IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene HNF1B Ensembl ENSG00000108753 Chromosome 17 Start 33120548 End 33179209
Description Hepatocyte nuclear factor 1-beta (HNF-1-beta)(HNF-1B)(Transcription factor 2)(TCF-2)(Variant hepatic nuclear factor 1)(vHNF1)(Homeoprotein LFB3) [Source:UniProtKB/Swiss-Prot;Acc:P35680]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 11630
     Entrez Gene : 6928
     UCSC : uc002hok.3
     GeneCards : 11630
     RefSeq : NM_000458
     CCDS : CCDS11324.1
     Uniprot : P35680
     Interpro : P35680
     OMIM : 189907
     GeneTests : HNF1B
     CGAP : HNF1B
     PMID : 1677179

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  33621_at  0.03  8.63e-1  9.03e-1  -1.32  1.43e-7  1.06e-6
 HG_U95  38506_at  -0.09  6.23e-1  7.12e-1  -1.86  1.78e-16  7.57e-15
 HG_U95  711_at  -0.49  3.04e-2  6.06e-2  -2.28  1.46e-17  8.01e-16
 HG_U133A  205313_at  -0.16  1.35e-1  1.72e-1  -2.34  3.13e-74  1.11e-73
 HG_U133A  208135_at  -0.43  3.23e-3  5.46e-3  -2.05  1.41e-34  2.51e-34
 HG_U133_Plus2  205313_at  -0.03  8.61e-1  8.96e-1  -1.57  3.19e-16  2.89e-15
 HG_U133_Plus2  208135_at  -0.52  1.48e-2  2.90e-2  -1.67  1.01e-16  9.71e-16

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  205313_at  -0.63  6.77e-2  7.29e-1  0.00  9.86e-1  1.00e+0
 HG_U133A  208135_at  -0.08  8.46e-1  9.88e-1  0.26  3.35e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 33621_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 38506_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 711_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 205313_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 208135_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 205313_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 208135_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
hnf1beta cystic disease These studies identify a link between two cystic disease genes, HNF1beta (MODY5) and PKHD1 (ARPKD). 15067314 Human
mody5 cystic disease These studies identify a link between two cystic disease genes, HNF1beta (MODY5) and PKHD1 (ARPKD). 15067314 Human
hnf1beta hepatoma This element increases activity and confers glucocorticoid induction to a heterologous as well as the homologous promoters in differentiated hepatoma cells and is transactivated by HNF4alpha1, HNF4alpha7, HNF1alpha and HNF1beta in dedifferentiated hepatom 11522818 Human
hnf1beta tumor As the HNF1alpha-related transcription factor HNF1beta was expressed in all these tumor cell lines, the loss of HNF1alpha expression was a specific event and was maintained in RCC cell lines. 10326868 Human
hnf-1beta hepatoma Endogenous hepatocyte nuclear factor-1beta (HNF-1beta) mRNA was efficiently degraded by transfection of mouse hepatoma cells with short interfering RNAs. 15148361 Mouse
hnf1beta cancer This down-regulation was correlated with the decrease of Cdx1 and HNF1beta expression in cancer tissue. 12855703 Human
vhnf-1 hepatoblastoma METHODS: The competitive reverse transcriptional polymerase chain reaction was employed to amplify HNF-1 and vHNF-1 mRNA simultaneously and to examine their expression ratio in total RNA extracted from frozen liver tissues of 37 patients with hepatocellul 8912143 Human
vhnf-1 hepatocellular carcinoma METHODS: The competitive reverse transcriptional polymerase chain reaction was employed to amplify HNF-1 and vHNF-1 mRNA simultaneously and to examine their expression ratio in total RNA extracted from frozen liver tissues of 37 patients with hepatocellul 8912143 Human
vhnf-1 hepatoblastoma RESULTS: The ratio of HNF-1 to vHNF-1 mRNA was higher in well-differentiated cases than in poorly-differentiated and undifferentiated cases, except that one poorly-differentiated hepatoblastoma displayed a high ratio. 8912143 Human
vhnf-1 hepatoblastoma CONCLUSIONS: These results suggested that the ratio of HNF-1 to vHNF-1 mRNA correlated with histological differentiation of HCC and hepatoblastoma. 8912143 Human
