IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene KRT13 Ensembl ENSG00000171401 Chromosome 17 Start 36898973 End 36915391
Description Keratin, type I cytoskeletal 13 (Cytokeratin-13)(CK-13)(Keratin-13)(K13) [Source:UniProtKB/Swiss-Prot;Acc:P13646]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 6415
     Entrez Gene : 3860
     UCSC : uc002hwu.1
     GeneCards : 6415
     RefSeq : NM_002274
     CCDS : CCDS11396.1
     Uniprot : P13646
     Interpro : P13646
     OMIM : 148065
     GeneTests : KRT13
     CGAP : KRT13
     PMID : 16831889

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  36883_at  0.19  1.34e-1  2.10e-1  3.09  9.58e-14  2.34e-12
 HG_U133A  207935_s_at  0.57  9.10e-4  1.66e-3  3.11  2.61e-58  6.84e-58
 HG_U133_Plus2  207935_s_at  -0.14  6.04e-1  6.83e-1  5.38  3.25e-25  8.21e-24
 Stanford  3026  0.10  8.53e-1  9.20e-1  3.12  2.64e-5  1.05e-3
 Stanford  19888  0.43  2.01e-1  3.91e-1  3.29  8.14e-5  2.36e-3
 Agilent_HS_21.6K  21580  0.19  1.39e-1  2.95e-1  1.18  5.41e-6  6.66e-5

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  207935_s_at  0.60  3.53e-1  8.90e-1  0.21  7.80e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 36883_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 207935_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 207935_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 3026    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 19888    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 21580    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
ck 13 hepatocellular carcinomas Because the major components of MBs are cytokeratins (CKs), CK profiles of MBs were examined immunohistochemically in 37 autopsied liver specimens (including a variety of nontumor pathological livers and hepatocellular carcinomas), using 13 antibodies aga 15221653 Human
ck13 cysts RESULTS: Of the maxillary cysts, 20, 29 and 19 squamous epithelial linings were positive for CK8, CK13 and CK18, respectively; of the mandibular cysts, 10, 20 and 11 linings were positive for these CKs, respectively. 11936454 Human
cytokeratin 13 tumor The two types of tumor differed in the prevalence of TP53 mutations (31% in ADCC and 50% in ADCE) and of MDM2 gene amplification (19% in ADCC and 4% in ADCE), and in the pattern of expression of cytokeratin 7 (positive in 100% of ADCE and in 41% of ADCC) 11141476 Human
k13 primary-effusion lymphoma We have previously examined the transcription and splicing of open reading frames (ORFS) 71 (K13), 72, and 73 of Kaposi's sarcoma-associated herpesvirus (KSHV) in the primary effusion lymphoma cell line BCP-1 (latently infected with KSHV) (45). 11160685 Human
ck13 brenner tumors As in normal and neoplastic bladder urothelium, urothelial markers, including uroplakin III, CK13, and CK20, were detected in the epithelial nests of Brenner tumors. 11253121 Human
k13 squamous cell carcinoma (scc) The aim of the study was to investigate the differentiation-specific keratins (K4, K13, K1 and K10) in oral epithelial dysplasia and squamous cell carcinoma (SCC). 11287279 Human
k13 poorly differentiated carcinomas In tumor islands of well and moderately differentiated SCCs, the K4/K13 complex was co-expressed with K1/K10, but in poorly differentiated carcinomas, differentiation keratins were absent. 11287279 Human
k13 tumor In tumor islands of well and moderately differentiated SCCs, the K4/K13 complex was co-expressed with K1/K10, but in poorly differentiated carcinomas, differentiation keratins were absent. 11287279 Human
ck13 barrett's esophagus RESULTS: No differences were encountered regarding staining patterns for CK13 and CaCO3/73 in Barrett's esophagus and cardia. 11521979 Human
ck 13 carcinomas Carcinomas of the anal margin showed expression of CK 5/6 and CK 13, whereas CK7, CK18 and CK19 were rarely expressed. 11787851 Human
keratin 13 invasive carcinomas Expression of keratins in reference exocervix, CIN III, and invasive carcinomas was as follows: keratin 8--0, 44.4%, and 57.1%, respectively; keratin 10-77.8%, 40%, and 19%, respectively; keratin 13--100%, 22.2%, and 25%, respectively; keratin 17-0, 40%, 15138927 Human
ck13 cervical lymph node metastasis As seen in SQUU-B cell line, SQUU-B of the cervical lymph node metastasis did not exhibit CK13, 14, or 16. 10751357 Human
ck13 cancer These results suggest that the loss or down-regulation of CK13, 14, or 16 is related to the invasive and metastatic ability of cancer. 10751357 Human
ck13 metaplasia Squamous differentiation was assessed via expression of cytokeratins CK13/CK4 and transglutaminase I (TGI), specific markers of metaplasia. 10805076 Human
ck13 metaplasia Treatment with RARalpha and beta agonists or RAR panagonist, but not the RARgamma agonist or RXR agonist, is required for the inhibition of squamous metaplasia, evidenced by inhibition of CK13/CK4 and TGI expression. 10805076 Human
k13 lymphatic metastases RT-PCR for 3 cytokeratins expressed in HNSCC (K4, K10 and K13) proved to be less sensitive in detecting occult lymphatic metastases. 10861506 Human
k13 keratoses Gene expression of differentiation-specific keratins (K4, K13, K1 and K10) in oral non-dysplastic keratoses and lichen planus. 10972346 Human
k13 keratoses Gene expression for the differentiation-specific keratins (K4, K13, K1 and K10) was analyzed in oral non-dysplastic keratoses, oral lichen planus (OLP) and lichenoid reactions (LR) by comparative in situ hybridization (ISH) and immunohistochemistry (IHC) 10972346 Human
ck13 mucoepidermoid carcinoma CK13 was expressed only by canalicular adenoma and mucoepidermoid carcinoma cells. 10981871 Human
ck13 adenoma CK13 was expressed only by canalicular adenoma and mucoepidermoid carcinoma cells. 10981871 Human
k13 tumors A complex keratin (K) pattern of stratified epithelia was typically seen in the SC tumors with extensive K7, K8, K17, K18, and K19, and variable K13 and K14 expression; EMA was also present. 11014583 Human
k13 tumors Other keratins seen in the epithelia of biphasic tumors included K17 (variable, in 77%), K13 (25%), K16 (23%), and K6 (24%) in the minority of biphasic tumors, predominantly in stratified-appearing epithelia. 11037348 Human
k13 actinic keratoses At baseline, in 8 actinic keratoses, a single cell expression pattern of K13 and/or K19 was found. 14726871 Human
k13 oral cancer It is suggested that K13 mRNA may be a promising tumor marker among these keratin genes for detecting the micrometastases in cervical LNs of oral cancer. 11098092 Human
k13 tumor It is suggested that K13 mRNA may be a promising tumor marker among these keratin genes for detecting the micrometastases in cervical LNs of oral cancer. 11098092 Human
ck13 metaplasia In contrast to normal and hyperplastic epithelium, squamous metaplasia disclosed CK5/6 in all epithelial layers, a loss of CK7 and a gain of CK13. 11193477 Human
ck 13 metastasis Tumours giving rise to recurrences, metachronous tumours, and distant metastasis were significantly associated with an absence of CK 13. 10625103 Human
ck 13 tumours Tumours giving rise to recurrences, metachronous tumours, and distant metastasis were significantly associated with an absence of CK 13. 10625103 Human
ck13 craniopharyngioma CK13 in craniopharyngioma versus related odontogenic neoplasms and human enamel organ. 10793828 Human
ck13 odontogenic neoplasms CK13 in craniopharyngioma versus related odontogenic neoplasms and human enamel organ. 10793828 Human
k13 invasive squamous cell carcinomas We examined normal squamous cell epithelia, hyperplasia, dysplasias of various grades, intraepithelial neoplasia and invasive squamous cell carcinomas of the pyriform fossa using K13 and KL1. 2480682 NA
