IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene CASC3 Ensembl ENSG00000108349 Chromosome 17 Start 35550033 End 35581957
Description Protein CASC3 (Cancer susceptibility candidate gene 3 protein)(Metastatic lymph node protein 51)(Protein MLN 51)(Protein barentsz)(Btz) [Source:UniProtKB/Swiss-Prot;Acc:O15234]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 17040
     Entrez Gene : 22794
     UCSC : uc002hue.2
     GeneCards : 17040
     RefSeq : NM_007359
     CCDS : CCDS11362.1
     Uniprot : O15234
     Interpro : O15234
     OMIM : 606504
     GeneTests : CASC3
     CGAP : CASC3
     PMID : 7490069

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  38437_at  -0.15  2.92e-2  5.85e-2  -0.10  3.21e-1  4.25e-1
 HG_U133A  207842_s_at  -0.31  7.33e-9  2.34e-8  -4.77  2.33e-106  1.87e-105
 HG_U133_Plus2  207842_s_at  -0.29  3.14e-6  1.31e-5  -0.14  7.85e-2  1.08e-1
 Agilent_HS_21.6K  14913  0.11  1.02e-1  2.38e-1  0.09  1.74e-1  3.11e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  207842_s_at  0.21  3.40e-1  8.87e-1  0.11  4.31e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 38437_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 207842_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 207842_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 14913    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
mln51 metastasis Metastatic Lymph Node 51 (MLN51) cDNA was isolated by differential screening of a human breast cancer metastasis cDNA library. 12080473 Human
mln51 human breast cancer Metastatic Lymph Node 51 (MLN51) cDNA was isolated by differential screening of a human breast cancer metastasis cDNA library. 12080473 Human
mln51 human breast carcinomas Human breast carcinomas show MLN51 overexpression in malignant epithelial cells. 12080473 Human
mln 51 breast cancer Several lines of evidence suggest that ERBB2 is the gene responsible for the emergence of this amplicon, but four novel genes (called MLN 50, MLN 51, MLN 62, and MLN 64) in 17q11-q21 have recently been found to be amplified and overexpressed in breast can 8752152 Human
mln51 breast cancer Association of the breast cancer protein MLN51 with the exon junction complex via its speckle localizer and RNA binding module. 15166247 Human
mln51 breast cancer MLN51 is a nucleocytoplasmic shuttling protein that is overexpressed in breast cancer. 15166247 Human
mln51 cancer Altogether our data demonstrate that MLN51 associates with EJC in the nucleus and remains stably associated with mRNA in the cytoplasm, suggesting that its overexpression might alter mRNA metabolism in cancer. 15166247 Human
mln51 breast cancer We found that the MLN51 (metastatic lymph node 51) gene, identified in breast cancer, is remarkably upregulated in the hyperactive RA FLSs. 17101062 Human

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