IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene PNMT Ensembl ENSG00000141744 Chromosome 17 Start 35077760 End 35080254
Description Phenylethanolamine N-methyltransferase (PNMTase)(EC 2.1.1.28)(Noradrenaline N-methyltransferase) [Source:UniProtKB/Swiss-Prot;Acc:P11086]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 9160
     Entrez Gene : 5409
     UCSC : uc002hsi.1
     GeneCards : 9160
     RefSeq : NM_002686
     CCDS : CCDS11343.1
     Uniprot : P11086
     Interpro : P11086
     OMIM : 171190
     GeneTests : PNMT
     CGAP : PNMT
     PMID : 3372503

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  32352_at  0.24  1.37e-2  3.08e-2  0.41  4.97e-4  1.67e-3
 HG_U133A  206793_at  -0.46  6.92e-5  1.47e-4  -1.27  1.40e-15  1.91e-15
 HG_U133_Plus2  206793_at  -0.38  1.21e-2  2.42e-2  -0.35  4.46e-2  6.45e-2
 Stanford  18400  0.14  6.60e-1  7.99e-1  0.38  4.48e-1  6.74e-1
 Agilent_HS_21.6K  6809  -0.27  1.57e-4  1.73e-3  -0.35  1.27e-13  1.92e-11

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  206793_at  0.36  3.67e-1  8.96e-1  0.27  3.02e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 32352_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 206793_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 206793_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 18400    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 6809    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
pnmt multiple endocrine neoplasia This study examined the mechanisms linking different biochemical and clinical phenotypes of pheochromocytoma in multiple endocrine neoplasia type 2 (MEN 2) and von Hippel-Lindau (VHL) syndrome to underlying differences in the expression of tyrosine hydrox 11344198 Human
phenylethanolamine n-methyltransferase multiple endocrine neoplasia This study examined the mechanisms linking different biochemical and clinical phenotypes of pheochromocytoma in multiple endocrine neoplasia type 2 (MEN 2) and von Hippel-Lindau (VHL) syndrome to underlying differences in the expression of tyrosine hydrox 11344198 Human
pnmt tumor Signs and symptoms of pheochromocytoma, plasma catecholamines and metanephrines, and tumor cell neurochemistry and expression of TH and PNMT were examined in 19 MEN 2 patients and 30 VHL patients with adrenal pheochromocytomas. 11344198 Human
pnmt tumors MATERIALS AND METHODS: As a first step toward understanding the molecular mechanisms by which adrenaline synthesis is controlled in these tumors, we measured the level of mRNA coding for the adrenaline-synthesizing enzyme phenylethanolamine N-methyl trans 10604389 Human
pnmt tumors PNMT immunoreactivity was only detected in the adrenaline-secreting tumors. 10604389 Human
pnmt tumors PNMT expression was found to be associated with 17alpha-hydroxylase expression in the tumors. 10604389 Human
pnmt tumors The glucocorticoid receptor expression was also correlated with PNMT expression in the tumors and the expression of Egr-1 was also high in 3 of the 4 specimens. 10604389 Human
pnmt sympathetic paraganglioma Classic neuroblastoma (NB) and its more highly differentiated stroma-rich subtypes, extra-adrenal sympathetic paraganglioma, and pheochromocytoma were examined for the presence of the developmentally characterized gene products NSE, S-100, CD44, Bcl-2, HN 9461120 Human
phenylethanolamine n-methyltransferase pancreatic cancers The G-protein coupled receptor RE2 and phenylethanolamine N-methyltransferase had negligible expression levels in all pancreatic cancers, whereas the syntaxin 1A and p120 catenin isoform were significantly up-regulated in pancreatic cancers containing K-r 13679043 Human
phenylethanolamine n-methyltransferase pancreatic cancer The G-protein coupled receptor RE2 and phenylethanolamine N-methyltransferase had negligible expression levels in all pancreatic cancers, whereas the syntaxin 1A and p120 catenin isoform were significantly up-regulated in pancreatic cancers containing K-r 13679043 Human
