IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene PCGF2 Ensembl ENSG00000056661 Chromosome 17 Start 34143676 End 34158084
Description Polycomb group RING finger protein 2 (DNA-binding protein Mel-18)(RING finger protein 110)(Zinc finger protein 144) [Source:UniProtKB/Swiss-Prot;Acc:P35227]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 12929
     Entrez Gene : 7703
     UCSC : uc002hqp.1
     GeneCards : 12929
     RefSeq : NM_007144
     CCDS : CCDS32638.1
     Uniprot : P35227
     Interpro : P35227
     OMIM : 600346
     GeneTests : PCGF2
     CGAP : PCGF2
     PMID : 8325509

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  32191_at  -0.26  1.31e-1  2.07e-1  -0.44  5.83e-2  1.04e-1
 HG_U95  32192_g_at  -0.10  1.72e-1  2.59e-1  -0.23  1.08e-3  3.32e-3
 HG_U133A  203792_x_at  0.30  1.42e-4  2.90e-4  0.62  2.53e-11  3.23e-11
 HG_U133A  203793_x_at  -0.27  6.56e-7  1.72e-6  -1.52  1.46e-51  3.42e-51
 HG_U133A  213551_x_at  -0.27  2.88e-7  7.85e-7  0.55  2.41e-15  3.27e-15
 HG_U133A  214239_x_at  -0.36  1.11e-6  2.84e-6  -0.18  2.09e-3  2.31e-3
 HG_U133_Plus2  203792_x_at  0.64  2.57e-7  1.28e-6  1.16  3.67e-12  2.09e-11
 HG_U133_Plus2  203793_x_at  0.02  8.04e-1  8.51e-1  0.33  1.22e-3  2.31e-3
 HG_U133_Plus2  213551_x_at  0.16  5.78e-2  9.55e-2  0.46  3.15e-7  9.86e-7
 HG_U133_Plus2  214239_x_at  0.04  6.68e-1  7.38e-1  -0.03  7.34e-1  7.75e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  203792_x_at  -0.17  4.93e-1  9.26e-1  0.02  8.79e-1  1.00e+0
 HG_U133A  203793_x_at  -0.24  1.85e-1  8.23e-1  -0.06  4.98e-1  1.00e+0
 HG_U133A  213551_x_at  -0.18  4.19e-1  9.08e-1  -0.05  6.61e-1  1.00e+0
 HG_U133A  214239_x_at  -0.04  8.44e-1  9.88e-1  0.11  4.28e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 32191_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 32192_g_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 203792_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 203793_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 213551_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 214239_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 203792_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 203793_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 213551_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 214239_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
mel-18 human breast cancer Mutation analysis of the mel-18 gene that shows decreased expression in human breast cancer cell lines. 12196719 Human
mel-18 mammary gland tumors Murine mel-18 negatively regulates the cell cycle through the c-myc/cdc25 cascade, and mice haploinsufficient for mel-18 develop mammary gland tumors. 12196719 Mouse
mel-18 breast cancer In addition, the human homolog of mel-18 is located at 17q, on which candidate tumor suppressor genes for breast cancer have been suggested for a long time. 12196719 Human
mel-18 tumor In addition, the human homolog of mel-18 is located at 17q, on which candidate tumor suppressor genes for breast cancer have been suggested for a long time. 12196719 Human
mel-18 breast cancer These observations indicate that the mel-18 gene may be a tumor suppressor gene for breast cancer. 12196719 Human
mel-18 tumor These observations indicate that the mel-18 gene may be a tumor suppressor gene for breast cancer. 12196719 Human
mel-18 familial breast cancers To investigate this possibility, we examined the expression of mel-18 mRNA in human breast cancer cell lines and searched for mel-18 gene mutations in sporadic and familial breast cancers. 12196719 Human
mel-18 human breast cancer To investigate this possibility, we examined the expression of mel-18 mRNA in human breast cancer cell lines and searched for mel-18 gene mutations in sporadic and familial breast cancers. 12196719 Human
