IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene STARD3 Ensembl ENSG00000131748 Chromosome 17 Start 35046938 End 35073248
Description StAR-related lipid transfer protein 3 (START domain-containing protein 3)(StARD3)(Metastatic lymph node protein 64)(Protein MLN 64)(Protein CAB1) [Source:UniProtKB/Swiss-Prot;Acc:Q14849]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :
     HGNC : 17579
     Entrez Gene : 10948
     UCSC : uc002hsd.2
     GeneCards : 17579
     RefSeq : NM_001165937
     CCDS : CCDS11341.1
     Uniprot : Q14849
     Interpro : Q14849
     OMIM : 607048
     GeneTests : STARD3
     CGAP : STARD3

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  37355_at  0.02  8.83e-1  9.17e-1  -0.23  4.20e-2  7.95e-2
 HG_U133A  202991_at  -0.20  6.32e-3  1.02e-2  0.35  1.54e-5  1.78e-5
 HG_U133_Plus2  202991_at  0.02  7.82e-1  8.33e-1  -0.26  8.69e-2  1.18e-1
 Agilent_HS_21.6K  12301  -0.10  6.44e-3  3.28e-2  -0.10  8.62e-4  4.79e-3

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  202991_at  0.01  9.46e-1  9.97e-1  0.07  4.69e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 37355_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 202991_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 202991_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 12301    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
cab1 cancers We previously reported that CAB1 and c-ERBB-2 genes were found to be located in a core amplified region of the 17q12 locus, which is frequently amplified in various cancers. 12460457 Human
cab1 human gastric cancer In many cases of human gastric cancer, a proto-oncogene ERBB-2 is co-amplified with CAB1 genes physically linked to ERBB-2, and both genes are over-expressed. 10967128 Human
mln64 glioblastoma A total of 14 clones could be matched to known genes and were categorized into four groups: A) transcription factors: prothymosin, CA150, p78 serine/threonine kinase, IL-1beta-stimulating gene, glucocorticoid receptor, MLN64/CAB1, gastrin-binding protein, 11146166 Human
cab1 glioblastoma A total of 14 clones could be matched to known genes and were categorized into four groups: A) transcription factors: prothymosin, CA150, p78 serine/threonine kinase, IL-1beta-stimulating gene, glucocorticoid receptor, MLN64/CAB1, gastrin-binding protein, 11146166 Human
cab1 primary gastric cancer Molecular cloning of human GRB-7 co-amplified with CAB1 and c-ERBB-2 in primary gastric cancer. 9125150 Human
mln64 human breast carcinomas MLN64 exhibits homology with the steroidogenic acute regulatory protein (STAR) and is over-expressed in human breast carcinomas. 9139840 Human
mln64 invasive breast carcinomas Of the 93 primary invasive breast carcinomas that were examined, 14 were found to over-express MLN64. 9139840 Human
mln64 breast carcinomas MLN64 mRNA and protein were specifically detected in malignant cells of breast carcinomas. 9139840 Human
mln64 tumors In this case, the high levels of MLN64 observed in some breast carcinomas could contribute to the progression of these tumors through increased intratumoral steroidogenesis. 9139840 Human
mln64 breast carcinomas In this case, the high levels of MLN64 observed in some breast carcinomas could contribute to the progression of these tumors through increased intratumoral steroidogenesis. 9139840 Human
mln64 breast carcinomas MLN64 is a protein that is highly expressed in certain breast carcinomas. 9237999 Human
cab1 esophageal cancer CAB1, GRB-7, and c-ERBB-2 were overexpressed in gastric and esophageal cancer cells in correspondence with the amplification. 9270027 Human
mln 64 breast cancer Several lines of evidence suggest that ERBB2 is the gene responsible for the emergence of this amplicon, but four novel genes (called MLN 50, MLN 51, MLN 62, and MLN 64) in 17q11-q21 have recently been found to be amplified and overexpressed in breast can 8752152 Human
mln 64 breast cancer Our results suggest that: (a) an independent, amplified region defined by MLN 62 (also called CART1 or TRAF4) is located in 17q11-q12; (b) in addition to ERBB2, MLN 64 is a major target for the 17q12-q21 amplicon; and (c) these MLN genes could be of patho 8752152 Human
cab1 mouse mammary tumor In addition to these differences, these analyses revealed that in contrast to the mouse mammary tumor virus-based Neu model, the endogenous promoter tumors expressed elevated levels of two genes (Grb7 and Cab1) that are closely linked to ErbB2 and often c 12941816 Human
cab1 noninvasive ductal carcinoma In addition to these differences, these analyses revealed that in contrast to the mouse mammary tumor virus-based Neu model, the endogenous promoter tumors expressed elevated levels of two genes (Grb7 and Cab1) that are closely linked to ErbB2 and often c 12941816 Human
cab1 tumors In addition to these differences, these analyses revealed that in contrast to the mouse mammary tumor virus-based Neu model, the endogenous promoter tumors expressed elevated levels of two genes (Grb7 and Cab1) that are closely linked to ErbB2 and often c 12941816 Human
stard3 gastric cancer PPP1R1B, STARD3, MGC9753, ERBB2 and GRB7 genes are co-amplified in several cases of gastric cancer. 12739007 Human
mln64 breast cancers Metastatic lymph node 64 (MLN64), a gene overexpressed in breast cancers, is regulated by Sp/KLF transcription factors. 12802284 Human
mln64 breast cancers MLN64, is invariably coamplified and coexpressed with erbB-2 in breast cancers. 12802284 Human
mln64 cancer To understand the molecular basis of MLN64 overexpression in cancer, the genomic region containing the MLN64 and ERBB2 genes was isolated and mapped. 12802284 Human
mln64 breast cancer The two genes, DARPP32 and Telethonin, flanking MLN64 respectively on its centromeric and telomeric sides, although coamplified, are not overexpressed in breast cancer cells, indicating that gene amplification is not sufficient to allow overexpression. 12802284 Human
mln64 breast tumors We speculate that, in addition to the oncogenic potential of erbB-2 overexpression, the unbalanced action of MLN64 contributes to the poor clinical outcome of breast tumors bearing this amplified region. 12802284 Human
cab1 ductal carcinoma in situ In addition to these differences, these analyses revealed that in contrast to the mouse mammary tumor virus-based Neu model, the endogenous promoter tumors expressed elevated levels of two genes (Grb7 and Cab1) that are closely linked to ErbB2 and often c 12941816 Human

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