IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene KRT9 Ensembl ENSG00000171403 Chromosome 17 Start 36975622 End 36981836
Description Keratin, type I cytoskeletal 9 (Cytokeratin-9)(CK-9)(Keratin-9)(K9) [Source:UniProtKB/Swiss-Prot;Acc:P35527]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 6447
     Entrez Gene : 3857
     UCSC : uc002hxe.3
     GeneCards : 6447
     RefSeq : NM_000226
     CCDS : CCDS32654.1
     Uniprot : P35527
     Interpro : P35527
     OMIM : 607606
     GeneTests : KRT9
     CGAP : KRT9
     PMID : 7512862

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  34556_at  0.17  3.15e-1  4.20e-1  0.37  1.15e-1  1.85e-1
 HG_U133A  208188_at  0.16  6.41e-2  8.72e-2  -0.63  1.44e-10  1.81e-10
 HG_U133_Plus2  208188_at  0.33  5.43e-2  9.05e-2  1.14  2.18e-8  7.89e-8
 Agilent_HS_21.6K  8654  -0.01  7.41e-1  8.49e-1  0.01  7.18e-1  8.17e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  208188_at  0.63  4.09e-2  7.08e-1  -0.11  4.69e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 34556_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 208188_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 208188_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 8654    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
keratin 9 epidermolytic palmoplantar keratoderma CONCLUSIONS: Like most of the other families with clinical features of epidermolytic palmoplantar keratoderma the mutation is found in exon 1 of the keratin 9 gene. 12046815 Human
keratin 9 epidermolytic palmoplantar keratoderma Diagnosis and confirmation of epidermolytic palmoplantar keratoderma by the identification of mutations in keratin 9 using denaturing high-performance liquid chromatography. 12072061 Human
keratin 9 epidermolytic palmoplantar keratoderma A keratin 9 Gene mutation (Asn160Ser) in a Japanese patient with epidermolytic palmoplantar keratoderma. 12532041 Human
keratin 9 epidermolytic palmoplantar keratoderma We described a 5-year-old Japanese girl with epidermolytic palmoplantar keratoderma and examined her for a keratin 9 gene mutation. 12532041 Human
keratin 9 epidermolytic palmoplantar keratoderma Epidermolytic palmoplantar keratoderma in a Hispanic kindred resulting from a mutation in the keratin 9 gene. 10844507 Human
keratin 9 epidermolytic palmoplantar keratoderma (eppk) Epidermolytic palmoplantar keratoderma (EPPK) is a localized keratinization disorder caused by mutations in the highly conserved coil 1A domain of the keratin 9 gene, KRT9. 10844507 Human
krt9 epidermolytic palmoplantar keratoderma (eppk) Epidermolytic palmoplantar keratoderma (EPPK) is a localized keratinization disorder caused by mutations in the highly conserved coil 1A domain of the keratin 9 gene, KRT9. 10844507 Human
keratin 9 breast tumor Verification by quantitative reverse transcriptase-PCR confirmed significantly increased expression of keratin 9 (>100-fold) in nonmetastatic breast tumor cells and of CD70 (fivefold) in metastatic cells. 14695344 Human
keratin 9 palmoplantar keratoderma R162W mutation of keratin 9 in a family with autosomal dominant palmoplantar keratoderma with unique histologic features. 10536990 Human
keratin 9 epidermolytic palmoplantar keratoderma A case of spontaneous mutation in the keratin 9 gene associated with epidermolytic palmoplantar keratoderma. 10570560 Human
keratin 9 epidermolytic palmoplantar keratoderma Epidermolytic palmoplantar keratoderma appears to be due to defects in keratin 9, the palmoplantar specific type 1 keratin. 10570560 Human
keratin 9 epidermolytic palmoplantar keratoderma Keratin 9 mutations in the coil 1A region in epidermolytic palmoplantar keratoderma. 10632938 Human
