IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene ACACA Ensembl ENSG00000132142 Chromosome 17 Start 32516036 End 32841015
Description Acetyl-CoA carboxylase 1 (EC 6.4.1.2)(ACC-alpha) [Includes Biotin carboxylase(EC 6.3.4.14)] [Source:UniProtKB/Swiss-Prot;Acc:Q13085]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :
     HGNC : 84
     Entrez Gene : 31
     UCSC : uc002hno.2
     GeneCards : 84
     RefSeq : NM_198834
     CCDS : CCDS11317.1
     Uniprot : Q86WB2
     Interpro : Q86WB2
     OMIM : 200350
     GeneTests : ACACA
     CGAP : ACACA

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  38528_at  0.25  3.28e-3  8.91e-3  0.24  1.66e-2  3.57e-2
 HG_U133A  212186_at  0.08  4.41e-1  4.97e-1  -6.21  6.05e-99  3.98e-98
 HG_U133A  214358_at  0.89  2.35e-8  7.13e-8  0.27  9.97e-2  1.05e-1
 HG_U133_Plus2  212186_at  0.19  3.96e-2  6.86e-2  0.28  2.85e-3  5.09e-3
 HG_U133_Plus2  214358_at  0.09  5.80e-1  6.61e-1  0.28  1.73e-1  2.21e-1
 Stanford  7738  0.20  3.25e-1  5.27e-1  -0.17  4.67e-1  6.89e-1
 Agilent_HS_21.6K  18951  -0.02  2.99e-1  4.86e-1  -0.02  4.09e-1  5.68e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  212186_at  -0.42  3.53e-1  8.90e-1  0.04  9.14e-1  1.00e+0
 HG_U133A  214358_at  0.18  7.37e-1  9.74e-1  0.23  5.36e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 38528_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 212186_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 214358_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 212186_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 214358_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 7738    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 18951    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
acca breast cancers Interestingly, ACCA originally known as a rate-limiting enzyme for fatty acids biosynthesis, has been recently shown to be over-expressed in breast cancers and considered as a potential target for anti-neoplastic therapy. 12360400 Human
acc-1 infiltrating carcinomas Using an indirect immunoperoxidase technique with a polyclonal antibody (CaMp) for calmodulin (CaM) and monoclonal antibodies against CaM activated form of cyclic nucleotide phosphodiesterase (ACAP-1) and calcium activated CaM (ACC-1), we have investigate 7682869 Human
acc-1 lobular carcinomas All cases of non-infiltrating as well as infiltrating ductal and lobular carcinomas were reactive with the above-mentioned antisera, although a marked variation both in the proportion of cells stained within a tumour and in the intensity of staining of th 7682869 Human
acc-1 tumour All cases of non-infiltrating as well as infiltrating ductal and lobular carcinomas were reactive with the above-mentioned antisera, although a marked variation both in the proportion of cells stained within a tumour and in the intensity of staining of th 7682869 Human
acc-alpha prostate cancer Silencing of the ACC-alpha gene resulted in a similar inhibition of cell proliferation and induction of caspase-mediated apoptosis of highly lipogenic LNCaP prostate cancer cells as observed after FAS RNAi. 16061653 Human
acc-alpha cancer These findings indicate that accumulation of malonyl-CoA is not a prerequisite for cytotoxicity induced by inhibition of tumor-associated lipogenesis and suggest that in addition to FAS, ACC-alpha is a potential target for cancer intervention. 16061653 Human
accalpha breast cancer The identification of an interaction between BRCA1 and acetyl-CoA carboxylase alpha (ACCalpha), a key enzyme in lipid synthesis, led us to investigate the role of ACCalpha in breast cancer development, where it might contribute to the energy-sensing mecha 15333468 Human
accalpha high-risk breast cancer In order to investigate if certain ACCalpha alleles may be high-risk breast cancer susceptibility alleles, 37 extended breast and breast/ovarian cancer families negative for BRCA1 and BRCA2 mutations were exhaustively screened for sequence variations in t 15333468 Human
accalpha breast-ovarian cancer In order to investigate if certain ACCalpha alleles may be high-risk breast cancer susceptibility alleles, 37 extended breast and breast/ovarian cancer families negative for BRCA1 and BRCA2 mutations were exhaustively screened for sequence variations in t 15333468 Human
accalpha breast cancer The prevalence of the ACCalpha haplotypes composed of common polymorphisms was determined in 453 breast cancer cases and 469 female controls. 15333468 Human
accalpha breast cancer Our results indicate that mutations in the ACCalpha gene are unlikely to be a major cause of high-risk breast cancer susceptibility; however, certain common ACCalpha alleles may influence breast cancer risk. 15333468 Human
accalpha high-risk breast cancer Our results indicate that mutations in the ACCalpha gene are unlikely to be a major cause of high-risk breast cancer susceptibility; however, certain common ACCalpha alleles may influence breast cancer risk. 15333468 Human
accalpha breast cancer This study provides the first insight into the involvement of the ACCalpha gene in breast cancer predisposition and calls for further, large-scale studies that will be needed to understand the role of ACCalpha in tumour susceptibility and development. 15333468 Human
accalpha tumour This study provides the first insight into the involvement of the ACCalpha gene in breast cancer predisposition and calls for further, large-scale studies that will be needed to understand the role of ACCalpha in tumour susceptibility and development. 15333468 Human

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