| hnf1beta |
cystic disease |
These studies identify a link between two cystic disease genes, HNF1beta (MODY5) and PKHD1 (ARPKD). |
15067314 |
Human |
| mody5 |
cystic disease |
These studies identify a link between two cystic disease genes, HNF1beta (MODY5) and PKHD1 (ARPKD). |
15067314 |
Human |
| hnf1beta |
hepatoma |
This element increases activity and confers glucocorticoid induction to a heterologous as well as the homologous promoters in differentiated hepatoma cells and is transactivated by HNF4alpha1, HNF4alpha7, HNF1alpha and HNF1beta in dedifferentiated hepatom |
11522818 |
Human |
| hnf1beta |
tumor |
As the HNF1alpha-related transcription factor HNF1beta was expressed in all these tumor cell lines, the loss of HNF1alpha expression was a specific event and was maintained in RCC cell lines. |
10326868 |
Human |
| hnf-1beta |
hepatoma |
Endogenous hepatocyte nuclear factor-1beta (HNF-1beta) mRNA was efficiently degraded by transfection of mouse hepatoma cells with short interfering RNAs. |
15148361 |
Mouse |
| hnf1beta |
cancer |
This down-regulation was correlated with the decrease of Cdx1 and HNF1beta expression in cancer tissue. |
12855703 |
Human |
| vhnf-1 |
hepatoblastoma |
METHODS: The competitive reverse transcriptional polymerase chain reaction was employed to amplify HNF-1 and vHNF-1 mRNA simultaneously and to examine their expression ratio in total RNA extracted from frozen liver tissues of 37 patients with hepatocellul |
8912143 |
Human |
| vhnf-1 |
hepatocellular carcinoma |
METHODS: The competitive reverse transcriptional polymerase chain reaction was employed to amplify HNF-1 and vHNF-1 mRNA simultaneously and to examine their expression ratio in total RNA extracted from frozen liver tissues of 37 patients with hepatocellul |
8912143 |
Human |
| vhnf-1 |
hepatoblastoma |
RESULTS: The ratio of HNF-1 to vHNF-1 mRNA was higher in well-differentiated cases than in poorly-differentiated and undifferentiated cases, except that one poorly-differentiated hepatoblastoma displayed a high ratio. |
8912143 |
Human |
| vhnf-1 |
hepatoblastoma |
CONCLUSIONS: These results suggested that the ratio of HNF-1 to vHNF-1 mRNA correlated with histological differentiation of HCC and hepatoblastoma. |
8912143 |
Human |
| lfb3 |
teratocarcinoma |
The absolute requirement of LFB3 as well as the cooperation among the three domains for cAMP regulation were confirmed by transient transfection assays in F9 teratocarcinoma cells, in which the level of LFB3 was negligible. |
7665606 |
Human |
| vhnf1 |
hepatoma |
This domain is proline and glutamine-rich and is highly homologous (66%) to a portion of vHNF1, an evolutionarily related gene first identified in dedifferentiated hepatoma cells. |
8288579 |
Human |
| vhnf1 |
embryonal carcinoma |
To assess the possible involvement of HNF1 and/or vHNF1 as transcriptional regulators in the early steps of visceral endoderm differentiation, we have analyzed the expression pattern of both factors both in vitro during differentiation of murine F9 embryo |
1363228 |
Human |
| lfb3 |
hepatoma |
However, LFB3 expression seems not to be directly correlated with the liver-specific phenotype, since it is detected in dedifferentiated hepatoma cell lines which express neither LFB1 nor several liver-specific genes. |
1673925 |
Human |
| lfb3 |
embryonic carcinoma |
LFB3 expression starts before that of LFB1 during mouse and rat development, and is strongly increased upon retinoic acid induced differentiation of F9 embryonic carcinoma cells. |
1673925 |
Mouse |
| vhnf1 |
hepatoma |
Nevertheless, we show by Northern blot analysis that vHNF1 transcripts are present in differentiated human HepG2 hepatoma cells as well as in rat liver and that this transcript level is 10-20 fold lower than that of HNF1. |
1677179 |
Rat |
| hnf1beta |
cysts |