lfb3 teratocarcinoma The absolute requirement of LFB3 as well as the cooperation among the three domains for cAMP regulation were confirmed by transient transfection assays in F9 teratocarcinoma cells, in which the level of LFB3 was negligible. 7665606 Human
vhnf1 hepatoma This domain is proline and glutamine-rich and is highly homologous (66%) to a portion of vHNF1, an evolutionarily related gene first identified in dedifferentiated hepatoma cells. 8288579 Human
vhnf1 embryonal carcinoma To assess the possible involvement of HNF1 and/or vHNF1 as transcriptional regulators in the early steps of visceral endoderm differentiation, we have analyzed the expression pattern of both factors both in vitro during differentiation of murine F9 embryo 1363228 Human
lfb3 hepatoma However, LFB3 expression seems not to be directly correlated with the liver-specific phenotype, since it is detected in dedifferentiated hepatoma cell lines which express neither LFB1 nor several liver-specific genes. 1673925 Human
lfb3 embryonic carcinoma LFB3 expression starts before that of LFB1 during mouse and rat development, and is strongly increased upon retinoic acid induced differentiation of F9 embryonic carcinoma cells. 1673925 Mouse
vhnf1 hepatoma Nevertheless, we show by Northern blot analysis that vHNF1 transcripts are present in differentiated human HepG2 hepatoma cells as well as in rat liver and that this transcript level is 10-20 fold lower than that of HNF1. 1677179 Rat
hnf1beta cysts In humans, heterozygous mutations in the HNF1beta gene are associated with young-onset diabetes as well as a variety of disorders of renal development with cysts as the most consistent feature. 12874457 Human
hnf1beta cystic disease Our results uncover a direct transcriptional hierarchy between HNF1beta and cystic disease genes. 15029248 Human
hnf1beta renal neoplasms The seminal observation of an ovarian carcinoma in a MODY5 patient who subsequently developed a chromophobe renal cell carcinoma, prompted us to screen for HNF1beta and HNF1alpha inactivation in a series of 20 ovarian and 35 renal neoplasms. 15649945 Human
hnf1beta ovarian carcinoma The seminal observation of an ovarian carcinoma in a MODY5 patient who subsequently developed a chromophobe renal cell carcinoma, prompted us to screen for HNF1beta and HNF1alpha inactivation in a series of 20 ovarian and 35 renal neoplasms. 15649945 Human
hnf1beta chromophobe renal-cell carcinoma The seminal observation of an ovarian carcinoma in a MODY5 patient who subsequently developed a chromophobe renal cell carcinoma, prompted us to screen for HNF1beta and HNF1alpha inactivation in a series of 20 ovarian and 35 renal neoplasms. 15649945 Human
hnf1beta chromophobe renal carcinomas Biallelic HNF1beta inactivation was found in two of 12 chromophobe renal carcinomas by association of a germline mutation and a somatic gene deletion. 15649945 Human
hnf1beta renal tumors Finally, these results suggest that germline mutations of HNF1beta and HNF1alpha may predispose to renal tumors. 15649945 Human
hnf1beta tumor Furthermore, we suggest that HNF1beta functions as a tumor suppressor gene in chromophobe renal cell carcinogenesis through a PKHD1 expression control. 15649945 Human
mody5 renal neoplasms The seminal observation of an ovarian carcinoma in a MODY5 patient who subsequently developed a chromophobe renal cell carcinoma, prompted us to screen for HNF1beta and HNF1alpha inactivation in a series of 20 ovarian and 35 renal neoplasms. 15649945 Human
mody5 ovarian carcinoma The seminal observation of an ovarian carcinoma in a MODY5 patient who subsequently developed a chromophobe renal cell carcinoma, prompted us to screen for HNF1beta and HNF1alpha inactivation in a series of 20 ovarian and 35 renal neoplasms. 15649945 Human
