently that cyclin-dependent kinase (Cdk)5 and p35Nck5a (p35) are expressed in human leukemia HL60 cells induced to differentiate to monocytes by an exposure to 1,25-dihydroxyvitamin D(3) (1,25D(3)), form a complex, and this complex has kina 15289351 Human
the p35 gene ganglioglioma One ganglioglioma patient showed a unique polymorphism in the p35 gene. 15175076 Human
p-35 hcl AHS 406 defined three cell surface antigens on HCL, P-30, P-35 and GP-135 (30,000, 35,000 and 135,000 daltons respectively). 6645081 Human
p35 hairy cell leukemia Spiro and coworkers found a 35000 dalton membrane protein (p35) expressed abundantly in hairy cells of a subset of white, American patients with hairy cell leukemia. 6084635 Human
p35 hairy cell leukemia Using related analytical techniques, we have studied leukemic cells of two blood and one splenic samples from three Japanese patients with hairy cell leukemia and have demonstrated abundance of p35 in the splenic and one of the blood samples. 6084635 Human
p35 hairy cell leukemia One can conclude that the Japanese form of hairy cell leukemia, while varying in several distinct clinical and laboratory features from hairy cell leukemia in caucasians, is characterized also by abundant expression of p35 as seen in a subset of white pat 6084635 Human
p35 hairy cell leukemia The abundant expression of Ii on butyrate-treated P3HR-1 cells mimicked the high level of expression of p35 or Ii on leukemic cells of a subset of patients with hairy cell leukemia. 6434395 Human
p35 hairy cell leukemia Identification of hairy cell leukemia subset defining p35 as the human homologue of Ii. 6583461 Human
p35 hairy cell leukemia Demonstration of p35 in hairy cell leukemia of Japanese patients. 6584195 Human
p35 hairy cell leukemia Using SDS polyacrylamide gel electrophoresis (SDS-PAGE), several coworkers isolated a unique membrane protein that they named p35 from hairy cells of white patients with hairy cell leukemia. 6584195 Human
p35 hairy cell leukemia In the current study using a similar technique, p35 was identified in hairy cells from 2 of 4 Japanese patients with hairy cell leukemia. 6584195 Human
p23 cell leukemia All HTLV-I and simian T cell leukemia virus type I sera tested reacted with p23. 8486936 Human
p25 all Results suggest that p24/BA-2 represents a surface structure present on lymphohemopoietic bone marrow progenitor cells and that most common types of ALL bear the p25/BA-2 structure. 6788880 Human
p25 pheochromocytoma Evidence of the presence of GTPase inhibiting proteins for a low M(r) GTP-binding protein, ram p25, in rat spleen and pheochromocytoma PC12 cells. 1451441 Rat
p23 ehrlich ascites tumor (eat) The growth-related protein p23 of the Ehrlich ascites tumor (EAT) is preferentially expressed in the exponentially growing tumor; its synthesis is translationally controlled. p23 mRNA is efficiently translated in the wheat germ cell-free lysate. 1726716 Human
p23 bovine leukemia Antigens associated with bovine leukemia virus (BLV) infection (gp 44/55 and p23) were identified by neutralization and immunofluorescent antibody (FA) tests. 200198 Cow
p25 ehrlich ascites tumor (eat) The growth-related 25-kDa protein (p25) of Ehrlich ascites tumor (EAT) has been characterized by molecular cloning and sequencing of cDNA clones detected by hybridization with oligonucleotide probes synthesized according to the amino acid sequence of a tr 2645135 Human
p25 bovine leukemia Addition of supramitogenic doses of phytohemagglutinin (PHA) to short-term cultures of neoplastic or nonneoplastic lymphocytes infected with bovine leukemia virus increased the synthesis of the major core virion antigen (p25) by 5- to 10-fold. 2987537 Human
p25 bovine leukemia In agreement with results from other laboratories, antisera to type-C and the non-type-C bovine leukemia and equine infectious anemia viruses did not precipitate 125I-labelled MPMV p25. 403148 Human
p25 bovine leukaemia Gel filtration chromatography of disrupted bovine leukaemia virus (BLV) resulted in the isolation of the 25000 mol. wt. major internal protein (p25), two previously uncharacterized proteins of mol. wt 65000 (p65) and 12000 (p12), and a mixture of p12 and 6154129 Human
p35 pheochromocytoma Recombinant adenoviruses carrying the hemagglutinin (HA)-tagged p73beta or p35, or the green fluorescent protein gene driven by the cytomegalovirus immediate-early promoter were constructed, and used to infect human SK-N-AS and SK-N-SH neuroblastoma, and 12750001 Human