pnmt tumors The tumors were variably positive for phenylethanolamine-N-methyltransferase (PNMT) and chromogranin A (CGA). 8885177 Human
pnmt individual tumors There did not appear to be a global association of specific cytological features with expression of TH, PNMT, or CGA, although cells of similar appearance often shared similar immunoreactivities within individual tumors. 8885177 Human
pnmt tumors In addition, the expression of immunoreactive PNMT by mouse pheochromocytomas suggests that these tumors are a potential source of epinephrine-producing cell lines, for which adequate models currently do not exist. 8885177 Human
phenylethanolamine n-methyltransferase tumors In a subset of differentiating, often extra-adrenal NB tumors in patients who frequently had a favorable outcome; advancing morphologic tumor cell differentiation spatially paralleled an advancing fetal extra-adrenal chromaffin marker gene expression phen 8941212 Human
phenylethanolamine n-methyltransferase tumor In a subset of differentiating, often extra-adrenal NB tumors in patients who frequently had a favorable outcome; advancing morphologic tumor cell differentiation spatially paralleled an advancing fetal extra-adrenal chromaffin marker gene expression phen 8941212 Human
pnmt cancer PNMT and/or NMT activity were present in red blood cells (RBCs), and cancer cell lines. 7769131 Human
pnmt extra-adrenal pheochromocytoma Discrepancy between PNMT presence and relative lack of adrenaline production in extra-adrenal pheochromocytoma. 7967610 Human
pnmt extra-adrenal pheochromocytoma Among catecholamine synthesizing enzymes, phenylethanolamine-N-methyltransferase (PNMT) exists only in adrenal and extra-adrenal pheochromocytoma has been believed not to produce adrenaline. 7967610 Human
pnmt adrenal pheochromocytoma The results showed that PNMT was expressed not only in many cases of adrenal pheochromocytoma, but also in extra-adrenal pheochromocytoma. 7967610 Human
pnmt extra-adrenal pheochromocytoma The results showed that PNMT was expressed not only in many cases of adrenal pheochromocytoma, but also in extra-adrenal pheochromocytoma. 7967610 Human
pnmt paraffin-embedded tumor METHODS: Paraffin-embedded tumor specimens from 21 midgut carcinoid patients and 20 pheochromocytoma patients (10 sporadic and 10 MEN type IIa-related tumors) were stained for TH, DBH, and PNMT, using a three-step biotin-avidin-peroxidase method. 12651811 Human
pnmt tumors METHODS: Paraffin-embedded tumor specimens from 21 midgut carcinoid patients and 20 pheochromocytoma patients (10 sporadic and 10 MEN type IIa-related tumors) were stained for TH, DBH, and PNMT, using a three-step biotin-avidin-peroxidase method. 12651811 Human
pnmt tumor The enzymes involved in catecholamine biosynthesis, including PNMT and tyrosine hydroxylase, were identified immunocytochemically in the tumor. 8099794 Human
pnmt paraganglioma This is the first report of PNMT in a functioning paraganglioma of the glomus jugulare region. 8099794 Human
pnmt breast cancer We report for the first time that phenylethanolamine N-methyltransferase (PNMT), proteasome subunit, beta type 3 (PSMB3), ribosomal protein L19 (RPL19), and nuclear receptor subfamily 1, group D, member 1 (NR1D1) are coexpressed with ERBB2 in 34 breast ca 12727839 Human
phenylethanolamine n-methyltransferase breast cancer We report for the first time that phenylethanolamine N-methyltransferase (PNMT), proteasome subunit, beta type 3 (PSMB3), ribosomal protein L19 (RPL19), and nuclear receptor subfamily 1, group D, member 1 (NR1D1) are coexpressed with ERBB2 in 34 breast ca 12727839 Human
pnmt tumors Chemically induced tumors showed intermediate PNMT staining. 12746566 Human
pnmt amelanotic melanoma Cell extracts from melanotic and amelanotic melanoma tissues did not contain a phenylethanolamine-N-methyltransferase (PNMT) for the biosynthesis of epinephrine from norepinephrine and S-adenosylmethionine. 1329982 Human