In humans, heterozygous mutations in the HNF1beta gene are associated with young-onset diabetes as well as a variety of disorders of renal development with cysts as the most consistent feature. |
12874457 |
Human |
| hnf1beta |
cystic disease |
Our results uncover a direct transcriptional hierarchy between HNF1beta and cystic disease genes. |
15029248 |
Human |
| hnf1beta |
renal neoplasms |
The seminal observation of an ovarian carcinoma in a MODY5 patient who subsequently developed a chromophobe renal cell carcinoma, prompted us to screen for HNF1beta and HNF1alpha inactivation in a series of 20 ovarian and 35 renal neoplasms. |
15649945 |
Human |
| hnf1beta |
ovarian carcinoma |
The seminal observation of an ovarian carcinoma in a MODY5 patient who subsequently developed a chromophobe renal cell carcinoma, prompted us to screen for HNF1beta and HNF1alpha inactivation in a series of 20 ovarian and 35 renal neoplasms. |
15649945 |
Human |
| hnf1beta |
chromophobe renal-cell carcinoma |
The seminal observation of an ovarian carcinoma in a MODY5 patient who subsequently developed a chromophobe renal cell carcinoma, prompted us to screen for HNF1beta and HNF1alpha inactivation in a series of 20 ovarian and 35 renal neoplasms. |
15649945 |
Human |
| hnf1beta |
chromophobe renal carcinomas |
Biallelic HNF1beta inactivation was found in two of 12 chromophobe renal carcinomas by association of a germline mutation and a somatic gene deletion. |
15649945 |
Human |
| hnf1beta |
renal tumors |
Finally, these results suggest that germline mutations of HNF1beta and HNF1alpha may predispose to renal tumors. |
15649945 |
Human |
| hnf1beta |
tumor |
Furthermore, we suggest that HNF1beta functions as a tumor suppressor gene in chromophobe renal cell carcinogenesis through a PKHD1 expression control. |
15649945 |
Human |
| mody5 |
renal neoplasms |
The seminal observation of an ovarian carcinoma in a MODY5 patient who subsequently developed a chromophobe renal cell carcinoma, prompted us to screen for HNF1beta and HNF1alpha inactivation in a series of 20 ovarian and 35 renal neoplasms. |
15649945 |
Human |
| mody5 |
ovarian carcinoma |
The seminal observation of an ovarian carcinoma in a MODY5 patient who subsequently developed a chromophobe renal cell carcinoma, prompted us to screen for HNF1beta and HNF1alpha inactivation in a series of 20 ovarian and 35 renal neoplasms. |
15649945 |
Human |
| mody5 |
chromophobe renal-cell carcinoma |
The seminal observation of an ovarian carcinoma in a MODY5 patient who subsequently developed a chromophobe renal cell carcinoma, prompted us to screen for HNF1beta and HNF1alpha inactivation in a series of 20 ovarian and 35 renal neoplasms. |
15649945 |
Human |
| vhnf-1 |
hcc |
CONCLUSIONS: These results suggested that the ratio of HNF-1 to vHNF-1 mRNA correlated with histological differentiation of HCC and hepatoblastoma. |
8912143 |
Human |
| hnf-1beta |
liver tumours |
When compared with the normal liver tissue, HNF-1beta, HNF-3alpha and HNF-3beta showed unchanged expression levels in the various liver tumours, which HNF-1alpha and HNF-4 mRNAs were lowered by 20-30%, and HNF-3gamma mRNA was increased by 50%. |
8631153 |
Human |
| hnf-1beta |
papillary cancer |
RT-PCR or Western blot analysis indicated that hepatocyte nuclear factor-1beta (HNF-1beta) was expressed in only papillary cancer cell lines with high NNMT gene expression. |
15486044 |
Human |
| hnf-1beta |
cancer |
HNF-1beta was not expressed or expressed very weakly in other papillary, follicular, and Hurthle cancer cell lines and primary cultures of normal thyroid cells and benign thyroid conditions. |
15486044 |
Human |
| hnf-1beta |
liver cancer |
Cotransfection of a HNF-1beta expression plasmid increased NNMT promoter activity significantly in both HNF-1beta-positive and -negative thyroid cancer cell lines and Hep G2 liver cancer cells. |
15486044 |
Human |
| hnf-1beta |
thyroid cancer |