p35 ganglioglioma One ganglioglioma patient showed a unique polymorphism in the p35 gene. 15175076 Human
p23 anaplastic large cell lymphoma Molecular characterization of the t(2;5) (p23; q35) translocation in anaplastic large cell lymphoma (Ki-1) and Hodgkin's disease. 8562933 Human
p23 acute myeloid leukemia (aml) We report a case of acute myeloid leukemia (AML) [FAB-M5a] showing a deletion of the short arm of chromosome 2 at band p23 as a sole abnormality in the bone marrow cells. 12034535 Human
p23 carcinomas Chaperone p23 is involved in the telomeric complex to a lesser extent, but its expression is stronger in carcinomas than in non-malignant thyroid tissues. 14621192 Human
nck5a rb Since RB has been shown recently to associate with D-type G1 cyclins and viral oncoproteins through a common peptide sequence motif of LXCXE, Nclk binding may be mediated by a related sequence motif (LXCXXE) found in p25(nck5a). 9038171 Human
p25 rb Since RB has been shown recently to associate with D-type G1 cyclins and viral oncoproteins through a common peptide sequence motif of LXCXE, Nclk binding may be mediated by a related sequence motif (LXCXXE) found in p25(nck5a). 9038171 Human
p35 colon cancer This is the first report of cdk5/p35 expression and kinase activity in colon cancer cells, which is associated with ciglitazone-induced antiproliferation in HT-29 cells. 16327995 Human
p35 metastatic prostate cancers P35, an activator of CDK5 that is indicative of its activity, is expressed in a panel of human and rat prostate cancer cell lines, and is also expressed in 87.5% of the human metastatic prostate cancers we examined. 16885348 Human
p35 rat prostate cancer P35, an activator of CDK5 that is indicative of its activity, is expressed in a panel of human and rat prostate cancer cell lines, and is also expressed in 87.5% of the human metastatic prostate cancers we examined. 16885348 Rat
p35 oncogene Altered expression and distribution of the cytoskeletal-associated p35 protein in NIH 3T3 cells transformed with the Harvey sarcoma virus v-ras oncogene. 2551751 Human
p35 oncogene The proto-oncogene cyclin D1 and the neuron-specific cyclins p35 and p39 are expressed during brain maturation. 9343422 Rat
p35 primary tumor Simultaneous infection of primary tumor cells with up to three rAAV vectors containing genes encoding the immunostimulatory proteins B7-2 (CD86), p35 subunit of IL-12, and p40 subunit of IL-12 resulted in high expression of B7-2 in more than 90% of the tu 9607416 Human
p35 primary tumor We inserted the genes coding for the p35 and p40 chain of interleukin-12 (IL-12) in two independent eukaryotic expression vectors and transduced melanoma cells of 15 different primary tumor cultures with both plasmids by a ballistic gene transfer approach 9614572 Human
p23 fibrosarcoma Normal p23 protein was detected in the human fibrosarcoma cell line HT1080 by immunoprecipitation with rabbit antibodies raised against an E. coli-expressed R-ras fusion protein. 3313005 Human
p23 oncogenes These data suggest that human R-ras p23 has biochemical properties very similar to those of the p21 products of the H-, K-, and N-ras proto-oncogenes. 3313005 Human
p23 mouse tumor The PsCaP23-encoded protein has high homology with an alfalfa callus protein or translationally controlled human or mouse tumor protein P23. 9426627 Human
p23 primary tumors No further upregulation of p23 transcripts was detectable in primary tumors of the breast and cervix. 9666514 Human
p23 oncogenes The conditional expression of the v-mos and Ha-ras(EJ) oncogenes in NIH 3T3 cells leads to the accumulation of a 23-kDa protein (p23) (R. 1846673 Human
nck5a oncoproteins Since RB has been shown recently to associate with D-type G1 cyclins and viral oncoproteins through a common peptide sequence motif of LXCXE, Nclk binding may be mediated by a related sequence motif (LXCXXE) found in p25(nck5a). 9038171 Cow
p25 oncoproteins Since RB has been shown recently to associate with D-type G1 cyclins and viral oncoproteins through a common peptide sequence motif of LXCXE, Nclk binding may be mediated by a related sequence motif (LXCXXE) found in p25(nck5a). 9038171 Cow
p25 gynecological cancer Breast and gynecological cancer-associated antigens RAK p120, p42 and p25 exhibit molecular, immunological and genetic homology to HIV-1 proteins. 9500213 Human
