IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene NAGLU Ensembl ENSG00000108784 Chromosome 17 Start 37941477 End 37949990
Description Alpha-N-acetylglucosaminidase Precursor (EC 3.2.1.50)(N-acetyl-alpha-glucosaminidase)(NAG) [Contains Alpha-N-acetylglucosaminidase 82 kDa form;Alpha-N-acetylglucosaminidase 77 kDa form] [Source:UniProtKB/Swiss-Prot;Acc:P54802]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :
     HGNC : 7632
     Entrez Gene : 4669
     UCSC : uc002hzv.2
     GeneCards : 7632
     RefSeq : NM_000263
     CCDS : CCDS11427.1
     Uniprot : P54802
     Interpro : P54802
     OMIM : 609701
     GeneTests : NAGLU
     CGAP : NAGLU

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  41596_s_at  0.00  9.63e-1  9.74e-1  -0.37  1.32e-4  5.12e-4
 HG_U133A  204360_s_at  0.30  1.78e-5  4.02e-5  1.33  1.87e-12  2.44e-12
 HG_U133A  215880_at  0.14  2.90e-1  3.42e-1  -1.26  1.97e-13  2.60e-13
 HG_U133_Plus2  204360_s_at  -0.07  3.13e-1  4.02e-1  -0.12  1.09e-1  1.45e-1
 HG_U133_Plus2  215880_at  -0.11  4.72e-1  5.61e-1  -0.27  1.18e-1  1.57e-1
 Stanford  23440  0.03  9.26e-1  9.61e-1  -0.27  2.53e-1  4.91e-1
 Agilent_HS_21.6K  16745  -0.13  8.60e-4  6.77e-3  -0.17  1.29e-5  1.40e-4

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  204360_s_at  0.01  9.52e-1  9.98e-1  -0.02  8.83e-1  1.00e+0
 HG_U133A  215880_at  -0.14  7.44e-1  9.74e-1  -0.20  4.93e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 41596_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 204360_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 215880_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 204360_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 215880_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 23440    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 16745    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
alpha-n-acetylglucosaminidase breast tumors In the gene encoding alpha-N-acetylglucosaminidase, approximately 100 kb proximal to the 650-kb linked region, somatic nonsense, missense, and splice junction mutations occurred in 3 breast tumors, but not in these patients' germline DNA nor in contr 7774926 Human
alpha-n-acetylglucosaminidase kidney carcinoma Biosynthesis of alpha-N-acetylglucosaminidase in cultured human kidney carcinoma cells. 4006900 Human
alpha-n-acetylglucosaminidase kidney carcinoma The biosynthesis of alpha-N-acetylglucosaminidase was studied in cultured human kidney carcinoma cells by labeling cells with 35S-methionine, isolation of the enzyme by immunoprecipitation and analysis on gel electrophoresis of the denatured polypeptide(s 4006900 Human
nag lung cancer The authors investigated the reductive effects of a Kunitz-type proteinase inhibitor, urinastatin, on the nephrotoxicity seen in lung cancer patients treated with cisplatin by measuring N-acetyl-beta-D-glucosaminidase (NAG) activity and beta 2-microglobul 2552802 Human
nag necrosis In the rats injected with p-aminophenol, necrosis of renal tubular epithelial cells and remarkable elevation of urinary N-acetyl-beta-D-glucosaminidase (NAG) and gamma-glutamyltranspeptidase (gamma-GTP) activities were observed. 2576285 Human
nag tumors Increase patterns of urinary beta-GL activities were similar to those of urinary NAG, but remarkably-high values of beta-GL activities were found in cases of urothelial tumors probably because urinary beta-GL derives from the kidney (lysosomes of tubular 2729012 Human
nag head and neck cancer [Measurement of creatinine clearance and urinary NAG for the evaluation of cis-platinum induced nephrotoxicity] Creatinine clearance and beta-D-acetyl-glucosaminidase (NAG) were useful markers for the evaluation of the renal function of 57 cases of head a 2774590 Human
nag lung cancer The protective effects of fosfomycin and steroids on the nephrotoxicity induced by cisplatin in lung cancer patients were studied by measuring N-acetyl-beta-D-glucosaminidase (NAG) activity in 24-hour urine, creatinine clearance, serum creatinine and bloo 2827472 Human
nag osteogenic sarcoma We measured urinary levels of total protein, N-acetyl-beta-D-glucosaminidase (NAG), alanine aminopeptidase, and adenosine deaminase-binding protein in ten children with osteogenic sarcoma who were receiving combination chemotherapy that included 12 doses 2877729 Human
