IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene IKZF3 Ensembl ENSG00000161405 Chromosome 17 Start 35174724 End 35273967
Description Zinc finger protein Aiolos (Ikaros family zinc finger protein 3) [Source:UniProtKB/Swiss-Prot;Acc:Q9UKT9]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 13178
     Entrez Gene : 22806
     UCSC : uc002hsu.2
     GeneCards : 13178
     RefSeq : NM_012481
     CCDS : CCDS11346.1
     Uniprot : Q9UKT9
     Interpro : Q9UKT9
     OMIM : 606221
     GeneTests : IKZF3
     CGAP : IKZF3
     PMID : 9155026

< Top >


Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  221092_at  0.44  5.70e-4  1.07e-3  0.30  1.69e-2  1.82e-2
 HG_U133_Plus2  221092_at  1.26  5.98e-9  3.76e-8  1.04  6.57e-5  1.51e-4

< Top >


Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  221092_at  0.40  3.58e-1  8.92e-1  -0.12  6.77e-1  1.00e+0

< Top >


Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U133A - 221092_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 221092_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

< Top >


Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
aiolos lymphoma In the present study, we analyzed expression of the Ikaros family genes Ikaros, Aiolos, and Helios in a panel of human T-cell leukemia/lymphoma cell lines and bone marrow samples of patients with T-cell acute lymphoblastic leukemia. 11937265 Human
aiolos human t-cell leukemia In the present study, we analyzed expression of the Ikaros family genes Ikaros, Aiolos, and Helios in a panel of human T-cell leukemia/lymphoma cell lines and bone marrow samples of patients with T-cell acute lymphoblastic leukemia. 11937265 Human
aiolos t-cell acute lymphoblastic leukemia In the present study, we analyzed expression of the Ikaros family genes Ikaros, Aiolos, and Helios in a panel of human T-cell leukemia/lymphoma cell lines and bone marrow samples of patients with T-cell acute lymphoblastic leukemia. 11937265 Human
aiolos lymphomas Aiolos knock-out mice have quantitatively normal lymphoid cells but have chronically activated B cells producing autoantibodies and develop lymphomas with increased frequency. 11997672 Human
aiolos acute lymphoblastic leukaemia (all) The Ikaros (Ik) gene family, which includes Ik, Aiolos (Ai), and Helios (He), is a primary regulator of lymphocyte differentiation, and is involved in the development of acute lymphoblastic leukaemia (ALL). 12028018 Human
aiolos leukemias Altered expression of Ikaros isoforms has been found in patients with acute lymphoblastic leukemia but it is not studied whether the altered expression of Aiolos isoforms also has a role in the development of leukemias or lymphomas. 12445735 Human
aiolos acute lymphoblastic leukemia Altered expression of Ikaros isoforms has been found in patients with acute lymphoblastic leukemia but it is not studied whether the altered expression of Aiolos isoforms also has a role in the development of leukemias or lymphomas. 12445735 Human
aiolos lymphomas Altered expression of Ikaros isoforms has been found in patients with acute lymphoblastic leukemia but it is not studied whether the altered expression of Aiolos isoforms also has a role in the development of leukemias or lymphomas. 12445735 Human
aiolos thymic lymphomas Genetic mapping and allelic loss analysis in mouse thymic lymphomas of Helios and Aiolos belonging to the Ikaros gene family. 11173542 Human
aiolos lymphomas However, 33 of the 34 lymphomas showing allelic loss at Aiolos were p53(KO / - ) and were accompanied by loss of the p53 wild-type allele on the same chromosome. 11173542 Human
aiolos thymic lymphomas These results do not suggest any obvious contribution of Helios or Aiolos to oncogenesis of the mouse thymic lymphomas. 11173542 Human
aiolos tumor Gene targeting studies in mice have shown that the transcription factor Ikaros plays an essential role in lymphoid development and as a tumor suppressor in T cells, whereas the related gene Aiolos functions as a tumor suppressor in B cells. 10945610 Human
aiolos adult acute lymphoblastic leukemia We analyzed the expression levels of the Ikaros gene family, Ikaros and Aiolos, in human bone marrow samples from patients with adult acute lymphoblastic leukemia [ALL (n = 46; B-cell ALL = 41; T-cell ALL = 5)]. 10945610 Human
aiolos lymphoid malignancies Ikaros, Aiolos and Helios: transcription regulators and lymphoid malignancies. 12752680 Human
aiolos human leukaemias Several reports reinforce the hypothesis that Ikaros, Aiolos and Helios expression is deregulated in human leukaemias. 12752680 Human
aiolos adult all We did not detect any overexpression of dominant negative isoforms of Aiolos in adult ALL patients. 10945610 Human

< Top >


Download all image files.
Save all PNG files.    Save all PDF files.    Save all PS files.