| grb7 |
cancers |
These peptides will be useful in the development of targeted molecular therapeutics for cancers overexpressing Grb7 and in the development of Grb7-specific inhibitors to gain a complete understanding of the physiological role of Grb7. |
11809769 |
Human |
| grb7 |
cancer |
GRB7 is tightly linked to ERBB2 and is coamplified and coexpressed with this gene in several cancer types. |
11956097 |
Human |
| grb7 |
embryonal carcinoma |
Stimulation of endogenous EphB1 in embryonal carcinoma P19 cells with its ligand ephrinB1 increased its association with Grb7, which is consistent with a role for the autophosphorylation of EphB1. |
12223469 |
Human |
| grb7 |
tumor |
Various isoforms of Grb10 have been shown to regulate cell proliferation and apoptosis, whereas Grb7 has been found to regulate cell migration and also implicated in tumor progression. |
11607834 |
Human |
| grb7 |
breast cancer |
We show here that Rnd1 and Grb7 interact, in two-hybrid assays, in vitro, and in pull-down experiments performed with SK-BR3, a breast cancer cell line that overexpresses Grb7. |
10664463 |
Human |
| grb7 |
esophageal carcinoma |
Grb7 signal transduction protein mediates metastatic progression of esophageal carcinoma. |
10797316 |
Human |
| growth factor receptor-bound protein 7 |
tumor |
We have previously reported the association of tumor cell invasion with expression of growth factor receptor-bound protein 7 (Grb7). |
10797316 |
Human |
| grb7 |
tumor |
We have previously reported the association of tumor cell invasion with expression of growth factor receptor-bound protein 7 (Grb7). |
10797316 |
Human |
| grb7 |
human esophageal carcinomas |
In the present study, Grb7 expression was analyzed in human esophageal carcinomas with or without metastatic spread. |
10797316 |
Human |
| grb7 |
lymph-node metastases |
The Grb7 protein was overexpressed in 14 of 31 esophageal carcinomas as compared to the adjacent normal mucosa (45%) and this finding was significantly correlated with the presence of lymph node metastases. |
10797316 |
Human |
| grb7 |
esophageal carcinomas |
The Grb7 protein was overexpressed in 14 of 31 esophageal carcinomas as compared to the adjacent normal mucosa (45%) and this finding was significantly correlated with the presence of lymph node metastases. |
10797316 |
Human |
| grb7 |
esophageal carcinoma |
We also identified that Grb7 protein in esophageal carcinoma cells was phosphorylated on tyrosine by epidermal growth factor as well as attachment to extracellular matrix proteins including fibronectin. |
10797316 |
Human |
| grb7 |
esophageal carcinoma |
Furthermore, ectopic expression of a Grb7-SH2 dominant-negative fragment inhibited the fibronectin-dependent phosphorylation of endogenous Grb7, and reduced migration of esophageal carcinoma cells into fibronectin. |
10797316 |
Human |
| grb7 |
human esophageal carcinoma |
Our results suggest a role of Grb7 mediated signal transduction in generation of an invasive cell phenotype against extracellular matrix, and thus contributes to metastatic progression of human esophageal carcinoma. |
10797316 |
Human |
| grb7 |
cancer |
The molecular adapter Grb7 is likely to be implicated in the development of certain cancer types. |
10803466 |
Human |
| grb7 |
tumor |
Recent studies have suggested that various isoforms of Grb10 play important roles in mediating insulin/insulin-like growth factor regulation of cell proliferation and apoptosis, whereas Grb7 mediates signaling pathways from FAK and EphB1 receptor to regul |
14766359 |
Human |
| grb7 |
human breast cancer |
In human breast cancer cell lines, co-immunoprecipitation of Grb7 with both receptors was detected upon heregulin stimulation. |
9516479 |
Human |
| grb7 |
esophageal carcinoma |
A novel variant of human Grb7 is associated with invasive esophageal carcinoma. |
9710451 |
Human |
| grb7 |
esophageal carcinoma |
The wild-type Grb7 protein, but not the Grb7V isoform, is rapidly tyrosyl phosphorylated in response to EGF stimulation in esophageal carcinoma cells. |
9710451 |
Human |
| grb7 |
esophageal carcinoma |