Cotransfection of a HNF-1beta expression plasmid increased NNMT promoter activity significantly in both HNF-1beta-positive and -negative thyroid cancer cell lines and Hep G2 liver cancer cells. |
15486044 |
Human |
| hnf-1beta |
papillary thyroid cancer |
In summary, HNF-1beta functions as a transcription activator for NNMT gene expression in some papillary thyroid cancer cells. |
15486044 |
Human |
| hnf-1beta |
kidney cysts |
Cyst formation correlates with inhibition of Pkhd1 expression, which argues that mutations of HNF-1beta produce kidney cysts by down-regulating the ARPKD gene, Pkhd1. |
15647252 |
Mouse |
| hnf-1beta |
cyst |
Cyst formation correlates with inhibition of Pkhd1 expression, which argues that mutations of HNF-1beta produce kidney cysts by down-regulating the ARPKD gene, Pkhd1. |
15647252 |
Mouse |
| hnf1beta |
chromophobe renal cell carcinoma |
Mutations in BHD and TP53 genes, but not in HNF1beta gene, in a large series of sporadic chromophobe renal cell carcinoma. |
17133269 |
Human |
| hnf1beta |
oncocytoma |
BHD, TP53, and HNF1beta on chromosome 17 were studied in 92 cases of renal cell carcinoma (46 chromophobe, 19 clear cell, 18 oncocytoma, and nine papillary). |
17133269 |
Human |
| hnf1beta |
renal cell carcinoma |
BHD, TP53, and HNF1beta on chromosome 17 were studied in 92 cases of renal cell carcinoma (46 chromophobe, 19 clear cell, 18 oncocytoma, and nine papillary). |
17133269 |
Human |
| hnf-1beta |
clear cell adenocarcinoma |
Previous studies using DNA microarrays have demonstrated that hepatocyte nuclear factor-1beta (HNF-1beta) is expressed specifically in clear cell adenocarcinoma (CCC). |
17270029 |
Human |
| hnf-1beta |
mucinous adenocarcinoma |
We first confirmed that HNF-1beta expression levels were significantly higher in CCC than in non-CCC (i.e. serous adenocarcinoma, mucinous adenocarcinoma and endometrioid adenocarcinoma) in 55 surgical specimens at both the mRNA (P < 0.05) and protein (P |
17270029 |
Human |
| hnf-1beta |
endometrioid adenocarcinoma |
We first confirmed that HNF-1beta expression levels were significantly higher in CCC than in non-CCC (i.e. serous adenocarcinoma, mucinous adenocarcinoma and endometrioid adenocarcinoma) in 55 surgical specimens at both the mRNA (P < 0.05) and protein (P |
17270029 |
Human |
| hnf-1beta |
serous adenocarcinoma |
We first confirmed that HNF-1beta expression levels were significantly higher in CCC than in non-CCC (i.e. serous adenocarcinoma, mucinous adenocarcinoma and endometrioid adenocarcinoma) in 55 surgical specimens at both the mRNA (P < 0.05) and protein (P |
17270029 |
Human |
| hnf-1beta |
ovarian carcinoma |
In conclusion, our findings indicate the specific expression of HNF-1beta in ovarian CCC and possible clinical applications of HNF-1beta immunocytochemical staining for the differential cytopathological diagnosis of CCC from non-CCC, as well as from mesot |
17270029 |
Human |
| hnf-1beta |
ovarian clear cell carcinoma |
Immunocytochemistry for hepatocyte nuclear factor-1beta (HNF-1beta): a marker for ovarian clear cell carcinoma. |
17351940 |
Human |
| hnf-1beta |
clear cell carcinoma (ccc) |
Recent microarray studies have shown that the expression of hepatocyte nuclear factor-1beta (HNF-1beta) was significantly up-regulated in clear cell carcinoma (CCC) of the ovary. |
17351940 |
Human |
| hnf-1beta |
ovarian cancers |
Five of 5 CCCs were distinctively positive for HNF-1beta, whereas all non-CCC ovarian cancers were negative for this protein. |
17351940 |
Human |
| tcf-2 |
colorectal carcinomas |
METHODS: The expression of cell cycle regulators cyclin D1, P16, P21WAF1/CIP1, P53, Rb and PCNA were detected by immunohistochemical staining, and MSI at six microsatellite loci (D18S34, D17S799, D5S409, TCF-2, Rb and P53) were examined by PCR-SSLP in 56 |
11776643 |
Human |
| vhnf1 |
embryonal carcinoma |