pnmt tumor Cells exposed to the tumor promoting phorbol esters (phorbol 12-myristate 13-acetate, phorbol 12,13-dibutyrate or 4-beta-phorbol 12,13-didecanoate) for 12 h differentially activated PNMT mRNA and ProEnk A mRNA expression. 1850068 Human
pnmt papilloma Bovine phenylethanolamine N-methyltransferase (PNMT) cDNA was inserted into a bovine papilloma virus-based expression vector and used to transfect a mouse C127 cell line. 1653389 Human
phenylethanolamine n-methyltransferase papilloma Bovine phenylethanolamine N-methyltransferase (PNMT) cDNA was inserted into a bovine papilloma virus-based expression vector and used to transfect a mouse C127 cell line. 1653389 Human
phenylethanolamine n-methyltransferase medulloblastoma The human medulloblastoma TE 671 cell line has been evaluated as a model for studying expression of transiently transfected phenylethanolamine N-methyltransferase (PNMT) promoter-fusion gene constructs. 8830318 Human
phenylethanolamine n-methyltransferase pheochromocytomas Advantages of the mouse lines include expression of substantial levels of the epinephrine-synthesizing enzyme, phenylethanolamine N-methyltransferase and expression of high levels of the receptor tyrosine kinase, Ret, which is characteristic of sporadic a 15168351 Human
pnmt pheochromocytomas E, NE, chromogranin, TH, DBH, and PNMT were found in the normal human adrenal medulla and in pheochromocytomas. 3777139 Human
pnmt cardiac paragangliomas E was found in a few neuroendocrine tissues outside of the adrenal, including cardiac paragangliomas, and the enzyme PNMT was localized in some of these neoplasms. 3777139 Human
pnmt medulloblastoma Regulation of PNMT gene promoter constructs transfected into the TE 671 human medulloblastoma cell line. 8830318 Human
pnmt medulloblastoma The human medulloblastoma TE 671 cell line has been evaluated as a model for studying expression of transiently transfected phenylethanolamine N-methyltransferase (PNMT) promoter-fusion gene constructs. 8830318 Human
pnmt pheochromocytomas In addition, the expression of immunoreactive PNMT by mouse pheochromocytomas suggests that these tumors are a potential source of epinephrine-producing cell lines, for which adequate models currently do not exist. 8885177 Human
pnmt pheochromocytomas METHODS: We measured the concentrations of mRNA coding for the catecholamine-synthesizing enzymes tyrosine hydroxylase, aromatic L-amino acid decarboxylase (AADC), dopamine beta-hydroxylase (DBH) and phenylethanolamine N-methyl transferase (PNMT) and for 9578504 Human
pnmt pheochromocytomas Conversely, the PNMT mRNA concentration in the pheochromocytomas was lower than that in the normal adrenal medullas. 9578504 Human
pnmt pheochromocytomas We evaluated the activity of phenylethanolamine-N-methyltransferase (PNMT) and dopamine-beta-hydroxylase (DBH) in 16 pheochromocytomas. 7323441 Human
pnmt pheochromocytomas All of the pheochromocytomas contained PNMT and DBH activity. 7323441 Human
pnmt pheochromocytomas There was a significant correlation between PNMT activity and epinephrine concentration in the pheochromocytomas (r=0.61); there was no significant correlation between PNMT activity and norepinephrine concentration (r=0.38) or DBH activity and norepinephr 7323441 Human
pnmt pheochromocytomas In general, the patients with the highest PNMT activity in their pheochromocytomas tended to have paroxysmal (rather than sustained) hypertension and to excrete more E than NE in their urine. 7323441 Human
pnmt pheochromocytomas MATERIALS AND METHODS: As a first step toward understanding the molecular mechanisms by which adrenaline synthesis is controlled in these tumors, we measured the level of mRNA coding for the adrenaline-synthesizing enzyme phenylethanolamine N-methyl trans 10604389 Human
pnmt pheochromocytomas RESULTS: In the 4 tissue specimens from 3 adrenaline-secreting pheochromocytomas, the contents of adrenaline and the PNMT mRNA expression were considerably greater than those of the normal adrenal medullas. 10604389 Human