k13 hyperplasia We examined normal squamous cell epithelia, hyperplasia, dysplasias of various grades, intraepithelial neoplasia and invasive squamous cell carcinomas of the pyriform fossa using K13 and KL1. 2480682 NA
k13 intraepithelial neoplasia We examined normal squamous cell epithelia, hyperplasia, dysplasias of various grades, intraepithelial neoplasia and invasive squamous cell carcinomas of the pyriform fossa using K13 and KL1. 2480682 NA
k13 carcinoma Positive staining for K13 was seen in all normal or hyperplastic benign epithelia, was inconstant in dysplasia, and intraepithelial neoplasia and carcinoma was negative. 2480682 Human
k13 intraepithelial neoplasia Positive staining for K13 was seen in all normal or hyperplastic benign epithelia, was inconstant in dysplasia, and intraepithelial neoplasia and carcinoma was negative. 2480682 Human
keratin 13 tumour These results suggest that tumour cells are unable to synthesize keratin 13 a finding which may be valuable in surgical pathology. 2480682 Human
cytokeratin 13 tumors Synthesis of cytokeratin 13, a component characteristic of internal stratified epithelia, is not induced in human epidermal tumors. 2483837 Human
cytokeratin 13 tumors As other groups have reported that, in the mouse, the synthesis of mRNA encoding the 47-kDa cytokeratin corresponding to human cytokeratin 13 is induced in epidermal keratinocytes during malignant transformation, we have examined the synthesis of cytokera 2483837 Human
cytokeratin 13 vulvar carcinoma We isolated two different cDNA clones from the vulvar carcinoma cell line A-431, in which this protein is abundant: One clone seems to represent the entire mRNA, whereas the other is only a minor component and encodes a truncated cytokeratin 13 lacking mo 2483837 Human
cytokeratin 13 tumors When human epidermis and a series of benign and malignant epidermal tumors were examined with these cDNA probes and cytokeratin-13-specific antibodies we did not find an induction of expression in keratinocytes, normal or malignantly transformed, except f 2483837 Human
cytokeratin 13 tumors We conclude that the gene(s) encoding cytokeratin 13 are not induced in human keratinocytes during epidermal carcinogenesis, in apparent contrast to reports of murine epidermal tumors, and we discuss possible explanations for this interspecies difference. 2483837 Human
k13 ductal carcinomas Previous electrophoretic analysis has indicated that keratins 13 and 16 (K13 and K16) are not present in normal human breast epithelium, but K16 is expressed in some ductal carcinomas (Moll et al., Cell, 31: 11-24, 1982). 2458830 Human
k13 carcinomas In extracts from a hyperplasia and two of four carcinomas, the antibody detected a Mr 54,000 polypeptide, as well as a Mr 48,000 band, properties consistent with K13 and K16, respectively. 2458830 Human
k13 hyperplasia In extracts from a hyperplasia and two of four carcinomas, the antibody detected a Mr 54,000 polypeptide, as well as a Mr 48,000 band, properties consistent with K13 and K16, respectively. 2458830 Human
k13 ductal carcinomas In addition, the data suggest that K13 may be expressed in some benign lesions and ductal carcinomas of the breast. 2458830 Human
k13 tumors Specific keratin cDNA probes and monospecific antikeratin antisera were used to analyze mouse epidermis and epidermal tumors for the expression of a type I 47-kDa keratin, K13, normally associated with terminal differentiation of internal stratified epith 3076454 Human
k13 papillomas In contrast, K13 was consistently expressed in squamous cell carcinomas of the skin induced by 7,12-dimethylbenz[a]anthracene and 12-O-tetradecanoylphorbol-13-acetate (TPA), whereas papillomas obtained by the same two-stage protocol were distinctly hetero 3076454 Human
k13 squamous-cell carcinomas In contrast, K13 was consistently expressed in squamous cell carcinomas of the skin induced by 7,12-dimethylbenz[a]anthracene and 12-O-tetradecanoylphorbol-13-acetate (TPA), whereas papillomas obtained by the same two-stage protocol were distinctly hetero 3076454 Human
k13 papillomas Papillomas collected from Sencar mice after 12 wk or from NMRI mice after 15 wk of promotion with TPA were either negative for K13 or elicited variable amounts of this keratin. 3076454 Mouse
k13 tumors In all cases of positive expression of K13 in tumors, as in normal stratified internal epithelia, both the keratin protein and its mRNA invariably occurred in the differentiating cell compartments. 3076454 Human
k13 papillomas Papillomas negative for the K13 protein were also devoid of K13 transcripts. 3076454 Human
k13 tumors This indicates that the aberrant K13 expression in tumors is regulated at the level of transcription. 3076454 Human
k13 oral squamous-cell carcinomas The mRNA levels of keratin K13, involucrin, protein kinase C alpha and epsilon, and interferon-gamma and its receptors were examined in biopsies from human oral squamous cell carcinomas. 10368655 Human
k13 tumor Markers of oral epithelial maturation (keratin K13 and involucrin) are less simply related to tumor histology. 10376801 Human
keratin 13 tumor Basal cells in these lesions did not express keratin 13, suggesting that the tumor, which was also keratin 13 negative, may have arisen from the expansion of these cells. 10383167 Human
ck13 cyst CK13 was positively stained in the transitional portion between the matricial structure and the column of shadow cells in the cyst wall in only one case. 10408348 Human
keratin 13 papillomas D/T/D/T papillomas exhibited increases in suprabasal S phase cells and keratin 13 expression when compared with D/T/A/T papillomas. 10469632 Human
k13 papillomas SENCAR B/Pt papillomas at 30 weeks of promotion have a higher and aberrant expression of K13, and loss of connexin 26. 9472703 Human
k13 tumors Expression of Hras-p21 and keratin K13 in UVR-induced skin tumors in Sencar mice. 9537281 Mouse
k13 spindle-cell tumors (scts) An ultraviolet radiation (UVR)-induced Sencar mouse skin carcinogenesis model was established to investigate the expression of Hras-p21 and keratin K13 in different stages of carcinogenesis, including UV-exposed nontumor skin, papillomas, squamous-cell ca 9537281 Human
k13 papillomas An ultraviolet radiation (UVR)-induced Sencar mouse skin carcinogenesis model was established to investigate the expression of Hras-p21 and keratin K13 in different stages of carcinogenesis, including UV-exposed nontumor skin, papillomas, squamous-cell ca 9537281 Human
k13 squamous-cell carcinomas An ultraviolet radiation (UVR)-induced Sencar mouse skin carcinogenesis model was established to investigate the expression of Hras-p21 and keratin K13 in different stages of carcinogenesis, including UV-exposed nontumor skin, papillomas, squamous-cell ca 9537281 Human
k13 paraffin-embedded tumor Expression of Hras-p21 and K13 was examined in paraffin-embedded tumor sections by using immunohistochemical, immunofluorescent, and double staining techniques with specific antibodies. 9537281 Human
keratin 13 tumours The benign tumours that arose had several hallmarks of tumours at a high risk of malignant progression, including suprabasal cell proliferation and heterogeneous expression of keratin 13. 9560338 Human
keratin 13 benign tumours The benign tumours that arose had several hallmarks of tumours at a high risk of malignant progression, including suprabasal cell proliferation and heterogeneous expression of keratin 13. 9560338 Human