In support of this idea, expression of vHNF1 but not HNF1 is induced upon treatment of the embryonal carcinoma cell line F9 with retinoic acid. |
8622679 |
Human |
| vhnf1 |
ovarian carcinomas |
Analysis of RNA from various cell lines and surgical specimens confirmed that vHNF1 is expressed in ovarian carcinomas. |
12566316 |
Human |
| vhnf1 |
ovarian carcinoma |
Thus, vHNF1 regulates tissue-specific transcription in ovarian carcinoma. |
12566316 |
Human |
| tcf2 |
chromophobe renal cell carcinoma |
Cystic kidney disease, chromophobe renal cell carcinoma and TCF2 (HNF1 beta) mutations. |
16932376 |
Human |
| tcf2 |
chromophobe renal cell carcinoma |
DIAGNOSIS: The proband was diagnosed with cystic kidney disease and chromophobe renal cell carcinoma, characterized by a 46delC germline mutation of TCF2 and a complete somatic deletion of TCF2 in the renal tumor. |
16932376 |
Human |
| tcf2 |
renal tumor |
DIAGNOSIS: The proband was diagnosed with cystic kidney disease and chromophobe renal cell carcinoma, characterized by a 46delC germline mutation of TCF2 and a complete somatic deletion of TCF2 in the renal tumor. |
16932376 |
Human |
| mody5 |
chromophobe renal cell carcinoma |
The seminal observation of an ovarian carcinoma in a MODY5 patient who subsequently developed a chromophobe renal cell carcinoma, prompted us to screen for HNF1beta and HNF1alpha inactivation in a series of 20 ovarian and 35 renal neoplasms. |
15649945 |
Human |
| hnf1beta |
chromophobe renal cell carcinoma |
The seminal observation of an ovarian carcinoma in a MODY5 patient who subsequently developed a chromophobe renal cell carcinoma, prompted us to screen for HNF1beta and HNF1alpha inactivation in a series of 20 ovarian and 35 renal neoplasms. |
15649945 |
Human |
| hnf-1beta |
cysts |
A new kindred with this "renal cysts and diabetes" syndrome is described, and nephrogenic HNF-1beta expression is defined. |
11562418 |
Human |
| hnf-1beta |
cysts |
In this review, we highlight recent insights into three types of disease associated with glomerular cysts: (1) mutations of the hepatocyte nuclear factor 1beta (HNF-1beta)in the recently described renal cysts and diabetes syndrome, (2) mutations of OFD1in |
11956871 |
Human |
| hnf1beta |
polycystic kidney and hepatic disease |
In these cases, the expression of PKHD1 (polycystic kidney and hepatic disease 1) and UMOD (Uromodulin), two genes regulated by HNF1beta, was turned off. |
15649945 |
Human |
| tcf2 |
cysts |
TCF2 anomalies were associated with bilateral renal anomalies (P < 0.001) and bilateral cortical cysts (P < 0.001). |
16371430 |
Human |
| tcf2 |
cancer |
Epigenetic inactivation of TCF2 in ovarian cancer and various cancer cell lines. |
16479257 |
Human |
| tcf2 |
ovarian cancer |
Epigenetic inactivation of TCF2 in ovarian cancer and various cancer cell lines. |
16479257 |
Human |
| tcf2 |
ovarian cancer |
Mutation of TCF2 has been observed in renal cell cancer, and by screening aberrantly methylated genes, we have now identified TCF2 as a target for epigenetic inactivation in ovarian cancer. |
16479257 |
Human |
| tcf2 |
renal cell cancer |
Mutation of TCF2 has been observed in renal cell cancer, and by screening aberrantly methylated genes, we have now identified TCF2 as a target for epigenetic inactivation in ovarian cancer. |
16479257 |
Human |
| tcf2 |
ovarian cancer |
TCF2 was methylated in 53% of ovarian cancer cell lines and 26% of primary ovarian cancers, resulting in loss of the gene's expression. |
16479257 |
Human |
| tcf2 |
primary ovarian cancers |
TCF2 was methylated in 53% of ovarian cancer cell lines and 26% of primary ovarian cancers, resulting in loss of the gene's expression. |
16479257 |
Human |
| tcf2 |
tumours |
Restoration of TCF2 expression induced expression of HNF4alpha, a transcriptional target of HNF1beta, indicating that epigenetic silencing of TCF2 leads to alteration of the hepatocyte nuclear factor network in tumours. |
