IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene THRA Ensembl ENSG00000126351 Chromosome 17 Start 35472678 End 35503644
Description Thyroid hormone receptor alpha (Nuclear receptor subfamily 1 group A member 1)(C-erbA-alpha)(c-erbA-1)(EAR-7)(EAR7) [Source:UniProtKB/Swiss-Prot;Acc:P10827]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 11796
     Entrez Gene : 7067
     UCSC : uc002htw.2
     GeneCards : 11796
     RefSeq : NM_003250
     CCDS : CCDS11360.1
     Uniprot : P10827
     Interpro : P10827
     OMIM : 190120
     GeneTests : THRA
     CGAP : THRA
     PMID : 6323162

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  1316_at  0.22  2.09e-2  4.40e-2  0.21  9.98e-2  1.64e-1
 HG_U95  35846_at  -0.77  1.15e-6  7.44e-6  -0.71  5.69e-4  1.88e-3
 HG_U95  616_s_at  -1.06  6.55e-14  1.72e-12  -0.94  3.76e-5  1.66e-4
 HG_U133A  1316_at  -0.22  8.38e-5  1.76e-4  5.30  4.67e-167  3.33e-165
 HG_U133A  204100_at  -0.50  1.65e-9  5.61e-9  4.78  1.26e-96  7.76e-96
 HG_U133A  214883_at  0.76  1.87e-9  6.34e-9  3.40  7.28e-92  3.96e-91
 HG_U133A  35846_at  -0.18  6.50e-2  8.83e-2  -0.37  1.15e-3  1.28e-3
 HG_U133_Plus2  1316_at  0.23  4.10e-3  9.23e-3  0.16  8.97e-2  1.22e-1
 HG_U133_Plus2  204100_at  -1.39  2.93e-14  3.63e-13  -1.25  1.17e-9  4.95e-9
 HG_U133_Plus2  214883_at  0.64  4.53e-4  1.26e-3  1.18  5.62e-9  2.18e-8
 HG_U133_Plus2  35846_at  -0.40  7.88e-4  2.09e-3  0.01  9.15e-1  9.32e-1
 Stanford  961  0.32  4.54e-1  6.44e-1  0.31  4.65e-1  6.88e-1
 Stanford  965  0.11  7.03e-1  8.29e-1  -0.27  2.82e-1  5.23e-1
 Stanford  10407  0.32  4.54e-1  6.44e-1  0.31  4.65e-1  6.88e-1
 Agilent_HS_21.6K  1906  -0.39  1.14e-10  8.69e-9  -0.49  2.47e-13  3.38e-11

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  1316_at  -0.07  6.96e-1  9.68e-1  0.20  8.83e-2  1.00e+0
 HG_U133A  204100_at  -0.00  9.93e-1  1.00e+0  0.09  6.12e-1  1.00e+0
 HG_U133A  214883_at  -0.67  8.71e-2  7.60e-1  -0.04  9.06e-1  1.00e+0
 HG_U133A  35846_at  -0.06  8.04e-1  9.83e-1  0.18  5.23e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 1316_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 35846_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 616_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 1316_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 204100_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 214883_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 35846_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 1316_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 204100_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 214883_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 35846_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 961    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 965    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 10407    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 1906    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
erba sarcoma Oncogene erbA activity is related to thyroid receptors to T3 and to development of sarcoma. 12066223 Human
erba sarcoma Cross talk of the sarcoma oncogene and the erbA might contribute to the development of sarcoma. 12066223 Human
erba human breast cancer Expression of thyroid hormone receptor/erbA genes is altered in human breast cancer. 12082618 Human
tralpha breast cancer Our results reveal specific alterations in the expression of TRbeta and TRalpha genes in a subset of breast cancer patients, suggesting that deregulation of thyroid hormone target genes may be involved in the generation of this neoplasia. 12082618 Human
