IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene PLXDC1 Ensembl ENSG00000161381 Chromosome 17 Start 34473083 End 34561298
Description Plexin domain-containing protein 1 Precursor (Tumor endothelial marker 7)(Tumor endothelial marker 3) [Source:UniProtKB/Swiss-Prot;Acc:Q8IUK5]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 20945
     Entrez Gene : 57125
     UCSC : uc002hrg.2
     GeneCards : 20945
     RefSeq : NM_020405
     CCDS : CCDS11333.1
     Uniprot : Q8IUK5
     Interpro : Q8IUK5
     OMIM : 606826
     GeneTests : PLXDC1
     CGAP : PLXDC1
     PMID : 10947988

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  34945_at  0.19  2.98e-1  4.03e-1  -0.00  9.88e-1  9.92e-1
 HG_U133A  214081_at  0.02  8.07e-1  8.36e-1  1.25  6.84e-24  1.05e-23
 HG_U133A  219700_at  0.20  1.92e-2  2.87e-2  -1.65  2.69e-53  6.47e-53
 HG_U133_Plus2  214081_at  0.22  5.07e-2  8.52e-2  0.24  1.55e-2  2.45e-2
 HG_U133_Plus2  219700_at  0.02  8.03e-1  8.50e-1  -0.11  2.56e-1  3.12e-1
 Agilent_HS_21.6K  13630  -0.10  1.43e-1  2.99e-1  -0.20  1.75e-3  8.60e-3

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  214081_at  0.21  3.68e-1  8.96e-1  -0.00  9.74e-1  1.00e+0
 HG_U133A  219700_at  0.37  1.39e-1  8.02e-1  0.14  4.46e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 34945_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 214081_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 219700_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 214081_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 219700_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 13630    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
tem-7 breast cancer In addition, elevated levels of TEM-4, TEM-5, TEM-6, TEM-7 and TEM-7R were also raised in breast cancer tissues. 15065600 Human
tem-7 colon cancer RESULTS: TEM-1 (P = 0.01), TEM-7 (P = 0.04), TEM-7R (P = 0.03), TEM-8 (P = 0.001) significantly raised in colon cancer tissues compared with the levels detected in normal background tissues. 15761964 Human
tem-7 colorectal cancer CONCLUSION: The level of the expression of TEM-1, TEM-7, TEM-7R and TEM-8 (but not TEM-2 and TEM-6) were associated with both nodal involvement and disease progression, and may therefore, have a prognostic value in colorectal cancer. 15761964 Human
tem7 solid tumors Tumor endothelial marker 7 (TEM7) was recently identified as an mRNA transcript overexpressed in the blood vessels of human solid tumors. 15574754 Human
tem7 tumor Here, we identify several new variants of TEM7, derived by alternative splicing, that are predicted to be intracellular (TEM7-I), secreted (TEM7-S), or on the cell surface membrane (TEM7-M) of tumor endothelium. 15574754 Human
tem7 tumor Using new antibodies against the TEM7 protein, we confirmed the predicted expression of TEM7 on the cell surface and demonstrated that TEM7-M protein, like its mRNA, is overexpressed on the endothelium of various tumor types. 15574754 Human
tem7 tumor We then used an affinity purification strategy to search for TEM7-binding proteins and identified cortactin as a protein capable of binding to the extracellular region of both TEM7 and its closest homologue, TEM7-related (TEM7R), which is also expressed i 15574754 Human
tem7 tumor These studies establish the overexpression of TEM7 protein in tumor endothelium and provide new opportunities for the delivery of therapeutic and imaging agents to the vessels of solid tumors. 15574754 Human
tem7 solid tumors These studies establish the overexpression of TEM7 protein in tumor endothelium and provide new opportunities for the delivery of therapeutic and imaging agents to the vessels of solid tumors. 15574754 Human
tem7 tumor Tumor endothelial marker7 (TEM7) is a putative transmembrane protein that is highly expressed in the tumor endothelium. 15893603 Human
tumor endothelial marker7 tumor Tumor endothelial marker7 (TEM7) is a putative transmembrane protein that is highly expressed in the tumor endothelium. 15893603 Human
tumor endothelial marker 7 solid tumors Tumor endothelial marker 7 (TEM7) was recently identified as an mRNA transcript overexpressed in the blood vessels of human solid tumors. 15574754 Human

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