cytokeratin 13 oral squamous-cell carcinomas STUDY DESIGN: Oral squamous cell carcinomas and lung squamous cell carcinomas were immunostained with cytokeratin 19, cytokeratin 10, and cytokeratin 13 antibodies. 9574953 Human
cytokeratin 13 lung squamous cell carcinomas STUDY DESIGN: Oral squamous cell carcinomas and lung squamous cell carcinomas were immunostained with cytokeratin 19, cytokeratin 10, and cytokeratin 13 antibodies. 9574953 Human
cytokeratin 13 oral cancers A marker for keratinizing cells (cytokeratin 10) and a marker for squamous cells (cytokeratin 13) were expressed more frequently and intensely in oral cancers (p < 0.01) than in lung cancers (p = 0.019). 9574953 Human
cytokeratin 13 lung cancers A marker for keratinizing cells (cytokeratin 10) and a marker for squamous cells (cytokeratin 13) were expressed more frequently and intensely in oral cancers (p < 0.01) than in lung cancers (p = 0.019). 9574953 Human
k13 tumors RESULTS: Keratin K13, as a suprabasal cell marker, tended to confirm the histological grading of the tumors (but was not otherwise useful in distinguishing tumors from normal tissue). 9707250 Human
keratin 13 oral squamous-cell carcinomas Expression of keratin 13, 14 and 19 in oral squamous cell carcinomas from Sudanese snuff dippers: lack of association with human papillomavirus infection. 9833698 Human
k13 oral carcinomas For the oral carcinomas from snuff dippers, moderate to intense expression of K13 (71%; 10/14), K14 (86%; 12/14) and K19 (93%; 13/14) was found. 9833698 Human
k13 oral carcinomas For the oral carcinomas from non-snuff dippers, weak to moderate expression of K13 (64%; 47/74), K14 (43%; 32/74) and K19 (45%; 33/74) was found. 9833698 Human
k13 oral carcinomas The present study shows that (i) there is a high level of expression of K13, K14 and K19 in oral carcinomas from snuff dippers compared to those from non-snuff dippers, (ii) this high level of expression may arise from dysregulation of keratinocyte prolif 9833698 Human
ck13 retention cysts The lining epithelia of the LEC and the ECAS, as well as those of retention cysts of the pancreas and epidermoid cysts of the spleen used for comparison, were similarly positive with AE1/3, CAM5.2, CK7, CK13, and carcinoembryonic antigen. 9872647 Human
ck13 epidermoid cysts The lining epithelia of the LEC and the ECAS, as well as those of retention cysts of the pancreas and epidermoid cysts of the spleen used for comparison, were similarly positive with AE1/3, CAM5.2, CK7, CK13, and carcinoembryonic antigen. 9872647 Human
ck 13 tumors In SCC, as well-differentiated tumors showed decreased immunoreactivity for CK 18, 19 and 14 with CK 13 showing a strong and focal (localized) immunoreactivity. 9253034 Human
ck 13 undifferentiated carcinomas Undifferentiated carcinomas totally lacked CK 13 reactivity. 9253034 Human
ck 13 tumor Our findings therefore suggest that expression of CK 18, 19 and 14 may be directly related to tumor grade and CK 13 may be a marker of differentiation in cervical lesions. 9253034 Human
ck13 adenocarcinomas The expressions of MUC1, MUC2, MUC5AC, MUC6, CK7, CK8, CK13, CK14, CK18, CK19 and CK20 were evaluated immunohistochemically in 426 adenocarcinomas and 60 hepatocellular carcinomas using the tissue-array method. 12748245 Human
ck13 hepatocellular carcinomas The expressions of MUC1, MUC2, MUC5AC, MUC6, CK7, CK8, CK13, CK14, CK18, CK19 and CK20 were evaluated immunohistochemically in 426 adenocarcinomas and 60 hepatocellular carcinomas using the tissue-array method. 12748245 Human
k13 tumor Whereas some keratins not found in normal epidermis (K6, K16, K13, and K8) are induced at different stages of tumor development, K1 and K10 expression is lost. 9328431 Human
keratin 13 tumors Beginning with very early papillomas (after 10 wk of promotion), expression of alpha6beta4 in suprabasal cells and small, focal staining for keratin 13 (K13) were seen in some tumors. 9328443 Human
k13 tumors Beginning with very early papillomas (after 10 wk of promotion), expression of alpha6beta4 in suprabasal cells and small, focal staining for keratin 13 (K13) were seen in some tumors. 9328443 Human
keratin 13 papillomas Beginning with very early papillomas (after 10 wk of promotion), expression of alpha6beta4 in suprabasal cells and small, focal staining for keratin 13 (K13) were seen in some tumors. 9328443 Human
k13 papillomas Beginning with very early papillomas (after 10 wk of promotion), expression of alpha6beta4 in suprabasal cells and small, focal staining for keratin 13 (K13) were seen in some tumors. 9328443 Human
k13 papillomas Cx26 and TGFalpha staining became patchier in some late-stage papillomas (30-40 wk), whereas suprabasal alpha6beta4, K13, and GGT expression progressively increased and K1 expression decreased. 9328443 Human
k13 skin papillomas Expression of the cell adhesion molecules E-cadherin, P-cadherin and alpha 6 beta 4 integrin and of the keratin K13 has been analyzed in chemically induced benign skin papillomas with genetically pre-determined risks for malignant conversion. 8567126 Human
k13 papillomas Aberrant keratin K13 expression was also detected in the majority of cases of all p53 genotypes, but again there was a clear decrease in expression levels in the p53 null papillomas. 8567126 Mouse
ck 13 tumours The luminal cells of ductal structures of the tumours reacted with all the CKs studied except for CK 13 and CK 10 and sometimes CK 14, showing an immunoprofile comparable to that of the intercalated segment of a normal salivary gland. 8729613 Human
keratin 13 tumors Grade IV tumors lacked or expressed reduced levels of keratin 13 but most resembled low-grade tumors. 8840999 Human
keratin 13 low-grade tumors Grade IV tumors lacked or expressed reduced levels of keratin 13 but most resembled low-grade tumors. 8840999 Human
keratin 13 tumors Keratin 13 showed a drastic decrease in grade IV tumors. 8840999 Human
cytokeratin 13 tumour Immunohistochemically, the tumour cells reacted positively for cytokeratin 7, 8, 19, epithelial membrane antigen (EMA), alpha-1-antichymotrypsin and carcinoembryonic antigen (CEA), but negative for cytokeratin 13, 14, smooth muscle actin (HHF35) and S-100 12509976 Human
keratin 13 tumor We found that the appearance of alpha-glutamyl transpeptidase (GGT) and keratin 13 and the lack of expression of keratins 1 and 10 are good markers for skin tumor progression. 9627710 Human
ck13 metaplasia EXPERIMENTAL DESIGN: The localization of CFTR parallel to markers of cell differentiation, such as cytokeratin 14 (CK14, a marker of basal cells), cytokeratin 18 (CK 18, a marker of ciliated and mucous cells), cytokeratin 13 (CK13, a marker of squamous me 7531792 Human
cytokeratin 13 metaplasia EXPERIMENTAL DESIGN: The localization of CFTR parallel to markers of cell differentiation, such as cytokeratin 14 (CK14, a marker of basal cells), cytokeratin 18 (CK 18, a marker of ciliated and mucous cells), cytokeratin 13 (CK13, a marker of squamous me 7531792 Human
ck13 basal-cell hyperplasia In basal cell hyperplasia, CFTR was poorly expressed in the cytoplasm of the more superficial cells, CK14 and CK13 were localized in basal cell multilayers, CK18 labeling was present in the more superficial cell layers, and DP 1 and 2 were preferentially 7531792 Human
ck13 metaplasia In squamous metaplasia, CFTR labeling was either very low or even undetectable, CK14 was found in focal areas of the more basal cell layers, CK18 labeling was either very low or undetectable, CK13 expression was restricted to the flattened cells toward th 7531792 Human