nag malignant tumors [Urinary NAG and gamma-GTP activities as indicators of CDDP renal toxicity: effect of fosfomycin on CDDP renal toxicity] Using urinary N-acetyl-beta-D-glucosaminidase (NAG) and gamma-glutamyl transpeptidase (gamma-GTP) activities as the indicator of renal 2880486 Human
nag bladder tumors [N-acetyl-beta-D-glucosaminidase (NAG) activity in human semen: its relation to gamma-glutamyl transpeptidase (gamma-GTP) activity in seminal plasma and reproductive tissues, and relation between seminal mucoprotein concentration and seminal NAG, and gamm 2891274 Human
nag gynecological cancer [Comparison of methods for evaluating the nephrotoxicity of cisplatin] The BUN, serum creatinine, creatinine clearance and the urinary excretion of leucine aminopeptidase (LAP), alkaline phosphatase (ALP), beta 2-microglobulin (beta-m), and N-acetyl-beta- 3044273 Human
nag leukaemia The activity of the lysosomal hydrolase N-acetyl-beta-D-glucosaminidase (NAG) was measured in the urine of patients with leukaemia or myeloma. 3467645 Human
nag myeloma The activity of the lysosomal hydrolase N-acetyl-beta-D-glucosaminidase (NAG) was measured in the urine of patients with leukaemia or myeloma. 3467645 Human
nag aml The ratio of the major isoenzymes of NAG, A/B was reduced significantly only in patients with AML. 3467645 Human
nag aml Following treatment, AML patients who entered remission demonstrated NAG levels which approached normal values. 3467645 Human
nag aml In those AML patients who were either in relapse, in the terminal phase of their illness or treated with aminoglycoside antibiotics, NAG enzymuria was similar to pre-treatment values. 3467645 Human
nag myeloma A reduction in urinary NAG levels and both serum and urine beta 2 microglobulin concentrations was also observed following treatment in myeloma patients. 3467645 Human
nag necrosis Increased urinary N-acetyl-beta-D-glucosaminidase (NAG) excretion caused by necrosis of renal tubular cells can be used as a marker for nephropathy. 3468929 Human
nag necrosis Increased NAG activity was observed in previously TRI-exposed persons, which might indicate induction of an autoimmune renal necrosis. 3468929 Human
nag burkitt's lymphoma Total NAG activity in myeloid, histiocytic, erythroleukemic cell lines were higher than Burkitt's lymphoma derived cell lines (B-lymphoid), T- or lymphoblastoid cell lines. 3488138 Human
nag necrosis Urinary N-acetyl-beta-D-glucosaminidase (NAG), an indicator of epithelial necrosis, was also evaluated. 3534746 Human
nag breast cancer Using high-pressure liquid chromatography (HPLC), we examined blood levels of AG and NAG in patients with breast cancer and compared the levels to the expression and frequency of drug symptoms. 3652603 Human
nag tumour From the renal point of view, there was the expected rise in serum urea after Neoplatin but not after CHIP and there was also a rise in urinary NAG after Neoplatin in tumour bearing mice. 3718829 Mouse
nag malignant tumors [Acute change in urinary NAG activity following CDDP administration] In the present paper, the acute change of urinary NAG activities following CDDP administration was studied in 8 patients with urological malignant tumors. 3728241 Human
nag advanced breast cancer Serum aminoglutethimide (AG) and N-acetylaminoglutethimide (NAG) concentrations were measured by high pressure liquid chromatography (HPLC) in 24 postmenopausal women with advanced breast cancer receiving increasing doses of oral AG. 3978028 Human
nag tumors VI. N-acetyl-beta-glucosaminidase] N-Acetyl-beta-Glucosaminidase (NAG) activity was investigated in 50 intrathoracic tumors with a histochemical method. 3984403 Human
nag epidermoid carcinomas Twelve of 14 adenocarcinomas and 3 of 3 alveolar cell carcinomas contained activities of NAG in tumor tissue, whereas 16 of 17 epidermoid carcinomas and 4 of 4 large cell carcinomas showed negative findings. 3984403 Human
nag large cell carcinomas Twelve of 14 adenocarcinomas and 3 of 3 alveolar cell carcinomas contained activities of NAG in tumor tissue, whereas 16 of 17 epidermoid carcinomas and 4 of 4 large cell carcinomas showed negative findings. 3984403 Human
nag tumor Twelve of 14 adenocarcinomas and 3 of 3 alveolar cell carcinomas contained activities of NAG in tumor tissue, whereas 16 of 17 epidermoid carcinomas and 4 of 4 large cell carcinomas showed negative findings. 3984403 Human
