IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene MMP28 Ensembl ENSG00000129270 Chromosome 17 Start 31116989 End 31146753
Description Matrix metalloproteinase-28 Precursor (MMP-28)(EC 3.4.24.-)(Epilysin) [Source:UniProtKB/Swiss-Prot;Acc:Q9H239]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 14366
     Entrez Gene : 79148
     UCSC : uc002hjy.1
     GeneCards : 14366
     RefSeq : NM_001032278
     CCDS : CCDS45651.1
     Uniprot : Q9H239
     Interpro : Q9H239
     OMIM : 608417
     GeneTests : MMP28
     CGAP : MMP28
     PMID : 11121398

< Top >


Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  219909_at  -2.51  2.39e-28  3.32e-27  -2.21  3.24e-37  6.03e-37
 HG_U133_Plus2  219909_at  -2.02  2.07e-12  2.04e-11  -3.14  4.91e-24  1.09e-22
 HG_U133_Plus2  222937_s_at  -0.99  8.47e-7  3.87e-6  -1.42  1.05e-15  8.88e-15
 HG_U133_Plus2  224207_x_at  -1.15  1.29e-10  1.01e-9  -1.52  6.07e-15  4.74e-14
 HG_U133_Plus2  239272_at  -1.64  3.96e-12  3.77e-11  -2.48  4.12e-30  1.94e-28
 HG_U133_Plus2  239273_s_at  -1.91  1.68e-12  1.68e-11  -3.02  2.18e-26  6.34e-25
 Agilent_HS_21.6K  20250  -0.38  1.54e-2  6.31e-2  -0.67  1.82e-8  5.08e-7

< Top >


Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  219909_at  0.66  3.40e-1  8.87e-1  -0.88  2.82e-2  1.00e+0

< Top >


Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U133A - 219909_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 219909_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 222937_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 224207_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 239272_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 239273_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 20250    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

< Top >


Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
epilysin skin cancers The aim of this study was to characterize in different types of wounds, skin cancers, and keratinocyte cultures factors that contribute to epilysin expression in vivo, as well as how and where it is induced in relation to other matrix metalloproteinases. 12164918 Human
epilysin ulcerated pyogenic granulomas An injury of epidermis was needed for epilysin induction as it was upregulated in ulcerated pyogenic granulomas and in suction blisters but was not detected in intact acanthotic or normal skin. 12164918 Human
epilysin squamous-cell cancers Unlike many other matrix metalloproteinases, epilysin was not detected in the invading cancer cell nests of sclerosing basal or squamous cell cancers of various grades. 12164918 Human
epilysin cancer Unlike many other matrix metalloproteinases, epilysin was not detected in the invading cancer cell nests of sclerosing basal or squamous cell cancers of various grades. 12164918 Human
epilysin carcinoma In primary keratinocyte, HaCaT, and A431 carcinoma cell cultures none of the 10 other growth factors or extracellular matrices studied were able to upregulate epilysin expression. 12164918 Human
mmp-28 tumors MMP-28, a new human matrix metalloproteinase with an unusual cysteine-switch sequence is widely expressed in tumors. 11255011 Human
mmp-28 carcinomas The broad range of expression in carcinomas as well as normal adult and fetal tissues suggests an important functional role for MMP-28. 11255011 Human
mmp-28 colon cancer Differential expression of three matrix metalloproteinases, MMP-19, MMP-26, and MMP-28, in normal and inflamed intestine and colon cancer. 15185874 Human
mmp-28 colon carcinomas In colon carcinomas, MMP-19 and MMP-28 expression was downregulated in tumor epithelium. 15185874 Human
mmp-28 tumor In colon carcinomas, MMP-19 and MMP-28 expression was downregulated in tumor epithelium. 15185874 Human
epilysin fibrosarcoma Expression of recombinant epilysin in HT-1080 fibrosarcoma cells indicated that epilysin was secreted as a major 48 kDa form and a minor 58 kDa form. 12803542 Mouse
mmp-28 ibd Our results suggest that MMP-19 is involved in epithelial proliferation and MMP-26 in enterocyte migration, while MMP-28 expression is not associated with inflammatory and destructive changes seen in IBD. 15185874 Human

< Top >


Download all image files.
Save all PNG files.    Save all PDF files.    Save all PS files.