mody5 chromophobe renal-cell carcinoma The seminal observation of an ovarian carcinoma in a MODY5 patient who subsequently developed a chromophobe renal cell carcinoma, prompted us to screen for HNF1beta and HNF1alpha inactivation in a series of 20 ovarian and 35 renal neoplasms. 15649945 Human
vhnf-1 hcc CONCLUSIONS: These results suggested that the ratio of HNF-1 to vHNF-1 mRNA correlated with histological differentiation of HCC and hepatoblastoma. 8912143 Human
hnf-1beta liver tumours When compared with the normal liver tissue, HNF-1beta, HNF-3alpha and HNF-3beta showed unchanged expression levels in the various liver tumours, which HNF-1alpha and HNF-4 mRNAs were lowered by 20-30%, and HNF-3gamma mRNA was increased by 50%. 8631153 Human
hnf-1beta papillary cancer RT-PCR or Western blot analysis indicated that hepatocyte nuclear factor-1beta (HNF-1beta) was expressed in only papillary cancer cell lines with high NNMT gene expression. 15486044 Human
hnf-1beta cancer HNF-1beta was not expressed or expressed very weakly in other papillary, follicular, and Hurthle cancer cell lines and primary cultures of normal thyroid cells and benign thyroid conditions. 15486044 Human
hnf-1beta liver cancer Cotransfection of a HNF-1beta expression plasmid increased NNMT promoter activity significantly in both HNF-1beta-positive and -negative thyroid cancer cell lines and Hep G2 liver cancer cells. 15486044 Human
hnf-1beta thyroid cancer Cotransfection of a HNF-1beta expression plasmid increased NNMT promoter activity significantly in both HNF-1beta-positive and -negative thyroid cancer cell lines and Hep G2 liver cancer cells. 15486044 Human
hnf-1beta papillary thyroid cancer In summary, HNF-1beta functions as a transcription activator for NNMT gene expression in some papillary thyroid cancer cells. 15486044 Human
hnf-1beta kidney cysts Cyst formation correlates with inhibition of Pkhd1 expression, which argues that mutations of HNF-1beta produce kidney cysts by down-regulating the ARPKD gene, Pkhd1. 15647252 Mouse
hnf-1beta cyst Cyst formation correlates with inhibition of Pkhd1 expression, which argues that mutations of HNF-1beta produce kidney cysts by down-regulating the ARPKD gene, Pkhd1. 15647252 Mouse
hnf1beta chromophobe renal cell carcinoma Mutations in BHD and TP53 genes, but not in HNF1beta gene, in a large series of sporadic chromophobe renal cell carcinoma. 17133269 Human
hnf1beta oncocytoma BHD, TP53, and HNF1beta on chromosome 17 were studied in 92 cases of renal cell carcinoma (46 chromophobe, 19 clear cell, 18 oncocytoma, and nine papillary). 17133269 Human
hnf1beta renal cell carcinoma BHD, TP53, and HNF1beta on chromosome 17 were studied in 92 cases of renal cell carcinoma (46 chromophobe, 19 clear cell, 18 oncocytoma, and nine papillary). 17133269 Human
hnf-1beta clear cell adenocarcinoma Previous studies using DNA microarrays have demonstrated that hepatocyte nuclear factor-1beta (HNF-1beta) is expressed specifically in clear cell adenocarcinoma (CCC). 17270029 Human
hnf-1beta mucinous adenocarcinoma We first confirmed that HNF-1beta expression levels were significantly higher in CCC than in non-CCC (i.e. serous adenocarcinoma, mucinous adenocarcinoma and endometrioid adenocarcinoma) in 55 surgical specimens at both the mRNA (P < 0.05) and protein (P 17270029 Human
hnf-1beta endometrioid adenocarcinoma We first confirmed that HNF-1beta expression levels were significantly higher in CCC than in non-CCC (i.e. serous adenocarcinoma, mucinous adenocarcinoma and endometrioid adenocarcinoma) in 55 surgical specimens at both the mRNA (P < 0.05) and protein (P 17270029 Human
hnf-1beta serous adenocarcinoma We first confirmed that HNF-1beta expression levels were significantly higher in CCC than in non-CCC (i.e. serous adenocarcinoma, mucinous adenocarcinoma and endometrioid adenocarcinoma) in 55 surgical specimens at both the mRNA (P < 0.05) and protein (P 17270029 Human
hnf-1beta ovarian carcinoma In conclusion, our findings indicate the specific expression of HNF-1beta in ovarian CCC and possible clinical applications of HNF-1beta immunocytochemical staining for the differential cytopathological diagnosis of CCC from non-CCC, as well as from mesot 17270029 Human
