IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene DDX52 Ensembl ENSG00000141141 Chromosome 17 Start 33046526 End 33077600
Description Probable ATP-dependent RNA helicase DDX52 (EC 3.6.1.-)(DEAD box protein 52)(ATP-dependent RNA helicase ROK1-like) [Source:UniProtKB/Swiss-Prot;Acc:Q9Y2R4]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 20038
     Entrez Gene : 11056
     UCSC : uc002hoi.1
     GeneCards : 20038
     RefSeq : NM_007010
     CCDS : CCDS11323.1
     Uniprot : Q9Y2R4
     Interpro : Q9Y2R4
     OMIM : 612500
     GeneTests : DDX52
     CGAP : DDX52
     PMID : 11124703

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  38358_at  0.43  2.45e-3  6.94e-3  0.41  4.47e-2  8.36e-2
 HG_U133A  210320_s_at  0.34  2.10e-8  6.41e-8  4.72  1.16e-79  4.65e-79
 HG_U133A  212834_at  0.37  1.17e-9  4.05e-9  1.93  8.03e-70  2.60e-69
 HG_U133_Plus2  1570415_at  -0.28  2.17e-1  2.96e-1  -0.32  1.86e-1  2.35e-1
 HG_U133_Plus2  210320_s_at  0.63  4.43e-15  6.06e-14  0.44  2.34e-6  6.53e-6
 HG_U133_Plus2  212834_at  0.16  2.60e-2  4.76e-2  0.24  1.95e-3  3.57e-3
 Agilent_HS_21.6K  6006  0.14  1.49e-3  1.05e-2  0.16  2.18e-4  1.53e-3

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  210320_s_at  0.02  9.15e-1  9.95e-1  0.05  7.54e-1  1.00e+0
 HG_U133A  212834_at  -0.06  7.60e-1  9.75e-1  0.12  4.69e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 38358_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 210320_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 212834_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 1570415_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 210320_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 212834_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 6006    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
rok1 metastasis We report here that HA-mediated CD168, a receptor for HA-mediated motility, and its downstream signal molecules, including ROK1, Gab-1, PI3K*p110alpha and eIF4E3, accelerate the progression of AI rather than androgen-dependent CaP and enhance AI cell inva 16864594 Human
rok1 cap We report here that HA-mediated CD168, a receptor for HA-mediated motility, and its downstream signal molecules, including ROK1, Gab-1, PI3K*p110alpha and eIF4E3, accelerate the progression of AI rather than androgen-dependent CaP and enhance AI cell inva 16864594 Human
rok1 cap MicroRNA-based small hairpin RNA-mediated suppression of ROK1 can reverse the malignant role of CD168 signaling in human AI CaP PC3 and DU145 cells. 16864594 Human

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