pnmt pheochromocytomas CONCLUSIONS: These findings indicate that adrenaline production in adrenaline-secreting pheochromocytomas is primarily controlled by the level of PNMT gene expression, and that the gene expression may be enhanced by both cortisol and Egr-1. 10604389 Human
pnmt pheochromocytomas Mouse pheochromocytomas are a new tool for studying genes and signaling pathways that regulate cell growth and differentiation in adrenal medullary neoplasms and are a unique model for studying the regulation of PNMT expression. 11151443 Human
pnmt adrenal pheochromocytomas Signs and symptoms of pheochromocytoma, plasma catecholamines and metanephrines, and tumor cell neurochemistry and expression of TH and PNMT were examined in 19 MEN 2 patients and 30 VHL patients with adrenal pheochromocytomas. 11344198 Human
pnmt pheochromocytomas The above differences in clinical presentation were largely explained by lower total tissue contents of catecholamines and expression of TH and negligible stores of epinephrine and expression of PNMT in pheochromocytomas from VHL than from MEN 2 patients. 11344198 Human
pnmt pheochromocytomas To address this question, we analyzed PACAP, PACAP receptor, and tyrosine hydroxylase (TH) and phenylethanolamine-N-methyltransferase (PNMT) mRNAs in pheochromocytomas. 12573802 Human
pnmt extra-adrenal pheochromocytomas METHODS: The levels of the mRNA for PACAP and vasoactive intestinal peptide (VIP), and their receptors, and for TH and PNMT were measured by RT-PCR or real-time PCR analysis, and the concentrations of catecholamines were measured by HPLC in 24 intra-adren 12573802 Human
pnmt pheochromocytomas PACAP mRNA expression correlated with TH (p=0.0018) and PNMT (p=0.05) mRNA expression, as well as epinephrine (p=0.0342) levels in 16 intra-adrenal pheochromocytomas. 12573802 Human
pnmt carcinoid METHODS: Paraffin-embedded tumor specimens from 21 midgut carcinoid patients and 20 pheochromocytoma patients (10 sporadic and 10 MEN type IIa-related tumors) were stained for TH, DBH, and PNMT, using a three-step biotin-avidin-peroxidase method. 12651811 Human
pnmt pheochromocytomas RESULTS: TH was demonstrated in 9 (43%) of 21 carcinoids and in all (100%) of 20 pheochromocytomas, DBH in 8 (38%) carcinoids and in 15 (75%) pheochromocytomas, and PNMT in 7 (33%) carcinoids and in 13 (65%) pheochromocytomas. 12651811 Human
pnmt pheochromocytomas The expression of phenylethanolamine-N-methyltransferase (PNMT), the enzyme responsible for production of epinephrine from norepinephrine, is common to both mouse and human pheochromocytomas. 12746566 Human
pnmt pheochromocytomas This investigation assessed the expression of the immunohistochemical markers PNMT, tyrosine hydroxylase (TH), and chromogranin A (CGA) in spontaneously occurring and chemically induced pheochromocytomas in the B6C3F1 mouse. 12746566 Mouse
pnmt pheochromocytomas A highly significant difference in PNMT expression (p < 0.01) occurred between spontaneously occurring pheochromocytomas classified as benign or "malignant" by the criteria of toxicologic pathology. 12746566 Mouse
pnmt pheochromocytomas PNMT expression is a tightly regulated component of the chromaffin cell phenotype and appears to be readily lost in mouse pheochromocytomas, particularly those with aggressive characteristics. 12746566 Mouse
pnmt pheochromocytomas Sequences at the 5' (-633 to -620) and 3' (-599 to -595) ends of this region are essential to convey nicotine responsiveness to PNMT promoter constructs expressed in primary bovine chromaffin cells and in selected lines derived from mouse pheoch 15968085 Human
pnmt pheochromocytoma Rabbit antibodies to TH (isolated from human pheochromocytoma), DDC, DBH and PNMT (the latter three isolated from bovine adrenal medulla) were used. 40700 Human
pnmt breast cancer We used a genetic association study design to determine if common genetic variation (frequency>or=5%) in a 400-kb region surrounding ERBB2 and containing the PPARBP, CRK7, NEUROD2, PPP1R1B, STARD3, TCAP, PNMT, CAB2, ERBB2, C17ORF37, GRB7 and ZNFN1A3 genes 17117180 Human