Finally, transfection of an antisense Grb7 RNA expression construct lowered endogenous Grb7 protein levels and suppressed the invasive phenotype exhibited by esophageal carcinoma cells. |
9710451 |
Human |
| grb7 |
human esophageal carcinomas |
These findings suggest that Grb7 isoforms are involved in cell invasion and metastatic progression of human esophageal carcinomas. |
9710451 |
Human |
| grb7 |
cancer |
Interestingly, Grb7 proteins exhibit differential expression amongst a variety of human cancers and cancer cell lines. |
9794242 |
Human |
| grb7 |
cancers |
Interestingly, Grb7 proteins exhibit differential expression amongst a variety of human cancers and cancer cell lines. |
9794242 |
Human |
| grb7 |
esophageal carcinoma |
Coexpression of Grb7 with epidermal growth factor receptor or Her2/erbB2 in human advanced esophageal carcinoma. |
8988034 |
Human |
| grb7 |
breast carcinomas |
The Grb7 gene has been found to be coamplified with Her2/erbB2 in breast carcinomas. |
8988034 |
Human |
| grb7 |
human esophageal cancers |
In this study, Grb7 expression was studied in 32 human esophageal cancers. |
8988034 |
Human |
| grb7 |
cancers |
Although there was no amplification of the Grb7 gene in esophageal cancers, Grb7 mRNA was found to be overexpressed in 14 cancers (43.8%) but not in adjacent normal esophageal mucosa. |
8988034 |
Human |
| grb7 |
esophageal cancers |
Although there was no amplification of the Grb7 gene in esophageal cancers, Grb7 mRNA was found to be overexpressed in 14 cancers (43.8%) but not in adjacent normal esophageal mucosa. |
8988034 |
Human |
| grb7 |
tumor |
It is noteworthy that coexpression of Grb7 with epidermal growth factor receptor or Her2/erbB2 was detected in 10 esophageal carcinomas (31.3%) and was significantly related to extramucosal tumor invasion (P = 0.02), whereas such a relationship was not sh |
8988034 |
Human |
| grb7 |
esophageal carcinomas |
It is noteworthy that coexpression of Grb7 with epidermal growth factor receptor or Her2/erbB2 was detected in 10 esophageal carcinomas (31.3%) and was significantly related to extramucosal tumor invasion (P = 0.02), whereas such a relationship was not sh |
8988034 |
Human |
| grb7 |
human esophageal cancer |
These findings suggest a possible relationship of Grb7 signaling in association with expression of tyrosine kinase receptors in aggressive human esophageal cancer. |
8988034 |
Human |
| grb-7 |
primary gastric cancer |
Molecular cloning of human GRB-7 co-amplified with CAB1 and c-ERBB-2 in primary gastric cancer. |
9125150 |
Human |
| grb7 |
human breast cancers |
The Src homology 2 (SH2) domain-containing protein Grb7 and the erbB2 receptor tyrosine kinase are overexpressed in a subset of human breast cancers. |
9079677 |
Human |
| grb7 |
breast cancers |
The functions of Grb7 and Grb10 are unknown, but Grb7 is overexpressed in certain breast cancers, where it is bound to the growth factor receptor HER2, while Grb10 has been implicated in insulin signaling. |
9142991 |
Human |
| grb-7 |
esophageal cancer |
CAB1, GRB-7, and c-ERBB-2 were overexpressed in gastric and esophageal cancer cells in correspondence with the amplification. |
9270027 |
Human |
| grb7 |
breast cancer |
Grb7 is an SH2 and PH domain-containing molecule that is known to be overexpressed in some breast cancer tissues and cell lines. |
8940081 |
Human |
| grb7 |
breast cancer |
Furthermore, complex formation between Shc and Grb7 was observed after ligand stimulation of PDGF alpha- or beta-receptors in cells transfected with Grb7 cDNA or in the breast cancer cell line BT-474. |
8940081 |
Human |
| grb7 |
mouse mammary tumor |
In addition to these differences, these analyses revealed that in contrast to the mouse mammary tumor virus-based Neu model, the endogenous promoter tumors expressed elevated levels of two genes (Grb7 and Cab1) that are closely linked to ErbB2 and often c |
12941816 |
Human |
| grb7 |
noninvasive ductal carcinoma |
In addition to these differences, these analyses revealed that in contrast to the mouse mammary tumor virus-based Neu model, the endogenous promoter tumors expressed elevated levels of two genes (Grb7 and Cab1) that are closely linked to ErbB2 and often c |
12941816 |
Mouse |
| grb7 |
tumors |