keratin 13 squamous-cell carcinoma Therefore, the characteristic profile of squamous cell carcinoma was a strong and diffuse expression of keratin 14 and 16, strong but localized expression of keratin 17, and loss of keratin 13 expression. 7536179 Human
ck13 tumours The tumours expressed CK19 in 86%, CK8 in 46%, CK18 in 97%, CK13 in 83%, CK10 in 34% and CK7 in 29% of cases. 7541275 Human
ck13 carcinomas CK13 (the so-called non-keratinizing squamous epithelial marker) was only infrequently demonstrated in the non-neoplastic oesophageal mucosa, and its expression was more frequent in carcinomas. 7541275 Human
keratin 13 papillomas A study of histochemical markers showed that gamma-glutamyltranspeptidase (GGT) and keratin 13, although good markers of malignant changes in early papillomas produced by two-stage carcinogenesis protocols, were mainly negative in dysplastic lesions produ 7542177 NA
k13 metaplasia It has been impossible so far to demonstrate that retinoids are able to provoke metaplasia of adult keratinocytes grown in vitro, although these agents have been shown to block terminal epidermal differentiation, to induce increased synthesis of mucopolys 7641980 Human
ck13 nasal polyps Our results show that the steady-state levels of CFTR, CK13, CK18, CK18, CK14, or DP 1 mRNA transcripts in delta F 508 CF nasal polyps were not significantly different from those of non-CF tissues. 7544810 Human
keratin 13 tumor The appearance of GGT and keratin 13 (K13) and the lack of expression of K1 and K10 were found to be good markers for skin tumor progression. 8532708 Human
k13 tumor The appearance of GGT and keratin 13 (K13) and the lack of expression of K1 and K10 were found to be good markers for skin tumor progression. 8532708 Human
k13 carcinoma Induction of differentiation may be mechanism of the response to RE-80 in vivo since carcinoma cells expressing K13 did not incorporate bromodeoxyuridine and were on a terminal pathway. 7553678 Human
cytokeratin 13 thymic carcinoma Cytokeratin 7 and cytokeratin 13 monoclonal antibodies reacted with almost all cases of thymic carcinoma. 8523878 Human
k13 oral carcinomas Oral carcinomas and dysplastic sites exhibited basal and suprabasal (spinous layer) high levels of k10, k13, and k8 staining. 7491297 Human
k13 squamous-cell carcinomas The identical situation is encountered in DMBA TPA-induced moderately differentiating epidermal squamous cell carcinomas with compartmentalized K13 expression. 1695590 Human
k13 papillomas In papillomas we observed a striking correlation between the extent of both suprabasally expressed K13 protein and demonstrable DNA copies carrying an unmethylated M1 site. 1695590 Human
k13 tumors These results strongly suggest that the sequence element around the demethylated M1 site is involved in a multi-level control mechanism mediating the selective expression of the K13 gene in internal squamous epithelia and in DMBA/TPA-induced epidermal tum 1695590 Human
k13 skin papillomas Early expression of type I K13 keratin in the progression of mouse skin papillomas. 1699681 Mouse
k13 tumors More recently, it has been shown that K13, a keratin normally present in internal epithelia but not in epidermis, is aberrantly expressed in epidermal tumors. 1699681 Human
k13 papillomas K13 and K1 expression in papillomas was studied using immunoblotting and immunostaining of consecutive sections, as previously described. 1699681 Human
k13 papillomas Conversely, K13 was expressed only as small foci in 10 out of 21 papillomas (48%). 1699681 Human
k13 papillomas Staining for K13 was positive in these papillomas with the exception of only one that was essentially negative, presenting only one small positive focus. 1699681 Human
k13 papillomas Some of the papillomas collected at week 35 were negative for K1, but immunostaining with K13 showed uniform staining of suprabasal cells in all the papillomas studied. 1699681 Human
k13 papillomas These results indicate that keratins K1 and K13 are coexpressed in most papillomas from 10 to 35 weeks of promotion. 1699681 Human
k13 papillomas However, analysis of adjacent sections showed that K13 positive areas are topographically located in the K1 negative areas of the papillomas, suggesting a shift in the differentiation program from epidermal to mucosal types of keratinization. 1699681 Human
k13 tumors Based on these and previous studies from our laboratory, we conclude that K13 is an early marker of papillomas progression, which occurs before gross chromosomal abnormalities are present in the stem line of the tumors, and precedes dysplastic changes and 1699681 Human
k13 papillomas Based on these and previous studies from our laboratory, we conclude that K13 is an early marker of papillomas progression, which occurs before gross chromosomal abnormalities are present in the stem line of the tumors, and precedes dysplastic changes and 1699681 Human
ck 13 tumors Patients with higher grade tumors had more cells positive for CK 13 than did patients with atypical or lower grade malignancies. 1706601 Human
ck13 calcifying odontogenic cyst (coc) The purpose of this study was to investigate a case of calcifying odontogenic cyst (COC) in which numerous calcifications were observed not only in the lining epithelium, but also in the cyst wall, using cytokeratins 13 (CK13), 19 (CK19), and core binding 12956090 Human
ck13 cyst The purpose of this study was to investigate a case of calcifying odontogenic cyst (COC) in which numerous calcifications were observed not only in the lining epithelium, but also in the cyst wall, using cytokeratins 13 (CK13), 19 (CK19), and core binding 12956090 Human
ck13 cyst Cells of the epithelial nests in the cyst wall were reactive for CK13, but their CK19 staining was similar to that observed in the lining epithelial cells. 12956090 Human
ck13 cyst In the lining epithelium of the cyst, the expressions of CK13 and CK19 were similar to their immunoreactions in the oral mucosa. 12956090 Human
ck13 head-and-neck cancer To identify early changes in differentiation markers during head and neck cancer development, we examined the expression of cytokeratins (CK1, CK8, CK13, and CK19) and involucrin by immuohistochemical methods in surgical specimens from 29 head and neck sq 8634660 Human
ck13 carcinoma To identify early changes in differentiation markers during head and neck cancer development, we examined the expression of cytokeratins (CK1, CK8, CK13, and CK19) and involucrin by immuohistochemical methods in surgical specimens from 29 head and neck sq 8634660 Human
ck13 head and neck squamous cell carcinoma To identify early changes in differentiation markers during head and neck cancer development, we examined the expression of cytokeratins (CK1, CK8, CK13, and CK19) and involucrin by immuohistochemical methods in surgical specimens from 29 head and neck sq 8634660 Human
ck13 oral leukoplakia To identify early changes in differentiation markers during head and neck cancer development, we examined the expression of cytokeratins (CK1, CK8, CK13, and CK19) and involucrin by immuohistochemical methods in surgical specimens from 29 head and neck sq 8634660 Human
ck13 cancer To identify early changes in differentiation markers during head and neck cancer development, we examined the expression of cytokeratins (CK1, CK8, CK13, and CK19) and involucrin by immuohistochemical methods in surgical specimens from 29 head and neck sq 8634660 Human
ck13 leukoplakia In the leukoplakia lesions, CK8 CK13, CK19 and involucrin were detected in 13.8, 100, 74.2 and 100% of the specimens, respectively. 8634660 Human
ck 13 vulvar carcinomas METHODS. The expression of several differentiation markers, i.e., cytokeratin (CK) 10, CK 13, and involucrin, was studied in samples of 41 vulvar carcinomas. 8625158 NA
