IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene CCR7 Ensembl ENSG00000126353 Chromosome 17 Start 35963550 End 35975250
Description C-C chemokine receptor type 7 Precursor (C-C CKR-7)(CC-CKR-7)(CCR-7)(MIP-3 beta receptor)(EBV-induced G-protein coupled receptor 1)(EBI1)(BLR2)(CDw197)(CD197 antigen) [Source:UniProtKB/Swiss-Prot;Acc:P32248]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 1608
     Entrez Gene : 1236
     UCSC : uc002huw.2
     GeneCards : 1608
     RefSeq : NM_001838
     CCDS : CCDS11369.1
     Uniprot : P32248
     Interpro : P32248
     OMIM : 600242
     GeneTests : CCR7
     CGAP : CCR7
     PMID : 8383238

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Experimental Evidence        (help)
Expression Sample Number Method Clinical information PubMed Reference
up 45/71(63%) RT-PCRNodal status(P=0.0001)//Stage(P<0.0001)//Lymphatic invasion(P=0.0454) 12673677 Int J Cancer. 2003 Jun 10;105(2):186-9.

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  1097_s_at  0.44  5.25e-5  2.30e-4  0.37  4.14e-3  1.07e-2
 HG_U133A  206337_at  -0.03  7.67e-1  8.01e-1  -1.64  1.68e-28  2.76e-28
 HG_U133_Plus2  206337_at  0.15  3.32e-1  4.21e-1  0.13  4.41e-1  5.02e-1
 HG_U133_Plus2  243107_at  0.22  1.84e-1  2.57e-1  0.14  3.95e-1  4.57e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  206337_at  0.57  1.36e-1  7.99e-1  -0.15  6.82e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 1097_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Gene expression figure

        HG_U133_Plus2 - 206337_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 243107_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
ccr7 hodgkin disease Up-regulation of the chemokine receptor CCR7 in classical but not in lymphocyte-predominant Hodgkin disease correlates with distinct dissemination of neoplastic cells in lymphoid organs. 11830455 Human
ccr7 chronic lymphocytic leukemia The chemokine receptor CCR7 and alpha4 integrin are important for migration of chronic lymphocytic leukemia cells into lymph nodes. 11929789 Human
ccr7 metastasis Recent studies have shown that CCR7 is involved in metastasis in some malignant diseases. 12960129 Human
ccr7 esophageal squamous-cell carcinoma The role of CCR7 in esophageal squamous cell carcinoma (SCC) has not yet been clarified. 12960129 Human
ccr7 esophageal cancer Immunoreactive CCR7 was found mainly in esophageal cancer cells. 12960129 Human
ccr7 lymph-node metastasis High CCR7 expression was significantly correlated with esophageal SCC lymphatic permeation, lymph node metastasis, tumor depth, and tumor-node-metastasis stage and was associated with poor survival. 12960129 Human
ccr7 tumor High CCR7 expression was significantly correlated with esophageal SCC lymphatic permeation, lymph node metastasis, tumor depth, and tumor-node-metastasis stage and was associated with poor survival. 12960129 Human
ccr7 lymph-node metastasis CONCLUSIONS: The results suggested that the CCR7/CCL21 receptor ligand system may play a role in the lymph node metastasis of esophageal SCC. 12960129 Human
ccr7 lymph-node metastasis Expression of chemokine receptor CCR7 is associated with lymph node metastasis of gastric carcinoma. 12019175 Human
ccr7 gastric carcinoma Expression of chemokine receptor CCR7 is associated with lymph node metastasis of gastric carcinoma. 12019175 Human
ccr7 gastric carcinoma In this study, we found that 4 of 6 (67%) gastric carcinoma cell lines tested expressed functional CCR7 for the chemokine CCL21/6Ckine, as demonstrated by calcium mobilization and actin polymerization assays. 12019175 Human
ccr7 gastric carcinoma Moreover, we also showed that signaling through CCR7 induced chemotactic and invasive responses in CCR7-positive gastric carcinoma cells. 12019175 Human
ccr7 lymph-node metastasis Stepwise regression analysis revealed that the most important factor related to lymph node metastasis was the expression of CCR7. 12019175 Human
ccr7 lymph-node metastasis These results indicated that CCR7 and its ligands interaction is associated with preferential lymph node metastasis of gastric carcinoma. 12019175 Human
ccr7 gastric carcinoma These results indicated that CCR7 and its ligands interaction is associated with preferential lymph node metastasis of gastric carcinoma. 12019175 Human
ccr7 metastasis Furthermore, recent studies have demonstrated organ-specific patterns of melanoma metastasis that correlate with their expression of specific chemokine receptors, including CXCR4, CCR7, and CCR10. 12060384 Human
ccr7 melanoma Furthermore, recent studies have demonstrated organ-specific patterns of melanoma metastasis that correlate with their expression of specific chemokine receptors, including CXCR4, CCR7, and CCR10. 12060384 Human
ccr7 classic hodgkin disease Recent results from our laboratory present evidence for the involvement of CCR7 in the dissemination of neoplastic cells in classic Hodgkin disease. 12101256 Human
ccr7 lymphoma We present a case of ETCL with involvement of the lungs and kidneys and report CC chemokine receptor 7 (CCR7) expression of lymphoma cells. 14979477 Human
ccr7 lymphoma The results for CCR7 expression of lymphoma cells in the lung and pleural effusion were negative. 14979477 Human
ccr7 tumours Here we report that the chemokine receptors CXCR4 and CCR7 are highly expressed in human breast cancer cells, malignant breast tumours and metastases. 11242036 Human
ccr7 metastases Here we report that the chemokine receptors CXCR4 and CCR7 are highly expressed in human breast cancer cells, malignant breast tumours and metastases. 11242036 Human
ccr7 human breast cancer Here we report that the chemokine receptors CXCR4 and CCR7 are highly expressed in human breast cancer cells, malignant breast tumours and metastases. 11242036 Human
ccr7 breast cancer In breast cancer cells, signalling through CXCR4 or CCR7 mediates actin polymerization and pseudopodia formation, and subsequently induces chemotactic and invasive responses. 11242036 Human
ccr7 breast cancer Malignant melanoma, which has a similar metastatic pattern as breast cancer but also a high incidence of skin metastases, shows high expression levels of CCR10 in addition to CXCR4 and CCR7. 11242036 Human