thra1 thyroid cancer PURPOSE: The purpose of this study was to determine whether the length of the THRA1 microsatellite, which resides in a noncoding portion of the thyroid hormone receptor-alpha1 gene, affects receptor expression and is linked to clinicopathological paramete 12231529 Human
thra1 thyroid cancer EXPERIMENTAL DESIGN: In 30 cases of surgically resected sporadic thyroid cancer, the length of the THRA1 microsatellite was determined by DNA sequence analysis, and expression of thyroid hormone receptor-alpha1 was assessed immunohistochemically in thin s 12231529 Human
thra1 tumor EXPERIMENTAL DESIGN: In 30 cases of surgically resected sporadic thyroid cancer, the length of the THRA1 microsatellite was determined by DNA sequence analysis, and expression of thyroid hormone receptor-alpha1 was assessed immunohistochemically in thin s 12231529 Human
thra1 cancer The length of THRA1 and expression of thyroid hormone receptor-alpha1 were also assessed in seven cancer cell lines. 12231529 Human
thra1 thyroid cancers RESULTS: A statistically significant correlation between the length of THRA1 and thyroid hormone receptor-alpha1 expression was observed in both cell lines and primary thyroid cancers. 12231529 Human
thra1 thyroid tumors Thyroid tumors that displayed higher than average thyroid hormone receptor-alpha1 expression had expanded THRA1 microsatellites and were less aggressive as judged by TNM ranking. 12231529 Human
thra1 thyroid cancer CONCLUSIONS: Less aggressive thyroid cancer was found to be linked to increased thyroid hormone receptor-alpha1 expression and an expanded THRA1 microsatellite. 12231529 Human
tralpha erythroleukemia The v-ErbA oncoprotein quenches the activity of an erythroid-specific enhancer. v-ErbA is a mutated variant of thyroid hormone receptor (TRalpha/NR1A1) borne by the Avian Erythroblastosis virus causing erythroleukemia. 11314012 Human
nr1a1 erythroleukemia The v-ErbA oncoprotein quenches the activity of an erythroid-specific enhancer. v-ErbA is a mutated variant of thyroid hormone receptor (TRalpha/NR1A1) borne by the Avian Erythroblastosis virus causing erythroleukemia. 11314012 Human
tralpha acute promyelocytic leukemia (apl) In human acute promyelocytic leukemia (APL) and avian erythroleukemia (AEL), chromosomal translocations and/or mutations in nuclear hormone receptors, RARalpha [NR1B1] and TRalpha [NR1A1], yielded oncoproteins that deregulate transcription and alter chrom 11420726 Human
nr1a1 acute promyelocytic leukemia (apl) In human acute promyelocytic leukemia (APL) and avian erythroleukemia (AEL), chromosomal translocations and/or mutations in nuclear hormone receptors, RARalpha [NR1B1] and TRalpha [NR1A1], yielded oncoproteins that deregulate transcription and alter chrom 11420726 Human
tralpha avian erythroleukemia (ael) In human acute promyelocytic leukemia (APL) and avian erythroleukemia (AEL), chromosomal translocations and/or mutations in nuclear hormone receptors, RARalpha [NR1B1] and TRalpha [NR1A1], yielded oncoproteins that deregulate transcription and alter chrom 11420726 Human
nr1a1 avian erythroleukemia (ael) In human acute promyelocytic leukemia (APL) and avian erythroleukemia (AEL), chromosomal translocations and/or mutations in nuclear hormone receptors, RARalpha [NR1B1] and TRalpha [NR1A1], yielded oncoproteins that deregulate transcription and alter chrom 11420726 Human
thra1 thyroid cancer EXPERIMENTAL DESIGN: Seventy-six cases of surgically resected thyroid cancer were screened for MSI at nine microsatellites: THRA1, TSHR, D2S123, D11S912, D2S115, D2S399, p53, RET, or BAT-26. 11705861 Human
tralpha tumors It was found that TRalpha (both alpha1 and alpha2) mRNA amount was significantly decreased in tumors while compared with healthy kidney tissue, and this decrease was deepest in G1 (well differentiated) RCCCs. 10822129 Human