pnmt pheochromocytoma Classic neuroblastoma (NB) and its more highly differentiated stroma-rich subtypes, extra-adrenal sympathetic paraganglioma, and pheochromocytoma were examined for the presence of the developmentally characterized gene products NSE, S-100, CD44, Bcl-2, HN 9461120 Human
pnmt pheochromocytoma Undifferentiated sympathoadrenal PC12 pheochromocytoma cells expressed very low basal levels of both mRNA variants, accompanied by a very low basal PNMT enzymatic activity. 10219960 Rat
pnmt pheochromocytoma This study examined the mechanisms linking different biochemical and clinical phenotypes of pheochromocytoma in multiple endocrine neoplasia type 2 (MEN 2) and von Hippel-Lindau (VHL) syndrome to underlying differences in the expression of tyrosine hydrox 11344198 Human
pnmt pheochromocytoma Signs and symptoms of pheochromocytoma, plasma catecholamines and metanephrines, and tumor cell neurochemistry and expression of TH and PNMT were examined in 19 MEN 2 patients and 30 VHL patients with adrenal pheochromocytomas. 11344198 Human
pnmt midgut carcinoid tumors As it is not clear whether these tumors contain specific enzymes for catecholamine synthesis, we aimed to detect catecholamine-synthesizing enzymes [tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH), and phenylethanolamine-N-methyltransferase (PN 12651811 Human
pnmt pheochromocytoma As it is not clear whether these tumors contain specific enzymes for catecholamine synthesis, we aimed to detect catecholamine-synthesizing enzymes [tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH), and phenylethanolamine-N-methyltransferase (PN 12651811 Human
pnmt tumors As it is not clear whether these tumors contain specific enzymes for catecholamine synthesis, we aimed to detect catecholamine-synthesizing enzymes [tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH), and phenylethanolamine-N-methyltransferase (PN 12651811 Human
pnmt pheochromocytoma METHODS: Paraffin-embedded tumor specimens from 21 midgut carcinoid patients and 20 pheochromocytoma patients (10 sporadic and 10 MEN type IIa-related tumors) were stained for TH, DBH, and PNMT, using a three-step biotin-avidin-peroxidase method. 12651811 Human
phenylethanolamine n-methyltransferase pheochromocytoma This study examined the mechanisms linking different biochemical and clinical phenotypes of pheochromocytoma in multiple endocrine neoplasia type 2 (MEN 2) and von Hippel-Lindau (VHL) syndrome to underlying differences in the expression of tyrosine hydrox 11344198 Human
phenylethanolamine n-methyltransferase pheochromocytoma In this report, we examined the interaction between butyrate differentiation of rat pheochromocytoma cells and cholinergic-nicotinic induction of the neuropeptide (enkephalin) and catecholamine-related biosynthetic enzymes (tyrosine hydroxylase, dopamine 12508089 Human
pnmt tumour PNMT also showed highly variable expression that was poorly correlated with tumour adrenaline content. 16047163 Human
pnmt phaeochromocytoma The altered pattern of expression for both NAT and PNMT in phaeochromocytoma indicates a significant disruption in the regulation and possibly in the function of these proteins in adrenal medullary tumours. 16047163 Human
pnmt tumours The altered pattern of expression for both NAT and PNMT in phaeochromocytoma indicates a significant disruption in the regulation and possibly in the function of these proteins in adrenal medullary tumours. 16047163 Human
phenylethanolamine n-methyltransferase phaeochromocytoma Expression of the noradrenaline transporter and phenylethanolamine N-methyltransferase in normal human adrenal gland and phaeochromocytoma. 16047163 Human
pnmt neoplasms E was found in a few neuroendocrine tissues outside of the adrenal, including cardiac paragangliomas, and the enzyme PNMT was localized in some of these neoplasms. 3777139 Human
pnmt tumors In the adrenal pheochromocytoma both DBH- and PNMT-positive cells were seen, whereas the two extra-adrenal tumors contained only DBH. 386355 Human