ccr7 malignant melanoma Malignant melanoma, which has a similar metastatic pattern as breast cancer but also a high incidence of skin metastases, shows high expression levels of CCR10 in addition to CXCR4 and CCR7. 11242036 Human
ccr7 metastases Malignant melanoma, which has a similar metastatic pattern as breast cancer but also a high incidence of skin metastases, shows high expression levels of CCR10 in addition to CXCR4 and CCR7. 11242036 Human
ccr7 tumor Tumor APCs-MB expressed messenger RNA for fractalkine and ABCD-1 chemokines, and for CC-type chemokine receptors CCR5 and CCR7, indicating the presence of mature dendritic cells (DCs). 11313275 Human
ccr7 small-lymphocytic lymphoma Expression of the chemokine receptors CXCR4 and CCR7 and disease progression in B-cell chronic lymphocytic leukemia/ small lymphocytic lymphoma. 15008605 Human
ccr7 b-cell chronic lymphocytic leukemia Expression of the chemokine receptors CXCR4 and CCR7 and disease progression in B-cell chronic lymphocytic leukemia/ small lymphocytic lymphoma. 15008605 Human
ccr7 breast cancer metastases The findings indicate that the chemokine receptors CXCR4 and CCR7 are found on breast cancer cells and their ligands are highly expressed at sites associated with breast cancer metastases. 11494314 Human
ccr7 breast cancer The findings indicate that the chemokine receptors CXCR4 and CCR7 are found on breast cancer cells and their ligands are highly expressed at sites associated with breast cancer metastases. 11494314 Human
ccr7 cancer These data indicate that CCR7 ligands may prove to be useful adjuvants for genetic vaccination against intracellular infection as well as cancer. 11535317 Human
ccr7 squamous cell carcinoma of the head and neck Expression pattern of chemokine receptor 6 (CCR6) and CCR7 in squamous cell carcinoma of the head and neck identifies a novel metastatic phenotype. 14996750 Mouse
ccr7 tumor Cells derived from a highly metastatic mouse model of SCCHN were used to confirm CCR7 up-regulation in tumor cells with higher metastatic potential. 14996750 Mouse
ccr7 metastasis Thus, CCR6, CCR7, and their ligands, normally important in controlling immune cell trafficking in response to inflammatory stimuli, may have an important role in determining the metastasis of SCCHN cells in vivo. 14996750 Mouse
ccr7 melanoma BACKGROUND: CC chemokine receptor-7 (CCR7), which plays a critical role in the migration of activated dendritic cells to regional lymph nodes via afferent lymphatic vessels, is also expressed by human breast and melanoma cell lines. 11698568 Human
ccr7 metastasis Because neoplastic cells also enter lymphatic vessels before metastasis to the lymph nodes, we investigated whether CCR7 expression enhances metastasis of B16 murine melanoma cells to regional lymph nodes. 11698568 Human
ccr7 melanoma Because neoplastic cells also enter lymphatic vessels before metastasis to the lymph nodes, we investigated whether CCR7 expression enhances metastasis of B16 murine melanoma cells to regional lymph nodes. 11698568 Human
ccr7 lymph-node metastases CCR7-B16 cells isolated from lymph node metastases retained functional CCR7 expression. 11698568 Human
ccr7 metastasis CONCLUSION: Expression of a single chemokine receptor gene, CCR7, increased B16 cell metastasis to draining lymph nodes, suggesting that cancer cells may co-opt normal mechanisms of lymph node homing during metastasis. 11698568 Human
ccr7 cancer CONCLUSION: Expression of a single chemokine receptor gene, CCR7, increased B16 cell metastasis to draining lymph nodes, suggesting that cancer cells may co-opt normal mechanisms of lymph node homing during metastasis. 11698568 Human
ccr7 tumor In contrast, tumor allografts transplanted from CCR7(-/-) donors onto CCR7(-/-) recipients showed allograft survival up to 28 days, suggesting a critical function of CCR7 on donor-type passenger leukocytes in the initiation of cytotoxic CD8(+) T cell resp 14768051 Human
ebi1 adult t-cell leukemia Increased chemokine receptor CCR7/EBI1 expression enhances the infiltration of lymphoid organs by adult T-cell leukemia cells. 10607681 Human
ccr7 adult t-cell leukemia Increased chemokine receptor CCR7/EBI1 expression enhances the infiltration of lymphoid organs by adult T-cell leukemia cells. 10607681 Human
ccr7 tumor Coculture of DCs and apoptotic tumor cells resulted in decreased expression of CC chemokine receptor (CCR) 1 and increased CCR7 expression at mRNA level without alteration in other phenotypical markers on DCs. 10786686 Human
ccr7 tumor Chemotaxis assay showed that CCR7 ligands, macrophage inflammatory protein 3beta and secondary lymphoid-tissue chemokine significantly (P < 0.05) induced the migration of DCs when cocultured with apoptotic tumor cells. 10786686 Human
ccr7 tumor These results suggest that the CCR7 expression of DCs is enhanced with direct contact with apoptotic tumor cells and may have a critical role for DC migrating to regional lymph nodes. 10786686 Human
ccr7 lymph-node metastasis Expression of vascular endothelial growth factor C and chemokine receptor CCR7 in gastric carcinoma and their values in predicting lymph node metastasis. 15040017 Human
ccr7 gastric carcinoma Expression of vascular endothelial growth factor C and chemokine receptor CCR7 in gastric carcinoma and their values in predicting lymph node metastasis. 15040017 Human
ccr7 lymph-node metastasis AIM: To study the expression of vascular endothelial growth factor C (VEGF-C) and chemokine receptor CCR7 in gastric carcinoma and to investigate their associations with lymph node metastasis of gastric carcinoma and their values in predicting lymph node 15040017 Human
ccr7 gastric carcinoma AIM: To study the expression of vascular endothelial growth factor C (VEGF-C) and chemokine receptor CCR7 in gastric carcinoma and to investigate their associations with lymph node metastasis of gastric carcinoma and their values in predicting lymph node 15040017 Human
ccr7 gastric carcinoma METHODS: The expression of VEGF-C and CCR7 in gastric carcinoma tissues obtained from 118 patients who underwent curative gastrectomy was examined by immunohistochemistry. 15040017 Human
