IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene SMARCE1 Ensembl ENSG00000073584 Chromosome 17 Start 36037511 End 36057629
Description SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 (BRG1-associated factor 57) [Source:UniProtKB/Swiss-Prot;Acc:Q969G3]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 11109
     Entrez Gene : 6605
     UCSC : uc002hux.2
     GeneCards : 11109
     RefSeq : NM_003079
     CCDS : CCDS11370.1
     Uniprot : Q969G3
     Interpro : Q969G3
     OMIM : 603111
     GeneTests : SMARCE1
     CGAP : SMARCE1
     PMID : 9435219

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  33828_at  -0.10  2.86e-1  3.89e-1  -0.58  2.93e-4  1.04e-3
 HG_U133A  211988_at  -0.15  1.08e-2  1.69e-2  -3.39  3.85e-81  1.60e-80
 HG_U133A  211989_at  0.85  3.15e-33  6.02e-32  0.59  1.22e-19  1.76e-19
 HG_U133_Plus2  211988_at  -0.24  3.99e-4  1.13e-3  -0.55  8.90e-10  3.82e-9
 HG_U133_Plus2  211989_at  0.25  3.45e-4  9.88e-4  0.37  1.46e-4  3.19e-4
 HG_U133_Plus2  229511_at  -0.22  2.50e-2  4.60e-2  -0.31  1.44e-2  2.29e-2
 Stanford  7385  0.69  1.44e-1  3.17e-1  0.17  5.92e-1  7.80e-1
 Stanford  20804  0.74  7.32e-3  5.26e-2  0.32  3.35e-1  5.74e-1
 Agilent_HS_21.6K  11804  -0.18  2.70e-3  1.68e-2  -0.23  3.75e-3  1.61e-2
 Agilent_HS_21.6K  18106  -0.03  4.61e-1  6.41e-1  -0.09  1.17e-1  2.33e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  211988_at  0.10  6.90e-1  9.67e-1  0.09  6.30e-1  1.00e+0
 HG_U133A  211989_at  -0.46  1.82e-1  8.22e-1  0.06  7.10e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 33828_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 211988_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 211989_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 211988_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 211989_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 229511_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 7385    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 20804    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 11804    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 18106    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
baf57 breast and ovarian cancer LOH has also been reported in breast and ovarian cancer within 17q12-25, a gene-rich area including BRCA1, BAF60B, and BAF57. 11147808 Human
baf57 pancreatic carcinoma In this study, we identified the first cell line negative for the BAF57 protein as well as a pancreatic carcinoma cell line negative for both the BRG-1 and hBRM proteins. 11147808 Human
baf57 prostatic adenocarcinoma We show that BAF57 is expressed in the luminal epithelia of the prostate and is required for AR-dependent transactivation in prostatic adenocarcinoma cells. 15743818 Human
baf57 prostatic adenocarcinoma Lastly, we demonstrate that both BAF57 and BRM are required for the proliferation of AR-dependent prostatic adenocarcinoma cells. 15743818 Human
baf57 tumor The BRG1- and hBRM-Associated Factor BAF57 Induces Apoptosis by Stimulating Expression of the Cylindromatosis Tumor Suppressor Gene. 16135788 Human
baf57 human tumors Mutation of BRG1, hBRM, and their associated factors, INI1 and BAF57, in primary human tumors has suggested that inactivation of human SWI/SNF (hSWI/SNF) complexes may be involved in neoplastic transformation. 16135788 Human
baf57 human breast carcinoma BT549 is an invasive human breast carcinoma cell line that lacks expression of BAF57, a key hSWI/SNF subunit that mediates interaction with transcriptional activators and corepressors. 16135788 Human
baf57 tumor Furthermore, microarray analysis revealed that BAF57-mediated cell death was associated with up-regulation of proapoptotic genes including the tumor suppressor familial cylindromatosis (CYLD), which was found to be a direct target of BAF57 as determined b 16135788 Human

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