hnf-1beta ovarian clear cell carcinoma Immunocytochemistry for hepatocyte nuclear factor-1beta (HNF-1beta): a marker for ovarian clear cell carcinoma. 17351940 Human
hnf-1beta clear cell carcinoma (ccc) Recent microarray studies have shown that the expression of hepatocyte nuclear factor-1beta (HNF-1beta) was significantly up-regulated in clear cell carcinoma (CCC) of the ovary. 17351940 Human
hnf-1beta ovarian cancers Five of 5 CCCs were distinctively positive for HNF-1beta, whereas all non-CCC ovarian cancers were negative for this protein. 17351940 Human
tcf-2 colorectal carcinomas METHODS: The expression of cell cycle regulators cyclin D1, P16, P21WAF1/CIP1, P53, Rb and PCNA were detected by immunohistochemical staining, and MSI at six microsatellite loci (D18S34, D17S799, D5S409, TCF-2, Rb and P53) were examined by PCR-SSLP in 56 11776643 Human
vhnf1 embryonal carcinoma In support of this idea, expression of vHNF1 but not HNF1 is induced upon treatment of the embryonal carcinoma cell line F9 with retinoic acid. 8622679 Human
vhnf1 ovarian carcinomas Analysis of RNA from various cell lines and surgical specimens confirmed that vHNF1 is expressed in ovarian carcinomas. 12566316 Human
vhnf1 ovarian carcinoma Thus, vHNF1 regulates tissue-specific transcription in ovarian carcinoma. 12566316 Human
tcf2 chromophobe renal cell carcinoma Cystic kidney disease, chromophobe renal cell carcinoma and TCF2 (HNF1 beta) mutations. 16932376 Human
tcf2 chromophobe renal cell carcinoma DIAGNOSIS: The proband was diagnosed with cystic kidney disease and chromophobe renal cell carcinoma, characterized by a 46delC germline mutation of TCF2 and a complete somatic deletion of TCF2 in the renal tumor. 16932376 Human
tcf2 renal tumor DIAGNOSIS: The proband was diagnosed with cystic kidney disease and chromophobe renal cell carcinoma, characterized by a 46delC germline mutation of TCF2 and a complete somatic deletion of TCF2 in the renal tumor. 16932376 Human
mody5 chromophobe renal cell carcinoma The seminal observation of an ovarian carcinoma in a MODY5 patient who subsequently developed a chromophobe renal cell carcinoma, prompted us to screen for HNF1beta and HNF1alpha inactivation in a series of 20 ovarian and 35 renal neoplasms. 15649945 Human
hnf1beta chromophobe renal cell carcinoma The seminal observation of an ovarian carcinoma in a MODY5 patient who subsequently developed a chromophobe renal cell carcinoma, prompted us to screen for HNF1beta and HNF1alpha inactivation in a series of 20 ovarian and 35 renal neoplasms. 15649945 Human
hnf-1beta cysts A new kindred with this "renal cysts and diabetes" syndrome is described, and nephrogenic HNF-1beta expression is defined. 11562418 Human
hnf-1beta cysts In this review, we highlight recent insights into three types of disease associated with glomerular cysts: (1) mutations of the hepatocyte nuclear factor 1beta (HNF-1beta)in the recently described renal cysts and diabetes syndrome, (2) mutations of OFD1in 11956871 Human
hnf1beta polycystic kidney and hepatic disease In these cases, the expression of PKHD1 (polycystic kidney and hepatic disease 1) and UMOD (Uromodulin), two genes regulated by HNF1beta, was turned off. 15649945 Human
tcf2 cysts TCF2 anomalies were associated with bilateral renal anomalies (P < 0.001) and bilateral cortical cysts (P < 0.001). 16371430 Human
tcf2 cancer Epigenetic inactivation of TCF2 in ovarian cancer and various cancer cell lines. 16479257 Human
tcf2 ovarian cancer Epigenetic inactivation of TCF2 in ovarian cancer and various cancer cell lines. 16479257 Human
tcf2 ovarian cancer Mutation of TCF2 has been observed in renal cell cancer, and by screening aberrantly methylated genes, we have now identified TCF2 as a target for epigenetic inactivation in ovarian cancer. 16479257 Human
