IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene GAST Ensembl ENSG00000184502 Chromosome 17 Start 37122139 End 37125746
Description Gastrin Precursor [Contains Gastrin-71(Gastrin component I);Gastrin-52(G52);Big gastrin(Gastrin-34)(G34)(Gastrin component II);Gastrin(Gastrin-17)(G17)(Gastrin component III);Gastrin-14(G14);Gastrin-6(G6)] [Source:UniProtKB/Swiss-Prot;Acc:P01350]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :
     HGNC : 4164
     Entrez Gene : 2520
     UCSC : uc002hxl.2
     GeneCards : 4164
     RefSeq : NM_000805
     CCDS : CCDS11404.1
     Uniprot : P01350
     Interpro : P01350
     OMIM : 137250
     GeneTests : GAST
     CGAP : GAST

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  34552_at  0.46  7.68e-3  1.86e-2  0.84  2.03e-3  5.75e-3
 HG_U133A  208138_at  0.00  9.45e-1  9.54e-1  4.17  3.49e-126  5.02e-125
 HG_U133_Plus2  208138_at  0.33  3.29e-2  5.84e-2  1.40  1.27e-12  7.64e-12

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  208138_at  -0.10  6.60e-1  9.62e-1  0.11  4.77e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 34552_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 208138_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 208138_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
the gastrin gene human colon cancer Suppression of the gastrin gene in human colon cancer cells by stably expressing antisense (AS) gastrin RNA results in significant growth suppression of AS cells. 10915781 Human
the gastrin gene ovarian cancer The purpose of our present study was to determine: (1) whether the gastrin gene and peptide could be detected in ovarian cancer cell lines, (2) if functional gastrin releasing peptide receptors (GRP-R) are present, and (3) whether gastrin gene expression 9690380 Human
the gastrin gene ovarian cancer The SW626 ovarian cancer cell line will provide a useful model to further define regulation and expression of both the gastrin gene and peptide in ectopic (nongastrointestinal) tissues. 9690380 Human
the gastrin gene human colon cancers The majority of human colon cancers express the gastrin gene, and a significant percentage bind gastrin-like peptides. 8797575 Human
the gastrin gene human colon cancers We believe that this is the first evidence that supports a possible critical role of gastrin gene expression in the tumorigenicity of human colon cancers that express the gastrin gene. 8797575 Human
the gastrin gene human colon cancers Because > 60-80% of human colon cancers express the gastrin gene, it can be expected that the growth of a significant percentage of these cancers may be critically dependent on the expression of gastrin gene products. 8797575 Human
the gastrin gene cancers Because > 60-80% of human colon cancers express the gastrin gene, it can be expected that the growth of a significant percentage of these cancers may be critically dependent on the expression of gastrin gene products. 8797575 Human
the gastrin gene bronchogenic carcinomas BACKGROUND: The gastrin gene is known to be expressed in all classes of bronchogenic carcinomas. 8994528 Human
the gastrin gene gastrinoma Southern blotting profiles for normal gastric antrum and gastrinoma DNA were indistinguishable from each other within the 18-kb region containing the gastrin gene, showing that no genomic rearrangements are associated with the gastrinoma formation. 3034736 Human
the gastrin gene tumor Thus, the overproduction of gastrin in this tumor is likely to be due to an aberrant expression control system of the cell, rather than a change in the control region of the gastrin gene. 3034736 Human
the gastrin gene tumor The tumor synthesis of gastrin/progastrin contrasts to the rare, sporadic expression of the gastrin gene in normal nerve tissue. 1702342 Human
the gastrin gene bronchogenic carcinomas The results show that the gastrin gene is expressed in all classes of bronchogenic carcinomas. 2720643 Human
the gastrin gene colorectal adenocarcinoma Expression of the gastrin gene in the normal human colon and colorectal adenocarcinoma. 8504433 Human
the gastrin gene gastrin-producing tumors Our results indicate that gastrin-producing tumors in the pancreas are not ectopic, but arise from cells that normally express the gastrin gene. 2296587 Human

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