tralpha nonfunctioning tumors Because TRalpha shows aberrant posttranscriptional processing, and TRbeta is under ligand-dependent autoregulation, we hypothesized that aberrant TR expression in nonfunctioning tumors may reflect mutation in receptor coding and regulatory sequences, and 10022432 Human
tralpha tumors Screening TRalpha mRNA in 23 tumors and subsequently sequencing candidate fragments identified one silent change from published sequences and three novel missense mutations, two in the common TRalpha region (ser45ile and lys370asn) and one that was alpha2 10022432 Human
tralpha tumor metastasis We investigated whether two subtypes of TR genes (TRalpha and TRbeta) are altered in human gastric cancer, as well as the role of such alterations in tumor metastasis. 11741739 Human
tralpha human gastric cancer We investigated whether two subtypes of TR genes (TRalpha and TRbeta) are altered in human gastric cancer, as well as the role of such alterations in tumor metastasis. 11741739 Human
tralpha metastasis The TRalpha alteration was associated with the development of distant (hematogenous) metastasis (P=0.0084) and high expression level of Nm23 protein (P=0.020). 11741739 Human
tralpha metastasis These findings suggest that TRalpha might be involved in tumorigenesis, and that interactions between the TRalpha and nm23 genes might take part in hematogenous metastasis of gastric cancer. 11741739 Human
tralpha gastric cancer These findings suggest that TRalpha might be involved in tumorigenesis, and that interactions between the TRalpha and nm23 genes might take part in hematogenous metastasis of gastric cancer. 11741739 Human
tralpha renal clear cell carcinoma (rccc) We have previously found aberrant expression of TRalpha and TRbeta mRNAs in renal clear cell carcinoma (RCCC), suggesting possible involvement of TRs in the carcinogenesis of RCCC. 11756220 Human
nr1a1 hepatoma L-T3 decreased chloramphenicol acetyltransferase activity in hepatoma cells cotransfected with a plasmid encoding the T3 receptor (TR) alpha [NR1a1] and a chimeric gene containing nucleotides -372 to +61 of the human CYP7A1 gene fused to the chloramphenic 11773435 Human
tralpha tumor Neither tumor examined expressed detectable levels of nuclear TRalpha or TRbeta proteins, in contrast to the normal pituitaries studied, which expressed all TR isoforms. 9492147 Human
tralpha tumors Semiquantitative RT-PCR revealed similar levels of expression of TRalpha and TRbeta isoform mRNAs in tumors and normal tissue, in contrast to the observed difference in TR proteins. 9492147 Human
tralpha adenomas Absent TRalpha and TRbeta protein expression, in association with normal mRNA levels, implies a post-transcriptional defect in TR mRNA processing in TSH-secreting adenomas. 9492147 Human
thra1 breast cancer These markers included polymorphisms within the thyroid hormone receptor alpha1 gene (THRA1), the breast cancer gene (BRCA1), GPIIb, GPIIIa, and an anonymous marker D17S579. 9695977 Human
thra tumour The most frequent incidence of LOH was found for the marker THRA1 (8/33, 24%) indicating that thra I gene becomes a strong candidate tumour suppressor gene, whereas of MI it was D10S109 (3/26, 12%). 9143412 Human
thra1 tumour The most frequent incidence of LOH was found for the marker THRA1 (8/33, 24%) indicating that thra I gene becomes a strong candidate tumour suppressor gene, whereas of MI it was D10S109 (3/26, 12%). 9143412 Human
thra1 invasive ductal carcinoma For BRCA1 (D17S855, THRA1, D17S579) losses could be detected in invasive ductal carcinoma (IDC; n = 108) in 32-38%, invasive lobular carcinoma (ILC; n = 19) in 21-42% depending on the marker applied, but not in benign breast tumours (n = 15). 8630282 Human