keratin 9 epidermolytic palmoplantar keratoderma (eppk) Recently different point mutations of the keratin 9 (K9) gene have been identified in unrelated families with epidermolytic palmoplantar keratoderma (EPPK). 10632938 Human
keratin 9 knuckle pads A novel mutation of keratin 9 in epidermolytic palmoplantar keratoderma combined with knuckle pads. 12838553 Human
keratin 9 epidermolytic palmoplantar keratoderma A novel mutation of keratin 9 in epidermolytic palmoplantar keratoderma combined with knuckle pads. 12838553 Human
keratin 9 acral-lentiginous melanoma Furthermore, pure epidermal sheets from nonpalmoplantar skin grafted on the human sole wounds due to burn, injury, and the resection of acral lentiginous melanoma, demonstrated adoption of palmoplantar phenotype and expressed keratin 9. 10201533 Human
keratin 9 epidermolytic palmoplantar keratoderma Epidermolytic palmoplantar keratoderma due to a novel type of keratin mutation, a 3-bp insertion in the keratin 9 helix termination motif. 10233272 Human
keratin 9 epidermolytic palmoplantar keratoderma A novel keratin 9 gene mutation (Asn160His) in a Taiwanese family with epidermolytic palmoplantar keratoderma. 15115518 Human
keratin 9 epidermolytic palmoplantar keratoderma Mutations in the 1A rod domain segment of the keratin 9 gene in epidermolytic palmoplantar keratoderma. 9833037 Human
eppk epidermolytic palmoplantar keratoderma Epidermolytic palmoplantar keratoderma (EPPK, MIM #144200) is an autosomal dominant disorder in which hyperkeratosis confined to the palms and soles is characterized histologically by cytolysis of suprabasal keratinocytes. 9856842 Human
keratin 9 epidermolytic palmoplantar keratoderma A novel mutation of a leucine residue in coil 1A of keratin 9 in epidermolytic palmoplantar keratoderma. 9204965 Human
keratin 9 epidermolytic palmoplantar keratoderma (eppk) Keratin 9 mutation was examined in a Japanese kindred of epidermolytic palmoplantar keratoderma (EPPK), which is a dominantly inherited autosomal disorder of keratinization characterized by diffuse thickening of the palms and soles and by epidermolytic hy 9204965 Human
keratin 9 epidermolytic palmoplantar keratoderma Novel N160I mutation of keratin 9 in a large pedigree from Hungary with epidermolytic palmoplantar keratoderma. 12926810 Human
keratin 9 epidermolytic hereditary palmoplantar keratoderma Keratin 9 point mutation in the pedigree of epidermolytic hereditary palmoplantar keratoderma perturbs keratin intermediate filament network formation. 8647270 Human
keratin 9 epidermolytic palmoplantar keratoderma De novo mutation of keratin 9 gene in two Taiwanese patients with epidermolytic palmoplantar keratoderma. 14517588 Human
keratin 9 epidermolytic palmoplantar keratoderma A novel mutation of keratin 9 in a large Chinese family with epidermolytic palmoplantar keratoderma. 15099359 Human
keratin 9 epidermolytic palmoplantar keratoderma An equivalent position in the sole and palm restricted keratin 9 appears to be the mutation hot spot in epidermolytic palmoplantar keratoderma. 7532198 Human
keratin 9 epidermolytic palmoplantar keratoderma Mutations in the 1A domain of keratin 9 in patients with epidermolytic palmoplantar keratoderma. 7532199 Human
keratin 9 epidermolytic palmoplantar keratoderma We have analyzed six unrelated incidences of epidermolytic palmoplantar keratoderma for mutations in their keratin 9 genes. 7532199 Human
keratin 9 palmoplantar keratoderma Recently, mutations in the keratin genes have been identified in palmoplantar keratoderma: mutations in the keratin 9 gene causing the epidermolytic form, and mutations in the keratin 1 gene in a non-epidermolytic form. 7544663 Human