ccr7 lymph-node metastasis CCR7 expression was significantly higher in patients with lymph node metastasis compared with those without lymph node metastasis (P<0.001) and was also associated with tumor size (P<0.01), depth of invasion (P<0.001), lymphatic invasion (P<0.001), and TN 15040017 Human
ccr7 tumor CCR7 expression was significantly higher in patients with lymph node metastasis compared with those without lymph node metastasis (P<0.001) and was also associated with tumor size (P<0.01), depth of invasion (P<0.001), lymphatic invasion (P<0.001), and TN 15040017 Human
ccr7 tumor However, the presence of CCR7 had no correlation to age at surgery, gender, tumor location, Lauren classification, and vascular invasion. 15040017 Human
ccr7 lymph-node metastasis Among the 39 patients who underwent MSCT examination, only CCR7 expression was related to lymph node metastasis determined by MSCT (P<0.05). 15040017 Human
ccr7 lymph-node metastasis In the current retrospective study, the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of VEGF-C and CCR7 expression in the diagnosis of lymph node metastasis for patients with gastric carcinoma we 15040017 Human
ccr7 gastric carcinoma In the current retrospective study, the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of VEGF-C and CCR7 expression in the diagnosis of lymph node metastasis for patients with gastric carcinoma we 15040017 Human
ccr7 lymph-node metastasis After subdivision according to the combination of VEGF-C and CCR7 expression, receiver operating characteristic (ROC) analysis showed that the accuracy of the combined examination of VEGF-C and CCR7 expression in predicting lymph node metastasis was relat 15040017 Human
ccr7 lymph-node metastasis CONCLUSION: The expression of VEGF-C and CCR7 is related to lymph node metastasis of gastric carcinoma and both of them may become new targets for the treatment of gastric carcinoma. 15040017 Human
ccr7 gastric carcinoma CONCLUSION: The expression of VEGF-C and CCR7 is related to lymph node metastasis of gastric carcinoma and both of them may become new targets for the treatment of gastric carcinoma. 15040017 Human
ccr7 lymph-node metastasis Furthermore, the combined examination of VEGF-C and CCR7 expression in endoscopic biopsy specimens may be useful in predicting lymph node metastasis of gastric carcinoma and deciding the extent of surgical lymph node resection. 15040017 Human
ccr7 gastric carcinoma Furthermore, the combined examination of VEGF-C and CCR7 expression in endoscopic biopsy specimens may be useful in predicting lymph node metastasis of gastric carcinoma and deciding the extent of surgical lymph node resection. 15040017 Human
ccr7 lymphoma It has been reported recently that CD30 up-regulates the transcription of CCR7 mRNA in YT lymphoma cells. 11756152 Human
ccr7 mycosis fungoides Within these samples, tumor mycosis fungoides cells exhibited high levels of CCR7, a chemokine receptor central for the entry of T cells to lymphatic tissue. 14708605 Human
ccr7 tumor Within these samples, tumor mycosis fungoides cells exhibited high levels of CCR7, a chemokine receptor central for the entry of T cells to lymphatic tissue. 14708605 Human
cmkbr7 cancer The candidate cancer genes included transcription factors (Fos, Gfi1, Lef1, Myb, Myc, Runx3, and Sox3), all three D cyclins, Ras signaling pathway components (Rras2/TC21 and Rasgrp1), and Cmkbr7/CCR7. 12525640 Human
ccr7 cancer The candidate cancer genes included transcription factors (Fos, Gfi1, Lef1, Myb, Myc, Runx3, and Sox3), all three D cyclins, Ras signaling pathway components (Rras2/TC21 and Rasgrp1), and Cmkbr7/CCR7. 12525640 Human
ccr7 melanoma To address this issue, CD8(+) T lymphocytes from tumor-invaded (n = 142) and tumor-free (n = 42) lymph nodes removed from the same nodal basin of melanoma patients were analyzed for the expression of CCR7, CD45RA, perforin, and granzyme B. 12902520 Human
ccr7 pulmonary metastasis Furthermore, slow release administration by subcutaneous injection using an Alzet osmotic pump of a potent and bio-stable T140 analog, 4F-benzoyl-TN14003, gave a partial, but statistically significant (P 12935890 Human
ccr7 non-hodgkin lymphoma Changes in blood dendritic cell (BDC) counts (CD123(hi)BDC and CD11c(+)BDC) and expression of CD62L, CCR7, and CD49d were analyzed in healthy donors, multiple myeloma (MM), and non-Hodgkin lymphoma (NHL) patients, who received granulocyte-colony stimulati 12406901 Human
ccr7 multiple myeloma (mm) Changes in blood dendritic cell (BDC) counts (CD123(hi)BDC and CD11c(+)BDC) and expression of CD62L, CCR7, and CD49d were analyzed in healthy donors, multiple myeloma (MM), and non-Hodgkin lymphoma (NHL) patients, who received granulocyte-colony stimulati 12406901 Human
ccr7 nonsmall-cell lung cancer Overexpression of CCR7 mRNA in nonsmall cell lung cancer: correlation with lymph node metastasis. 12673677 Human
ccr7 lymph-node metastasis Overexpression of CCR7 mRNA in nonsmall cell lung cancer: correlation with lymph node metastasis. 12673677 Human
ccr7 tumor CCR7 has been shown to play an important role in tumor cell migration and lymph node metastasis. 12673677 Human
ccr7 lymph-node metastasis CCR7 has been shown to play an important role in tumor cell migration and lymph node metastasis. 12673677 Human
ccr7 nonsmall-cell lung cancers The aim of our study was to evaluate the expression of CCR7 in nonsmall cell lung cancers (NSCLCs). 12673677 Human
ccr7 tumor We investigated CCR7 expression in 71 patients with NSCLC who underwent curative tumor resection by means of reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemistry. 12673677 Human
ccr7 lymph-node metastasis The CCR7 mRNA expression was significantly associated with lymph node metastasis, stage, lymphatic invasion, CCR7 protein and CXCR4 protein (p = 0.0001 for lymph node metastasis; p < 0.0001 for stage; p = 0.0454 for lymphatic invasion; p < 0.0001 for CCR7 12673677 Human
ccr7 cancer Twenty-six (57.8%) of 45 cases with CCR7 mRNA expression in their cancer tissues were node-positive, whereas only 3 (11.5%) of 26 cases without CCR7 mRNA expression were node-positive. 12673677 Human