16479257 |
Human |
| tcf2 |
ovarian cancers |
These results suggest that TCF2 is involved in the development of ovarian cancers and may represent a useful target for their detection and treatment. |
16479257 |
Human |
| mody5 |
kidney cysts |
Transgenic mice expressing mutant HNF-1beta under the control of a kidney-specific promoter develop kidney cysts and renal failure, which is similar to the phenotype of humans with MODY5. |
16221171 |
Mouse |
| mody5 |
cyst |
They establish a previously unrecognized link between two renal cystic diseases, MODY5 and ARPKD, and suggest that the mechanism of cyst formation in humans with mutations of HNF-1beta involves down-regulation of PKHD1 gene transcription. |
16221171 |
Human |
| hnf1beta |
cancer of the ovary |
Furthermore, HNF1beta overexpression has been observed in clear cell cancer of the ovary. |
16297991 |
Human |
| hnf1beta |
clear cell carcinoma |
Since nine of the potential HNF1beta target genes are deregulated in clear cell carcinoma of the ovary, we propose that HNF1beta overexpression in the ovarian cancer participates in the altered expression pattern. |
16297991 |
Human |
| hnf1beta |
ovarian cancer |
Since nine of the potential HNF1beta target genes are deregulated in clear cell carcinoma of the ovary, we propose that HNF1beta overexpression in the ovarian cancer participates in the altered expression pattern. |
16297991 |
Human |
| hnf1beta |
tumours |
Restoration of TCF2 expression induced expression of HNF4alpha, a transcriptional target of HNF1beta, indicating that epigenetic silencing of TCF2 leads to alteration of the hepatocyte nuclear factor network in tumours. |
16479257 |
Human |
| hnf-1beta |
kidney cysts |
Transgenic mice expressing mutant HNF-1beta under the control of a kidney-specific promoter develop kidney cysts and renal failure, which is similar to the phenotype of humans with MODY5. |
16221171 |
Mouse |
| hnf-1beta |
renal cyst |
Similarly, kidney-specific deletion of HNF-1beta using Cre/loxP recombination results in renal cyst formation. |
16221171 |
Human |
| hnf-1beta |
cyst |
They establish a previously unrecognized link between two renal cystic diseases, MODY5 and ARPKD, and suggest that the mechanism of cyst formation in humans with mutations of HNF-1beta involves down-regulation of PKHD1 gene transcription. |
16221171 |
Human |
| hnf-1beta |
clear cell tumors |
Expression of hepatocyte nuclear factor-1beta (HNF-1beta) in clear cell tumors and endometriosis of the ovary. |
16258507 |
Human |
| hnf-1beta |
clear cell carcinoma |
Microarray analysis revealed recently that hepatocyte nuclear factor-1beta (HNF-1beta) was significantly upregulated in clear cell carcinoma of the ovary. |
16258507 |
Human |
| hnf-1beta |
brenner tumors |
All of the 30 clear cell tumors, including borderline and benign ones, showed immunohistochemical expression of HNF-1beta in the nucleus, while other types of ovarian epithelial tumors (endometrioid, serous, mucinous, and Brenner tumors) rarely expressed |
16258507 |
Human |
| hnf-1beta |
brenner tumors |
All of the 30 clear cell tumors, including borderline and benign ones, showed immunohistochemical expression of HNF-1beta in the nucleus, while other types of ovarian epithelial tumors (endometrioid, serous, mucinous, and Brenner tumors) rarely expressed |
16258507 |
Human |
| hnf-1beta |
clear cell tumors |
All of the 30 clear cell tumors, including borderline and benign ones, showed immunohistochemical expression of HNF-1beta in the nucleus, while other types of ovarian epithelial tumors (endometrioid, serous, mucinous, and Brenner tumors) rarely expressed |
16258507 |
Human |
| hnf-1beta |
ovarian epithelial tumors |
