IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene LASP1 Ensembl ENSG00000002834 Chromosome 17 Start 34279894 End 34331541
Description LIM and SH3 domain protein 1 (LASP-1)(MLN 50) [Source:UniProtKB/Swiss-Prot;Acc:Q14847]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 6513
     Entrez Gene : 3927
     UCSC : uc010cvq.2
     GeneCards : 6513
     RefSeq : NM_006148
     CCDS : CCDS11331.1
     Uniprot : Q14847
     Interpro : Q14847
     OMIM : 602920
     GeneTests : LASP1
     CGAP : LASP1
     PMID : 7490069

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  36181_at  -0.06  5.55e-1  6.54e-1  -0.32  5.43e-4  1.81e-3
 HG_U133A  200618_at  0.03  5.90e-1  6.38e-1  2.03  2.53e-127  3.78e-126
 HG_U133_Plus2  200618_at  0.36  1.25e-5  4.69e-5  0.20  1.14e-2  1.85e-2
 Agilent_HS_21.6K  10114  -0.06  2.39e-1  4.22e-1  -0.15  8.73e-4  4.84e-3

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  200618_at  -0.09  6.00e-1  9.52e-1  -0.01  9.65e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 36181_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 200618_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 200618_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 10114    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
lasp-1 neuroblastoma As expected from its structural similarity to lasp-1, lasp-2 possessed actin-binding activity and localized with actin filament in filopodia of neuroblastoma. 14672696 Human
lasp-1 breast carcinomas The deduced amino acid sequence for pp40 is 93.5%, homologous with the putative protein product of the human gene lasp-1, which was recently identified based on its overexpression in some breast carcinomas. 9688835 Human
lasp-1 human breast cancers The Lasp-1 gene, which has been localized to the q12-q21 region of human chromosome 17, is amplified and overexpressed in human breast cancers. 9848085 Human
lasp-1 epithelial cancer In addition, confocal analysis of the Lasp-1 subcellular distribution shows that the protein is colocalized with actin at peripheral cell extensions in individual epithelial cancer cells and in transformed fibroblastic cells. 9848085 Human
lasp1 breast cancer LASP1 (also known as MLN50) gene, located centromeric to the PPP1R1B-ERBB2-GRB7 locus on human chromosome 17q12, is amplified and over-expressed in breast cancer. 12883659 Human
mln50 breast cancer LASP1 (also known as MLN50) gene, located centromeric to the PPP1R1B-ERBB2-GRB7 locus on human chromosome 17q12, is amplified and over-expressed in breast cancer. 12883659 Human
mln 50 breast cancer Several lines of evidence suggest that ERBB2 is the gene responsible for the emergence of this amplicon, but four novel genes (called MLN 50, MLN 51, MLN 62, and MLN 64) in 17q11-q21 have recently been found to be amplified and overexpressed in breast can 8752152 Human
mln-50 familial breast cancer Thirty clones were sequenced, and of these three showed strong homologies to GenEmbl sequences: (1) to sheep, mouse, human, and rat mammary gland factor (MGF); (2) to MLN-50, a gene that is amplified in human familial breast cancer and is present on human 8703117 Human
lasp1 acute myeloid leukemia The human LASP1 gene is fused to MLL in an acute myeloid leukemia with t(11;17)(q23;q21). 12527918 Human
lasp1 breast cancer Rapid amplification of cDNA ends (RACE) revealed an in-frame fusion of MLL to LASP1, a gene that is amplified and overexpressed in breast cancer. 12527918 Human
mln 50 breast cancer metastasis MLN 50 was previously identified in a cDNA library of breast cancer metastasis. 7589475 Human
mln 50 human breast carcinomas In this study, we show that MLN 50, which is expressed at a basal level in normal tissues, is overexpressed in 8% of human breast carcinomas most often together with c-erbB-2. 7589475 Human
lasp-1 human breast cancers Lasp-1 is a ubiquitously expressed actin-binding protein with a unique domain configuration containing SH3 and LIM domains, and is overexpressed in 8-12% of human breast cancers. 15138294 Human
lasp-1 metastasis In MCF-7 cells IGF-I induced expression of two genes, lasp-1 and mystique, which could contribute to metastasis. 15940254 Human
lasp1 human tumors MLLT6, MLLT10 and LASP1 genes are fusion partners of MLL gene in hematological malignancies, while RNF110, PIP5K2B, LASP1 and BMI1 genes are amplified in human tumors. 15254754 Human
lasp1 hematological malignancies MLLT6, MLLT10 and LASP1 genes are fusion partners of MLL gene in hematological malignancies, while RNF110, PIP5K2B, LASP1 and BMI1 genes are amplified in human tumors. 15254754 Human

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