IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene CDC6 Ensembl ENSG00000094804 Chromosome 17 Start 35697672 End 35712939
Description Cell division control protein 6 homolog (CDC6-related protein)(p62(cdc6))(HsCDC6)(HsCDC18) [Source:UniProtKB/Swiss-Prot;Acc:Q99741]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 1744
     Entrez Gene : 990
     UCSC : uc002huj.1
     GeneCards : 1744
     RefSeq : NM_001254
     CCDS : CCDS11365.1
     Uniprot : Q99741
     Interpro : Q99741
     OMIM : 602627
     GeneTests : CDC6
     CGAP : CDC6
     PMID : 8990175

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Experimental Evidence        (help)
Expression Sample Number Method Clinical information PubMed Reference
up 38/75(50%) RT-PCR- 15466399 Am J Pathol. 2004 Oct;165(4):1351-65.

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  1536_at  1.04  3.60e-5  1.64e-4  2.33  2.37e-11  3.58e-10
 HG_U95  36839_at  0.45  1.07e-2  2.48e-2  1.13  2.66e-5  1.21e-4
 HG_U133A  203967_at  1.56  1.43e-28  2.02e-27  2.94  2.65e-58  6.93e-58
 HG_U133A  203968_s_at  0.78  1.69e-17  1.10e-16  2.32  5.96e-64  1.72e-63
 HG_U133_Plus2  203967_at  2.58  2.03e-38  3.55e-36  3.28  1.26e-34  1.03e-32
 HG_U133_Plus2  203968_s_at  1.88  1.01e-30  7.52e-29  2.59  4.88e-34  3.67e-32
 Stanford  18173  2.67  1.28e-9  1.26e-6  3.32  2.80e-9  2.21e-6
 Agilent_HS_21.6K  20784  0.51  7.27e-6  1.33e-4  0.77  1.39e-11  1.06e-9