ck 13 tumor A relationship between tumor growth pattern and the concordant expression of differentiation markers was observed: in 55% of type A tumors and in none of type B tumors, concordant expression of CK 10, CK 13, and involucrin was found. 8625158 Human
ck 13 tumors A relationship between tumor growth pattern and the concordant expression of differentiation markers was observed: in 55% of type A tumors and in none of type B tumors, concordant expression of CK 10, CK 13, and involucrin was found. 8625158 Human
ck13 ameloblastoma Cells similar to the stellate reticulum, present in the ameloblastoma and in the ameloblastic fibroma, were positive for CK13, which indicates a nature other than that of the stellate reticulum of the normal dental germ. 12617250 Human
ck13 ameloblastic fibroma Cells similar to the stellate reticulum, present in the ameloblastoma and in the ameloblastic fibroma, were positive for CK13, which indicates a nature other than that of the stellate reticulum of the normal dental germ. 12617250 Human
keratin 13 metaplasia The determination of the keratin pattern expressed by cells grown on gel revealed an expression of keratin 13, already considered as a specific marker of squamous metaplasia, that diminished with retinoic acid treatment. 7514938 Human
cytokeratin 13 tumor Immunohistochemically, tumor cells stained positive for cytokeratin 13, synaptophysin, protein gene product 9.5, neuron-specific enolase, chromogranin A, calcitonin gene-related peptide, serotonin (5-HT), and Leu-7. 12637763 Human
k13 benign tumors All lesions expressed keratin genes K1, K6, and K13 in a fashion characteristic of hyperproliferative or benign tumors with no evidence of malignant conversion. 7522035 Human
cytokeratin 13 tumor Expression of cytokeratin 13 and involucrin was associated with tumor grade (P = 0.01). 7522949 Human
cytokeratin 13 tumors Within the lymph node-positive group, however, the survival rate of patients with tumors with cytokeratin 13 expression was significantly higher than that of patients with tumors lacking cytokeratin 13 expression (P = 0.02). 7522949 Human
k13 tumors The type I keratin K13, normally restricted to suprabasal cells of internal stratified epithelia, is aberrantly expressed in 7,12-dimethylbenz[a]anthracene (DMBA)-12-O-tetradecanoyl-phorbol-13-acetate-induced murine epidermal tumors and constitutes an ear 7525098 Mouse
k13 tumors Aberrant K13 expression also occurs in epidermal cell lines derived from DMBA-TPA-induced tumors. 7525098 Human
k13 carcinoma K13, normally synthesized in internal stratified epithelia, is anomalously induced in mouse epidermal tumors and has been used as an early marker of carcinoma progression. 7677983 Mouse
k13 tumors K13, normally synthesized in internal stratified epithelia, is anomalously induced in mouse epidermal tumors and has been used as an early marker of carcinoma progression. 7677983 Mouse
k13 tumors In tumors induced by the cell lines upon injection in mice, K8 is found in the less differentiated regions as opposite to K13, restricted to the differentiating areas of the tumors. 7677983 Mouse
k13 carcinomas In PDV, PDVCM1, PDVCM2, and PDVCV1 carcinomas the overall expression of K13 is higher than that of K8. 7677983 Human
keratin 13 papilloma Removal of EGF from papilloma cells cultured on collagen rafts permitted normal stratification and differentiation, as determined by synthesis of keratin 13. 7679053 Human
keratin 13 tumors Low frequency of codon 61 Ha-ras mutations and lack of keratin 13 expression in 7,12-dimethylbenz[a]-anthracene-induced hamster skin tumors. 7681292 others
keratin 13 tumors In this study, we investigated whether the loss of epidermal keratin 1 (K1) and its replacement by mucosal keratin 13 (K13) is unique to mouse skin tumors induced by 7,12-dimethylbenz[a]anthracene (DMBA) and 12-O-tetradecanoylphorbol-13-acetate (TPA), sin 7681292 NA
k13 tumors In this study, we investigated whether the loss of epidermal keratin 1 (K1) and its replacement by mucosal keratin 13 (K13) is unique to mouse skin tumors induced by 7,12-dimethylbenz[a]anthracene (DMBA) and 12-O-tetradecanoylphorbol-13-acetate (TPA), sin 7681292 NA
k13 tumors With that purpose, we analyzed the keratin profiles of 16 DMBA-induced hamster skin tumors using monospecific antibodies against K1 and K13. 7681292 Human
k13 tumors Although all the tumors expressed K1, they also showed an overall tendency towards loss of this keratin; furthermore, none of the tumors expressed K13. 7681292 Human
k13 tumors Previous studies have suggested that the induction of K13 in mouse skin is related to the mutation of the Ha-ras gene by the initiating agent DMBA, a mutation consistently found in murine DMBA/TPA-induced tumors and rarely found in human skin tumors. 7681292 Mouse
ck 13 pancreas cancers To analyze whether CK of complex or stratified epithelia are abnormally expressed in pancreas cancers, we have used polypeptide-specific mouse monoclonal antibodies (MAbs) detecting CK 5, CK 10, CK 13, CK 14 and CK 17, and an antibody detecting CK 13, CK 7686885 Human
ck 13 pancreas cancers In tumors, CK 14, CK 15/16 and CK 17 were detected in the majority of cases studied; CK 5, CK 10 and CK 13 were present in a sub-population of pancreas cancers. 7686885 Human
ck 13 tumors In tumors, CK 14, CK 15/16 and CK 17 were detected in the majority of cases studied; CK 5, CK 10 and CK 13 were present in a sub-population of pancreas cancers. 7686885 Human
keratin 13 tumors In tumors, loss of TGF-beta is controlled at the posttranscriptional level and is associated with expression of keratin 13, a documented marker of malignant progression. 7687059 Human
k13 papillomas Both papillomas and squamous cell carcinomas (SCC) induced in mouse epidermis by initiation with 7,12-dimethylbenz[a]anthracene (DMBA) and promotion with 12-O-tetradecanoylphorbol-13-acetate (TPA) exhibit aberrant expression of a type I keratin, K13, that 7688967 Human
k13 squamous cell carcinomas (scc) Both papillomas and squamous cell carcinomas (SCC) induced in mouse epidermis by initiation with 7,12-dimethylbenz[a]anthracene (DMBA) and promotion with 12-O-tetradecanoylphorbol-13-acetate (TPA) exhibit aberrant expression of a type I keratin, K13, that 7688967 Human
k13 tumors To assess the general validity of this hypothesis, we investigated both aberrant K13 expression and activation of each of the three members of the ras gene family in epidermal tumors induced in four different mouse strains (SKH-1 hr, SENCAR, BALB/c, and C 7688967 Human
k13 tumors Aberrant K13 expression occurred in only five of 39 tumors and was restricted to SCC of both types. 7688967 Human
k13 tumors This indicates that aberrant K13 expression in UV-induced epidermal tumors was intrinsically different from that in chemically induced tumors. 7688967 Human
k13 tumor Although this tumor was also positive for aberrant K13 expression, such a correlation could not be made for the remaining K13-expressing tumors. 7688967 Human
k13 tumors Although this tumor was also positive for aberrant K13 expression, such a correlation could not be made for the remaining K13-expressing tumors. 7688967 Human
ck13 tumours The tumours expressed CK5/6 in 55%, CK8 in 76%, CK13 in 43% and CK19 in 95% of cases. 7690007 Human
keratin 13 papillomas When tumors first appeared at 8 weeks after promotion, high risk papillomas demonstrated basal and suprabasal alpha 6 beta 4 expression, loss of keratin 1, and aberrant expression of keratin 13. 8402665 Human