nag epidermoid carcinomas The fact that also non-differentiated solid adenocarcinomas, often in histological picture not to differentiate from large cell carcinomas or non-differentiated epidermoid carcinomas, exhibit NAG seems to be an useful aid in differential diagnosis between 3984403 Human
nag large cell carcinomas The fact that also non-differentiated solid adenocarcinomas, often in histological picture not to differentiate from large cell carcinomas or non-differentiated epidermoid carcinomas, exhibit NAG seems to be an useful aid in differential diagnosis between 3984403 Human
nag tumor The fact that also non-differentiated solid adenocarcinomas, often in histological picture not to differentiate from large cell carcinomas or non-differentiated epidermoid carcinomas, exhibit NAG seems to be an useful aid in differential diagnosis between 3984403 Human
nag penile cancer [Effects of combination chemotherapy with cis-diamminedichloroplatinum (II) (CDDP) on renal function in patients with urogenital malignancies] The renal function in 23 patients with advanced urogenital cancers (10 testicular, 8 uroepithelial, 3 prostatic 4040315 Human
nag prostatic cancers [Effects of combination chemotherapy with cis-diamminedichloroplatinum (II) (CDDP) on renal function in patients with urogenital malignancies] The renal function in 23 patients with advanced urogenital cancers (10 testicular, 8 uroepithelial, 3 prostatic 4040315 Human
nag testicular cancers Patients with testicular cancers (group 1) who received the cumulative CDDP dose of 360-1966 mg (on average 868 mg), the decrease in Ccr and increase in FE beta 2 MG and NAG were temporary during each chemotherapy cycle. 4040315 Human
nag testicular cancer Patients with urogenital cancers other than testicular cancer (group 2) who received the cumulative CDDP dose of 80-480 mg (on average 217 mg), and who had decreased Ccr and tubular damage prior to treatment, even though the cumulative dose was lower than 4040315 Human
nag crohn's disease In 9 patients treated chronically for their Crohn's disease with 3 X 0.5 g 5-ASA daily in form of suppositories and an oral preparation urinary excretions of NAG, AAP and serum creatinine were also monitored before and during therapy. 6147767 Human
nag benign prostatic hyperplasia In most patients with benign prostatic hyperplasia, prostate cancer and bladder cancer, activity of urinary NAG was elevated (92.9%), especially in cases of indwelling catheterization or poor visualization of IVU. 6391119 Human
nag bladder cancer In most patients with benign prostatic hyperplasia, prostate cancer and bladder cancer, activity of urinary NAG was elevated (92.9%), especially in cases of indwelling catheterization or poor visualization of IVU. 6391119 Human
nag prostate cancer In most patients with benign prostatic hyperplasia, prostate cancer and bladder cancer, activity of urinary NAG was elevated (92.9%), especially in cases of indwelling catheterization or poor visualization of IVU. 6391119 Human
nag multiple myeloma In 34 patients with multiple myeloma we have studied urinary N-acetyl-beta-D-glucosaminidase (NAG) as an index of tubular injury and related it to urinary light chain excretion and serum creatinine. 6426824 Human
nag multiple myeloma Clinically, urinary NAG appears to be a useful index of early tubular damage in multiple myeloma. 6426824 Human
nag hodgkin's disease To evaluate metabolic functionality of monocytes and lymphocytes in Hodgkin's disease (HD) we studied 3 enzymes of the intermediary metabolism, G-6-PDH, PHI, ICDH, and the acid hydrolases, NAG and ACP. 6683171 Human
nag gliomas Isozyme patterns for five acid hydrolases, acid phosphatase (AP), aryl-sulfate (AS), beta-glucuronidase (beta-Glu), N-acetylglucosaminidase (NAG) and beta-galactosidase (beta-Gal), were studied in isolated lysosomes from ethylnitrosourea (ENU)-induced gli 6811278 Human
nag tumors For NAG the acidic form was elevated by 9-19% in tumors, while newborn brains showed a 19% decrease. 6811278 Human
nag cancer The urinary excretion of leucine aminopeptidase (LAP), N-acetyl-beta-glucosaminidase (NAG), and beta 2-microglobulin was measured in 12 cancer patients receiving cis-platinum to evaluate the sensitivity of these indices for renal tubular damage. 6987030 Human