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  203967_at  0.13  8.20e-1  9.84e-1  -0.01  9.53e-1  1.00e+0
 HG_U133A  203968_s_at  -0.29  1.74e-1  8.18e-1  0.05  7.65e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 1536_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 36839_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 203967_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 203968_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 203967_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 203968_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 18173    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 20784    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
cdc6 prostate cancer Down-regulation of Cdc6, a cell cycle regulatory gene, in prostate cancer. 12006585 Human
cdc6 prostate cancer We have found that Cdc6 expression is down-regulated in prostate cancer as detected by semiquantitative reverse transcriptase-PCR of prostate cell lines and laser-captured microdissected prostate tissues. 12006585 Human
cdc6 prostate cancer Our study suggests a potential use of the lack of CDC6 expression as an index of prostate cancer development. 12006585 Human
cdc6 carcinoma Recent studies indicate that Cdc6 may be a marker for cervical intraepithelial neoplasia (CIN) and carcinoma; however, the histologic distribution of Cdc6 has not been explicitly defined. 12296751 Human
cdc6 cervical intraepithelial neoplasia (cin) Recent studies indicate that Cdc6 may be a marker for cervical intraepithelial neoplasia (CIN) and carcinoma; however, the histologic distribution of Cdc6 has not been explicitly defined. 12296751 Human
cdc6 metaplasia Cdc6 staining was rarely present in specimens of normal cervical squamous mucosa (2/84, 2.4%) or in specimens with squamous metaplasia (3/59, 5.1%) and was not detected in normal endocervical glands (0/84). 12296751 Human
cdc6 squamous-cell carcinomas The proportion of cells staining for Cdc6 increased with the grade of dysplasia, and the proportion of stained cells in squamous cell carcinomas was similar to that in lesions of high-grade dysplasia. 12296751 Human
cdc6 adenocarcinoma in situ Cdc6 staining was present in the majority of cases in glandular lesions including adenocarcinoma in situ (11/14, 79%) and adenocarcinoma (8/10, 80%). 12296751 Human
cdc6 adenocarcinoma Cdc6 staining was present in the majority of cases in glandular lesions including adenocarcinoma in situ (11/14, 79%) and adenocarcinoma (8/10, 80%). 12296751 Human
cdc6 carcinoma CONCLUSION: Cdc6 expression is a marker for high-grade cervical squamous and glandular dysplasia and carcinoma and is associated with HPV infection. 12296751 Human
cdc6 meningiomas We performed immunohistochemical analysis with MIB-1 and antibody against Cdc6 on 35 brain tumors, including tumors of neuroepithelial tissue, vestibular schwannomas, meningiomas, and pituitary adenomas. 11496317 Human
cdc6 tumors We performed immunohistochemical analysis with MIB-1 and antibody against Cdc6 on 35 brain tumors, including tumors of neuroepithelial tissue, vestibular schwannomas, meningiomas, and pituitary adenomas. 11496317 Human
cdc6 pituitary adenomas We performed immunohistochemical analysis with MIB-1 and antibody against Cdc6 on 35 brain tumors, including tumors of neuroepithelial tissue, vestibular schwannomas, meningiomas, and pituitary adenomas. 11496317 Human
cdc6 tumor Reactivity in most brain tumors was significantly higher for Cdc6 than for MIB-1, but reactivity of Cdc6 was independent of tumor grade. 11496317 Human
cdc6 human tumor Immunodepletion of Cdc6 by microinjection of anti-Cdc6 antibody blocks initiation of DNA replication in a human tumor cell line. 9520412 Human
cdc6 cancer Overexpression of the replication initiation factors Cdt1 and Cdc6 along with cyclin A-cdk2 promotes rereplication in human cancer cells with inactive p53 but not in cells with functional p53. 12718885 Human
cdc6 brain tumors Cdc6 expression as a marker of proliferative activity in brain tumors. 11496317 Human
cdc6 schwannomas We performed immunohistochemical analysis with MIB-1 and antibody against Cdc6 on 35 brain tumors, including tumors of neuroepithelial tissue, vestibular schwannomas, meningiomas, and pituitary adenomas. 11496317 Human
cdc6 brain tumors We performed immunohistochemical analysis with MIB-1 and antibody against Cdc6 on 35 brain tumors, including tumors of neuroepithelial tissue, vestibular schwannomas, meningiomas, and pituitary adenomas. 11496317 Human
cdc6 tumors of neuroepithelial tissue We performed immunohistochemical analysis with MIB-1 and antibody against Cdc6 on 35 brain tumors, including tumors of neuroepithelial tissue, vestibular schwannomas, meningiomas, and pituitary adenomas. 11496317 Human
cdc6 brain tumors Reactivity in most brain tumors was significantly higher for Cdc6 than for MIB-1, but reactivity of Cdc6 was independent of tumor grade. 11496317 Human
cdc6 brain tumors Detection of Cdc6 expression might be useful for the estimation of proliferative activity in brain tumors. 11496317 Human
cdc6 bph Concentration of the E2F and Oct1 transcription factors that have putative binding sites in the Cdc6 promoter was substantially low in PC3 cells compared with BPH cells. 12006585 Human
cdc6 bph Mutagenesis of the two E2F binding sites on the Cdc6 promoter resulted in increased promoter activity in PC3 cells owing to elimination of the negative regulation by pRb.E2F complex but not to the level of that obtained in BPH cells. 12006585 Human
cdc6 neoplasia Immunohistochemical localization of cdc6 in squamous and glandular neoplasia of the uterine cervix. 12296751 Human
cdc6 cervical cancer p16INK4A, CDC6, and MCM5: predictive biomarkers in cervical preinvasive neoplasia and cervical cancer. 15858126 Human
cdc6 neoplasia p16INK4A, CDC6, and MCM5: predictive biomarkers in cervical preinvasive neoplasia and cervical cancer. 15858126 Human
cdc6 neoplasia AIM: To analyse and compare expression patterns of three potential biomarkers-p16(INK4A), CDC6, and MCM5-and evaluate their use as predictive biomarkers in squamous and glandular cervical preinvasive neoplasia. 15858126 Human
cdc6 adenocarcinoma METHODS: Immunocytochemical analysis of p16(INK4A), MCM5, and CDC6 expression was performed on 20 normal, 38 cervical intraepithelial neoplasia 1 (CIN1), 33 CIN2, 46 CIN3, 10 squamous cell carcinoma, 19 cervical glandular intraepithelial neoplasia (cGIN), 15858126 NA
cdc6 cervical intraepithelial neoplasia METHODS: Immunocytochemical analysis of p16(INK4A), MCM5, and CDC6 expression was performed on 20 normal, 38 cervical intraepithelial neoplasia 1 (CIN1), 33 CIN2, 46 CIN3, 10 squamous cell carcinoma, 19 cervical glandular intraepithelial neoplasia (cGIN), 15858126 NA
cdc6 squamous-cell carcinoma METHODS: Immunocytochemical analysis of p16(INK4A), MCM5, and CDC6 expression was performed on 20 normal, 38 cervical intraepithelial neoplasia 1 (CIN1), 33 CIN2, 46 CIN3, 10 squamous cell carcinoma, 19 cervical glandular intraepithelial neoplasia (cGIN), 15858126 NA
cdc6 cervical glandular intraepithelial neoplasia METHODS: Immunocytochemical analysis of p16(INK4A), MCM5, and CDC6 expression was performed on 20 normal, 38 cervical intraepithelial neoplasia 1 (CIN1), 33 CIN2, 46 CIN3, 10 squamous cell carcinoma, 19 cervical glandular intraepithelial neoplasia (cGIN), 15858126 NA
cdc6 invasive squamous cell carcinoma CDC6 protein was preferentially expressed in high grade lesions and in invasive squamous cell carcinoma. 15858126 Human
cdc6 cervical intraepithelial neoplasia Quantitation of CDC6 and MCM5 mRNA in cervical intraepithelial neoplasia and invasive squamous cell carcinoma of the cervix. 15696126 Human
cdc6 invasive squamous cell carcinoma Quantitation of CDC6 and MCM5 mRNA in cervical intraepithelial neoplasia and invasive squamous cell carcinoma of the cervix. 15696126 Human
cdc6 cervical intraepithelial neoplasia Using a quantitative real-time RT PCR assay, we compared CDC6 and MCM5 mRNA expression in normal cervical epithelium, cervical intraepithelial neoplasia and invasive squamous cell carcinoma of the cervix. 15696126 Human
cdc6 invasive squamous cell carcinoma Using a quantitative real-time RT PCR assay, we compared CDC6 and MCM5 mRNA expression in normal cervical epithelium, cervical intraepithelial neoplasia and invasive squamous cell carcinoma of the cervix. 15696126 Human
cdc6 invasive cervical carcinoma A linear increase in MCM5 and CDC6 mRNA expression is observed in normal cervix, CIN3 and invasive cervical carcinoma. 15696126 Human
cdc6 cervical squamous cell carcinoma An increase in CDC6 mRNA expression in CIN3 and invasive cervical squamous cell carcinoma was observed; however, the overall difference between cohort groups was not found to be statistically significant (P=0.104). 15696126 Human
cdc6 prostate cancer AR may play an important role in the onset of DNA synthesis in prostate cancer cells by regulating the expression and stability of Cdc6, which is critically required for the assembly of the pre-replication complex(pre-RC). 15887248 Human
cdc6-related protein papillary carcinoma Four of the genes (CDC6-related protein, CCNC, GAS1 and TFDP2) were decreased in human papillary carcinoma tissues. 15619007 Human

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