IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene ACCN1 Ensembl ENSG00000108684 Chromosome 17 Start 28364221 End 29507664
Description Amiloride-sensitive cation channel 1, neuronal (Amiloride-sensitive brain sodium channel)(Amiloride-sensitive cation channel neuronal 1)(Acid-sensing ion channel 2)(ASIC2)(Brain sodium channel 1)(BNaC1)(BNC1)(Mammalian degenerin homolog) [Source:UniProtKB/Swiss-Prot;Acc:Q16515]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 99
     Entrez Gene : 40
     UCSC : uc002hhu.2
     GeneCards : 99
     RefSeq : NM_001094
     CCDS : CCDS11276.1
     Uniprot : Q16515
     Interpro : Q16515
     OMIM : 601784
     GeneTests : ACCN1
     CGAP : ACCN1
     PMID : 8921408

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  40317_at  0.40  2.24e-3  6.38e-3  0.31  8.33e-2  1.41e-1
 HG_U133A  206690_at  -0.45  4.60e-6  1.11e-5  3.42  1.05e-69  3.41e-69
 HG_U133_Plus2  206690_at  0.38  3.13e-2  5.59e-2  0.59  3.21e-3  5.69e-3
 HG_U133_Plus2  241552_at  0.09  5.16e-1  6.02e-1  0.57  1.35e-5  3.39e-5
 Agilent_HS_21.6K  6359  -0.01  6.56e-1  7.92e-1  -0.01  7.14e-1  8.14e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  206690_at  -0.59  4.41e-3  6.53e-1  0.08  7.19e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 40317_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 206690_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 206690_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 241552_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 6359    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
degenerin cancer A novel strategy for cancer therapy by mutated mammalian degenerin gene transfer. 11059692 Human
bnac1 tumors RT-PCR analyses demonstrated the presence of mRNA for either BNaC1 or BNaC2 in these tumors and in normal astrocytes. 10362604 Human
asic2 tumor Our previous studies suggested that differential regulation of ASIC2 expression occurs between high-grade glial-derived tumor cells and normal astrocytes. 12957380 Human
asic2 tumor There was no mutation in the CpG island in six glioma cell lines, but methylation-specific PCR showed methylation in some of glioma cell lines and tumor tissues, and treatment with the methylation inhibitor 5-Aza-2'-deoxycytidine could partially rest 12957380 Human
asic2 glioma There was no mutation in the CpG island in six glioma cell lines, but methylation-specific PCR showed methylation in some of glioma cell lines and tumor tissues, and treatment with the methylation inhibitor 5-Aza-2'-deoxycytidine could partially rest 12957380 Human
asic2 low-grade tumor Differential gene profiling data showed that ASIC1 and ASIC2 mRNA were present in normal and low grade tumor cells. 12584187 Human
asic2 gliomas Our results show that 1) gain-of-function mutations of ASIC1 were not present in a number of freshly resected and cultured high grade gliomas, 2) syntaxin 1A inhibited ASIC currents only when ASIC1 and ASIC2 were co-expressed, and 3) the inhibition of ASI 12584187 Human
asic2 gliomas Transfection of cultured cells originally derived from high grade gliomas (U87-MG and SK-MG1) with ASIC2 abolished basal amiloride-sensitive sodium conductance; this inhibition was reversed by dialysis of the cell interior with Munc-18, a syntaxin-binding 12584187 Human

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