In addition to these differences, these analyses revealed that in contrast to the mouse mammary tumor virus-based Neu model, the endogenous promoter tumors expressed elevated levels of two genes (Grb7 and Cab1) that are closely linked to ErbB2 and often c |
12941816 |
Mouse |
| grb-7 |
breast cancer |
The SH2 domain protein GRB-7 is co-amplified, overexpressed and in a tight complex with HER2 in breast cancer. |
7907978 |
Human |
| grb-7 |
breast cancer |
We find that GRB-7 is amplified in concert with HER2 in several breast cancer cell lines and that GRB-7 is overexpressed in both cell lines and breast tumors. |
7907978 |
Human |
| grb-7 |
breast tumors |
We find that GRB-7 is amplified in concert with HER2 in several breast cancer cell lines and that GRB-7 is overexpressed in both cell lines and breast tumors. |
7907978 |
Human |
| grb-7 |
breast cancers |
The fact that GRB-7 and HER2 are both overexpressed and bound tightly together suggests that this basic signaling pathway is greatly amplified in certain breast cancers. |
7907978 |
Human |
| grb7 |
human breast cancers |
Moreover, the structure suggests the mechanism by which the Grb7 SH2 domain binds selectively to pTyr-1139 (pYVNQ) in Her2, which along with Grb7 is co-amplified in human breast cancers. |
12551896 |
Human |
| grb7 |
gastric cancer |
PPP1R1B, STARD3, MGC9753, ERBB2 and GRB7 genes are co-amplified in several cases of gastric cancer. |
12739007 |
Human |
| grb7 |
breast cancer |
Our results point to the involvement of several ErbB-specific ligands (amphiregulin and neuregulin 1) and enzymes or adaptor molecules (PI3K, Src, Shc and Grb7) in the ErbB pathway dysregulation associated with breast cancer. |
12866037 |
Human |
| grb7 |
ductal carcinoma in situ |
In addition to these differences, these analyses revealed that in contrast to the mouse mammary tumor virus-based Neu model, the endogenous promoter tumors expressed elevated levels of two genes (Grb7 and Cab1) that are closely linked to ErbB2 and often c |
12941816 |
Human |
| grb7 |
carcinoma |
Coamplification and coexpression of GRB7 and ERBB2 is found in high grade intraepithelial neoplasia and in invasive Barrett's carcinoma. |
15386389 |
Human |
| grb7 |
high grade intraepithelial neoplasia |
Coamplification and coexpression of GRB7 and ERBB2 is found in high grade intraepithelial neoplasia and in invasive Barrett's carcinoma. |
15386389 |
Human |
| grb7 |
tumor |
The human growth factor receptor-bound protein 7 gene (GRB7), the founding member of a family of adaptor molecules has been shown to regulate cell migration and has been implicated in tumor progression. |
15386389 |
Human |
| grb7 |
barrett's adenocarcinoma |
GRB7 is localized in close proximity to the ERBB2 gene within an amplicon previously identified in Barrett's adenocarcinoma (BCA). |
15386389 |
Human |
| grb7 |
carcinoma |
We evaluated gene amplification and mRNA expression of GRB7 and ERBB2 in Barrett's carcinoma and its associated precursor lesions to assess their possible role in Barrett's malignant transformation. |
15386389 |
Human |
| grb7 |
carcinomas |
Copy number and expression levels were analyzed by Q-PCR (GRB7, ERBB2) and QRT-PCR (GRB7, ERBB2) using TaqMan technology and fluorescence in situ hybridization (ERBB2) in a series of 24 laser-microdissected samples of Barrett's carcinomas and 32 samp |
15386389 |
Human |
| grb7 |
carcinomas |
Parallel analysis of gene copy number changes and expression levels demonstrated that GRB7 and ERBB2 displayed concomitant elevated expression levels and increased copy numbers in 32% of Barrett's carcinomas. |
15386389 |
Human |
| grb7 |
intraepithelial neoplasia |
Moreover, coamplification (r(s) = 0.97, p < 0.001) and coexpression (r(s) = 0.81, p < 0.001) of GRB7 and ERBB2 are shown to be already present in a subset of BCA associated high-grade intraepithelial neoplasia (HGIN), possibly reflecting a role of a conce |
15386389 |
Human |
| grb7 |
barrett's esophagus |
No alterations, neither gene amplification nor overexpression were detected in Barrett's carcinoma associated low grade intraepithelial neoplasia (LGIN), intestinal metaplasia (IM) and squamous epithelium, indicating that alterations of GRB7 and ERBB |