All of the 30 clear cell tumors, including borderline and benign ones, showed immunohistochemical expression of HNF-1beta in the nucleus, while other types of ovarian epithelial tumors (endometrioid, serous, mucinous, and Brenner tumors) rarely expressed |
16258507 |
Human |
| hnf-1beta |
cysts |
Furthermore, 16 of 40 (40%) endometriotic cysts without a neoplasm also expressed HNF-1beta, and the expression was almost exclusively observed in the epithelium showing inflammatory atypia. |
16258507 |
Human |
| hnf-1beta |
neoplasm |
Furthermore, 16 of 40 (40%) endometriotic cysts without a neoplasm also expressed HNF-1beta, and the expression was almost exclusively observed in the epithelium showing inflammatory atypia. |
16258507 |
Human |
| hnf-1beta |
clear cell tumors |
Our results indicate that HNF-1beta is an excellent molecular marker for ovarian clear cell tumors, including benign, borderline and malignant lesions. |
16258507 |
Human |
| hnf-1beta |
papillary thyroid cancer |
In summary, depsipeptide represses NNMT and HNF-1beta gene expression in some papillary thyroid cancer cells. the repression of NNMT by depsipeptide is at the transcription level through downregulation of transcription activator HNF-1beta. |
16676400 |
Human |
| hnf-1beta |
clear-cell carcinomas |
Clear-cell carcinomas are characterized by mutations of TGFbetaR2 and over-expression of HNF-1beta, and probably arise from ovarian endometriosis. |
16776856 |
Human |
| hnf-1beta |
congenital cystic diseases |
Roles of HNF-1beta in kidney development and congenital cystic diseases. |
16221171 |
Human |
| hnf-1beta |
clear cell tumor |
In nine of the 12 cases, distinct nuclear immunostaining for HNF-1beta was detected in the endometriotic epithelium, as well as in the clear cell tumor. |
16258507 |
Human |
| hnf-1beta |
polycystic diseases |
This is associated with abnormal development of primary cilia at the apical pole of the duct cells and with reduced expression of a set of genes involved in polycystic diseases, namely those coding for HNF-1beta and for the cilium-associated proteins poly |
16472605 |
Human |
| hnf1beta |
rcc |
As the HNF1alpha-related transcription factor HNF1beta was expressed in all these tumor cell lines, the loss of HNF1alpha expression was a specific event and was maintained in RCC cell lines. |
10326868 |
Human |
| hnf1beta |
carcinogenesis |
Furthermore, we suggest that HNF1beta functions as a tumor suppressor gene in chromophobe renal cell carcinogenesis through a PKHD1 expression control. |
15649945 |
Human |
| hnf-1beta |
hepatoma |
Comprehensive search for HNF-1beta-regulated genes in mouse hepatoma cells perturbed by transcription regulatory factor-targeted RNAi. |
15148361 |
Mouse |
| hnf-1beta |
papillary cancer |
NNMT promoter activity was significantly reduced in the HNF-1beta-positive BHP 18-21 cells but not in the HNF-1beta-negative BHP 14-9 papillary cancer cells. |
16676400 |
Human |
| hnf1beta |
polycystic liver disease |
Loss of Hhex in the embryonic liver (Alfp-Cre;Hhex(d2,3/-)) caused irregular development of intrahepatic bile ducts and an absence of Hnf1beta in many (cystic) biliary epithelial cells, which resulted in a slow, progressive form of polycystic liver diseas |
17580084 |
Human |
| hnf1beta |
liver metastases |
Notably, the genes coding for HNF6, HNF1beta, and C/EBPgamma were selectively regulated in liver metastases. |
17283222 |
Human |
| hnf-1beta |
ovarian carcinomas |
We examined HNF-1beta expression immunohistochemically in 186 ovarian carcinomas, including 40 CCAs; 33 endometrial carcinomas, including 5 CCAs; 22 endometria at different stages of the menstrual cycle (5 in the proliferative, 12 in the secretory, and 5 |
17442376 |
Human |
| hnf-1beta |
endometrial carcinomas |
We examined HNF-1beta expression immunohistochemically in 186 ovarian carcinomas, including 40 CCAs; 33 endometrial carcinomas, including 5 CCAs; 22 endometria at different stages of the menstrual cycle (5 in the proliferative, 12 in the secretory, and 5 |