keratin 13 tumors When tumors first appeared at 8 weeks after promotion, high risk papillomas demonstrated basal and suprabasal alpha 6 beta 4 expression, loss of keratin 1, and aberrant expression of keratin 13. 8402665 Human
keratin 13 tumors In contrast, alpha 6 beta 4 immunostaining was confined to basal cells in low risk tumors, keratin 1 was abundant, and keratin 13 was absent in the majority of this group, while proliferating cells were largely in the basal compartment. 8402665 Human
k13 carcinomas Strong expression was noted in 108 carcinomas (76.1%) for K6, in 18 (12.7%) for K19 and in 21 (14.8%) for K13 (P = .001). 7505082 Human
k13 tumors One hundred thirty-six (96%) tumors were positive for K6, and their PSA ranged from 0.6% to 48.8%; K19, 48 cases (0.2-44%); K13, 59 (0.2-38.1%). 7505082 Human
k13 carcinomas K19 was expressed mainly in moderately and poorly differentiated tumors, and K13 was manifest more in well-differentiated carcinomas or in keratinized areas of less-differentiated ones. 7505082 Human
k13 tumors K19 was expressed mainly in moderately and poorly differentiated tumors, and K13 was manifest more in well-differentiated carcinomas or in keratinized areas of less-differentiated ones. 7505082 Human
k13 tumors Nineteen (13.38%) tumors were positive for both K13 and K19. 7505082 Human
k13 tumor K19 thus was related to tumor progression and K13 to differentiation. 7505082 Human
cytokeratin-13 metaplasia As mineral particles, especially asbestos, are suspected to induce squamous metaplasia, we chose to study two specific transformations of the epithelium: the expression of cytokeratin-13 and the formation of cross-linked envelopes. 8119255 Human
cytokeratin-13 metaplasia Under our culture conditions, nemalite and chrysotile increased the expression of the cytokeratin-13, a specific marker of squamous metaplasia, whereas nemalite was the only particle able to strongly induce the formation of cross-linked envelopes. 8119255 Human
ck 13 metaplasia Foci of squamous metaplasia expressed CK 13 but showed partial loss of expression of CK 7, 8, 18, and 19. 1372155 Human
keratin 13 carcinomas The predominance of alpha 6 beta 4 in the proliferating cells during progression is associated with decreased expression of keratin 13 in carcinomas. 1533815 Human
keratin 13 tumors Cells in foci, but not v-rasHa control cells, expressed keratin 13, a marker which is strongly associated with the malignant progression of skin tumors in vivo. 1375535 Human
k13 papillomas It was also observed that the expression of markers of premalignant progression (i.e., dysplasia, expression of keratin K13, and loss of keratin K1 expression) was markedly suppressed in SSIN papillomas. 1375869 Human
ck 13 carcinomas Antibodies to CK 1, CK 1/2/10/14, CK 1/5/10/11, CK 13, CK 14 and CK 20 did not stain any of the carcinomas. 1380481 Human
k13 tumors Double-label immunofluorescence staining using TROMA-1 and RK13 antibodies demonstrated that K8 did not generally colocalize with K13, a keratin normally found in internal stratified epithelial but aberrantly expressed in mouse epidermal tumors. 1382441 Mouse
k13 tumors Furthermore, tumors expressing high levels of K8 showed a reduced expression of K13. 1382441 Mouse
k13 tumors Histological examination of immunoperoxidase-stained tumors demonstrated that K8-positive cells were mainly found in anaplastic areas, whereas K13 foci were restricted to well-differentiated regions. 1382441 Mouse
k13 metaplasia Successive layers of suprabasal squamous cells found in squamous metaplasia failed to express normal epidermal differentiation marker keratins K1 and K10 but expressed the proliferation marker keratin K6 and the internal stratified epithelium keratin K13, 1384955 Human
keratin 13 synovial sarcomas Furthermore keratin 13 was seen focally in 4 of 9 synovial sarcomas. 1704194 Human
keratin 13 epithelial neoplasms Expression of keratin 13 in human epithelial neoplasms. 1706547 Human
k13 squamous-cell carcinomas Recently, however, we were able to show that K13 is aberrantly but constitutively expressed without its normal type II partner K4 also in differentiating parts of 7,12-dimethylbenz(a)anthracene (DMBA/TPA) 12-O-tetradecanoylphorbol-13-acetate-induced squam 1711471 Mouse
k13 papillomas Recently, however, we were able to show that K13 is aberrantly but constitutively expressed without its normal type II partner K4 also in differentiating parts of 7,12-dimethylbenz(a)anthracene (DMBA/TPA) 12-O-tetradecanoylphorbol-13-acetate-induced squam 1711471 Mouse
k13 tumors Whereas in the latter case, K13 expression occurs without concomitant induction of morphological differentiation of the cells, Ca2+ elevation in the culture medium induces squamous differentiation and K13 expression occurs only in differentiating cells, t 1711471 Human
ck 13 tumors Immunohistochemistry was performed on the induced tumors using four commercially available monoclonal antibodies specific for CK 18 (TR1031), CK 13 (K8.12), CK 19 (K4.62), and the CKs 5, 7, and 8 (K8.13). 1713770 Human
ck13 tumor 2) Although in general the expression of CK13 in local TCC is decreased with increase of histopathologic parameters for progression, ie, grade and stage, an extensive proportion of CK13-positive tumor cells still can be found in some TCCs, even in metasta 1721491 Human
ck13 metastases 2) Although in general the expression of CK13 in local TCC is decreased with increase of histopathologic parameters for progression, ie, grade and stage, an extensive proportion of CK13-positive tumor cells still can be found in some TCCs, even in metasta 1721491 Human
ck13 tumor The tumor cells expressed different cytokeratin proteins (CK8, CK13, CK18, CK19, KL1, AE1/AE3, MNF16) in 3 of 11 cases. 1723829 Human
k13 skin papillomas v-Ha-ras-induced mouse skin papillomas exhibit aberrant expression of keratin K13 as do their 7,12-dimethylbenz[a]anthracene/12-O-tetradecanoylphorbol-13-acetate -induced analogues. 1724371 Mouse
k13 papillomas In this study, we investigated v-Ha-ras-induced papillomas for aberrant expression of type I keratin K13, previously described in 7,12-dimethylbenz[a]anthracene/12-O-tetradecanoylphorbol-13- acetate (DMBA/TPA)-induced mouse epidermal tumors. 1724371 NA
k13 tumors In this study, we investigated v-Ha-ras-induced papillomas for aberrant expression of type I keratin K13, previously described in 7,12-dimethylbenz[a]anthracene/12-O-tetradecanoylphorbol-13- acetate (DMBA/TPA)-induced mouse epidermal tumors. 1724371 NA
k13 papillomas Combined analysis of the grafts by western blotting of extracted keratins and immunofluorescence studies of frozen sections with a K13-monospecific antibody revealed K13 expression in all v-Ha-ras-induced papillomas and absence of this keratin in all cont 1724371 Mouse
k13 papillomas Analysis of genomic DNA from v-Ha-ras-induced papillomas for the methylation state of a CpG dinucleotide in the distant promoter region of the K13 gene revealed the occurrence of unmethylated DNA copies that were generated at the expense of methylated DNA 1724371 Mouse
k13 papillomas Thus, all features of aberrant K13 expression previously described in DMBA/TPA-induced papillomas were shared by v-Ha-ras-induced papillomas. 1724371 Human
ck13 tumors In low-grade TCCs (G1-G2), the CK distribution was comparable to that in normal urothelium, however with a variable expression of CK13 in the different tumors and a uniform distribution of CK7. 1689541 Human
ck13 urothelial carcinomas The distribution of cytokeratin (CK) expression in 22 cases was investigated and compared with normal urothelium and urothelial carcinomas: CK7/8, basal increased positivity; CK13, diffuse positivity; CK18, loss of intensity and loss of umbrella cell stai 7510066 Human
