IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene MED1 Ensembl ENSG00000125686 Chromosome 17 Start 34814075 End 34861053
Description Mediator of RNA polymerase II transcription subunit 1 (Mediator complex subunit 1)(Peroxisome proliferator-activated receptor-binding protein)(PPAR-binding protein)(PBP)(Thyroid hormone receptor-associated protein complex 220 kDa component)(Trap220)(Thyroid receptor-interacting protein 2)(TRIP-2)(p53 regulatory protein RB18A)(Vitamin D receptor-interacting protein complex component DRIP205)(Activator-recruited cofactor 205 kDa component)(ARC205) [Source:UniProtKB/Swiss-Prot;Acc:Q15648]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 9234
     Entrez Gene : 5469
     UCSC : uc002hrv.3
     GeneCards : 9234
     RefSeq : NM_004774
     CCDS : CCDS11336.1
     Uniprot : Q15648
     Interpro : Q15648
     OMIM : 604311
     GeneTests : MED1
     CGAP : MED1
     PMID : 9325263

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  32064_at  0.23  5.24e-2  9.59e-2  0.16  3.04e-1  4.06e-1
 HG_U133A  203496_s_at  1.27  1.48e-10  5.56e-10  5.68  5.17e-98  3.31e-97
 HG_U133A  203497_at  0.22  6.81e-4  1.27e-3  0.77  1.46e-18  2.08e-18
 HG_U133_Plus2  203496_s_at  0.09  5.50e-1  6.34e-1  -0.29  1.17e-1  1.55e-1
 HG_U133_Plus2  203497_at  -0.07  2.99e-1  3.86e-1  -0.28  1.52e-3  2.83e-3
 HG_U133_Plus2  225452_at  0.56  1.53e-12  1.54e-11  0.55  6.03e-11  2.97e-10
 HG_U133_Plus2  225456_at  0.04  6.39e-1  7.13e-1  -0.18  1.01e-1  1.35e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  203496_s_at  -0.25  7.47e-1  9.74e-1  0.22  6.33e-1  1.00e+0
 HG_U133A  203497_at  0.14  4.99e-1  9.27e-1  0.12  3.49e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 32064_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 203496_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 203497_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 203496_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 203497_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 225452_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 225456_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
pbp prostate cancer Immunohistochemistry and Western blot analysis were used to evaluate PBP expression in the prostate and prostate cancer cells. 14991861 Human
rb18a cancers In addition, fluorescence in situ hybridization mapping led to localizing the RB18A gene on chromosome 17q12-q21.1, loci associated with human cancers. 11118038 Human
pparbp breast cancer Amplification and overexpression of peroxisome proliferator-activated receptor binding protein (PBP/PPARBP) gene in breast cancer. 10485914 Human
peroxisome proliferator-activated receptor binding protein breast cancer Amplification and overexpression of peroxisome proliferator-activated receptor binding protein (PBP/PPARBP) gene in breast cancer. 10485914 Human
pbp breast cancer Amplification and overexpression of peroxisome proliferator-activated receptor binding protein (PBP/PPARBP) gene in breast cancer. 10485914 Human
pbp breast tumors To examine whether overexpression of PBP plays a role in breast cancer because of its coactivator function in ER signaling, we determined the levels of PBP expression in breast tumors. 10485914 Human
pbp breast cancer To examine whether overexpression of PBP plays a role in breast cancer because of its coactivator function in ER signaling, we determined the levels of PBP expression in breast tumors. 10485914 Human
pbp primary breast cancers High levels of PBP expression were detected in approximately 50% of primary breast cancers and breast cancer cell lines by ribonuclease protection analysis, in situ hybridization, and immunoperoxidase staining. 10485914 Human
pbp breast cancer High levels of PBP expression were detected in approximately 50% of primary breast cancers and breast cancer cell lines by ribonuclease protection analysis, in situ hybridization, and immunoperoxidase staining. 10485914 Human
pbp breast cancers Fluorescence in situ hybridization of human chromosomes revealed that the PBP gene is located on chromosome 17q12, a region that is amplified in some breast cancers. 10485914 Human
pbp breast tumors We found PBP gene amplification in approximately 24% (6/25) of breast tumors and approximately 30% (2/6) of breast cancer cell lines, implying that PBP gene overexpression can occur independent of gene amplification. 10485914 Human
pbp breast cancer We found PBP gene amplification in approximately 24% (6/25) of breast tumors and approximately 30% (2/6) of breast cancer cell lines, implying that PBP gene overexpression can occur independent of gene amplification. 10485914 Human
pbp advanced ovarian cancer PURPOSE: We performed a pilot phase II study to evaluate the potential for delivery of rapidly sequenced high-dose chemotherapy treatments rescued with autologous peripheral-blood progenitor cells (PBP) in patients with previously untreated, advanced ovar 9586901 Human