ccr7 lymph-node metastasis Furthermore, expression of CCR7 mRNA was shown to be an independent predictor of lymph node metastasis by multivariate analysis (p = 0.0117). 12673677 Human
ccr7 lymph-node metastasis Our study demonstrates that CCR7 might be related to the development of lymph node metastasis in NSCLC. 12673677 Human
ccr7 metastasis The chemokine receptor CCR7, which is responsible for directing T cells, B cells, and dendritic cells (DCs) into secondary lymphoid organs and their precise positioning therein, has already been implicated in lymphoid organ infiltration by neoplastic cell 12727629 Human
ccr7 tumor We have shown that the differential expression of CCR7 by neoplastic cells in two entities of Hodgkin's disease (HD), classic HD (cHD) and the nodular lymphocyte predominant HD (NLPHD), may account for the differences observed in tumor cell dissemina 12727629 Human
ccr7 tumour Freshly sorted metastatic cells and tumour cell lines derived from the liver of BALB/c mice overexpressed functional CCR6 and CCR7 molecules compared with primary tumour. 12791091 Mouse
ccr7 malignant breast tumours Here we report that the chemokine receptors CXCR4 and CCR7 are highly expressed in human breast cancer cells, malignant breast tumours and metastases. 11242036 Human
ccr7 skin metastases Malignant melanoma, which has a similar metastatic pattern as breast cancer but also a high incidence of skin metastases, shows high expression levels of CCR10 in addition to CXCR4 and CCR7. 11242036 Human
ccr7 cll Furthermore, the expression of CCR7, the receptor for both CCL21 and CCL19, correlated with clinical lymphadenopathy, and blocking of CCR7 inhibited CLL cell TEM. 11929789 Human
ccr7 granulomatous lesions In keeping with their advanced maturation, DCs in the granulomatous lesions possess the chemokine receptor, CCR7. 12414528 Human
ccr7 rosai-dorfman disease Histiocytes in Rosai-Dorfman disease and hemophagocytic syndrome also coexpressed CCR6 and CCR7, suggesting that this may be a general attribute of abnormal histiocytes. 12642342 Human
ccr7 tumor cell migration CCR7 has been shown to play an important role in tumor cell migration and lymph node metastasis. 12673677 Human
ccr7 nsclc We investigated CCR7 expression in 71 patients with NSCLC who underwent curative tumor resection by means of reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemistry. 12673677 Human
ccr7 nsclc Our study demonstrates that CCR7 might be related to the development of lymph node metastasis in NSCLC. 12673677 Human
ccr7 nsclc The expression of CCR7 mRNA could open up a new window for the diagnostic staging and treatment of NSCLC. 12673677 Human
ccr7 hodgkin's disease We have shown that the differential expression of CCR7 by neoplastic cells in two entities of Hodgkin's disease (HD), classic HD (cHD) and the nodular lymphocyte predominant HD (NLPHD), may account for the differences observed in tumor cell dissemina 12727629 Human
ccr7 primary tumour Freshly sorted metastatic cells and tumour cell lines derived from the liver of BALB/c mice overexpressed functional CCR6 and CCR7 molecules compared with primary tumour. 12791091 Mouse
ccr7 esophageal scc EXPERIMENTAL DESIGN: We performed reverse transcription-PCR analysis for CCR7 in 20 esophageal SCC cell lines and immunohistochemical analysis of 96 esophageal SCC samples. 12960129 Human
ccr7 esophageal scc We then performed a cell migration assay, F-actin polymerization, and a phagokinetic assay on esophageal SCC cell lines in the presence of CCL21, a ligand of CCR7. 12960129 Human
ccr7 esophageal scc RESULTS: CCR7 mRNA was detected in 9 of 20 esophageal SCC cell lines. 12960129 Human
ccr7 esophageal scc High CCR7 expression was significantly correlated with esophageal SCC lymphatic permeation, lymph node metastasis, tumor depth, and tumor-node-metastasis stage and was associated with poor survival. 12960129 Human
ccr7 esophageal scc CONCLUSIONS: The results suggested that the CCR7/CCL21 receptor ligand system may play a role in the lymph node metastasis of esophageal SCC. 12960129 Human
ccr7 tumor cell migration CONCLUSIONS: CCR7 and CXCR4 ligands may play a key role in tumor cell migration and spreading in vivo. 14871974 Human
ccr7 human t-cell lymphoma However, only activation by CCL19, not CCL21, promotes robust desensitization of endogenous CCR7 in the human T cell lymphoma cell line H9. 15054093 Human
ccr7 tumors These findings provide evidence for the role of CCR7, CXCR4, and CXCR5 in determining the pattern of lymphoid organ involvement of B tumors. 15155773 Human
ccr7 multiple myeloma (mm) Multiple myeloma (MM) cells did not express CCR7 nor CXCR5 and did not migrate in response to their ligands; a moderate expression of CXCR4 on MM cells was accompanied by a migratory response to its ligand, CXCL12. 15155773 Human
ccr7 b cell chronic lymphocytic leukemia (b-cll) By contrast, cells from B cell chronic lymphocytic leukemia (B-CLL) expressed the highest levels of these chemokine receptors and efficiently migrated in response to all ligands of CCR7, CXCR4, and CXCR5. 15155773 Human
ccr7 tumor In addition, the migration index of B-CLL cells in response to both of the CCR7 ligands correlated with the presence of clinical lymphadenopathy, thus indicating that the high expression of functional chemokine receptors justifies the widespread character 15155773 Human
ccr7 tumor We found both in skin lesions and in invaded lymph nodes an expression by tumor cells of CXCR3, CXCR4, and CCR7, and the concomitant expression by cells in the microenvironment of their respective ligands CXCL9, CXCL12, and CCL19. 15284853 Human
ccr7 fresh tumor We show that fresh tumor cells are able to migrate in response to CXCR4, CCR2, CCR5, CCR6, and CCR7 ligands, and the ability of CXCR3 ligands to increase the responsiveness to CXCL12. 15284853 Human
ccr7 lymphoma Raji (lymphoma cell line) strongly expressed CCR7 and CXCR4. 15332556 Human
ccr7 lymphoma Strong CCR7 and CXCR4 expressions in the lymphoma cell may explain the organ specificity of lymphoma for lymphoid organs as well. 15332556 Human
