IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene AATF Ensembl ENSG00000108270 Chromosome 17 Start 32380288 End 32488283
Description Protein AATF (Apoptosis-antagonizing transcription factor)(Rb-binding protein Che-1) [Source:UniProtKB/Swiss-Prot;Acc:Q9NY61]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 19235
     Entrez Gene : 26574
     UCSC : uc002hni.2
     GeneCards : 19235
     RefSeq : NM_012138
     CCDS : CCDS32632.1
     Uniprot : Q9NY61
     Interpro : Q9NY61
     OMIM : 608463
     GeneTests : AATF
     CGAP : AATF
     PMID : 11027528

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  32117_at  0.22  9.86e-3  2.31e-2  0.32  1.27e-3  3.83e-3
 HG_U133A  209165_at  0.32  2.65e-10  9.74e-10  1.30  5.26e-38  9.89e-38
 HG_U133_Plus2  209165_at  0.57  1.41e-18  2.88e-17  0.78  9.89e-20  1.32e-18
 Agilent_HS_21.6K  6487  -0.09  8.69e-2  2.14e-1  -0.01  8.37e-1  9.00e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  209165_at  0.21  2.63e-1  8.61e-1  -0.04  7.45e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 32117_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 209165_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 209165_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 6487    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
che-1 human colon carcinoma Che-1 arrests human colon carcinoma cell proliferation by displacing HDAC1 from the p21WAF1/CIP1 promoter. 12847090 Human
che-1 cancer By hybridization of cancer profile arrays, we found that Che-1 expression is strongly down-regulated in several tumors, including colon and kidney carcinomas, compared with the relative normal tissues. 12847090 Human
che-1 tumors By hybridization of cancer profile arrays, we found that Che-1 expression is strongly down-regulated in several tumors, including colon and kidney carcinomas, compared with the relative normal tissues. 12847090 Human
che-1 kidney carcinomas By hybridization of cancer profile arrays, we found that Che-1 expression is strongly down-regulated in several tumors, including colon and kidney carcinomas, compared with the relative normal tissues. 12847090 Human
che-1 human colon carcinoma Consistent with these data, Che-1 overexpression inhibits proliferation of HCT116 and LoVo human colon carcinoma cell lines by activation of the cyclin-dependent kinase inhibitor p21WAF1/Cip1 in a p53-independent manner and by promoting growth arrest at t 12847090 Human
che-1 colon carcinoma Taken together, our results indicate that Che-1 can be considered a general HDAC1 competitor and its down-regulation is involved in colon carcinoma cell proliferation. 12847090 Human
ded tumor However, in tumors and tumor cell lines, they are overexpressed, and their silencing leads to restoration of efficient apoptosis via enhanced activation of DED caspases. 15069192 Human
ded tumors However, in tumors and tumor cell lines, they are overexpressed, and their silencing leads to restoration of efficient apoptosis via enhanced activation of DED caspases. 15069192 Human
apoptosis antagonizing transcription factor osteosarcoma CONCLUSION: Apoptosis antagonizing transcription factor may play an important role in promoting metastasis of osteosarcoma. 12479059 Human
apoptosis antagonizing transcription factor metastasis CONCLUSION: Apoptosis antagonizing transcription factor may play an important role in promoting metastasis of osteosarcoma. 12479059 Human
ded malignancy The antiapoptotic principle, Ded protein, found in both cell lineages may stand for immortalization but could also determine malignancy per se in medulloblastoma. 12973738 Human
ded medulloblastoma The antiapoptotic principle, Ded protein, found in both cell lineages may stand for immortalization but could also determine malignancy per se in medulloblastoma. 12973738 Human
apoptosis antagonizing transcription factor human osteosarcoma [Apoptosis antagonizing transcription factor is a gene highly expressed in highly metastatic human osteosarcoma cell lines] BACKGROUND & OBJECTIVE: Osteosarcoma is the most common malignant bone tumor in adolescents and yound adults. 12479059 Human
apoptosis antagonizing transcription factor malignant bone tumor [Apoptosis antagonizing transcription factor is a gene highly expressed in highly metastatic human osteosarcoma cell lines] BACKGROUND & OBJECTIVE: Osteosarcoma is the most common malignant bone tumor in adolescents and yound adults. 12479059 Human
apoptosis antagonizing transcription factor osteosarcoma [Apoptosis antagonizing transcription factor is a gene highly expressed in highly metastatic human osteosarcoma cell lines] BACKGROUND & OBJECTIVE: Osteosarcoma is the most common malignant bone tumor in adolescents and yound adults. 12479059 Human
apoptosis antagonizing transcription factor osteosarcoma [Apoptosis antagonizing transcription factor is a gene highly expressed in highly metastatic human osteosarcoma cell lines] BACKGROUND & OBJECTIVE: Osteosarcoma is the most common malignant bone tumor in adolescents and yound adults. 12479059 Human
apoptosis antagonizing transcription factor osteosarcoma CONCLUSION: Apoptosis antagonizing transcription factor may play an important role in promoting metastasis of osteosarcoma. 12479059 Human
che-1 tumor These Che-1 modifications induce transcription of p53, and Che-1 depletion strongly sensitizes tumor cells to anticancer drugs. 18049476 Human

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