rb18a b lymphoma Immunological screening with the anti-p53 moAb, PAb1801 of a cDNA expression library, prepared from human B lymphoma cells, led us to identify a new human 205 kDa protein called RB18A for 'Recognized By PAb1801 moAntibody'. 9444950 Human
pbp hepatocellular carcinoma (hcc) The present study was aimed at determining the incidence of bile duct necrosis and biloma in hepatocellular carcinoma (HCC) after transcatheter arterial embolization therapy (TAE) or hepatic arterial infusion chemotherapy (HAI), and also clarifying the re 8395764 Human
pbp carcinomas Similarly, higher concentrations (expressed as nanograms per milligram of cytosol protein) of GCDFP-15 (2110 +/- 840 versus 210 +/- 40, p less than 0.001) and PBP (4920 +/- 1200 versus 370 +/- 60, P less than 0.001) were found in grade 1 as compared with 7202259 Human
drip205 breast cancer In ZR-75 breast cancer cells treated with 17beta-estradiol (E2) and transfected with a construct containing three tandem estrogen responsive elements (pERE(3)), DRIP205 coactivates ERalpha-mediated transactivation. 15471764 Human
med-1 cancer The choice of the start point of transcription in a multiple start site window is related to an upstream MED-1 cis-element, the sequence and configuration of which are specific to human MDR1 gene expressed in Pgp-overproducing cancer cells. 10918491 Human
med-1 medulloblastomas METHODS: Three human medulloblastomas cell lines (HTB-186, CRL-8805 and MED-1) were treated with genistein at 6 microM, the maximum reported dietary plasma level in children, combined with cisplatin (0-10 microM) or vincristine (0-1 microM). 11096359 Human
med1 carcinomas The DNA repair gene MBD4 (MED1) is mutated in human carcinomas with microsatellite instability. 10545939 Human
med1 pancreatic cancers Interestingly, frameshift mutations of the MED1 gene have been reported in human colorectal, endometrial, and pancreatic cancers. 11056019 Human
med1 cancer Role of MED1 (MBD4) Gene in DNA repair and human cancer. 11267993 Human
med1 cancer Mutagenesis caused by these deamination events is a frequent mechanism of genetic instability in cancer; thus, based on the biochemical activity of its gene product, MED1 is a candidate tumor suppressor gene. 11267993 Human
med1 tumor Mutagenesis caused by these deamination events is a frequent mechanism of genetic instability in cancer; thus, based on the biochemical activity of its gene product, MED1 is a candidate tumor suppressor gene. 11267993 Human
med1 pancreatic cancer Indeed, frameshift mutations of the MED1 gene have been reported in human colorectal, gastric, endometrial, and pancreatic cancer. 11267993 Human
med1 cancer In the future, efforts should be directed toward investigations of the functional role of the MED1 gene in the pathogenesis, prevention, and treatment of human cancer. 11267993 Human
med1 glioma We found expression of MBDs including MBD1, MBD2, MBD3 and MBD4/MED1 in all glioma cell lines and glioma biopsies. 11836615 Human
med1 malignancy MBD3 and MBD4/MED1, however, showed a correlation of expression with the grade of malignancy. 11836615 Human
med1 primary gastric cancer Frameshift mutations in the MBD4/MED1 gene in primary gastric cancer with high-frequency microsatellite instability. 12430186 Human
med1 colon cancers To assess its role in gastric cancers, we investigated MBD4/MED1 mutations in sporadic gastric cancers, compared with colon cancers. 12430186 Human
med1 gastric cancers To assess its role in gastric cancers, we investigated MBD4/MED1 mutations in sporadic gastric cancers, compared with colon cancers. 12430186 Human
med1 estrogen-dependent breast cancer Finally, RNAi studies show that MED1/TRAP220 is required for ER-mediated transcription and estrogen-dependent breast cancer cell growth. 15989967 Human
pbp hyperplastic Here, we report that targeted deletion of PBP in liver parenchymal cells (PBP(Liv-/-)) results in the abrogation of hypertrophic and hyperplastic influences in liver mediated by constitutive androstane receptor (CAR) ligands phenobarbital (PB) and 1,4-bis 16109766 Human
the pbp gene breast cancers Fluorescence in situ hybridization of human chromosomes revealed that the PBP gene is located on chromosome 17q12, a region that is amplified in some breast cancers. 10485914 Human
trap220 necrosis The reduced expression in hypomorphs results in hepatic necrosis, defects in hematopoiesis, and hypoplasia of the ventricular myocardium, similar to that observed in TRAP220 null embryos at an earlier stage. 14500757 Human
trap220 tumor These results suggested that a TRAP220 complex play an important role as putative co-activator complexes in BRCA1-mediated tumor suppression. 15208681 Human
trap220 estrogen-dependent breast cancer Finally, RNAi studies show that MED1/TRAP220 is required for ER-mediated transcription and estrogen-dependent breast cancer cell growth. 15989967 Human

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