ccr7 cancer Such "alpha-type-1-polarized DC(s)" (alphaDC1) show high migratory responses to the CCR7 ligand, 6C-kine but produce much higher levels of IL-12p70 as compared to TNFalpha/IL-1beta/IL-6/prostaglandin E2 (PGE2)-matured DCs (sDC), the current &quo 15342370 Human
ccr7 tumors EXPERIMENTAL DESIGN: Quantitative real-time reverse transcriptase-PCR (qRT) assay and immunohistochemistry (IHC) were used to assess the level of CCR7 expression in melanoma cell lines and in primary and metastatic melanoma tumors. 15073111 Human
ccr7 metastatic melanoma EXPERIMENTAL DESIGN: Quantitative real-time reverse transcriptase-PCR (qRT) assay and immunohistochemistry (IHC) were used to assess the level of CCR7 expression in melanoma cell lines and in primary and metastatic melanoma tumors. 15073111 Human
ccr7 melanoma EXPERIMENTAL DESIGN: Quantitative real-time reverse transcriptase-PCR (qRT) assay and immunohistochemistry (IHC) were used to assess the level of CCR7 expression in melanoma cell lines and in primary and metastatic melanoma tumors. 15073111 Human
ccr7 tumors RESULTS: Melanoma cell lines and tumors demonstrated heterogeneous expression of CCR7 mRNA by qRT assay. 15073111 Human
ccr7 melanoma RESULTS: Melanoma cell lines and tumors demonstrated heterogeneous expression of CCR7 mRNA by qRT assay. 15073111 Human
ccr7 melanomas IHC evidence of CCR7 expression in primary melanomas significantly (P = 0.02) correlated with Breslow thickness. 15073111 Human
ccr7 malignant ascites EXPERIMENTAL DESIGN: We analyzed the expression of a broad range of adhesion molecules and chemokine receptors (CD62L, CD56, CCR4, CCR5, CCR7, CXCR3, CLA, and integrin alpha 4 beta 7) on tumor-associated lymphocytes in effusions and peripheral blood lymph 15102661 Human
ccr7 lymph-node metastases Two chemokine receptors and their ligands stand out as likely targets for therapeutics: CCR7/CCL21 for lymph node metastases, and CXCR4/CXCL12 for lung, liver, bone marrow, and brain metastases. 15246053 Human
ccr7 brain metastases Two chemokine receptors and their ligands stand out as likely targets for therapeutics: CCR7/CCL21 for lymph node metastases, and CXCR4/CXCL12 for lung, liver, bone marrow, and brain metastases. 15246053 Human
ccr7 skin metastasis In particular, we describe roles for CC chemokine receptor 7 (CCR7) in lymph node metastasis, CXC chemokine receptor 4 (CXCR4) in pulmonary metastasis, and CCR10 in skin metastasis, using a mouse model of melanoma. 15519136 Human
ccr7 lymph-node metastasis In particular, we describe roles for CC chemokine receptor 7 (CCR7) in lymph node metastasis, CXC chemokine receptor 4 (CXCR4) in pulmonary metastasis, and CCR10 in skin metastasis, using a mouse model of melanoma. 15519136 Human
ccr7 pulmonary metastasis In particular, we describe roles for CC chemokine receptor 7 (CCR7) in lymph node metastasis, CXC chemokine receptor 4 (CXCR4) in pulmonary metastasis, and CCR10 in skin metastasis, using a mouse model of melanoma. 15519136 Human
ccr7 melanoma In particular, we describe roles for CC chemokine receptor 7 (CCR7) in lymph node metastasis, CXC chemokine receptor 4 (CXCR4) in pulmonary metastasis, and CCR10 in skin metastasis, using a mouse model of melanoma. 15519136 Human
ccr7 metastasis Thus, CCR6, CCR7 and their ligands, normally important in controlling immune cell trafficking in response to inflammatory stimuli, may have an important role in determining the metastasis of HNSCC cells in vivo. 15608423 Human
ccr7 cll In contrast, SLL cells failed to express CCR7, but were otherwise similar to CLL cells. 15621766 Human
ccr7 sll In contrast, SLL cells failed to express CCR7, but were otherwise similar to CLL cells. 15621766 Human
ccr7 hcl HCL cells showed absence of CXCR5 and CCR7, but interestingly all but one case expressed CCR5, whilst CD25-negative "variant" HCL cells did not express CCR5. 15621766 Human
ccr7 other cancers Likewise, CCR7 is expressed in breast and other cancers and, in some cases, is associated with more aggressive disease. 15687714 Human
ccr7 gastric carcinoma The chemokine receptor CCR7 is expressed on epithelium of non-inflamed gastric mucosa, Helicobacter pylori gastritis, gastric carcinoma and its precursor lesions and up-regulated by H. pylori. 15654831 Human
ccr7 tumour CCR7 chemokine-receptor expression on tumour cells of gastric carcinoma has been associated with lymph-node metastasis and is thought to play an important role in metastasis. 15654831 Human
ccr7 gastric carcinoma CCR7 chemokine-receptor expression on tumour cells of gastric carcinoma has been associated with lymph-node metastasis and is thought to play an important role in metastasis. 15654831 Human
ccr7 metastasis CCR7 chemokine-receptor expression on tumour cells of gastric carcinoma has been associated with lymph-node metastasis and is thought to play an important role in metastasis. 15654831 Human
ccr7 lymph-node metastasis CCR7 chemokine-receptor expression on tumour cells of gastric carcinoma has been associated with lymph-node metastasis and is thought to play an important role in metastasis. 15654831 Human
ccr7 gastric carcinoma However, so far it is unknown whether CCR7 is newly up-regulated on gastric carcinoma or already expressed in non-neoplastic gastric epithelium. 15654831 Human
ccr7 metaplasia Therefore, epithelial CCR7 expression was investigated in the process of gastric carcinogenesis: non-inflamed mucosa --Helicobacter pylori gastritis -- intestinal metaplasia/dysplasia -- gastric carcinoma. 15654831 Human
ccr7 gastric carcinoma Therefore, epithelial CCR7 expression was investigated in the process of gastric carcinogenesis: non-inflamed mucosa --Helicobacter pylori gastritis -- intestinal metaplasia/dysplasia -- gastric carcinoma. 15654831 Human
ccr7 metaplasia CCR7 was expressed by gastric epithelium in non-inflamed gastric mucosa (n = 5), H. pylori gastritis (n = 17), intestinal metaplasia (n = 10), dysplasia (n = 3) and on tumour cells in 20 of 24 patients with gastric carcinoma (13/14 intestinal-type; 7/10 d 15654831 Human
ccr7 tumour CCR7 was expressed by gastric epithelium in non-inflamed gastric mucosa (n = 5), H. pylori gastritis (n = 17), intestinal metaplasia (n = 10), dysplasia (n = 3) and on tumour cells in 20 of 24 patients with gastric carcinoma (13/14 intestinal-type; 7/10 d 15654831 Human