pnmt adrenal pheochromocytoma In the adrenal pheochromocytoma both DBH- and PNMT-positive cells were seen, whereas the two extra-adrenal tumors contained only DBH. 386355 Human
pnmt neuroblastoma Classic neuroblastoma (NB) and its more highly differentiated stroma-rich subtypes, extra-adrenal sympathetic paraganglioma, and pheochromocytoma were examined for the presence of the developmentally characterized gene products NSE, S-100, CD44, Bcl-2, HN 9461120 Human
pnmt retinal tumors We have recently described a class of immortalized neurons which were derived from retinal tumors induced in PNMT-SV40 transgenic mice (TgBri59)9. 1718559 Human
pnmt oncogene The mice carry the SV40 T-antigen under the control of 5' flanking sequences from the human phenylethanolamine N-methyltransferase (PNMT) gene in order to target oncogene expression to adrenergic cell types. 2344410 Human
pent necrosis These pent-up secretions may result in pressure necrosis of the inferior or posterior sinus wall. 10740736 Human
phenylethanolamine n-methyltransferase oncogene The mice carry the SV40 T-antigen under the control of 5' flanking sequences from the human phenylethanolamine N-methyltransferase (PNMT) gene in order to target oncogene expression to adrenergic cell types. 2344410 Human
pnmt neoplasms Mouse pheochromocytomas are a new tool for studying genes and signaling pathways that regulate cell growth and differentiation in adrenal medullary neoplasms and are a unique model for studying the regulation of PNMT expression. 11151443 Human
pnmt neuroblastomas Sequences at the 5' (-633 to -620) and 3' (-599 to -595) ends of this region are essential to convey nicotine responsiveness to PNMT promoter constructs expressed in primary bovine chromaffin cells and in selected lines derived from mouse pheoch 15968085 Human
pnmt pheochromocytomas Pheochromocytomas in multiple endocrine neoplasia type 2 (MEN-2) express phenylethanolamine N-methyltransferase (PNMT), the enzyme that catalyzes conversion of norepinephrine to epinephrine, whereas those in von Hippel-Lindau (VHL) syndrome do not. 17102092 Human
pnmt multiple endocrine neoplasia Pheochromocytomas in multiple endocrine neoplasia type 2 (MEN-2) express phenylethanolamine N-methyltransferase (PNMT), the enzyme that catalyzes conversion of norepinephrine to epinephrine, whereas those in von Hippel-Lindau (VHL) syndrome do not. 17102092 Human
pnmt tumor This study examined whether transcription factors known to regulate expression of PNMT explain the different tumor phenotypes in these syndromes. 17102092 Human
pnmt pheochromocytomas Thus, our results do not support a role for the above transcription factors in determining differences in expression of PNMT in pheochromocytomas from patients with VHL syndrome and MEN-2. 17102092 Human
phenylethanolamine n-methyltransferase pheochromocytomas Transcriptional regulation of phenylethanolamine N-methyltransferase in pheochromocytomas from patients with von Hippel-Lindau syndrome and multiple endocrine neoplasia type 2. 17102092 Human
phenylethanolamine n-methyltransferase multiple endocrine neoplasia Transcriptional regulation of phenylethanolamine N-methyltransferase in pheochromocytomas from patients with von Hippel-Lindau syndrome and multiple endocrine neoplasia type 2. 17102092 Human
phenylethanolamine n-methyltransferase pheochromocytomas Pheochromocytomas in multiple endocrine neoplasia type 2 (MEN-2) express phenylethanolamine N-methyltransferase (PNMT), the enzyme that catalyzes conversion of norepinephrine to epinephrine, whereas those in von Hippel-Lindau (VHL) syndrome do not. 17102092 Human
phenylethanolamine n-methyltransferase multiple endocrine neoplasia Pheochromocytomas in multiple endocrine neoplasia type 2 (MEN-2) express phenylethanolamine N-methyltransferase (PNMT), the enzyme that catalyzes conversion of norepinephrine to epinephrine, whereas those in von Hippel-Lindau (VHL) syndrome do not. 17102092 Human

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