IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene TAF15 Ensembl ENSG00000172660 Chromosome 17 Start 31160596 End 31198350
Description TATA-binding protein-associated factor 2N (RNA-binding protein 56)(TAFII68)(TAF(II)68) [Source:UniProtKB/Swiss-Prot;Acc:Q92804]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 11547
     Entrez Gene : 8148
     UCSC : uc002hkd.2
     GeneCards : 11547
     RefSeq : NM_003487
     CCDS : CCDS32623.1
     Uniprot : Q92804
     Interpro : Q92804
     OMIM : 601574
     GeneTests : TAF15
     CGAP : TAF15
     PMID : 8954779

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  36822_at  0.47  3.11e-5  1.44e-4  0.64  1.32e-4  5.12e-4
 HG_U133A  202840_at  0.86  3.80e-31  6.35e-30  2.85  1.57e-95  9.36e-95
 HG_U133_Plus2  202840_at  0.69  1.06e-9  7.38e-9  0.67  1.95e-6  5.49e-6
 HG_U133_Plus2  227884_at  0.62  6.40e-4  1.73e-3  0.50  2.20e-5  5.38e-5
 HG_U133_Plus2  227891_s_at  -0.18  1.94e-1  2.70e-1  -0.45  3.88e-4  7.95e-4
 HG_U133_Plus2  234168_at  0.39  4.42e-2  7.57e-2  0.32  1.52e-1  1.96e-1
 HG_U133_Plus2  241885_at  0.06  7.95e-1  8.44e-1  -0.61  5.70e-3  9.70e-3
 Agilent_HS_21.6K  10980  0.02  6.36e-1  7.79e-1  0.01  6.50e-1  7.67e-1
 Agilent_HS_21.6K  19444  0.04  5.15e-1  6.87e-1  0.03  5.70e-1  7.06e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  202840_at  -0.56  1.58e-2  6.83e-1  -0.07  6.13e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 36822_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 202840_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 202840_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 227884_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 227891_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 234168_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 241885_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 10980    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 19444    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
taf15 acute leukemia Recurrent rearrangement of the Ewing's sarcoma gene, EWSR1, or its homologue, TAF15, with the transcription factor CIZ/NMP4 in acute leukemia. 12359745 Human
taf15 ewing's sarcoma Fusions of the TET-proteins (TLS/FUS, EWSR1, and TAF15/RBP56) to different transcription factors are involved in various malignancies including Ewing's sarcoma, primitive neuroectodermal tumors, and acute myeloid leukemia. 12359745 Human
rbp56 ewing's sarcoma Fusions of the TET-proteins (TLS/FUS, EWSR1, and TAF15/RBP56) to different transcription factors are involved in various malignancies including Ewing's sarcoma, primitive neuroectodermal tumors, and acute myeloid leukemia. 12359745 Human
taf15 acute myeloid leukemia Fusions of the TET-proteins (TLS/FUS, EWSR1, and TAF15/RBP56) to different transcription factors are involved in various malignancies including Ewing's sarcoma, primitive neuroectodermal tumors, and acute myeloid leukemia. 12359745 Human
rbp56 acute myeloid leukemia Fusions of the TET-proteins (TLS/FUS, EWSR1, and TAF15/RBP56) to different transcription factors are involved in various malignancies including Ewing's sarcoma, primitive neuroectodermal tumors, and acute myeloid leukemia. 12359745 Human
taf15 primitive neuroectodermal tumors Fusions of the TET-proteins (TLS/FUS, EWSR1, and TAF15/RBP56) to different transcription factors are involved in various malignancies including Ewing's sarcoma, primitive neuroectodermal tumors, and acute myeloid leukemia. 12359745 Human
rbp56 primitive neuroectodermal tumors Fusions of the TET-proteins (TLS/FUS, EWSR1, and TAF15/RBP56) to different transcription factors are involved in various malignancies including Ewing's sarcoma, primitive neuroectodermal tumors, and acute myeloid leukemia. 12359745 Human
taf15 acute leukemia We show that, as result of a t(12;17)(p13;q11) or its variant t(12;22)(p13;q12), the transcription factor gene CIZ/NMP4 is recurrently involved in acute leukemia through fusion with either EWSR1 or TAF15. 12359745 Human
rbp56 extraskeletal myxoid chondrosarcoma Molecular genetic characterization of the EWS/CHN and RBP56/CHN fusion genes in extraskeletal myxoid chondrosarcoma. 12378528 Human