tcf2 renal cell cancer Mutation of TCF2 has been observed in renal cell cancer, and by screening aberrantly methylated genes, we have now identified TCF2 as a target for epigenetic inactivation in ovarian cancer. 16479257 Human
tcf2 ovarian cancer TCF2 was methylated in 53% of ovarian cancer cell lines and 26% of primary ovarian cancers, resulting in loss of the gene's expression. 16479257 Human
tcf2 primary ovarian cancers TCF2 was methylated in 53% of ovarian cancer cell lines and 26% of primary ovarian cancers, resulting in loss of the gene's expression. 16479257 Human
tcf2 tumours Restoration of TCF2 expression induced expression of HNF4alpha, a transcriptional target of HNF1beta, indicating that epigenetic silencing of TCF2 leads to alteration of the hepatocyte nuclear factor network in tumours. 16479257 Human
tcf2 ovarian cancers These results suggest that TCF2 is involved in the development of ovarian cancers and may represent a useful target for their detection and treatment. 16479257 Human
mody5 kidney cysts Transgenic mice expressing mutant HNF-1beta under the control of a kidney-specific promoter develop kidney cysts and renal failure, which is similar to the phenotype of humans with MODY5. 16221171 Mouse
mody5 cyst They establish a previously unrecognized link between two renal cystic diseases, MODY5 and ARPKD, and suggest that the mechanism of cyst formation in humans with mutations of HNF-1beta involves down-regulation of PKHD1 gene transcription. 16221171 Human
hnf1beta cancer of the ovary Furthermore, HNF1beta overexpression has been observed in clear cell cancer of the ovary. 16297991 Human
hnf1beta clear cell carcinoma Since nine of the potential HNF1beta target genes are deregulated in clear cell carcinoma of the ovary, we propose that HNF1beta overexpression in the ovarian cancer participates in the altered expression pattern. 16297991 Human
hnf1beta ovarian cancer Since nine of the potential HNF1beta target genes are deregulated in clear cell carcinoma of the ovary, we propose that HNF1beta overexpression in the ovarian cancer participates in the altered expression pattern. 16297991 Human
hnf1beta tumours Restoration of TCF2 expression induced expression of HNF4alpha, a transcriptional target of HNF1beta, indicating that epigenetic silencing of TCF2 leads to alteration of the hepatocyte nuclear factor network in tumours. 16479257 Human
hnf-1beta kidney cysts Transgenic mice expressing mutant HNF-1beta under the control of a kidney-specific promoter develop kidney cysts and renal failure, which is similar to the phenotype of humans with MODY5. 16221171 Mouse
hnf-1beta renal cyst Similarly, kidney-specific deletion of HNF-1beta using Cre/loxP recombination results in renal cyst formation. 16221171 Human
hnf-1beta cyst They establish a previously unrecognized link between two renal cystic diseases, MODY5 and ARPKD, and suggest that the mechanism of cyst formation in humans with mutations of HNF-1beta involves down-regulation of PKHD1 gene transcription. 16221171 Human
hnf-1beta clear cell tumors Expression of hepatocyte nuclear factor-1beta (HNF-1beta) in clear cell tumors and endometriosis of the ovary. 16258507 Human
hnf-1beta clear cell carcinoma Microarray analysis revealed recently that hepatocyte nuclear factor-1beta (HNF-1beta) was significantly upregulated in clear cell carcinoma of the ovary. 16258507 Human
hnf-1beta brenner tumors All of the 30 clear cell tumors, including borderline and benign ones, showed immunohistochemical expression of HNF-1beta in the nucleus, while other types of ovarian epithelial tumors (endometrioid, serous, mucinous, and Brenner tumors) rarely expressed 16258507 Human
hnf-1beta brenner tumors All of the 30 clear cell tumors, including borderline and benign ones, showed immunohistochemical expression of HNF-1beta in the nucleus, while other types of ovarian epithelial tumors (endometrioid, serous, mucinous, and Brenner tumors) rarely expressed 16258507 Human