17442376 |
Human |
| hnf1b |
prostate cancer |
Two studies have identified a version (allele) of a variant in the HNF1B (also known as TCF2) gene that predisposes to type 2 diabetes, and one of them showed that the same allele protects men from prostate cancer. |
18696045 |
Human |
| hnf1b |
prostate cancer |
Evidence for two independent prostate cancer risk-associated loci in the HNF1B gene at 17q12. |
18758462 |
Human |
| hnf1b |
prostate cancer |
We carried out a fine-mapping study in the HNF1B gene at 17q12 in two study populations and identified a second locus associated with prostate cancer risk, approximately 26 kb centromeric to the first known locus (rs4430796); these loci are separated by a |
18758462 |
Human |
| tcf2 |
ovarian tumors |
We obtain the genes HNF1-beta (TCF2) and GGT1 as the best markers for the clear cell and CEACAM6 (NCA) as the best marker for mucinous ovarian tumors. |
17503391 |
Human |
| tcf2 |
prostate cancer |
Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes. |
17603485 |
Human |
| tcf2 |
pancreatic cancer |
In the present study, the role of ONECUT1 and its targeted genes TCF2, PKHD1 and CYS1 was analyzed in human pancreatic ductal adenocarcinoma (PDAC). mRNA levels of ONECUT1, TCF2, PKHD1 and CYS1 were measured in pancreatic tissues and pancreatic cancer cel |
18097590 |
Human |
| tcf2 |
pancreatic ductal adenocarcinoma |
In the present study, the role of ONECUT1 and its targeted genes TCF2, PKHD1 and CYS1 was analyzed in human pancreatic ductal adenocarcinoma (PDAC). mRNA levels of ONECUT1, TCF2, PKHD1 and CYS1 were measured in pancreatic tissues and pancreatic cancer cel |
18097590 |
Human |
| tcf2 |
pancreatic cancer |
Transfection of ONECUT1 into pancreatic cancer cells resulted in up-regulation of the target gene TCF2, a reduction in invasiveness, but no change in adhesion or growth. |
18097590 |
Human |
| tcf2 |
prostate cancer |
Two studies have identified a version (allele) of a variant in the HNF1B (also known as TCF2) gene that predisposes to type 2 diabetes, and one of them showed that the same allele protects men from prostate cancer. |
18696045 |
Human |
| hnf1beta |
ovarian tumors |
We obtain the genes HNF1-beta (TCF2) and GGT1 as the best markers for the clear cell and CEACAM6 (NCA) as the best marker for mucinous ovarian tumors. |
17503391 |
Human |
| hnf-1beta |
clear cell carcinoma |
Hypomethylation of hepatocyte nuclear factor-1beta (HNF-1beta) CpG island in clear cell carcinoma of the ovary. |
18066692 |
Human |
| hnf-1beta |
ovarian clear cell carcinoma |
Expression of hepatocyte nuclear factor-1beta (HNF-1beta) is significantly up-regulated in ovarian clear cell carcinoma (CCC). |
18066692 |
Human |
| hnf-1beta |
serous adenocarcinomas |
In archival surgical specimens, 20 of 20 CCCs were immunohistochemically positive for HNF-1beta, whereas none of 20 serous adenocarcinomas (SAs) or 12 normal ovaries were positive for it. |
18066692 |
Human |
| hnf-1beta |
cyst |
Knockout of HNF-1beta in the mouse kidney results in cyst formation. |
18077349 |
Mouse |
| hnf-1beta |
clear cell carcinoma |
Overexpression of osteopontin in clear cell carcinoma of the ovary: close association with HNF-1beta expression. |
18393978 |
Human |
| hnf-1beta |
tumors |
Our previous study showed that HNF-1beta was highly expressed in papillary thyroid cancer cell lines and tumors. |
18399756 |
Human |
| hnf-1beta |
papillary thyroid cancer |
Our previous study showed that HNF-1beta was highly expressed in papillary thyroid cancer cell lines and tumors. |
18399756 |
Human |
| vhnf1 |
hepatoma |
Sequence comparison of our clone with a rat variant HNF1 (vHNF1) clone, isolated in parallel in our laboratory from the dedifferentiated H5 hepatoma cell line, identified our cDNA as human vHNF1. vHNF1 is a nuclear protein recognizing the same binding sit |
1677179 |
NA |