rbp56 neoplasm Extraskeletal myxoid chondrosarcoma (EMC) is a soft-tissue neoplasm cytogenetically characterized by the translocations t(9;22)(q22;q11-12) or t(9;17)(q22;q11), generating EWS/CHN or RBP56/CHN fusion genes, respectively. 12378528 Human
rbp56 extraskeletal myxoid chondrosarcoma Extraskeletal myxoid chondrosarcoma (EMC) is a soft-tissue neoplasm cytogenetically characterized by the translocations t(9;22)(q22;q11-12) or t(9;17)(q22;q11), generating EWS/CHN or RBP56/CHN fusion genes, respectively. 12378528 Human
rbp56 tumors In all tumors with RBP56/CHN fusion, exon 6 of RBP56 was fused to exon 3 of CHN. 12378528 Human
tafii68 cancers EWS and related TAFII68 and TLS/FUS genes are fused with different genes encoding transcription factors in various human cancers. 11422378 Human
taf2n extraskeletal myxoid chondrosarcoma Fusion of the EWS-related gene TAF2N to TEC in extraskeletal myxoid chondrosarcoma. 10537274 Human
rbp56 sarcomas RBP56 has not previously been shown to be involved in tumorigenesis but it encodes a putative RNA-binding protein similar to the EWS and FUS (TLS) proteins known to play a pathogenetic role in several sarcomas. 10602519 Human
htafii68 extraskeletal myxoid chondrosarcoma Identification of a novel fusion gene involving hTAFII68 and CHN from a t(9;17)(q22;q11.2) translocation in an extraskeletal myxoid chondrosarcoma. 10602520 Human
htafii68 tumour The involvement of RBP56/hTAFII68 may explain some unusual features of the tumour. 10602520 Human
rbp56 tumour The involvement of RBP56/hTAFII68 may explain some unusual features of the tumour. 10602520 Human
rbp56 myxoid chondrosarcomas Fusion of the RBP56 and CHN genes in extraskeletal myxoid chondrosarcomas with translocation t(9;17)(q22;q11). 10602519 Human
rbp56 extraskeletal myxoid chondrosarcoma Extraskeletal myxoid chondrosarcoma (EMC) is characterized by recurrent chromosomal translocations resulting in fusions of the nuclear receptor gene NOR1 (also known as CHN or TEC) to various N-terminal partners, including EWS and TAF2N (or RBP56). 15188455 Human
taf15 extraskeletal myxoid chondrosarcoma Extraskeletal myxoid chondrosarcoma (EMC) is a rare mesenchymal tumor cytogenetically characterized by reciprocal translocations, such as t(9;22)(q22;q12) and t(9;17)(q22;q11), which result in EWSR1/NR4A3 and TAF15/NR4A3 fusion genes (alias EWS/NOR1, TAF2 15262426 Human
taf15 mesenchymal tumor Extraskeletal myxoid chondrosarcoma (EMC) is a rare mesenchymal tumor cytogenetically characterized by reciprocal translocations, such as t(9;22)(q22;q12) and t(9;17)(q22;q11), which result in EWSR1/NR4A3 and TAF15/NR4A3 fusion genes (alias EWS/NOR1, TAF2 15262426 Human
taf15 acute leukaemia Molecular cloning of the translocations t(12;22)(p13;q12) and t(12;17)(p13;q11) in acute leukaemia showed that either EWSR1 or its homologue TAF15 are fused to the transcription factor CIZ. 15669012 Human
taf2n myxoid chondrosarcomas Extraskeletal myxoid chondrosarcomas (EMCs) are characterized by recurrent t(9;22) or t(9;17) translocations resulting in fusions of the NH2-terminal transactivation domains of EWS or TAF2N to the entire TEC protein. 11156374 Human
taf2n extraskeletal myxoid chondrosarcoma Extraskeletal myxoid chondrosarcoma (EMC) is characterized by recurrent chromosomal translocations resulting in fusions of the nuclear receptor gene NOR1 (also known as CHN or TEC) to various N-terminal partners, including EWS and TAF2N (or RBP56). 15188455 Human
taf2n extraskeletal myxoid chondrosarcoma Extraskeletal myxoid chondrosarcoma (EMC) is a rare mesenchymal tumor cytogenetically characterized by reciprocal translocations, such as t(9;22)(q22;q12) and t(9;17)(q22;q11), which result in EWSR1/NR4A3 and TAF15/NR4A3 fusion genes (alias EWS/NOR1, TAF2 15262426 Human
taf2n mesenchymal tumor Extraskeletal myxoid chondrosarcoma (EMC) is a rare mesenchymal tumor cytogenetically characterized by reciprocal translocations, such as t(9;22)(q22;q12) and t(9;17)(q22;q11), which result in EWSR1/NR4A3 and TAF15/NR4A3 fusion genes (alias EWS/NOR1, TAF2 15262426 Human

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