keratin 9 palmoplantar keratoderma Two different forms of palmoplantar keratoderma have recently been shown to be caused by mutations in the body site-specific keratin 9 gene and in the keratin 1 gene, respectively. 8666405 Human
keratin 9 breast and ovarian cancer Epidermolytic palmoplantar keratoderma cosegregates with a keratin 9 mutation in a pedigree with breast and ovarian cancer. 7511021 Human
keratin 9 epidermolytic palmoplantar keratoderma Epidermolytic palmoplantar keratoderma cosegregates with a keratin 9 mutation in a pedigree with breast and ovarian cancer. 7511021 Human
keratin 9 epidermolytic palmoplantar keratoderma (eppk) Keratin 9 gene mutations in epidermolytic palmoplantar keratoderma (EPPK). 7512862 Human
keratin 9 epidermolytic palmoplantar keratoderma Keratin 9 gene mutational heterogeneity in patients with epidermolytic palmoplantar keratoderma. 7516304 Human
keratin 9 palmoplantar keratoderma (ppk) Mutations in the human keratin 9 gene have recently been shown to be involved in the etiology of palmoplantar keratoderma (PPK). 7516304 Human
keratin 9 palmar-plantar keratoderma (ppk) Mutations in keratin 9 have been found in families with an epidermolytic form of palmar-plantar keratoderma (PPK). 7528239 Human
keratin 9 palmoplantar keratoderma The palmoplantar keratoderma variant investigated in this study is thus genetically different from epidermolytic palmoplantar keratoderma, which recently has been shown to result from mutations in the gene for the type I keratin 9. 7531539 Human
keratin 9 epidermolytic palmoplantar keratoderma The palmoplantar keratoderma variant investigated in this study is thus genetically different from epidermolytic palmoplantar keratoderma, which recently has been shown to result from mutations in the gene for the type I keratin 9. 7531539 Human
keratin 9 epidermolytic palmoplantar keratoderma A de novo mutation in the keratin 9 gene in a family with epidermolytic palmoplantar keratoderma from northern Sweden. 12735645 Human
epidermolytic palmoplantar keratoderma breast and ovarian cancer Epidermolytic palmoplantar keratoderma cosegregates with a keratin 9 mutation in a pedigree with breast and ovarian cancer. 7511021 Human
epidermolytic palmoplantar keratoderma palmoplantar keratoderma The palmoplantar keratoderma variant investigated in this study is thus genetically different from epidermolytic palmoplantar keratoderma, which recently has been shown to result from mutations in the gene for the type I keratin 9. 7531539 Human
epidermolytic palmoplantar keratoderma nevus These include ichthyosis bullosa of Siemens (K2e), epidermolytic palmoplantar keratoderma (K1, K9), pachyonychia congenita (K6a, K6b, K16, K17), white sponge nevus (K4, K13), Meesmann's corneal dystrophy (K3, K12), cryptogenic cirrhosis (K8, K18) and 12688839 Human
epidermolytic palmoplantar keratoderma knuckle pads A novel mutation of keratin 9 in epidermolytic palmoplantar keratoderma combined with knuckle pads. 12838553 Human
keratin 9 keratoderma Point mutations in the keratin 9 gene, which has been mapped to chromosome 17q21, can be a cause of epidermolytic keratoderma of palms and soles. 7499131 Human
keratin 9 palmoplantar keratoderma These findings give further evidence that palmoplantar keratoderma of Vörner represents the same entity as palmoplantar keratoderma of Thost, which was recently re-evaluated in Thost's original family and shown to be caused by a similar mutation, R1 12192490 Human
krt9 epidermolytic palmoplantar keratoderma (eppk) BACKGROUND: Epidermolytic palmoplantar keratoderma (EPPK) is an autosomal dominant genodermatosis characterized by epidermolytic hyperkeratosis strictly confined to the palms and soles, and usually associated with mutations in the keratin K9 gene (KRT9). 15214894 Human

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