nag necrosis Increased NAG activity in hypertension could not be ascribed to tissue necrosis because the serum levels of several commonly measured cytosolic enzymes were within normal limits. 7074994 Human
nag granuloma The granuloma formed by day 7 is characterized by the formation of a vascularized fibrous capsule containing fibroblasts and infiltrating mononuclear cells which are rich in N-acetyl-beta-D-glucosaminidase (NAG). 7092916 Rat
nag granuloma Granuloma development was quantitated by dry weight measurements, and its cellular content was measured by assaying activity of NAG and total nucleic acid content. 7092916 Human
nag granuloma In contrast, the NAG activity did not change significantly until after day 5 when a large increase in the amount of enzyme extractable from the granuloma was seen. 7092916 Rat
nag granuloma Systemic treatment of the animal with dexamethasone or indomethacin resulted in an inhibition of granuloma weight gain, NAG activity and nucleic acid levels. 7092916 Human
nag necrosis Although immediate recovery from these nephrotoxic effects of aminoglycosides and the elevation of urinary NAG activity occurs on prompt withdrawal of the drugs, two autopsied cases receiving prolonged administration of gentamicin, followed marked NAG ele 7221185 Human
nag cancer [Comparative study on urinary parameters reflecting renal damage during chemotherapy for urological cancer] We analyzed the excretion of the three urinary enzymes, N-acetyl-beta-D-glucosaminidase (NAG), alanine aminopeptidase (AAP), and glycyl-prolyl dipe 7682030 Human
nag prostatic cancer [Comparative study on urinary parameters reflecting renal damage during chemotherapy for urological cancer] We analyzed the excretion of the three urinary enzymes, N-acetyl-beta-D-glucosaminidase (NAG), alanine aminopeptidase (AAP), and glycyl-prolyl dipe 7682030 Human
nag urological cancer [Comparative study on urinary parameters reflecting renal damage during chemotherapy for urological cancer] We analyzed the excretion of the three urinary enzymes, N-acetyl-beta-D-glucosaminidase (NAG), alanine aminopeptidase (AAP), and glycyl-prolyl dipe 7682030 Human
nag urothelial cancer [Comparative study on urinary parameters reflecting renal damage during chemotherapy for urological cancer] We analyzed the excretion of the three urinary enzymes, N-acetyl-beta-D-glucosaminidase (NAG), alanine aminopeptidase (AAP), and glycyl-prolyl dipe 7682030 Human
nag renal cell carcinomas [Study on the enzymatic properties of N-acetyl-beta, D-glucosaminidase A (NAG A) from the tissue of renal cell carcinomas: comparison of the enzymatic properties with those of normal renal tissues, with special regard to sugar-chain structures] The enzyma 8258938 Human
nag necrosis Urinary NAG levels increased significantly in 13/16 first rejection episodes and 4/4 instances of acute tubular necrosis and graft infarction. 104810 Human
nag multiple myeloma [Urinary N-acetyl-beta-D-glucosaminidase and gamma-glutamyl-transpeptidase activities for evaluation of renal disturbance in patients with multiple myeloma] The activities of N-acetyl-beta-D-glucosaminidase (NAG), gamma-glutamyl-transpeptidase (gamma-GTP) 1363243 Human
nag myeloma Mean urinary NAG activity in the patients with myeloma was significantly higher than that in the controls (20.1 +/- 3.3 vs 4.3 +/- 0.3U/g. cr; p < 0.001). 1363243 Human
nag multiple myeloma Therefore, urinary NAG activity may be a good index for proximal tubular disturbance, and NAG/gamma-GTP ratio may be an index for the extensive damage of nephrons in addition to the damage of tubular cells in multiple myeloma. 1363243 Human
nag hyperplasia Histologically, OKY-046 (thromboxane synthetase inhibitor) decreased tubular damage, although JG hyperplasia was not eradicated, while biochemically the excretion of TxB2 decreased significantly (P < 0.02), and both the decrease in the urine creatinine le 14621878 Human
nag lung cancer The following results were obtained; 1) Over 45% of patients with lung cancer showed transient hyperexcretion of urinary NAG and BMG after CDDP administration. 1479719 Human
nag pancreatic cancer In 30 controls, 45 patients with pancreatic cancer, 54 with chronic pancreatitis, and 64 with extrapancreatic diseases, serum and urinary PLA2, pancreatic isoamylase and RNase, and urinary N-acetylglucosaminidase (NAG) were measured. 1517657 Human
