IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene ACLY Ensembl ENSG00000131473 Chromosome 17 Start 37276696 End 37328798
Description ATP-citrate synthase (EC 2.3.3.8)(ATP-citrate (pro-S-)-lyase)(Citrate cleavage enzyme) [Source:UniProtKB/Swiss-Prot;Acc:P53396]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 115
     Entrez Gene : 47
     UCSC : uc002hyg.2
     GeneCards : 115
     RefSeq : NM_001096
     CCDS : CCDS11412.1
     Uniprot : P53396
     Interpro : P53396
     OMIM : 108728
     GeneTests : ACLY
     CGAP : ACLY
     PMID : 1371749

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  40881_at  0.25  3.19e-3  8.70e-3  0.37  1.26e-3  3.81e-3
 HG_U133A  201127_s_at  0.64  4.04e-18  2.77e-17  0.42  1.10e-10  1.40e-10
 HG_U133A  201128_s_at  0.52  9.78e-18  6.49e-17  -2.37  4.39e-92  2.40e-91
 HG_U133A  210337_s_at  1.17  1.24e-25  1.43e-24  0.11  4.82e-1  4.92e-1
 HG_U133_Plus2  201127_s_at  0.55  1.63e-11  1.43e-10  0.98  1.39e-22  2.60e-21
 HG_U133_Plus2  201128_s_at  0.52  1.32e-12  1.33e-11  0.74  5.94e-16  5.20e-15
 HG_U133_Plus2  210337_s_at  0.45  1.24e-3  3.14e-3  0.64  7.11e-6  1.86e-5
 Stanford  13886  0.59  1.23e-2  7.35e-2  0.54  1.74e-2  1.01e-1
 Stanford  22966  0.57  1.01e-1  2.51e-1  0.49  1.35e-1  3.31e-1
 Agilent_HS_21.6K  12948  0.15  6.22e-3  3.21e-2  0.20  2.69e-3  1.23e-2

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  201127_s_at  0.02  9.34e-1  9.96e-1  -0.21  2.01e-1  1.00e+0
 HG_U133A  201128_s_at  0.06  7.75e-1  9.78e-1  -0.09  5.34e-1  1.00e+0
 HG_U133A  210337_s_at  0.37  2.60e-1  8.59e-1  -0.53  3.52e-2  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 40881_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 201127_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 201128_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 210337_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 201127_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 201128_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 210337_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 13886    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 22966    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 12948    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
atp citrate lyase breast carcinoma Enzyme activities in breast carcinoma were 4--160 x those determined in normal tissue according to the following sequence : phosphofructokinase less than malate NADP dehydrogenase less than hexokinase less than lactate dehydrogenase less than isocitrate N 444407 Human
acl human hepatoma ACL promoter activity was markedly stimulated by the overexpression of SREBP-1a and, to a lesser extent, by SREBP-2 in Alexander human hepatoma cells. 10801800 Human
acl tumor ACL inhibition by RNAi or the chemical inhibitor SB-204990 limits in vitro proliferation and survival of tumor cells displaying aerobic glycolysis. 16226706 Human
atp citrate lyase tumor ATP citrate lyase inhibition can suppress tumor cell growth. 16226706 Human
atp citrate lyase cancer While fatty acid synthase is further established as a target for antineoplastic intervention, recent findings show that interference with acetyl-CoA carboxylase-alpha, ATP citrate lyase or the AMP-activated protein kinase limits cancer cell proliferation 16778563 Human
acl tumorigenesis However, ACL knockdown significantly impairs Akt-mediated tumorigenesis in vivo. 16007201 Human

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