ck13 hyperplastic To identify early changes in differentiation markers during head and neck cancer development, we examined the expression of cytokeratins (CK1, CK8, CK13, and CK19) and involucrin by immuohistochemical methods in surgical specimens from 29 head and neck sq 8634660 Human
ck13 hyperplastic In contrast to normal and hyperplastic epithelium, squamous metaplasia disclosed CK5/6 in all epithelial layers, a loss of CK7 and a gain of CK13. 11193477 Human
ck13 human nasopharyngeal carcinoma [The role of cytokeratin 13 gene in human nasopharyngeal carcinoma] OBJECTIVE: To study the significance of cytokeratin 13 (CK13) gene expression and its methylation in human nasopharyngeal carcinoma (NPC). 11776622 NA
ck13 human nasopharyngeal carcinoma [Cytokeratin 13 gene expression in human nasopharyngeal carcinoma] OBJECTIVE: To investigate the possible pathogenetic role of cytokeratin 13 (CK13) gene expression in human nasopharyngeal carcinoma (NPC). 11776639 NA
ck13 cervical lymph node metastasis Significantly higher CK13 expression was demonstrated in patients with cervical lymph node metastasis, as compared to those without (P < 0.05). 11776639 Human
ck13 laryngeal squamous-cell carcinoma [Studies of the deletion and expression of cytokeratin 13 gene in laryngeal squamous cell carcinoma] In order to investigate the role of Cytokeratin 13(CK13) gene in laryngeal carcinogenesis, we detected the deletion of CK13 gene through LOH analysis indi 12043564 Human
ck13 squamous-cell carcinoma [Studies of the deletion and expression of cytokeratin 13 gene in laryngeal squamous cell carcinoma] In order to investigate the role of Cytokeratin 13(CK13) gene in laryngeal carcinogenesis, we detected the deletion of CK13 gene through LOH analysis indi 12043564 Human
ck13 laryngeal squamous-cell carcinoma CK13 gene might play an important role in the laryngeal carcinogenesis, acting as a novel tumor suppressor gene, and may be relevant to laryngeal squamous cell carcinoma diagnosis and prognosis. 12043564 Human
ck13 tumor CK13 gene might play an important role in the laryngeal carcinogenesis, acting as a novel tumor suppressor gene, and may be relevant to laryngeal squamous cell carcinoma diagnosis and prognosis. 12043564 Human
ck13 oral cancer To provide a useful method for the detection of micrometastases, we analyzed 115 LNs from 10 patients with oral cancer using real-time quantitative polymerase chain reaction (PCR) based on the expression of squamous cell carcinoma antigen (SCCA) and cytok 14654899 Human
ck13 rb Ki67 parameters, cell cycle regulators (Rb, p53, Cyclin A, E and D, p16, p21, p27, and telomerase), and cellular differentiation products (involucrin, CK13, CK14) were compared in the basal zone as well as the deeper and upper halves of the epithelium. 15084837 Human
ck13 rb CIN progressors showed decreased Rb, CK13, CK14, and involucrin, but increased p21 and p27 expression. 15084837 Human
ck13 rb Combined quantitation of Ki67, Rb, CK13, and CK14 gives accurate information about the progression risk of early CIN lesions. 15084837 Human
ck13 tumor The tumor cells were immunoreactive to AE1/AE3, CK19 and S-100, were partially positive for CK7, CK8, GFAP and PCNA, but were negative for SMA, CK13, CK14 and vimentin. 15960160 Human
k13 ductal carcinomas of the breast In addition, the data suggest that K13 may be expressed in some benign lesions and ductal carcinomas of the breast. 2458830 Human
k13 squamous cell carcinomas of the skin In contrast, K13 was consistently expressed in squamous cell carcinomas of the skin induced by 7,12-dimethylbenz[a]anthracene and 12-O-tetradecanoylphorbol-13-acetate (TPA), whereas papillomas obtained by the same two-stage protocol were distinctly hetero 3076454 Human
k13 hyperplastic Positive staining for K13 was seen in all normal or hyperplastic benign epithelia, was inconstant in dysplasia, and intraepithelial neoplasia and carcinoma was negative. 2480682 Human
k13 hyperplastic Furthermore, expression of the K13 differentiation-associated keratin was preserved in this hyperplastic epithelium during all the stages of carcinogenesis, including either anaplastic or differentiated areas. 1694722 Human
k13 skin tumors In this study, we investigated whether the loss of epidermal keratin 1 (K1) and its replacement by mucosal keratin 13 (K13) is unique to mouse skin tumors induced by 7,12-dimethylbenz[a]anthracene (DMBA) and 12-O-tetradecanoylphorbol-13-acetate (TPA), sin 7681292 NA
k13 skin tumors With that purpose, we analyzed the keratin profiles of 16 DMBA-induced hamster skin tumors using monospecific antibodies against K1 and K13. 7681292 Human
k13 skin tumors Previous studies have suggested that the induction of K13 in mouse skin is related to the mutation of the Ha-ras gene by the initiating agent DMBA, a mutation consistently found in murine DMBA/TPA-induced tumors and rarely found in human skin tumors. 7681292 Mouse
k13 neoplasias ras gene activation and aberrant expression of keratin K13 in ultraviolet B radiation-induced epidermal neoplasias of mouse skin. 7688967 Mouse
k13 hyperplastic In addition, hyperplastic HK1.fos/alpha epidermis exhibited aberrant loricrin, filaggrin and novel K13 expression associated with v-fos expression. 7530825 Human
k13 skin tumor The appearance of GGT and keratin 13 (K13) and the lack of expression of K1 and K10 were found to be good markers for skin tumor progression. 8532708 Human
k13 nevus Recently, mutation of mucosal keratin pair K4 and K13 has been shown to underlie white sponge nevus (WSN). 9028791 Human
k13 skin tumors Expression of Hras-p21 and keratin K13 in UVR-induced skin tumors in Sencar mice. 9537281 Mouse
k13 hyperplastic In the Sudanese lesions, expression of K13 showed a distinct pattern through the oral mucosa and its verrucous projections, with an increase towards the superficial cell layers of dysplastic, but not hyperplastic epithelium. 9584046 Human
k13 nevus These include ichthyosis bullosa of Siemens (K2e), epidermolytic palmoplantar keratoderma (K1, K9), pachyonychia congenita (K6a, K6b, K16, K17), white sponge nevus (K4, K13), Meesmann's corneal dystrophy (K3, K12), cryptogenic cirrhosis (K8, K18) and 12688839 Human
k13 necrosis Interestingly, death effector domain-containing proteins such as MC159, E8, K13, and cellular FLIP, but not the apoptosis inhibitors Bcl-xL, p35, and XIAP, potently suppressed programmed necrosis. 14532286 Human
k13 papilloma We conclude that PI3K activation is an important regulator of expression of K13, a marker for the normal differentiation process in human mucosal keratinocytes, that this function does not require activation of Akt-1, and that the failure to express K13 i 16029072 Human
keratin-13 tumor They included c-JUN, JUNB, JUND, FREAC-1/FoxF1, ZNF-44/KOX7, plectin, filamin, keratin-13, G(0)S2, and the putative tumor suppressors NES-1 and protease M. 14633706 Human
keratin 13 cancer The patchwise expression of acidic keratin 13 in related primaries confirms their heterogeneous phenotype, and may be explained, in part, by cancer cells no longer resistant to terminal differentiation as a result perhaps of an altered micro-environment a 2448570 Human
keratin 13 skin tumors Cells in foci, but not v-rasHa control cells, expressed keratin 13, a marker which is strongly associated with the malignant progression of skin tumors in vivo. 1375535 Human
keratin 13 skin tumors Low frequency of codon 61 Ha-ras mutations and lack of keratin 13 expression in 7,12-dimethylbenz[a]-anthracene-induced hamster skin tumors. 7681292 others