15386389 |
Human |
| grb7 |
metaplasia |
No alterations, neither gene amplification nor overexpression were detected in Barrett's carcinoma associated low grade intraepithelial neoplasia (LGIN), intestinal metaplasia (IM) and squamous epithelium, indicating that alterations of GRB7 and ERBB |
15386389 |
Human |
| grb7 |
low grade intraepithelial neoplasia |
No alterations, neither gene amplification nor overexpression were detected in Barrett's carcinoma associated low grade intraepithelial neoplasia (LGIN), intestinal metaplasia (IM) and squamous epithelium, indicating that alterations of GRB7 and ERBB |
15386389 |
Human |
| grb7 |
carcinoma |
No alterations, neither gene amplification nor overexpression were detected in Barrett's carcinoma associated low grade intraepithelial neoplasia (LGIN), intestinal metaplasia (IM) and squamous epithelium, indicating that alterations of GRB7 and ERBB |
15386389 |
Human |
| grb7 |
invasive carcinoma |
These findings may be of particular interest because the transition from high grade intraepithelial neoplasia to invasive carcinoma is a crucial step in malignant transformation in Barrett's carcinogenesis and might underline the putative role of GRB |
15386389 |
Human |
| grb7 |
tumor |
These findings may be of particular interest because the transition from high grade intraepithelial neoplasia to invasive carcinoma is a crucial step in malignant transformation in Barrett's carcinogenesis and might underline the putative role of GRB |
15386389 |
Human |
| grb7 |
high grade intraepithelial neoplasia |
These findings may be of particular interest because the transition from high grade intraepithelial neoplasia to invasive carcinoma is a crucial step in malignant transformation in Barrett's carcinogenesis and might underline the putative role of GRB |
15386389 |
Human |
| grb7 |
metastasis |
Transcripts from genes that flank ERBB2 including GRB7, a protein linked to metastasis in esophageal cancer, also showed high levels of expression. |
15511476 |
Human |
| grb7 |
esophageal cancer |
Transcripts from genes that flank ERBB2 including GRB7, a protein linked to metastasis in esophageal cancer, also showed high levels of expression. |
15511476 |
Human |
| grb7 |
chronic lymphocytic leukemia |
Grb7 expression and cellular migration in chronic lymphocytic leukemia: a comparative study of early and advanced stage disease. |
15470489 |
Human |
| grb7 |
metastatic solid tumors |
Grb7, a noncatalytic intracellular adaptor protein involved in cell migration, is overexpressed in certain invasive and metastatic solid tumors. |
15470489 |
Human |
| grb7 |
between chronic lymphocytic leukemia |
We found a highly significant difference in the level of expression of Grb7 between chronic lymphocytic leukemia (CLL) cells obtained from stage I and stage IV patients (P<0.001). |
15470489 |
Human |
| grb7 |
cll |
We found a highly significant difference in the level of expression of Grb7 between chronic lymphocytic leukemia (CLL) cells obtained from stage I and stage IV patients (P<0.001). |
15470489 |
Human |
| grb7 |
breast cancers |
In particular, Grb7 (along with the receptor tyrosine kinase erbB2) is overexpressed in 20%-30% of breast cancers. |
15930003 |
Human |
| grb7 |
metastases |
Grb7 binds to erbB2 and may be involved in cell signaling pathways that promote the formation of metastases and inflammatory responses. |
15930003 |
Human |
| grb7 |
breast cancer |
Growth factor receptor bound protein 7 (Grb7) is an adaptor protein that is co-overexpressed and forms a tight complex with the ErbB2 receptor in a number of breast tumours and breast cancer cell lines. |
15841400 |
Human |
| grb7 |
breast tumours |
Growth factor receptor bound protein 7 (Grb7) is an adaptor protein that is co-overexpressed and forms a tight complex with the ErbB2 receptor in a number of breast tumours and breast cancer cell lines. |
15841400 |
Human |
| growth factor receptor-bound protein 7 |
tumor |
The human growth factor receptor-bound protein 7 gene (GRB7), the founding member of a family of adaptor molecules has been shown to regulate cell migration and has been implicated in tumor progression. |
15386389 |
Human |