hnf-1beta clear cell tumors All of the 30 clear cell tumors, including borderline and benign ones, showed immunohistochemical expression of HNF-1beta in the nucleus, while other types of ovarian epithelial tumors (endometrioid, serous, mucinous, and Brenner tumors) rarely expressed 16258507 Human
hnf-1beta ovarian epithelial tumors All of the 30 clear cell tumors, including borderline and benign ones, showed immunohistochemical expression of HNF-1beta in the nucleus, while other types of ovarian epithelial tumors (endometrioid, serous, mucinous, and Brenner tumors) rarely expressed 16258507 Human
hnf-1beta cysts Furthermore, 16 of 40 (40%) endometriotic cysts without a neoplasm also expressed HNF-1beta, and the expression was almost exclusively observed in the epithelium showing inflammatory atypia. 16258507 Human
hnf-1beta neoplasm Furthermore, 16 of 40 (40%) endometriotic cysts without a neoplasm also expressed HNF-1beta, and the expression was almost exclusively observed in the epithelium showing inflammatory atypia. 16258507 Human
hnf-1beta clear cell tumors Our results indicate that HNF-1beta is an excellent molecular marker for ovarian clear cell tumors, including benign, borderline and malignant lesions. 16258507 Human
hnf-1beta papillary thyroid cancer In summary, depsipeptide represses NNMT and HNF-1beta gene expression in some papillary thyroid cancer cells. the repression of NNMT by depsipeptide is at the transcription level through downregulation of transcription activator HNF-1beta. 16676400 Human
hnf-1beta clear-cell carcinomas Clear-cell carcinomas are characterized by mutations of TGFbetaR2 and over-expression of HNF-1beta, and probably arise from ovarian endometriosis. 16776856 Human
hnf-1beta congenital cystic diseases Roles of HNF-1beta in kidney development and congenital cystic diseases. 16221171 Human
hnf-1beta clear cell tumor In nine of the 12 cases, distinct nuclear immunostaining for HNF-1beta was detected in the endometriotic epithelium, as well as in the clear cell tumor. 16258507 Human
hnf-1beta polycystic diseases This is associated with abnormal development of primary cilia at the apical pole of the duct cells and with reduced expression of a set of genes involved in polycystic diseases, namely those coding for HNF-1beta and for the cilium-associated proteins poly 16472605 Human
hnf1beta rcc As the HNF1alpha-related transcription factor HNF1beta was expressed in all these tumor cell lines, the loss of HNF1alpha expression was a specific event and was maintained in RCC cell lines. 10326868 Human
hnf1beta carcinogenesis Furthermore, we suggest that HNF1beta functions as a tumor suppressor gene in chromophobe renal cell carcinogenesis through a PKHD1 expression control. 15649945 Human
hnf-1beta hepatoma Comprehensive search for HNF-1beta-regulated genes in mouse hepatoma cells perturbed by transcription regulatory factor-targeted RNAi. 15148361 Mouse
hnf-1beta papillary cancer NNMT promoter activity was significantly reduced in the HNF-1beta-positive BHP 18-21 cells but not in the HNF-1beta-negative BHP 14-9 papillary cancer cells. 16676400 Human
hnf1beta polycystic liver disease Loss of Hhex in the embryonic liver (Alfp-Cre;Hhex(d2,3/-)) caused irregular development of intrahepatic bile ducts and an absence of Hnf1beta in many (cystic) biliary epithelial cells, which resulted in a slow, progressive form of polycystic liver diseas 17580084 Human
hnf1beta liver metastases Notably, the genes coding for HNF6, HNF1beta, and C/EBPgamma were selectively regulated in liver metastases. 17283222 Human
hnf-1beta ovarian carcinomas We examined HNF-1beta expression immunohistochemically in 186 ovarian carcinomas, including 40 CCAs; 33 endometrial carcinomas, including 5 CCAs; 22 endometria at different stages of the menstrual cycle (5 in the proliferative, 12 in the secretory, and 5 17442376 Human
