IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene CCL1 Ensembl ENSG00000108702 Chromosome 17 Start 29711512 End 29714365
Description C-C motif chemokine 1 Precursor (Small-inducible cytokine A1)(T lymphocyte-secreted protein I-309) [Source:UniProtKB/Swiss-Prot;Acc:P22362]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 10609
     Entrez Gene : 6346
     UCSC : uc002hid.1
     GeneCards : 10609
     RefSeq : NM_002981
     CCDS : CCDS11282.1
     Uniprot : P22362
     Interpro : P22362
     OMIM : 182281
     GeneTests : CCL1
     CGAP : CCL1
     PMID : 2212659

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  33965_at  0.71  6.36e-4  2.11e-3  1.26  6.82e-5  2.83e-4
 HG_U133A  207533_at  -0.34  1.78e-7  4.95e-7  1.96  2.66e-47  5.80e-47
 HG_U133_Plus2  207533_at  -0.23  1.61e-1  2.30e-1  -0.36  5.78e-2  8.17e-2
 Agilent_HS_21.6K  7603  0.04  7.07e-1  8.26e-1  0.05  6.08e-1  7.36e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  207533_at  0.26  2.22e-1  8.43e-1  -0.22  1.13e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 33965_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 207533_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 207533_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 7603    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
i-309 kaposi sarcoma The chemokine receptor CCR8 mediates human endothelial cell chemotaxis induced by I-309 and Kaposi sarcoma herpesvirus-encoded vMIP-I and by lipoprotein(a)-stimulated endothelial cell conditioned medium. 11133740 Human
i-309 kaposi sarcoma Immunohistochemical studies identified CCR8 and I-309 on the endothelium of human atherosclerotic plaques and in endothelial-derived spindle cells of Kaposi sarcoma. 11133740 Human
i-309 cancer In addition, we report several novel effects of deactivators and infection on the expression of known genes: (1) IL-4 caused pronounced upregulation of ABCG2, coding for an ATP-binding cassette transporter highly expressed in the placenta, which mediates 11345586 Human
i-309 adult t-cell leukemia Autocrine antiapoptotic stimulation of cultured adult T-cell leukemia cells by overexpression of the chemokine I-309. 11493464 Human
tca3 granulomas Neutralization of IL-12 or gamma interferon during egg deposition reversed the effects of prior treatment with rIL-12, leading to a return to larger granulomas; persistently elevated expression of TCA3, eotaxin, and MIP-1alpha; and a marked reduction in t 11598048 Human
tca-3 tumors Finally, levels of mRNA for the chemokines IP-10 and TCA-3 were higher in tumors treated with the combination of cytokine plasmids than in tumors treated with either cytokine gene alone. 10986558 Human
tca3 tumor In mice, chemokines, such as IP-10, RANTES, and TCA3, have resulted in tumor regression and immunity to subsequent tumor challenge. 10068274 Mouse
i-309 thymic lymphoma The purified I-309 also improved the survival of two other mouse thymic lymphoma cell lines. 8805659 Human
ccl1 thymic lymphoma It was previously demonstrated that the CC chemokine CCL1 (I-309) rescues thymic lymphoma cells from apoptosis by unknown mechanisms. 12525579 Human
i-309 thymic lymphoma It was previously demonstrated that the CC chemokine CCL1 (I-309) rescues thymic lymphoma cells from apoptosis by unknown mechanisms. 12525579 Human
ccl1 thymic lymphoma The aim of our study was to characterize the role of the CC chemokine receptor 8 (CCR8), the only described receptor for CCL1, in the rescue of murine thymic lymphoma cells and murine thymocytes from dexamethasone (dex)-induced apoptosis. 12525579 Human
ccl1 thymic lymphoma We show here that the CCR8-restricted agonist Kaposi sarcoma-associated herpesvirus-encoded chemokine viral macrophage-inflammatory protein-1 (vMIP-1) rescues thymic lymphoma cells from dex-induced apoptosis, similar to CCL1, and that such rescue is extra 12525579 Human
i-309 mast-cell leukemia In this study we show that the human mast cell leukemia line HMC-1 is a source of multiple chemokines, including I-309, monocyte chemoattractant protein 1, macrophage inflammatory protein-1 alpha, macrophage inflammatory protein-1 beta, RANTES, and interl 8188667 Human
ccl1 thymic lymphomas We have previously shown that the CC-chemokine 1-309 (CCL1) protects mouse thymic lymphomas against corticoid-induced apoptosis. 12645948 Mouse
tca3 tumor Inhibition of in vivo tumor growth by the beta chemokine, TCA3. 7963535 Human
tca3 myeloma To assess the in vivo functions of TCA3, the cDNA was expressed in two mouse myeloma cell lines. 7963535 Human
tca3 tumor necrosis Histologic evaluation of the injection sites demonstrated that TCA3 expression resulted in an early neutrophil and monocyte infiltrate accompanied by tumor necrosis. 7963535 Mouse
tca3 tumor In contrast, priming with irradiated tumor cells provided little protection against challenge with nontransfected tumor, which indicates that TCA3 specifically augments tumor immunogenicity. 7963535 Mouse
tca3 tumor The data suggest that TCA3 may perform two roles in tumor protection: it induces lymphocyte-independent antitumor activity and stimulates tumor-specific immunity. 7963535 Mouse
i-309 melanoma Those human cytokines known as interleukin 8, platelet factor 4, beta thromboglobulin, IP-10 and melanoma growth stimulating factor or GRO can be assigned to a subfamily based on their location on chromosome 4 and unique structural features, whereas the s 1910690 Human
i-309 mast cell leukemia In this study we show that the human mast cell leukemia line HMC-1 is a source of multiple chemokines, including I-309, monocyte chemoattractant protein 1, macrophage inflammatory protein-1 alpha, macrophage inflammatory protein-1 beta, RANTES, and interl 8188667 Human
i-309 t cell lymphomas I-309/T cell activation gene-3 chemokine protects murine T cell lymphomas against dexamethasone-induced apoptosis. 8805659 Mouse
ccl1 cancer Activation of CCR8 by its ligand CCL1 may play an important role in diseases such as asthma, multiple sclerosis, and cancer. 16640325 Human
tca3 tumors Although the transfected and control cells had similar growth rates in vitro, TCA3-expressing tumors demonstrated impaired growth in both normal and immunodeficient mice. 7963535 Mouse
tca3 tumor There was complete regression of the TCA3-transfected tumor in some immunocompetent syngeneic mice. 7963535 Mouse
tca3 tumor The TCA3-transfected cells induced specific and long-lasting immunity in mice that showed complete tumor regression; these animals were resistant to challenge with nontransfected tumor cells. 7963535 Mouse
tca3 tumor Mixing TCA3-transfected cells with normal tumor cells causes retarded growth of the normal tumor cells provided the latter are injected into the same site. 7963535 Mouse
ccl1 bph RESULTS: Significantly increased levels of cytokines (IL-1alpha, IL-1beta, IL-6, IL-10, IL12p70) and chemokines (CCL1, CCL3, CCL4, CCL17, CCL22, CXCL8/IL-8) were observed in seminal plasmas from patients with CP/CPPS or BPH. 16905241 Human
tca3 esophageal cancer CONCLUSIONS: Genetically fixed STR polymorphism TCA3/TCA3 in exon 4 of ECRG2 is associated with poor clinical outcome in surgically treated esophageal cancer patients and might be a potential prognostic marker. 17693286 Human
p500 nsclc These results support the use of P500 as a second- and third-line treatment of NSCLC. 18594001 Human

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