IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene ATP6V0A1 Ensembl ENSG00000033627 Chromosome 17 Start 37864388 End 37928122
Description V-type proton ATPase 116 kDa subunit a isoform 1 (V-ATPase 116 kDa isoform a1)(Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1)(Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit)(Vacuolar proton pump subunit 1)(Vacuolar adenosine triphosphatase subunit Ac116) [Source:UniProtKB/Swiss-Prot;Acc:Q93050]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 865
     Entrez Gene : 535
     UCSC : uc002hzs.2
     GeneCards : 865
     RefSeq : NM_001130020
     CCDS : CCDS11426.1
     Uniprot : Q93050
     Interpro : Q93050
     OMIM : 192130
     GeneTests : ATP6V0A1
     CGAP : ATP6V0A1
     PMID : 7774924

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  39326_at  -1.12  8.16e-9  8.47e-8  -1.73  1.25e-11  2.00e-10
 HG_U133A  205095_s_at  0.05  6.66e-1  7.09e-1  -0.65  1.27e-4  1.45e-4
 HG_U133A  212383_at  -0.25  3.66e-6  8.90e-6  -5.93  1.38e-109  1.22e-108
 HG_U133_Plus2  1559374_at  0.12  5.13e-1  6.00e-1  -0.32  1.10e-1  1.46e-1
 HG_U133_Plus2  205095_s_at  0.60  3.64e-3  8.29e-3  0.81  3.56e-4  7.33e-4
 HG_U133_Plus2  212383_at  0.01  9.21e-1  9.42e-1  0.21  6.63e-2  9.26e-2
 Agilent_HS_21.6K  11006  0.05  2.43e-1  4.25e-1  0.06  1.28e-1  2.49e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  205095_s_at  -0.51  2.66e-1  8.61e-1  -0.29  2.38e-1  1.00e+0
 HG_U133A  212383_at  -0.08  6.72e-1  9.65e-1  -0.06  5.98e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 39326_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 205095_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 212383_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 1559374_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 205095_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 212383_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 11006    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
vpp1 tumors Analysis of TRAMP tumors demonstrated a dramatic decrease in the level of Vpp1 mRNA. 11920954 Mouse
the a1 protein malignant transformation These results suggest that perturbations in RNA splicing mechanisms may contribute to malignant transformation and provide direct evidence that the A1 protein is not required for cell growth. 1406633 Human
atp6v0a1 colorectal cancer POLR2F, ATP6V0A1 and PRNP expression in colorectal cancer: new molecules with prognostic significance? 18505059 Human
atp6v0a1 carcinogenesis BACKGROUND: DNA-directed RNA polymerase II subunit F (POLR2F), a subunit of the V0 domain of the vacuolar ATPase (ATP6V0A1) and the prion protein (PRNP) are molecules of potential importance in carcinogenesis and targeted cancer therapy. 18505059 Human
atp6v0a1 cancer BACKGROUND: DNA-directed RNA polymerase II subunit F (POLR2F), a subunit of the V0 domain of the vacuolar ATPase (ATP6V0A1) and the prion protein (PRNP) are molecules of potential importance in carcinogenesis and targeted cancer therapy. 18505059 Human
atp6v0a1 colorectal carcinoma PATIENTS AND METHODS: Expression microarray data were analyzed using a novel computational tool to reveal elevated levels of POLR2F, ATP6V0A1 and PRNP in relapsed colorectal carcinoma patients. 18505059 Human
atp6v0a1 colorectal carcinomas The mRNA levels of POLR2F, ATP6V0A1 and PRNP were evaluated by quantitative RT-PCR in 70 colorectal carcinomas and 17 normal tissue specimens and were correlated with clinicopathological parameters. 18505059 Human
atp6v0a1 hepatoblastoma Moreover, the analysis of hepatoblastoma cells using the gene Chip gene expression analysis arrays showed that three of the 27 V-ATPase-related transcripts (ATP6V0D2, ATP6V1B1, and ATP6V0A1) were more weakly expressed in the Baf-A1-treated cells than in t 18712525 Human
atp6v0a1 hepatoblastoma Given that three V-ATPase-related genes (ATP6V0D2, ATP6V1B1, and ATP6V0A1) were more weakly expressed in the hepatoblastoma cells of the Baf-A1-treated group than in the Baf-A1-free cells, drug development targeting V-ATPase gene of hepatoblastomas is exp 18712525 Human

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