IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene CCL18 Ensembl ENSG00000006074 Chromosome 17 Start 31415756 End 31422953
Description C-C motif chemokine 18 Precursor (Small-inducible cytokine A18)(Macrophage inflammatory protein 4)(MIP-4)(Pulmonary and activation-regulated chemokine)(CC chemokine PARC)(Alternative macrophage activation-associated CC chemokine 1)(AMAC-1)(Dendritic cell chemokine 1)(DC-CK1) [Contains CCL18(1-68);CCL18(3-69);CCL18(4-69)] [Source:UniProtKB/Swiss-Prot;Acc:P55774]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 10616
     Entrez Gene : 6362
     UCSC : uc002hku.2
     GeneCards : 10616
     RefSeq : NM_002988
     CCDS : CCDS11306.1
     Uniprot : P55774
     Interpro : P55774
     OMIM : 603757
     GeneTests : CCL18
     CGAP : CCL18
     PMID : 9233607

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  32128_at  -0.77  8.13e-3  1.96e-2  -1.22  1.95e-4  7.25e-4
 HG_U133A  209924_at  -0.77  3.81e-6  9.26e-6  -0.23  7.24e-2  7.67e-2
 HG_U133A  32128_at  -0.68  7.04e-5  1.49e-4  -4.22  1.14e-78  4.48e-78
 HG_U133_Plus2  209924_at  -0.84  3.22e-4  9.26e-4  -1.09  8.67e-5  1.95e-4
 HG_U133_Plus2  32128_at  -0.67  2.11e-3  5.10e-3  -1.14  6.36e-5  1.46e-4
 Agilent_HS_21.6K  4052  -0.11  3.47e-1  5.35e-1  -0.16  1.79e-1  3.18e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  209924_at  0.66  1.88e-1  8.25e-1  -0.52  2.23e-1  1.00e+0
 HG_U133A  32128_at  0.66  1.18e-1  7.86e-1  -0.67  1.44e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 32128_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 209924_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 32128_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 209924_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 32128_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 4052    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
ccl18 ovarian carcinoma Identification of biologically active chemokine isoforms from ascitic fluid and elevated levels of CCL18/pulmonary and activation-regulated chemokine in ovarian carcinoma. 11978786 Human
pulmonary and activation-regulated chemokine ovarian carcinoma Identification of biologically active chemokine isoforms from ascitic fluid and elevated levels of CCL18/pulmonary and activation-regulated chemokine in ovarian carcinoma. 11978786 Human
ccl18 ovarian carcinoma In ascitic fluids from patients with ovarian carcinoma (n = 12), significantly higher levels of CXCL8 and CCL18 (2.0 versus 0.7 ng/ml (p = 0.01) and 120 versus 44 ng/ml (p = 0.0002), respectively) were detected compared with those in nonovarian carcinoma 11978786 Human
ccl18 carcinoma In ascitic fluids from patients with ovarian carcinoma (n = 12), significantly higher levels of CXCL8 and CCL18 (2.0 versus 0.7 ng/ml (p = 0.01) and 120 versus 44 ng/ml (p = 0.0002), respectively) were detected compared with those in nonovarian carcinoma 11978786 Human
ccl18 carcinoma In contrast to CXCL8, CCL18 was not inducible in carcinoma cell lines. 11978786 Human
ccl18 ovarian carcinoma Immunostaining showed CCL18 expression in tumor-infiltrating cells with monocyte/macrophage morphology but not in the ovarian carcinoma cells. 11978786 Human
ccl18 epithelial ovarian cancer This points to a delicate balance of chemokines in epithelial ovarian cancer and to a potentially major role for CXCL8 and CCL18 in this tumor. 11978786 Human
ccl18 tumor This points to a delicate balance of chemokines in epithelial ovarian cancer and to a potentially major role for CXCL8 and CCL18 in this tumor. 11978786 Human
parc tumor CONCLUSIONS:Our results suggest that IL-2 induces inflammation at tumor sites with three predominant secondary effects: activation of antigen-presenting monocytes; massive production of chemoattractants that may recruit other immune cells to the tumor (in 12184809 Human
parc glioma For the 8 chemokines examined (LARC, TARC, ELC, SLC, PARC, LEC, HCC-2, and SCM-1alpha), expression of LARC was clearly detectable in all 12 glioma cell lines by RT-PCR. 12239608 Human
pulmonary and activation-regulated chemokine acute myeloid leukemia (aml) Here, the CC chemokine pulmonary and activation-regulated chemokine (PARC)/CCL18 was measured in pediatric patients with acute lymphoblastic leukemia (ALL) or acute myeloid leukemia (AML). 14578205 Human
pulmonary and activation-regulated chemokine acute lymphoblastic leukemia (all) Here, the CC chemokine pulmonary and activation-regulated chemokine (PARC)/CCL18 was measured in pediatric patients with acute lymphoblastic leukemia (ALL) or acute myeloid leukemia (AML). 14578205 Human
parc leukemia Serum PARC levels thus constitute a novel leukemia marker, possibly reflecting tumor/host cell interactions in the circulation. 14578205 Human
parc tumor Serum PARC levels thus constitute a novel leukemia marker, possibly reflecting tumor/host cell interactions in the circulation. 14578205 Human
ccl18 tumor METHODS: We identified a specific gene of interest, chemokine (C-C motif) ligand 18 (CCL18), on the basis of a high absolute standardized log Cox hazard ratio, a high variance in expression among all tumor samples, and putative biologic function. 15300578 Human
ccl18 tumor In multivariate analysis, tumor stage and CCL18 levels were independent prognostic factors for predicting both overall and disease-free survival. 15300578 Human
ccl18 tumor We found that CCL18 was expressed by a subpopulation of tumor-associated macrophages that were preferentially located at the tumor invasion front. 15300578 Human
ccl18 gastric cancer Our study suggests CCL18 as a novel candidate for antitumor therapeutics and risk stratification in gastric cancer patients. 15300578 Human
dc-ck1 necrosis Specific signals were detected for DC-CK1 mRNA in mononuclear cells mainly in the portal area and for RANTES mRNA in the portal area and at sites of piecemeal necrosis in the liver of patients with chronic hepatitis C. 10744077 Human
parc t-all Furthermore, PARC serum levels were significantly increased in children with T-ALL and prepreB-ALL compared to control serum samples, whereas serum levels in AML and preB-ALL patients were not significantly different from controls. 14578205 Human
parc aml Furthermore, PARC serum levels were significantly increased in children with T-ALL and prepreB-ALL compared to control serum samples, whereas serum levels in AML and preB-ALL patients were not significantly different from controls. 14578205 Human
parc neuroblastoma Western blot analysis revealed that PARC was down-regulated in one neuroblastoma cell line but not expressed in the second. 15492248 Human
parc tumor Therefore, decreased PARC expression could not fully account for relieving p53 sequestration in the neuroblastoma tumor cells. 15492248 Human
parc neuroblastoma Therefore, decreased PARC expression could not fully account for relieving p53 sequestration in the neuroblastoma tumor cells. 15492248 Human

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