thra1 tumours For BRCA1 (D17S855, THRA1, D17S579) losses could be detected in invasive ductal carcinoma (IDC; n = 108) in 32-38%, invasive lobular carcinoma (ILC; n = 19) in 21-42% depending on the marker applied, but not in benign breast tumours (n = 15). 8630282 Human
thra1 invasive lobular carcinoma For BRCA1 (D17S855, THRA1, D17S579) losses could be detected in invasive ductal carcinoma (IDC; n = 108) in 32-38%, invasive lobular carcinoma (ILC; n = 19) in 21-42% depending on the marker applied, but not in benign breast tumours (n = 15). 8630282 Human
tralpha human breast carcinoma Ligand-occupied TRalpha or TRbeta, but not the unliganded receptor, strongly suppressed transactivation of a progesterone-responsive reporter gene by endogenous PRs in human breast carcinoma T47D cells. 8662980 Human
thra1 tumour We applied this methodology to a laryngeal tumour with LOH at markers D9S171, D9S157, D8S87 and THRA1 and found that LOH at D9S171 is the commonest aberration among the tumour cells, while LOH at the THRA1 marker is present in only a small subset of the t 8692204 Human
erba endometrial cancers We studied the expressions of aberrant epidermal growth factor receptor (EGFR) gene or erbB-2, which is highly homologous to EGFR gene, and erbA or estrogen receptor (ER) gene, which is highly homologous to erbA, as a preliminary study, to know which onco 7744115 Human
erba endometrial cancer The behavior of aberrant erbB-2 and ER gene co-expressions is considered of similar to that of erbA and erbB co-expressions in the chicken introduced by the avian erythroblastosis virus, which leads to the development of erythroblastosis in the chick, and 7744115 Human
erba carcinomas Transcripts coding for transcription factors (RB, P53, FOS, MYC, MYB, ERBA, REL), growth factors (FGF1, FGF2, INT2, TGFA, TGFB, PDGF, IGF1, IGF2), interleukins, (IL1, IL2, IL3, IL4, IL6, TNF), growth-factor receptors or cytosolic protein kinases (RAF, PIM 7768644 Human
erba benign tumours Transcripts coding for transcription factors (RB, P53, FOS, MYC, MYB, ERBA, REL), growth factors (FGF1, FGF2, INT2, TGFA, TGFB, PDGF, IGF1, IGF2), interleukins, (IL1, IL2, IL3, IL4, IL6, TNF), growth-factor receptors or cytosolic protein kinases (RAF, PIM 7768644 Human
erba leukemia In contrast, no leukemia was observed with a myb IRES virus, with spliced vectors containing v-erbA alone or v-erbA in combination with v-myb, nor with erbA IRES and erbA/myb IRES viruses produced in the absence of helper virus. 7566959 Human
erba leukemia The average latency of leukemia induction was shorter for the erbA/myb IRES virus (3.5 weeks) than for the erbA IRES virus (5 weeks). 7566959 Human
erba tumor Sis and N-ras were moderately hyperexpressed, raf, Blym, and erbA were slightly hyperexpressed, and abl, erbB, fes/fps, fgr, fos, mos, myb, myc, N-myc, rasHarvey, rasKirsten, ros, src, and yes were not hyperexpressed in the tumor compared to the control t 3105396 Human
c-erba1 acute promyelocytic leukaemia Localization of the oncogene c-erbA1 immediately proximal to the acute promyelocytic leukaemia breakpoint on chromosome 17. 3865620 Human
c-erba1 acute promyelocytic leukaemia Previous work has shown that c-erbA1 is proximal to the translocation breakpoint on chromosome 17 in the t(15;17)(q22;q12-21) in acute promyelocytic leukaemia. 3865620 Human
erba avian sarcoma The following onc sequences were tested for homology to the genomes of the three new avian sarcoma viruses: src, fps, yes, myc, myb, erbA, and erbB. 6100634 Human
erba leukemias Chickens inoculated with erbA -B + virus or with erbA -B +-transformed cells developed sarcomas or atypical erythroid leukemias. 6297784 Human