p35 oncoprotein A 35-kDa protein (designated p35) showing antigenic homology with an N-terminal epitope on the SV-40 large T-antigen oncoprotein was purified from transformed cardiomyocytes. 10600238 Human
p35 gbm Because human tumors of glial origin can express neuronal proteins, we examined whether Cdk5 and its activator protein, P35, are present in early passage human glioblastoma multiforme (GBM) cells lines and primary tumor specimens. 11296485 Human
p35 primary tumor Because human tumors of glial origin can express neuronal proteins, we examined whether Cdk5 and its activator protein, P35, are present in early passage human glioblastoma multiforme (GBM) cells lines and primary tumor specimens. 11296485 Human
p35 gbm Here we report the expression of Cdk5 and an "active" proteolytic form of P35 in human GBM cells and demonstrate kinase activity of the holoenzyme. 11296485 Human
p35 gbm We also show that Cdk5 kinase activity and expression of its activator protein, P35, is increased in the human GBM cell line M059J after exposure to ionizing radiation and that P35 is localized within M059J cells undergoing apoptosis. 11296485 Human
p35 rb TNFalpha reduced the transcripts and protein levels of phosphorylated retinoblastoma protein (Rb), Rb, E2F1, and Cdk4 only in drug-resistant p35-colo201 cells. 15611081 Human
p35 neuroblastoma To investigate if Cdk5 plays a role in the establishment of functional synapses, we have characterized the expression of Cdk5, p35, and p39 in the neuroblastoma-glioma cell line NG108-15, and recorded postsynaptic activity in myotubes in response to presy 15908038 Human
p35 invasive breast cancer J. Cell Biochem. 91, 398-409], here we not only demonstrate first that Cdk5, p35, and p25 proteins were all expressed in invasive breast cancer cells MDA-MB231 but also showed that cdk5 expression regulates MDA-MB231 cell proliferation. 17081516 Human
p25 human neuroblastoma The effects of 34 indirubin derivatives on CDK1/cyclin B, CDK5/p25, and GSK-3, as well as on SH-SY5Y human neuroblastoma cell survival, were investigated. 16759872 Human
p25 invasive breast cancer J. Cell Biochem. 91, 398-409], here we not only demonstrate first that Cdk5, p35, and p25 proteins were all expressed in invasive breast cancer cells MDA-MB231 but also showed that cdk5 expression regulates MDA-MB231 cell proliferation. 17081516 Human
p25 retinoblastoma However, cdk5/p25 could phosphorylate other substrates such as tau and p53, as well as the retinoblastoma protein pRb. 17160145 Human
p35 human neuroblastoma In addition, we show that in a human neuroblastoma cell line treated with CD40L, cdk5 and p35/p25 are increased. 18606155 Human
p23 hnscc The biological meaning of cPGES/p23 overexpression in HNSCC is not yet clear. 18642283 Human
p23 prostatic intraepithelial neoplasias (pin) We immunohistochemically analyzed 60 prostate carcinomas, 50 prostatic intraepithelial neoplasias (PIN) and 25 benign prostatic tissues to determine whether hsp90/p23 expression correlates with advancing stage and whether chaperone distribution overlaps w 18695913 Human
p23 prostate carcinomas We immunohistochemically analyzed 60 prostate carcinomas, 50 prostatic intraepithelial neoplasias (PIN) and 25 benign prostatic tissues to determine whether hsp90/p23 expression correlates with advancing stage and whether chaperone distribution overlaps w 18695913 Human
p23 carcinomas Strong expression of hsp90/p23 was detected in approximately 95% of PIN and carcinomas without relationship to Gleason score. 18695913 Human
p23 pin Strong expression of hsp90/p23 was detected in approximately 95% of PIN and carcinomas without relationship to Gleason score. 18695913 Human
p23 carcinomas While hsp90/p23 immunostaining was predominantly diffuse and cytoplasmic, nuclear immunoreactivity was observed in several moderate-to-high grade carcinomas, and those carcinomas with nuclear chaperone staining exhibited detectable hTERT. 18695913 Human
p25 human neuroblastoma In addition, we show that in a human neuroblastoma cell line treated with CD40L, cdk5 and p35/p25 are increased. 18606155 Human
p23 prostatic intraepithelial neoplasias We immunohistochemically analyzed 60 prostate carcinomas, 50 prostatic intraepithelial neoplasias (PIN) and 25 benign prostatic tissues to determine whether hsp90/p23 expression correlates with advancing stage and whether chaperone distribution overlaps w 18695913 Human

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