IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene CCL16 Ensembl ENSG00000161573 Chromosome 17 Start 31327651 End 31332645
Description C-C motif chemokine 16 Precursor (Small-inducible cytokine A16)(IL-10-inducible chemokine)(Chemokine LEC)(Liver-expressed chemokine)(Monotactin-1)(MTN-1)(Chemokine CC-4)(HCC-4)(NCC-4)(Lymphocyte and monocyte chemoattractant)(LMC)(LCC-1) [Source:UniProtKB/Swiss-Prot;Acc:O15467]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 10614
     Entrez Gene : 6360
     UCSC : uc002hkl.2
     GeneCards : 10614
     RefSeq : NM_004590
     CCDS : CCDS11303.1
     Uniprot : O15467
     Interpro : O15467
     OMIM : 601394
     GeneTests : CCL16
     CGAP : CCL16
     PMID : 8661057

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  34434_at  -0.02  9.21e-1  9.42e-1  0.08  7.23e-1  7.96e-1
 HG_U133A  207354_at  -0.56  2.02e-6  5.05e-6  -0.42  1.52e-3  1.68e-3
 HG_U133_Plus2  207354_at  0.03  8.90e-1  9.19e-1  0.14  5.70e-1  6.26e-1
 Agilent_HS_21.6K  8399  -0.01  8.96e-1  9.43e-1  -0.01  8.85e-1  9.31e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  207354_at  -0.07  8.57e-1  9.89e-1  -0.14  6.09e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 34434_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 207354_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 207354_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 8399    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
lec glioma For the 8 chemokines examined (LARC, TARC, ELC, SLC, PARC, LEC, HCC-2, and SCM-1alpha), expression of LARC was clearly detectable in all 12 glioma cell lines by RT-PCR. 12239608 Human
lmc leptomeningeal carcinomatosis We analyzed 19 cases of cytologically confirmed leptomeningeal carcinomatosis (LMC) treated at our institution over the past 11 years. 15015782 Human
lcc-1 hepatoma LCC-1 is constitutively expressed in human HepG2 hepatoma cells and is induced by hypoxic exposure. 10671294 Human
lec tumor Tumor rejection and immune memory elicited by locally released LEC chemokine are associated with an impressive recruitment of APCs, lymphocytes, and granulocytes. 10706711 Human
lec tumor These studies showed no significant improvement indicating that combination therapy with anti-CD25(+) antisera requires LEC localization to tumor to produce complete regression. 14679000 Human
lec solid tumors These studies suggest that LEC/monoclonal antibody fusion proteins, when used in combination with CD25(+) T-cell depletion, is a viable method of immunotherapy for the treatment of solid tumors. 14679000 Human
ccl16 tumor Furthermore, cytolytic T cells generated in the presence of CCL16 display a higher cytotoxicity and activate caspase-8 in tumor target cells. 14525962 Human
lec tumors Because of its potency as a chemoattractant for immune cells, LEC was used to genetically engineer a fusion protein with chTNT-3, a monoclonal antibody previously shown to target tumors by binding to DNA exposed in necrotic zones. 12843794 Human
lec myeloma Because the N-terminus of chemokines is important for their activity, the C-terminus of LEC was genetically linked to the chTNT-3 heavy chain variable region and, along with the light chain gene, cotransfected into NSO murine myeloma cells using the gluta 12843794 Human
lec tumors The targeting of LEC to necrotic areas of tumors where the release of tumor antigens is prevalent may be a new approach for the immunotherapy of solid tumors. 12843794 Human
lec solid tumors The targeting of LEC to necrotic areas of tumors where the release of tumor antigens is prevalent may be a new approach for the immunotherapy of solid tumors. 12843794 Human
lec tumor The targeting of LEC to necrotic areas of tumors where the release of tumor antigens is prevalent may be a new approach for the immunotherapy of solid tumors. 12843794 Human
lec liver cancer We analyzed the kinase activity of pp60c-src in normal liver tissue, chronic hepatitis liver tissue, and tumorous and adjacent nontumorous portions of HCC tissue from patients and Long-Evans cinnamon (LEC) rats that are known to develop liver cancer spont 9581679 Human
lec hepatoma We have examined changes in the expression of heme oxygenase-1 (HO-1), an inducible isoform and HO-2, a constitutive isoform, in the liver of Long-Evans with a Cinnamon-like color (LEC) rat, a mutant strain which spontaneously develops acute hepatitis and 9684983 Human
lec colon adenocarcinomas We analyzed p53 mutations in 17 N-butyl-N-(4-hydroxybutyl) nitrosamine-induced bladder transitional cell carcinomas (TCCs) with or without areas of squamous cell carcinoma (SCC) of Long-Evans Cinnamon (LEC) and F344 rats, and in 7 N-methyl-N-nitrosourea-i 9233835 Human
lec squamous cell carcinoma (scc) We analyzed p53 mutations in 17 N-butyl-N-(4-hydroxybutyl) nitrosamine-induced bladder transitional cell carcinomas (TCCs) with or without areas of squamous cell carcinoma (SCC) of Long-Evans Cinnamon (LEC) and F344 rats, and in 7 N-methyl-N-nitrosourea-i 9233835 Human
lec bladder transitional cell carcinomas We analyzed p53 mutations in 17 N-butyl-N-(4-hydroxybutyl) nitrosamine-induced bladder transitional cell carcinomas (TCCs) with or without areas of squamous cell carcinoma (SCC) of Long-Evans Cinnamon (LEC) and F344 rats, and in 7 N-methyl-N-nitrosourea-i 9233835 Human
lec hepatoma We examined age-related changes in the protein and the mRNA expression of aldose reductase in livers of Long-Evans with a cinnamon-like color (LEC) rats, which develop hereditary hepatitis and hepatoma with aging, using Long-Evans with an agouti color rat 8641963 Human
lec hepatic tumors We examined the effects of trientine on the spontaneous development of hepatitis and hepatic tumors, by its short-term and long-term administration to Long-Evans cinnamon (LEC) rats with an accumulation of copper in the liver, as animal models of Wilson&a 8666330 Human
lec hepatocellular carcinomas We have studied the expressions of nine proto-oncogenes (c-myc, N-myc, c-fos, C-jun, p53, H-ras, N-ras, c-raf, hst) and two other genes (PCNA, GST-P) during the spontaneous development of hepatocellular carcinomas (HCCs) in LEC rats. 1976434 Human
lec hepatoma We studied the copper concentrations in the non-cancerous and cancerous liver tissues of LEC rats with hereditary hepatitis and spontaneous hepatoma by atomic absorption spectrophotometry. 1905694 Human
lec hepatomas We have studied the neutral glycolipid composition of spontaneous hepatomas in LEC female rats. 7532009 NA

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