ccr7 gastric carcinoma CCR7 was expressed by gastric epithelium in non-inflamed gastric mucosa (n = 5), H. pylori gastritis (n = 17), intestinal metaplasia (n = 10), dysplasia (n = 3) and on tumour cells in 20 of 24 patients with gastric carcinoma (13/14 intestinal-type; 7/10 d 15654831 Human
ccr7 gastric carcinoma Epithelial CCR7 up-regulation by H. pylori may alter the metastatic fate of gastric carcinoma. 15654831 Human
ccr7 gastric carcinoma Additionally, CCR7 expression not only on gastric carcinoma, but also on non-neoplastic gastric epithelium, suggests a novel biological function. 15654831 Human
ccr7 sezary syndrome Circulating clonal CLA(+) and CD4(+) T cells in Sezary syndrome express the skin-homing chemokine receptors CCR4 and CCR10 as well as the lymph node-homing chemokine receptor CCR7. 15727636 Human
ccr7 sezary syndrome OBJECTIVES: To investigate the expression of CCR4, CCR7 and CCR10 on skin-homing CLA(+) and CD4(+) T cells in the peripheral blood of patients with Sezary syndrome (SS), a rare leukaemic variant of cutaneous T-cell lymphoma. 15727636 Human
ccr7 cutaneous t-cell lymphoma OBJECTIVES: To investigate the expression of CCR4, CCR7 and CCR10 on skin-homing CLA(+) and CD4(+) T cells in the peripheral blood of patients with Sezary syndrome (SS), a rare leukaemic variant of cutaneous T-cell lymphoma. 15727636 Human
ccr7 granulomas Although sinusoidal granulomas contained numerous CD11c+ DCs at day 7, expressions of CCR7, IL-12p40 by these DCs were dramatically decreased in IL-1ra-deficient mice, suggesting aberrant DC maturation and sinusoid portal migration in the absence of endog 15749858 Mouse
ccr7 melanoma We hypothesized that chemokine receptors C-C chemokine receptor 7 (CCR7) and C-X-C chemokine receptor 4 (CXCR4) on melanoma cells undergo epigenetic regulation. 15753377 Human
ccr7 melanoma We investigated whether a histone deacetylase inhibitor and a demethylating agent influence CCR7 and CXCR4 expression on melanoma cells. 15753377 Human
ccr7 melanoma Treatment with TSA or 5-Aza increased gene expression of both CCR7 and CXCR4 in melanoma lines. 15753377 Human
ccr7 melanoma Melanoma cell migration in TSA- and 5-Aza-treated cells was 7- and 2-fold higher than control cells for CCR7 and CXCR4, respectively. 15753377 Human
ccr7 melanoma In summary, a histone deacetylase inhibitor and a demethylating agent up-regulated CCR7 and CXCR4 expression on melanoma cells. 15753377 Human
ccr7 human colorectal cancer Effect of Chemokine Receptors CXCR4 and CCR7 on the Metastatic Behavior of Human Colorectal Cancer. 15755995 Human
ccr7 tumor PURPOSE: The expression of chemokine receptors CXCR4 and CCR7 has been associated with tumor dissemination and poor prognosis in a limited number of tumor entities. 15755995 Human
ccr7 colorectal cancers However, no data are currently available on the impact of chemokine receptor expression on disease progression and prognosis in human colorectal cancer.EXPERIMENTAL DESIGN: The expression of CXCR4 and CCR7 was evaluated in 96 patients with histologically 15755995 Human
ccr7 colorectal cancer However, no data are currently available on the impact of chemokine receptor expression on disease progression and prognosis in human colorectal cancer.EXPERIMENTAL DESIGN: The expression of CXCR4 and CCR7 was evaluated in 96 patients with histologically 15755995 Human
ccr7 human colorectal cancer Furthermore, cell migration assays were done with SW480, SW620, and LS174T cancer cells to confirm the effect of the CXCR4 ligand stromal cell-derived factor 1alpha on migration.RESULTS: Human colorectal cancer specimens and cell lines displayed a CXCR4 a 15755995 Human
ccr7 cancer Furthermore, cell migration assays were done with SW480, SW620, and LS174T cancer cells to confirm the effect of the CXCR4 ligand stromal cell-derived factor 1alpha on migration.RESULTS: Human colorectal cancer specimens and cell lines displayed a CXCR4 a 15755995 Human
ccr7 metastasis Interestingly, strong expression of CXCR4, but not of CCR7, was significantly associated with higher Union International Contre Cancer stages 3/4 (P = 0.0017), lymph node metastasis (P = 0.00375), and distant metastasis (P = 0.00003) and further correlate 15755995 Human
ccr7 cancer Interestingly, strong expression of CXCR4, but not of CCR7, was significantly associated with higher Union International Contre Cancer stages 3/4 (P = 0.0017), lymph node metastasis (P = 0.00375), and distant metastasis (P = 0.00003) and further correlate 15755995 Human
ccr7 lymph-node metastasis Interestingly, strong expression of CXCR4, but not of CCR7, was significantly associated with higher Union International Contre Cancer stages 3/4 (P = 0.0017), lymph node metastasis (P = 0.00375), and distant metastasis (P = 0.00003) and further correlate 15755995 Human
ccr7 primary tumor Strong CXCR4 and CCR7 expression positively correlated with the location of the primary tumor in the rectum (P < 0.01). 15755995 Human
ccr7 tumor Two tumor cell supernatants, MDA468 and 293T, were found to be able to affect the in vitro differentiation of DCs from monocytic precursors, leading to the generation of a distinct type of DC with markedly reduced expression of DC-SIGN, downregulation of 15864737 Human
ccr7 gastric cancer Here we evaluated the expression profiles of the chemokine receptors CCR7 and CXCR4 in gastric cancer, and their potential use as prognostic markers. 15867478 Human
ccr7 human gastric cancer The expressions of CCR7 and CXCR4 mRNA were analyzed by RT-PCR in 10 human gastric cancer cell lines and in 43 gastric cancer tissues, and in an additional 307 gastric cancer tissues by immunohistochemistry. 15867478 Human
ccr7 gastric cancer The expressions of CCR7 and CXCR4 mRNA were analyzed by RT-PCR in 10 human gastric cancer cell lines and in 43 gastric cancer tissues, and in an additional 307 gastric cancer tissues by immunohistochemistry. 15867478 Human
ccr7 gastric cancer CCR7 and CXCR4 mRNA were found to be expressed in all gastric cancer cell lines, whereas their mRNA expression rates in gastric cancer tissues were 83.7% (36/43) and 100% (43/43), respectively. 15867478 Human