nag breast cancer [Relationship between plasma and urinary platinum pharmacokinetics with cisplatin nephrotoxicity in breast cancer patients] In 25 cycles of 20 breast cancer patients who received 26 cycles of high-dose cisplatin (100 mg/m2, iv drip), the urinary Alb, IgG 1618086 Human
nag lung cancer [Prophylactic effect of ulinastatin on cisplatin-induced renal disorders in lung cancer patients] In order to determine whether ulinastatin (US) can prevent renal dysfunction due to cisplatin (CDDP) or not, we comparatively studied serum BUN, serum creati 1625386 Human
nag primary lung cancer [Prophylactic effect of ulinastatin on cisplatin-induced renal disorders in lung cancer patients] In order to determine whether ulinastatin (US) can prevent renal dysfunction due to cisplatin (CDDP) or not, we comparatively studied serum BUN, serum creati 1625386 Human
nag necrosis Sodium-dependent uptakes of Pi and alpha-methylglucopyranoside (MGP) and enzymatic activities (lactate dehydrogenase [LDH] released as a marker of cell necrosis and gamma-glutamyltransferase [GGT] and N-acetyl-beta-D-glucosaminidase [NAG] present in the h 1673835 Human
nag renal cell carcinoma [Urinary excretion of glycine.prolile dipeptidile aminopeptidase, N-acetyl-beta-D-glucosaminidase, alanine aminopeptidase and low molecular protein in patients with renal cell carcinoma] Urinary excretion of glycine.prolile dipeptidile aminopeptidase (GP- 1698011 Human
nag granulomas Aqueous extracts of both granulomas contained high levels of lysosomal enzymes N-acetyl-beta-D-glucosaminidase (NAG) and lysozyme. 1718910 Human
nag esophageal cancer [Clinical study of nephrotoxicity following cis-diamminedichloroplatinum (II) (CDDP) combination chemotherapy assessed by 131I-OIH renogram] The renal function in 26 patients with malignant tumors (19 non-small cell lung cancers, 4 small cell lung cancers 2089371 Human
nag malignant lymphoma [Clinical study of nephrotoxicity following cis-diamminedichloroplatinum (II) (CDDP) combination chemotherapy assessed by 131I-OIH renogram] The renal function in 26 patients with malignant tumors (19 non-small cell lung cancers, 4 small cell lung cancers 2089371 Human
nag malignant thymoma [Clinical study of nephrotoxicity following cis-diamminedichloroplatinum (II) (CDDP) combination chemotherapy assessed by 131I-OIH renogram] The renal function in 26 patients with malignant tumors (19 non-small cell lung cancers, 4 small cell lung cancers 2089371 Human
nag malignant tumors [Clinical study of nephrotoxicity following cis-diamminedichloroplatinum (II) (CDDP) combination chemotherapy assessed by 131I-OIH renogram] The renal function in 26 patients with malignant tumors (19 non-small cell lung cancers, 4 small cell lung cancers 2089371 Human
nag non-small cell lung cancers [Clinical study of nephrotoxicity following cis-diamminedichloroplatinum (II) (CDDP) combination chemotherapy assessed by 131I-OIH renogram] The renal function in 26 patients with malignant tumors (19 non-small cell lung cancers, 4 small cell lung cancers 2089371 Human
nag small cell lung cancers [Clinical study of nephrotoxicity following cis-diamminedichloroplatinum (II) (CDDP) combination chemotherapy assessed by 131I-OIH renogram] The renal function in 26 patients with malignant tumors (19 non-small cell lung cancers, 4 small cell lung cancers 2089371 Human
nag benign prostatic hypertrophy On the other hand, in the seminal tract disease patients, the urinary NAG level was high in benign prostatic hypertrophy with a catheter indwelling and in prostatitis. 2445186 Human
nag malignant tumors [Studies on serum and urinary alpha 1-microglobulin levels as parameter of the renal function--renal function observed after CDDP administration] To evaluate the clinical usefulness of alpha 1-microglobulin (alpha 1-MG) as parameter of renal function, we 2459938 Human
nag alveolar cell carcinomas Twelve of 14 adenocarcinomas and 3 of 3 alveolar cell carcinomas contained activities of NAG in tumor tissue, whereas 16 of 17 epidermoid carcinomas and 4 of 4 large cell carcinomas showed negative findings. 3984403 Human