mel-18 breast cancer METHODS: The expression of mel-18 mRNA was examined in five breast cancer cell lines by RT-PCR, and somatic and germline mutations of the mel-18 gene were analyzed by the PCR-SSCP and sequence methods in 48 sporadic breast cancers, including 16 cases with 12196719 Human
mel-18 sporadic breast cancers METHODS: The expression of mel-18 mRNA was examined in five breast cancer cell lines by RT-PCR, and somatic and germline mutations of the mel-18 gene were analyzed by the PCR-SSCP and sequence methods in 48 sporadic breast cancers, including 16 cases with 12196719 Human
mel-18 human breast cancers CONCLUSION: Our results reveal that mel-18 gene mutations are exceedingly rare in human breast cancers, and a reduction of mel-18 expression in human breast cancer cell lines would support a role for mel-18 haploinsufficiency in breast carcinogenesis. 12196719 Human
mel-18 human breast cancer CONCLUSION: Our results reveal that mel-18 gene mutations are exceedingly rare in human breast cancers, and a reduction of mel-18 expression in human breast cancer cell lines would support a role for mel-18 haploinsufficiency in breast carcinogenesis. 12196719 Human
mel-18 tumor Suppression of tumor growth by the 3' untranslated region of mel-18 in 3Y1 cells transformed by the E6 and E7 genes of human papillomavirus type 18. 9233832 Human
mel-18 tumor Previously, we have shown that mouse Mel-18, a Pc-G protein, has tumor suppressor gene-like activity and negatively regulates transcription. 12480532 Mouse
mel-18 tumor mel-18, a Polycomb group-related mammalian gene, encodes a transcriptional negative regulator with tumor suppressive activity. 8521824 Human
mel-18 tumor We also demonstrate that mel-18 has tumor suppressor activity, in contrast to bmi-1, which has been defined as a proto-oncogene. 8521824 Human
mel-18 melanoma We have isolated from B16 mouse melanoma cells a complementary DNA (Mel-18), whose deduced amino acid sequence possesses a characteristic zinc finger structure. 2246278 Human
mel-18 tumor At the transcriptional level the Mel-18 mRNA was detected in all tumor cells examined as well as melanoma cells (ontogenically of neural origin) but was scarcely present in normal tissues except neural organs. 2246278 Human
mel-18 melanoma At the transcriptional level the Mel-18 mRNA was detected in all tumor cells examined as well as melanoma cells (ontogenically of neural origin) but was scarcely present in normal tissues except neural organs. 2246278 Human
mel18 breast cancer Here, we observe that purified RINGs from a variety of functionally unrelated proteins, including promyelocytic leukemia protein, KAP-1TIF1beta, Z, Mel18, breast cancer susceptibility gene product 1 (BRCA1), and BRCA1-associated RING domain (BARD1), self- 12438698 Human
mel18 hl In this study, a large-scale analysis of PcG protein expression (BMI1, MEL18, PH1, RNF2, RING1, and RYBP) was performed in 321 Hodgkin's lymphoma (HL) biopsies and in reactive lymphoid tissues using tissue microarrays. 15470680 Human
mel18 hodgkin's lymphoma In this study, a large-scale analysis of PcG protein expression (BMI1, MEL18, PH1, RNF2, RING1, and RYBP) was performed in 321 Hodgkin's lymphoma (HL) biopsies and in reactive lymphoid tissues using tissue microarrays. 15470680 Human
rnf110 human tumors MLLT6, MLLT10 and LASP1 genes are fusion partners of MLL gene in hematological malignancies, while RNF110, PIP5K2B, LASP1 and BMI1 genes are amplified in human tumors. 15254754 Human
rnf110 hematological malignancies MLLT6, MLLT10 and LASP1 genes are fusion partners of MLL gene in hematological malignancies, while RNF110, PIP5K2B, LASP1 and BMI1 genes are amplified in human tumors. 15254754 Human

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