ccr7 gastric cancer Immunohistochemical staining of the 307 gastric cancer tissues showed that the expression rates of CCR7 and CXCR4 were 22.5% (69/307) and 36.5% (112/307), respectively. 15867478 Human
ccr7 cancer Multivariate analysis of the immunohistochemistry results showed that the expression rate of CCR7 was significantly higher in differentiated than in undifferentiated gastric cancertypes (35.1 vs. 15.3%, p<0.001), and that CXCR4 was expressed at a higher r 15867478 Human
ccr7 intestinal cancer Multivariate analysis of the immunohistochemistry results showed that the expression rate of CCR7 was significantly higher in differentiated than in undifferentiated gastric cancertypes (35.1 vs. 15.3%, p<0.001), and that CXCR4 was expressed at a higher r 15867478 Human
ccr7 lymph-node metastasis However, in contrast to previous studies, the expressions of CCR7 or CXCR4 were not associated with lymph node metastasis. 15867478 Human
ccr7 intestinal-type gastric cancers In conclusion, the expressions of the chemokine receptors CCR7 and CXCR4 were found to be high in differentiated and intestinal-type gastric cancers, respectively. 15867478 Human
ccr7 primary central-nervous-system lymphoma Expression of the chemokine receptors CXCR4, CXCR5, and CCR7 in primary central nervous system lymphoma. 15967804 Human
ccr7 murine neuroblastoma Murine neuroblastoma attenuates dendritic cell cysteine cysteine receptor 7 (CCR7) expression. 15991182 Human
ccr7 tumors Tumors may inhibit CCR7 expression to evade immunodetection. 15991182 Human
ccr7 neuroblastoma CONCLUSION: Neuroblastoma initially upregulates CCR7 expression by DC. 15991182 Human
ccr7 nasopharyngeal carcinoma This study was done to evaluate the contribution of chemokine receptors CXCR4 and CCR7 to metastasis of human nasopharyngeal carcinoma. 16000558 Human
ccr7 tumor EXPERIMENTAL DESIGN: Reverse transcription-PCR, immunohistochemistry, and flow cytometry were used to evaluate mRNA and protein expression of CXCR4 and CCR7 in nasopharyngeal carcinoma tumor tissues and cell lines. 16000558 Human
ccr7 metastasis This study was done to evaluate the contribution of chemokine receptors CXCR4 and CCR7 to metastasis of human nasopharyngeal carcinoma. 16000558 Human
ccr7 nasopharyngeal carcinoma Chemotaxis assays were used to evaluate the function of CXCR4 in nasopharyngeal carcinoma cells. 16000558 Human
ccr7 metastatic nasopharyngeal carcinoma Transfection of antisense CXCR4 in metastatic nasopharyngeal carcinoma cells inhibited the expression of CXCR4 and SDF-1alpha-induced cell migration in vitro and reduced the capacity of the tumor cells to form metastasis in the lungs and lymph nodes when 16000558 Human
ccr7 metastasis Transfection of antisense CXCR4 in metastatic nasopharyngeal carcinoma cells inhibited the expression of CXCR4 and SDF-1alpha-induced cell migration in vitro and reduced the capacity of the tumor cells to form metastasis in the lungs and lymph nodes when 16000558 Human
ccr7 human nasopharyngeal carcinoma This study was done to evaluate the contribution of chemokine receptors CXCR4 and CCR7 to metastasis of human nasopharyngeal carcinoma. 16000558 Human
ccr7 tumor Chemotaxis assays were used to evaluate the function of CXCR4 in nasopharyngeal carcinoma cells. 16000558 Human
ccr7 lymph-node metastases On the other hand, the transcripts for CCR7 were detected only in four primary nasopharyngeal carcinoma tissues and in none of the nasopharyngeal carcinoma cell lines. 16000558 Human
ccr7 human nasopharyngeal carcinoma CONCLUSION: The expression of functional CXCR4 but not CCR7 is correlated with the metastatic potential of human nasopharyngeal carcinoma cells. 16000558 Human
ccr7 b16 melanoma In an in vitro study, when immature DCs were pulsed with mouse B16 melanoma cells heated at 43 degrees C, major histocompatibility complex (MHC) class I/II, costimulatory molecules CD80/CD86 and CCR7 in the DCs were upregulated, thus resulting in DC matur 15825167 Human
ccr7 prostate cancer Expression of the chemokine receptor CCR7 in prostate cancer presenting with generalized lymphadenopathy: report of a case, review of the literature, and analysis of chemokine receptor expression. 16018941 Human
ccr7 tumor Monoclonal antibodies to CCR7 showed intense staining in the patient's tumor epithelium. 16018941 Human
ccr7 prostate cancer In this case, expression of CCR7 may have accounted for the unusual predilection of this patient's prostate cancer for lymph nodes. 16018941 Human
ccr7 lymph-node metastasis Prediction of lymph node metastasis in colorectal carcinoma by expressionof chemokine receptor CCR7. 15828050 Human
ccr7 colorectal carcinoma Prediction of lymph node metastasis in colorectal carcinoma by expressionof chemokine receptor CCR7. 15828050 Human
ccr7 colorectal carcinomas In a retrospective study, expression levels of the chemokine receptors CCR7, CXCR4 and CXCR5 were determined by immunohistochemistry on paraffin-embedded specimens of 99 colorectal carcinomas, which were curatively operated on, comprising all stages of th 15828050 Human
ccr7 colorectal carcinoma CCR7 plays an important role in the mechanism of lymph node spread in colorectal carcinoma. 15828050 Human
ccr7 breast cancer CCR7 and CXCR4 as Novel Biomarkers Predicting Axillary Lymph Node Metastasis in T1 Breast Cancer. 16115904 Human
ccr7 axillary lymph node metastasis CCR7 and CXCR4 as Novel Biomarkers Predicting Axillary Lymph Node Metastasis in T1 Breast Cancer. 16115904 Human
ccr7 metastasis PURPOSE: The chemokine receptors CCR7 and CXCR4 have been shown to play an important role in cancer metastasis. 16115904 Human
ccr7 cancer PURPOSE: The chemokine receptors CCR7 and CXCR4 have been shown to play an important role in cancer metastasis. 16115904 Human
ccr7 tumors RESULTS: Lymph node-positive tumors showed higher rates of high cytoplasmic CCR7 staining (21.5% versus 8.5%, P = 0.013) and HER2-neu overexpression (21.5% versus 9.3%, P = 0.019) than did lymph node-negative tumors. 16115904 Human
ccr7 breast cancer We therefore studied the differential expression of CCR7 and CXCR4, along with that of the biomarker HER2-neu, to evaluate whether these biomarkers could predict axillary lymph node metastasis in breast cancer. 16115904 Human