nag urogenital cancers [Effects of combination chemotherapy with cis-diamminedichloroplatinum (II) (CDDP) on renal function in patients with urogenital malignancies] The renal function in 23 patients with advanced urogenital cancers (10 testicular, 8 uroepithelial, 3 prostatic 4040315 Human
nag urogenital cancers Patients with urogenital cancers other than testicular cancer (group 2) who received the cumulative CDDP dose of 80-480 mg (on average 217 mg), and who had decreased Ccr and tubular damage prior to treatment, even though the cumulative dose was lower than 4040315 Human
nag human renal cell carcinomas [Study on the enzymatic properties of N-acetyl-beta, D-glucosaminidase A (NAG A) from the tissue of renal cell carcinomas: comparison of the enzymatic properties with those of normal renal tissues, with special regard to sugar-chain structures] The enzyma 8258938 Human
nag urogenital cancers The renal function in 8 patients with advanced urogenital cancers treated with cis-diammine-dichloroplatinum (CDDP) was examined by measuring 24 Ccr, alpha 1-MG, and beta 2-MG in serum and urine and urinary NAG. 2459938 Human
nag cancer We have investigated urinary zinc and N-acetyl-beta-D-glucosaminidase (NAG), an indicator of renal tubular cell dysfunction, as well as serum neopterin, an index of systemic immune activation, in 22 patients with cancer and seven controls. 7647517 Human
nag cancer Both serum neopterin and urinary zinc were significantly elevated in cancer patients (15.8 +/- 12.7 versus 7.3 +/- 2.3 nmol l-1 and 1.77 +/- 0.80 versus 1.21 +/- 0.41 mmol mol-1 creatinine, P < 0.02 and P < 0.05, respectively), while NAG was similar in ca 7647517 Human
nag cancer As recent studies have raised the question of the role of renal tubular cell dysfunction in the elevation of urinary zinc output, we have examined urinary zinc excretion and the excretion of N-acetyl-beta-D-glucosaminidase (NAG), an indicator of tubular c 7667608 Human
nag necrosis Gentamicin (80 mg/kg/day intramuscularly for 6 days) produced the typical pattern of nephrotoxicity as shown by increases in serum creatinine and urea concentrations, and urinary N-acetyl-beta-D-glucosaminidase (NAG) activity and proximal renal tubular ne 7702362 Human
nag neoplasms N-Acetyl-beta-glucosaminidase (NAG) and beta-glucuronidase were measured in the serum of 70 patients with breast and digestive-tract neoplasms and in 70 healthy subjects. 7860621 Human
nag pancreas cancer The mean value of the NAG activity was significantly (P < 0.001) elevated in patients with gastric, liver and pancreas cancer as compared with the reference population. 7860621 Human
nag breast cancer NAG elevations above normal were observed in 14 (78%) patients with breast cancer, in 11 (100%) with gastric cancer, in 17 (70%) with colorectal cancer, in 8 (100%) with liver cancer and in 9 (100%) with pancreas cancer. 7860621 Human
nag colorectal cancer NAG elevations above normal were observed in 14 (78%) patients with breast cancer, in 11 (100%) with gastric cancer, in 17 (70%) with colorectal cancer, in 8 (100%) with liver cancer and in 9 (100%) with pancreas cancer. 7860621 Human
nag gastric cancer NAG elevations above normal were observed in 14 (78%) patients with breast cancer, in 11 (100%) with gastric cancer, in 17 (70%) with colorectal cancer, in 8 (100%) with liver cancer and in 9 (100%) with pancreas cancer. 7860621 Human
nag liver cancer NAG elevations above normal were observed in 14 (78%) patients with breast cancer, in 11 (100%) with gastric cancer, in 17 (70%) with colorectal cancer, in 8 (100%) with liver cancer and in 9 (100%) with pancreas cancer. 7860621 Human
nag pancreas cancer NAG elevations above normal were observed in 14 (78%) patients with breast cancer, in 11 (100%) with gastric cancer, in 17 (70%) with colorectal cancer, in 8 (100%) with liver cancer and in 9 (100%) with pancreas cancer. 7860621 Human
nag benign breast tumors N-acetyl-beta-glucosaminidase (NAG) and its isoenzymes were measured in 60 patients with breast cancer and in 30 patients suffering from benign breast tumors. 7889495 Human
nag breast cancer N-acetyl-beta-glucosaminidase (NAG) and its isoenzymes were measured in 60 patients with breast cancer and in 30 patients suffering from benign breast tumors. 7889495 Human
nag cancer NAG activity was significantly increased (P < 0.001) in cancer patients. 7889495 Human