erba sarcomas Chickens inoculated with erbA -B + virus or with erbA -B +-transformed cells developed sarcomas or atypical erythroid leukemias. 6297784 Human
triiodothyronine receptor tumors Liver triiodothyronine receptor concentrations were approximately 5-fold those of tumors; they were unaffected by low serum thyroid hormone levels and were similar to those of non-tumor-bearing, euthyroid controls. 6303577 Human
erba tumor The incidence of p-myc positivity (alone or combined with erbA positivity) in the nodules decreased from the nodule to the tumor stage. 2164893 Human
c-erba-1 breast cancers c-erbB-2 and c-erbA-1 (ear-1) gene amplification and c-erbB-2 protein expression in Japanese breast cancers: their relationship to the histology and other disease parameters. 1976118 Human
c-erba-1 breast cancers We studied c-erbB-2 and c-erbA-1 (ear-1) gene amplification, and c-erbB-2 protein expression in 123 primary Japanese breast cancers. c-erbB-2 amplification was found in 19 of the 123 tumors (15%), and c-erbA-1 was coamplified in 7 of the 19. 1976118 Human
c-erba-1 tumors We studied c-erbB-2 and c-erbA-1 (ear-1) gene amplification, and c-erbB-2 protein expression in 123 primary Japanese breast cancers. c-erbB-2 amplification was found in 19 of the 123 tumors (15%), and c-erbA-1 was coamplified in 7 of the 19. 1976118 Human
c-erba-1 tumors There were no differences in the histologic type, cellular atypism, mitotic index, and other disease parameters between tumors with c-erbB-2 amplification only and those with coamplification of c-erbB-2 and c-erbA-1. 1976118 Human
erba1 acute promyelocytic leukemia (apl) The gene cluster including ErbA1 is known to be flanked by the constitutional 15;17 translocation breakpoint in hybrid SP3 and by the acute promyelocytic leukemia (APL) breakpoint, which provides the following gene and breakpoint order: cen-SP3-(D17S33,CR 2491776 Human
erba-alpha colon carcinoma In contrast, expression of the two erbA-alpha transcripts was the same in both colon carcinoma and noninvolved mucosa. 2553781 Human
thra1 tumors These tumors were examined for LOH using genetic markers flanking and within BRCA1, including THRA1, D17S856, EDH17B1, EDH17B2, and D17S183. 9816013 Human
thra1 breast cancer Mutation analysis of the THRA1 gene in breast cancer: deletion/fusion of the gene to a novel sequence on 17q in the BT474 cell line. 7511052 Human
thra1 breast cancer Southern analysis revealed a rearrangement of THRA1 in the BT474 breast cancer cell line. 7511052 Human
thra1 breast cancer To search for additional mutations in the THRA1 gene, all nine protein-encoding exons of THRA1 were examined for point mutations via single strand conformation analysis in a series of primary breast tumors, breast cancer cell lines, and lymphoblastoid cel 7511052 Human
thra1 breast tumors To search for additional mutations in the THRA1 gene, all nine protein-encoding exons of THRA1 were examined for point mutations via single strand conformation analysis in a series of primary breast tumors, breast cancer cell lines, and lymphoblastoid cel 7511052 Human
thra1 sporadic breast cancer We have thus excluded THRA1 as a commonly mutated sporadic breast cancer tumor suppressor gene and as the BRCA1 gene. 7511052 Human
thra1 tumor We have thus excluded THRA1 as a commonly mutated sporadic breast cancer tumor suppressor gene and as the BRCA1 gene. 7511052 Human
thra tumor While their role in tumor generation or progression is currently unclear, both gross chromosomal and minor mutations (deletions, aberrant splicing, point mutations) and changes in the level of expression of THRA and THRB genes have been found. 12668276 Human