ccr7 axillary lymph node metastasis We therefore studied the differential expression of CCR7 and CXCR4, along with that of the biomarker HER2-neu, to evaluate whether these biomarkers could predict axillary lymph node metastasis in breast cancer. 16115904 Human
ccr7 breast cancer CONCLUSIONS: Our results suggest that the chemokine receptor CCR7 is a novel biomarker that can predict lymph node metastases in breast cancer. 16115904 Human
ccr7 lymph-node metastases When all three biomarkers (CCR7, CXCR4, HER2-neu) were utilized together, 50.0% of lymph node-positive tumors highly expressed one of these biomarkers compared with 18.8% of the lymph node-negative tumors (P < 0.0001). 16115904 Human
ccr7 tumors When all three biomarkers (CCR7, CXCR4, HER2-neu) were utilized together, 50.0% of lymph node-positive tumors highly expressed one of these biomarkers compared with 18.8% of the lymph node-negative tumors (P < 0.0001). 16115904 Human
ccr7 lymph-node metastases CONCLUSIONS: Our results suggest that the chemokine receptor CCR7 is a novel biomarker that can predict lymph node metastases in breast cancer. 16115904 Human
ccr7 squamous cell carcinoma of the head and neck Chemokine receptor 7 (CCR7) upregulation, which mediates immune cell survival and migration to lymph nodes, has recently been associated with nodal metastasis of squamous cell carcinoma of the head and neck (SCCHN). 16007209 Human
ccr7 metastasis Chemokine receptor 7 (CCR7) upregulation, which mediates immune cell survival and migration to lymph nodes, has recently been associated with nodal metastasis of squamous cell carcinoma of the head and neck (SCCHN). 16007209 Human
ccr7 tumor However, the mechanism of CCR7 in tumor progression, its downstream signaling mediators, and interactions with other pathways contributing to metastasis of SCCHN have not been determined. 16007209 Human
ccr7 metastasis However, the mechanism of CCR7 in tumor progression, its downstream signaling mediators, and interactions with other pathways contributing to metastasis of SCCHN have not been determined. 16007209 Human
chemokine receptor-7 tumor CC chemokine receptor-7 on dendritic cells is induced after interaction with apoptotic tumor cells: critical role in migration from the tumor site to draining lymph nodes. 10786686 Human
chemokine receptor-7 metastasis Lessons learned from lymphocytes: CC chemokine receptor-7 involved in lymphogenic metastasis of melanoma. 11698555 Human
chemokine receptor-7 melanoma Lessons learned from lymphocytes: CC chemokine receptor-7 involved in lymphogenic metastasis of melanoma. 11698555 Human
chemokine receptor-7 regional lymph node metastasis Expression of CC chemokine receptor-7 and regional lymph node metastasis of B16 murine melanoma. 11698568 Human
chemokine receptor-7 melanoma Expression of CC chemokine receptor-7 and regional lymph node metastasis of B16 murine melanoma. 11698568 Human
chemokine receptor-7 melanoma BACKGROUND: CC chemokine receptor-7 (CCR7), which plays a critical role in the migration of activated dendritic cells to regional lymph nodes via afferent lymphatic vessels, is also expressed by human breast and melanoma cell lines. 11698568 Human
chemokine receptor 7 esophageal squamous-cell carcinoma Association of CC chemokine receptor 7 with lymph node metastasis of esophageal squamous cell carcinoma. 12960129 Human
chemokine receptor 7 lymph-node metastasis Association of CC chemokine receptor 7 with lymph node metastasis of esophageal squamous cell carcinoma. 12960129 Human
chemokine receptor 7 enteropathy-type t-cell lymphoma Extranodal multiple involvement of enteropathy-type T-cell lymphoma without expression of CC chemokine receptor 7. 14979477 Human
chemokine receptor 7 lymphoma We present a case of ETCL with involvement of the lungs and kidneys and report CC chemokine receptor 7 (CCR7) expression of lymphoma cells. 14979477 Human
chemokine receptor 7 skin metastasis In particular, we describe roles for CC chemokine receptor 7 (CCR7) in lymph node metastasis, CXC chemokine receptor 4 (CXCR4) in pulmonary metastasis, and CCR10 in skin metastasis, using a mouse model of melanoma. 15519136 Human
chemokine receptor 7 lymph-node metastasis In particular, we describe roles for CC chemokine receptor 7 (CCR7) in lymph node metastasis, CXC chemokine receptor 4 (CXCR4) in pulmonary metastasis, and CCR10 in skin metastasis, using a mouse model of melanoma. 15519136 Human
chemokine receptor 7 pulmonary metastasis In particular, we describe roles for CC chemokine receptor 7 (CCR7) in lymph node metastasis, CXC chemokine receptor 4 (CXCR4) in pulmonary metastasis, and CCR10 in skin metastasis, using a mouse model of melanoma. 15519136 Human
chemokine receptor 7 melanoma In particular, we describe roles for CC chemokine receptor 7 (CCR7) in lymph node metastasis, CXC chemokine receptor 4 (CXCR4) in pulmonary metastasis, and CCR10 in skin metastasis, using a mouse model of melanoma. 15519136 Human
chemokine receptor 7 melanoma Epigenetic Up-regulation of C-C Chemokine Receptor 7 and C-X-C Chemokine Receptor 4 Expression in Melanoma Cells. 15753377 Human
chemokine receptor 7 melanoma We hypothesized that chemokine receptors C-C chemokine receptor 7 (CCR7) and C-X-C chemokine receptor 4 (CXCR4) on melanoma cells undergo epigenetic regulation. 15753377 Human
chemokine receptor 7 head-and-neck cancer Chemokine receptor 7 activates phosphoinositide-3 kinase-mediated invasive and prosurvival pathways in head and neck cancer cells independent of EGFR. 16007209 Human
chemokine receptor 7 squamous cell carcinoma of the head and neck Chemokine receptor 7 (CCR7) upregulation, which mediates immune cell survival and migration to lymph nodes, has recently been associated with nodal metastasis of squamous cell carcinoma of the head and neck (SCCHN). 16007209 Human
chemokine receptor 7 metastasis Chemokine receptor 7 (CCR7) upregulation, which mediates immune cell survival and migration to lymph nodes, has recently been associated with nodal metastasis of squamous cell carcinoma of the head and neck (SCCHN). 16007209 Human

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