nag breast cancer It seems from this study that the determination of the isoenzyme NAG B activity may be useful for better diagnosis of breast cancer. 7889495 Human
nag testicular cancer To assess the value of endothelin-1 (ET-1) in estimating renal injury in patients receiving high doses of cisplatin, urinary excretion of ET-1-like immunoreactivity (U-ET-1), beta 2-microglobulin (U-beta 2-MG), and N-acetyl-beta-d-glucosaminidase (NAG) we 8023817 Human
nag renal cell cancer To assess the value of endothelin-1 (ET-1) as a parameter of renal functional overload and the process of hyperfiltration, urinary excretion of ET-1-like immunoreactivity (U-ET-1) and urinary excretion of other parameters [beta 2-microglobulin (beta 2-MG) 8072606 Human
nag acute lymphoblastic leukaemia [Nephrotoxicity evaluation of cytostatic agents in children with acute lymphoblastic leukemia] Urinary excretion of the markers of tubular nephrotoxicity, total NAG and isoenzymes A and B and B-2-M, were evaluated in urine of 21 children with acute lympho 8677156 Human
nag acute lymphoblastic leukemia [Nephrotoxicity evaluation of cytostatic agents in children with acute lymphoblastic leukemia] Urinary excretion of the markers of tubular nephrotoxicity, total NAG and isoenzymes A and B and B-2-M, were evaluated in urine of 21 children with acute lympho 8677156 Human
nag giant cell carcinoma of the lung By NAG enzyme assay, MNO was not cytotoxic and showed no synergism with BAM against PG cells, a cell line derived from a highly metastatic human giant cell carcinoma of the lung. 8701742 Human
nag necrosis For comparison, NAG was also quantitated in the following groups of non-BMT patients: (1) toxic/ischemic acute tubular necrosis (ATN) (N = 10); (2) jaundice without azotemia (N = 5); and (3) HRS (N = 6). 8749694 Human
nag granuloma Intraperitoneal administration of the test drugs, in rats subjected to inflammation, produced: (1) a significant inhibition of carrageenan-induced paw oedema, (2) a marked reduction of the paw oedema of the Freund's adjuvant arthritis animals, (3) a 8868057 Rat
nag bladder cancer Examples are; elevated serum AST/ALT ratio and methionine content in chronic schistosomiasis, elevated serum urea/creatinine ratio and leucine content in all schistosomal patients and extremely high levels of N-acetyl-beta-D-glucosaminidase (NAG) in the u 8875115 Human
nag breast cancer N-acetyl-beta-glucosaminidase (NAG) activity measured in sera from 129 breast cancer patients was elevated (mean 18.2 units/l) compared with that in sera from 28 healthy women (11.6 units/l) (p=0.001). 10427956 Human
nag tumour There was a weak correlation between NAG activity and carcinoembryonic antigen (CEA) and CA-153, but no relationship to age, menopausal status, node status, stage, histology of tumour or to steroid receptors. 10427956 Human
nag necrosis AIM: The study aimed at investigating urinary neopterin, a marker of cellular immune response, and urinary N-acetyl-beta-D-glucosaminidase (NAG), a marker of tubular damage, as noninvasive means to differentiate between acute tubular necrosis (ATN) and re 10720893 Human
nag granuloma Inflammation was assessed by measurement of NO and prostaglandin E2 (PGE2) levels and the lysosomal leakage of the enzyme N-acetyl-B-D-glucosaminidase (NAG) into the exudate of the granuloma pouch 4 h after carrageenan injection. 10858872 Human
nag granuloma Results of the study showed that the administration of either NG-nitro-L-arginine methyl ester (L-NAME, non-selective cNOS/iNOS inhibitor) or aminoguanidine (AG, selective iNOS inhibitor), prior to carrageenan injection or during development of adjuvant a 10858872 Rat
nag cancer No correlation was found between the 51Cr assay and the MTT assay (P>0.05) or the N-acetyl-beta-D-glycosaminidase (NAG) release assay (P>0.05) in 16 cancer patients. 11292477 Human
nag inflammatory bowel disease AIMS: To identify whether markers of early renal disease (urinary albumin, alpha-1-microglobulin [alpha-1-M] and N-acetyl-beta-D-glucosaminidase [NAG], and serum cystatin C) are useful in the assessment of renal function in inflammatory bowel disease pati 11472315 Human
nag tumor CONCLUSION: The reduction of MAB/C and NAG/C by Amifostin in group A demonstrates that: Amifostin is able to effectively protect the renal function, regardless of the type of tumor. 11977638 Human