keratin 13 skin tumors In this study, we investigated whether the loss of epidermal keratin 1 (K1) and its replacement by mucosal keratin 13 (K13) is unique to mouse skin tumors induced by 7,12-dimethylbenz[a]anthracene (DMBA) and 12-O-tetradecanoylphorbol-13-acetate (TPA), sin 7681292 NA
keratin 13 skin tumor The appearance of GGT and keratin 13 (K13) and the lack of expression of K1 and K10 were found to be good markers for skin tumor progression. 8532708 Human
keratin 13 nevus Keratin 13 point mutation underlies the hereditary mucosal epithelial disorder white sponge nevus. 7493031 Human
keratin 13 skin tumor We found that the appearance of alpha-glutamyl transpeptidase (GGT) and keratin 13 and the lack of expression of keratins 1 and 10 are good markers for skin tumor progression. 9627710 Human
keratin 13 hyperplastic Expression of keratin 13, 14 and 19 in oral hyperplastic and dysplastic lesions from Sudanese and Swedish snuff-dippers: association with human papillomavirus infection. 9584046 Human
keratin 13 nevus A novel mutation in the keratin 13 gene causing oral white sponge nevus. 11379896 Human
keratin 13 nevus Constitutional mutation of keratin 13 gene in familial white sponge nevus. 14600690 Human
keratin 13 nevus CONCLUSION: We identified a novel heterozygous missense mutation at 332T>C in the keratin 13 gene believed to be related to the development of white sponge nevus. 14600690 Human
keratin 13 oral squamous carcinoma Treatment of SCC25 oral squamous carcinoma cells with sodium butyrate (SB) at 0.5-5 mM or all-trans retinoic acid (ATRA) at 3-300 microM inhibited cell growth and induced apoptosis in a dose-dependent manner with concomittant increases in expression of ke 15645120 Human
keratin 13 tumors Injection of SB or ATRA near SCC25-derived tumors in nude mice resulted in inhibition of growth and elevation of differentiation of the tumor accompanied by marked keratinization and increased expression of keratin 13 and decreased expression of COX-2. 15645120 Mouse
keratin 13 tumor Injection of SB or ATRA near SCC25-derived tumors in nude mice resulted in inhibition of growth and elevation of differentiation of the tumor accompanied by marked keratinization and increased expression of keratin 13 and decreased expression of COX-2. 15645120 Mouse
keratin 13 tumors Among the proteins differentially expressed, keratin 13 was much lower in tumors, whereas heat-shock (Hsp) family members were highly expressed in neoplastic cells. 15695121 Human
keratin 13 tumors Immunohistochemical analysis of HNSCC tissues revealed lack of keratin 13 in tumor tissues, and strong staining in normal epithelia, and high expression of Hsp90 in tumors. 15695121 Human
keratin 13 tumor Immunohistochemical analysis of HNSCC tissues revealed lack of keratin 13 in tumor tissues, and strong staining in normal epithelia, and high expression of Hsp90 in tumors. 15695121 Human
the k13 gene tumors These results strongly suggest that the sequence element around the demethylated M1 site is involved in a multi-level control mechanism mediating the selective expression of the K13 gene in internal squamous epithelia and in DMBA/TPA-induced epidermal tum 1695590 Human
the k13 gene papillomas Analysis of genomic DNA from v-Ha-ras-induced papillomas for the methylation state of a CpG dinucleotide in the distant promoter region of the K13 gene revealed the occurrence of unmethylated DNA copies that were generated at the expense of methylated DNA 1724371 Mouse
the k13 protein papillomas Papillomas negative for the K13 protein were also devoid of K13 transcripts. 3076454 Human
ck-13 poorly differentiated carcinomas CK-13, on the other hand, was negative in poorly differentiated carcinomas but positive in keratinized cells of moderately or well differentiated carcinomas. 1709968 Human
ck-13 well differentiated carcinomas CK-13, on the other hand, was negative in poorly differentiated carcinomas but positive in keratinized cells of moderately or well differentiated carcinomas. 1709968 Human
ck 13 squamous-cell carcinoma Moreover, it was found that the presence of ck 13 in a squamous cell carcinoma is correlated with the less aggressive forms, as indicated in the literature. 9199086 Human
ck 13 ks RESULTS: The mouse monoclonal anti-CK antibodies [(AB) D5/16B4, Ks 13.1, E 3, K8.12, Ks 18.04, against CK 5-6, CK 13, CK 17, CK 13-15-16, CK 18) and the polyclonal anti-vimentin AB GP53 identified different epithelia and mesenchymal structures in rat SG t 11326640 Human
ck 13 carcinomas of the anal margin Carcinomas of the anal margin showed expression of CK 5/6 and CK 13, whereas CK7, CK18 and CK19 were rarely expressed. 11787851 Human
cytokeratin 13 malignancy It has been suggested that cytokeratin 13 is a useful marker of malignancy. 2480682 Human
cytokeratin 13 hyperplastic The mesonephric cells retained their pattern for intermediate filaments during ontogenesis, as well as in the mature, hyperplastic, and neoplastic states: they expressed cytokeratin 8, cytokeratin 13, and vimentin, the two latter in variable amounts. 1692008 Human
cytokeratin 13 cyst In this report we describe a case in which the urothelial origin of the cyst was documented by immunohistochemistry for cytokeratin 13. 8037806 Human
cytokeratin 13 inverted papilloma An immunohistochemical analysis of the cytokeratin profile revealed for the first time that the inverted papilloma, when compared to the normal surface epithelium of the nasal cavity and the paranasal sinuses, exhibits increased expression of cytokeratin 9264595 Human
cytokeratin 13 hyperplastic Unlike normal epithelia, the hyperplastic epithelia of CF bronchioles were enriched in cytokeratin 13, a 55-kDa protein that has previously been shown to act as a receptor in vitro for cable-piliated B. cepacia. 11023184 Human
cytokeratin 13 human nasopharyngeal carcinoma [The role of cytokeratin 13 gene in human nasopharyngeal carcinoma] OBJECTIVE: To study the significance of cytokeratin 13 (CK13) gene expression and its methylation in human nasopharyngeal carcinoma (NPC). 11776622 NA
cytokeratin 13 human nasopharyngeal carcinoma [Cytokeratin 13 gene expression in human nasopharyngeal carcinoma] OBJECTIVE: To investigate the possible pathogenetic role of cytokeratin 13 (CK13) gene expression in human nasopharyngeal carcinoma (NPC). 11776639 NA
cytokeratin 13 laryngeal squamous-cell carcinoma [Studies of the deletion and expression of cytokeratin 13 gene in laryngeal squamous cell carcinoma] In order to investigate the role of Cytokeratin 13(CK13) gene in laryngeal carcinogenesis, we detected the deletion of CK13 gene through LOH analysis indi 12043564 Human
cytokeratin 13 oral cancer To provide a useful method for the detection of micrometastases, we analyzed 115 LNs from 10 patients with oral cancer using real-time quantitative polymerase chain reaction (PCR) based on the expression of squamous cell carcinoma antigen (SCCA) and cytok 14654899 Human
cytokeratin 13 oral squamous-cell carcinoma (oscc) [Expression and significance of cytokeratin 13 gene in oral squamous cell carcinoma] PURPOSE: To investigate the expression and its significance of cytokeratin 13 gene in oral squamous cell carcinoma (OSCC). 16155702 NA
k 13 tumour The gingival epithelium-like structure reconstituted on 3T3 feeder layer expressed some cytokeratins characteristic of the in situ gingival epithelium (K 5, 6, 14, 16, 17) and some which do not exist in the normal tissue (K 8, 18, 19, traces of K 13 and K 1708229 Human

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