IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene NR1D1 Ensembl ENSG00000126368 Chromosome 17 Start 35502567 End 35510499
Description Nuclear receptor subfamily 1 group D member 1 (V-erbA-related protein EAR-1)(Rev-erbA-alpha) [Source:UniProtKB/Swiss-Prot;Acc:P20393]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 7962
     Entrez Gene : 9572
     UCSC : uc002htz.1
     GeneCards : 7962
     RefSeq : NM_021724
     CCDS : CCDS11361.1
     Uniprot : P20393
     Interpro : P20393
     OMIM : 602408
     GeneTests : NR1D1
     CGAP : NR1D1
     PMID : 1971514

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  204760_s_at  0.66  2.16e-4  4.29e-4  3.86  8.52e-65  2.51e-64
 HG_U133A  217476_at  -0.08  3.72e-1  4.27e-1  2.31  4.28e-70  1.40e-69
 HG_U133A  31637_s_at  -0.05  5.35e-1  5.86e-1  -3.05  2.73e-60  7.40e-60
 HG_U133_Plus2  204760_s_at  0.57  1.18e-2  2.38e-2  1.46  1.88e-7  6.05e-7
 HG_U133_Plus2  217476_at  0.01  9.53e-1  9.67e-1  -0.12  4.46e-1  5.07e-1
 HG_U133_Plus2  31637_s_at  1.49  2.61e-18  5.18e-17  2.43  2.21e-23  4.57e-22
 Stanford  23475  0.17  5.28e-1  7.03e-1  -0.26  4.83e-1  7.03e-1
 Agilent_HS_21.6K  3206  0.06  4.97e-1  6.72e-1  0.04  6.31e-1  7.53e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  204760_s_at  0.23  7.00e-1  9.68e-1  0.04  9.22e-1  1.00e+0
 HG_U133A  217476_at  0.30  3.67e-1  8.96e-1  0.13  6.18e-1  1.00e+0
 HG_U133A  31637_s_at  0.21  3.41e-1  8.87e-1  0.16  2.71e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U133A - 204760_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 217476_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 31637_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 204760_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 217476_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 31637_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 23475    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 3206    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
thra1 tumours For BRCA1 (D17S855, THRA1, D17S579) losses could be detected in invasive ductal carcinoma (IDC; n = 108) in 32-38%, invasive lobular carcinoma (ILC; n = 19) in 21-42% depending on the marker applied, but not in benign breast tumours (n = 15). 8630282 Human
ear-1 breast cancers c-erbB-2 and c-erbA-1 (ear-1) gene amplification and c-erbB-2 protein expression in Japanese breast cancers: their relationship to the histology and other disease parameters. 1976118 Human
ear-1 breast cancers We studied c-erbB-2 and c-erbA-1 (ear-1) gene amplification, and c-erbB-2 protein expression in 123 primary Japanese breast cancers. c-erbB-2 amplification was found in 19 of the 123 tumors (15%), and c-erbA-1 was coamplified in 7 of the 19. 1976118 Human
ear-1 lymph-node metastasis Amplification of c-erbB-2 and/or ear-1 was strongly correlated with poor prognosis in all 176 patients, especially those with lymph node metastasis. 2566377 Human
nr1d1 breast cancer We report for the first time that phenylethanolamine N-methyltransferase (PNMT), proteasome subunit, beta type 3 (PSMB3), ribosomal protein L19 (RPL19), and nuclear receptor subfamily 1, group D, member 1 (NR1D1) are coexpressed with ERBB2 in 34 breast ca 12727839 Human

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