nag ehrlich carcinoma The antitumor activity was studied in ascitic or solid Ehrlich carcinoma bearing mice while nephrotoxicity was monitored in male Wistar rats by means of histopathological findings of renal specimens and of biochemical investigation on urinary parameters ( 15223355 Human
nag tumor Using an in vivo tumor model, we report that thalidomide (100 mg kg(-1)day(-1)) or clotrimazole (120 mg kg(-1) day(-1)), inhibit blood vessel formation (determined by hemoglobin content), leukocyte recruitment [myeloperoxidase (MPO) activity; N-acetylgluc 15581054 Mouse
nag tumor Thalidomide was able to reduce the inflammatory reaction (MPO and NAG activities) by 50% to 70%, but was unable to delay tumor development. 15581054 Human
nag cancer In a previous study on cancer patients we have observed an increase in the urinary activity of N-acetyl-beta-D-glucosaminidase (NAG), an indicator of renal tubular cell dysfunction that was accompanied by increased urinary zinc loss. 15743027 Human
nag breast cancer Because an increase in NAG activity was reported after the treatment with anthracyclines, we hypothesized that an increase in urinary NAG activity in breast cancer patients treated with anthracycline-based regimens will be accompanied by hyperzincuria and 15743027 Human
nag breast cancer Urinary and serum zinc, urinary NAG and serum creatinine were examined during chemotherapy in 26 breast cancer patients treated with anthracycline-based chemotherapy. 15743027 Human
nag renal pelvic cancer To assess the value of endothelin-1 (ET-1) as a parameter of renal functional overload and the process of hyperfiltration, urinary excretion of ET-1-like immunoreactivity (U-ET-1) and urinary excretion of other parameters [beta 2-microglobulin (beta 2-MG) 8072606 Human
nag ureteral cancer To assess the value of endothelin-1 (ET-1) as a parameter of renal functional overload and the process of hyperfiltration, urinary excretion of ET-1-like immunoreactivity (U-ET-1) and urinary excretion of other parameters [beta 2-microglobulin (beta 2-MG) 8072606 Human
nag tumor Likewise, the inflammatory process in the muscle, as assessed by myeloperoxidase (MPO) and n-acethylglucosaminidase (NAG) activities and the levels of the chemokines, keratinocyte-derived chemokine (CXC1-3/KC) and macrophage-chemoattractant protein (CCL2/ 16313924 Mouse
nag neuroblastoma Urinary excretion of beta 2-microglobulin and N-acetyl-beta-D-glucosaminidase (NAG) were determined in eight patients with advanced neuroblastoma receiving cis-diamminedichloroplatinum(II) (CDDP). 3278937 Human
nag adenocarcinomas Twelve of 14 adenocarcinomas and 3 of 3 alveolar cell carcinomas contained activities of NAG in tumor tissue, whereas 16 of 17 epidermoid carcinomas and 4 of 4 large cell carcinomas showed negative findings. 3984403 Human
nag adenocarcinomas The fact that also non-differentiated solid adenocarcinomas, often in histological picture not to differentiate from large cell carcinomas or non-differentiated epidermoid carcinomas, exhibit NAG seems to be an useful aid in differential diagnosis between 3984403 Human
nag digestive neoplasms N-Acetyl-beta-glucosaminidase (NAG) and beta-glucuronidase were measured in the serum of 70 patients with breast and digestive-tract neoplasms and in 70 healthy subjects. 7860621 Human
nag necrosis [Evaluation of the liberation of urinary necrosis enzymes (NAG-AAP) after administration of plasma expanders: study of dextran 40, hydroxyethyl starch and polymerized gelatin] We studied the 24-hour urinary elimination of enzymatic markers of renal tubula 2483317 Human
nag lymphoma Pathologically elevated urinary NAG was noted in 38% of leukemia/lymphoma, 54% of solid tumor, 20% of WT survivors. 15390293 Human
nag leukemia Pathologically elevated urinary NAG was noted in 38% of leukemia/lymphoma, 54% of solid tumor, 20% of WT survivors. 15390293 Human
nag solid tumor Pathologically elevated urinary NAG was noted in 38% of leukemia/lymphoma, 54% of solid tumor, 20% of WT survivors. 15390293 Human
nag necrosis At 72 h, after treatment with any of the three nephrotoxicants, there was increased Kim-1 immunoreactivity and necrosis involving approximately 50% of the proximal tubules; however, only urinary Kim-1 was significantly increased, while BUN, serum creatini 17934191 Human

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