hnf-1beta endometrial carcinomas We examined HNF-1beta expression immunohistochemically in 186 ovarian carcinomas, including 40 CCAs; 33 endometrial carcinomas, including 5 CCAs; 22 endometria at different stages of the menstrual cycle (5 in the proliferative, 12 in the secretory, and 5 17442376 Human
hnf1b prostate cancer Two studies have identified a version (allele) of a variant in the HNF1B (also known as TCF2) gene that predisposes to type 2 diabetes, and one of them showed that the same allele protects men from prostate cancer. 18696045 Human
hnf1b prostate cancer Evidence for two independent prostate cancer risk-associated loci in the HNF1B gene at 17q12. 18758462 Human
hnf1b prostate cancer We carried out a fine-mapping study in the HNF1B gene at 17q12 in two study populations and identified a second locus associated with prostate cancer risk, approximately 26 kb centromeric to the first known locus (rs4430796); these loci are separated by a 18758462 Human
tcf2 ovarian tumors We obtain the genes HNF1-beta (TCF2) and GGT1 as the best markers for the clear cell and CEACAM6 (NCA) as the best marker for mucinous ovarian tumors. 17503391 Human
tcf2 prostate cancer Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes. 17603485 Human
tcf2 pancreatic cancer In the present study, the role of ONECUT1 and its targeted genes TCF2, PKHD1 and CYS1 was analyzed in human pancreatic ductal adenocarcinoma (PDAC). mRNA levels of ONECUT1, TCF2, PKHD1 and CYS1 were measured in pancreatic tissues and pancreatic cancer cel 18097590 Human
tcf2 pancreatic ductal adenocarcinoma In the present study, the role of ONECUT1 and its targeted genes TCF2, PKHD1 and CYS1 was analyzed in human pancreatic ductal adenocarcinoma (PDAC). mRNA levels of ONECUT1, TCF2, PKHD1 and CYS1 were measured in pancreatic tissues and pancreatic cancer cel 18097590 Human
tcf2 pancreatic cancer Transfection of ONECUT1 into pancreatic cancer cells resulted in up-regulation of the target gene TCF2, a reduction in invasiveness, but no change in adhesion or growth. 18097590 Human
tcf2 prostate cancer Two studies have identified a version (allele) of a variant in the HNF1B (also known as TCF2) gene that predisposes to type 2 diabetes, and one of them showed that the same allele protects men from prostate cancer. 18696045 Human
hnf1beta ovarian tumors We obtain the genes HNF1-beta (TCF2) and GGT1 as the best markers for the clear cell and CEACAM6 (NCA) as the best marker for mucinous ovarian tumors. 17503391 Human
hnf-1beta clear cell carcinoma Hypomethylation of hepatocyte nuclear factor-1beta (HNF-1beta) CpG island in clear cell carcinoma of the ovary. 18066692 Human
hnf-1beta ovarian clear cell carcinoma Expression of hepatocyte nuclear factor-1beta (HNF-1beta) is significantly up-regulated in ovarian clear cell carcinoma (CCC). 18066692 Human
hnf-1beta serous adenocarcinomas In archival surgical specimens, 20 of 20 CCCs were immunohistochemically positive for HNF-1beta, whereas none of 20 serous adenocarcinomas (SAs) or 12 normal ovaries were positive for it. 18066692 Human
hnf-1beta cyst Knockout of HNF-1beta in the mouse kidney results in cyst formation. 18077349 Mouse
hnf-1beta clear cell carcinoma Overexpression of osteopontin in clear cell carcinoma of the ovary: close association with HNF-1beta expression. 18393978 Human
hnf-1beta tumors Our previous study showed that HNF-1beta was highly expressed in papillary thyroid cancer cell lines and tumors. 18399756 Human
hnf-1beta papillary thyroid cancer Our previous study showed that HNF-1beta was highly expressed in papillary thyroid cancer cell lines and tumors. 18399756 Human
vhnf1 hepatoma Sequence comparison of our clone with a rat variant HNF1 (vHNF1) clone, isolated in parallel in our laboratory from the dedifferentiated H5 hepatoma cell line, identified our cDNA as human vHNF1. vHNF1 is a nuclear protein recognizing the same binding sit 1677179 NA

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