thra cancer Together with other in vitro data indicating connections between TR and p53, Rb, cyclin D and other cell cycle regulators and oncogenes, these results suggest that THRA and THRB may be involved in human cancer. 12668276 Human
thra1 breast-ovarian cancer THRA1 and D17S183 flank an interval of < 4 cM for the breast-ovarian cancer gene (BRCA1) on chromosome 17q21. 8460637 Human
thra1 breast and ovarian cancer In order to pinpoint the locale of the gene for early-onset familial breast and ovarian cancer (BRCA1), polymorphisms were developed within the locus for thyroid hormone receptor alpha (THRA1) and for several anonymous sequences at chromosome 17q12-q21. 8460637 Human
thra1 breast and ovarian cancer Gene mapping in extended families with inherited, early-onset breast and ovarian cancer indicates that BRCA1 is distal to THRA1 and proximal to D17S183 (SCG43), an interval of < 4 cM. 8460637 Human
erba tumor ErbA: tumor suppressor turned oncogene? 8102105 Human
thra1 tumor We found that D17S250 was deleted in 50% (7 of 14), THRA1 in 79% (11 of 14), D17S579 in 59% (11 of 19), NME1 in 29% (5 of 17), MPO in 36% (4 of 11), and GH in 25% (4 of 16) in the tumor set examined. 1568230 Human
erba tumors Expression of genes related to the human erbB, erbA, pdgf and pdgf-r in tumors of different etiology in Xiphophorus. 1323541 Human
erba melanoma Therefore, the backcross procedure dismantles the regulatory gene systems thus permitting Tu-directed melanoma formation. x-erbB* derived from the platyfish, together with the swordtail-derived oncogenes src, sis, pdgf-r, ras, myc, erbA are expressed or o 1878604 Human
erba retinoblastoma Chromosomal assignment of five cancer-associated rat genes: two thyroid hormone receptor (ERBA) genes, two ERBB genes and the retinoblastoma gene. 1679528 Human
erba1 retinoblastoma Using a panel of somatic cell hybrids that segregate rat chromosomes, the localization of five cancer-related rat genes was determined: (i) two thyroid receptor genes, THRA1/ERBA1 and THRB/ERBA2 on chromosomes 10 and 15 respectively, (ii) two ERBB genes, 1679528 Human
thra1 retinoblastoma Using a panel of somatic cell hybrids that segregate rat chromosomes, the localization of five cancer-related rat genes was determined: (i) two thyroid receptor genes, THRA1/ERBA1 and THRB/ERBA2 on chromosomes 10 and 15 respectively, (ii) two ERBB genes, 1679528 Human
triiodothyronine receptor tumor Triiodothyronine receptor concentration was not correlated with age or endocrine status of the patient or with extension or histological grading of the tumor. 6269737 Human
tralpha neoplasia Our results reveal specific alterations in the expression of TRbeta and TRalpha genes in a subset of breast cancer patients, suggesting that deregulation of thyroid hormone target genes may be involved in the generation of this neoplasia. 12082618 Human
erba neoplasia Our results indicate that the erbA oncogene may play a previously unanticipated role in neoplasia by interfering with RXR function. 8105369 Human
erba neoplasia Members of the erbA gene family are involved both in control of differentiation and in neoplasia. 2553781 Human
erba hodgkin's disease PURPOSE: The purpose of this randomized trial was to compare the efficacy of eight cycles of chlorambucil, vincristine, procarbazine, and prednisone (LOPP) with four cycles of LOPP that alternate with four cycles of etoposide, vinblastine, Adriamycin (dox 1634914 NA
erba hodgkin's disease PURPOSE: With the aim of decreasing undesirable side effects of therapy, we investigated the reduction of both chemotherapy and radiation therapy (RT) in children with Hodgkin's disease, and compared Adriamycin (doxorubicin; Farmitalia Carlo Erba, Ru 1383434 NA

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