IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene HSD17B1 Ensembl ENSG00000108786 Chromosome 17 Start 37954758 End 37960750
Description Estradiol 17-beta-dehydrogenase 1 (EC 1.1.1.62)(17-beta-hydroxysteroid dehydrogenase type 1)(17-beta-HSD 1)(Placental 17-beta-hydroxysteroid dehydrogenase)(20 alpha-hydroxysteroid dehydrogenase)(20-alpha-HSD)(E2DH) [Source:UniProtKB/Swiss-Prot;Acc:P14061]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 5210
     Entrez Gene : 3292
     UCSC : uc002hzw.2
     GeneCards : 5210
     RefSeq : NM_000413
     CCDS : CCDS11428.1
     Uniprot : P14061
     Interpro : P14061
     OMIM : 109684
     GeneTests : HSD17B1
     CGAP : HSD17B1
     PMID : 2330005

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  33141_at  0.87  1.21e-7  9.79e-7  1.17  9.49e-7  5.97e-6
 HG_U95  602_s_at  0.41  4.05e-2  7.74e-2  0.59  3.23e-2  6.34e-2
 HG_U133A  205829_at  1.03  9.45e-9  2.99e-8  2.51  2.02e-30  3.41e-30
 HG_U133_Plus2  205829_at  1.15  9.35e-9  5.73e-8  1.97  5.24e-14  3.65e-13
 HG_U133_Plus2  228595_at  0.52  1.63e-10  1.26e-9  0.27  2.13e-2  3.27e-2
 Agilent_HS_21.6K  14739  0.28  1.98e-2  7.58e-2  0.68  3.40e-7  6.19e-6

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  205829_at  -1.23  2.96e-2  6.99e-1  -0.26  6.05e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 33141_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 602_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 205829_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 205829_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 228595_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 14739    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
hsd17b1 breast cancer Building a multigenic model of breast cancer susceptibility: CYP17 and HSD17B1 are two important candidates. 11212283 Human
hsd17b1 breast cancer We conducted a nested case-control study to evaluate whether polymorphisms in two genes involved in estrogen metabolism, CYP17 and HSD17B1, were useful in developing a breast cancer risk model that could help discriminate women who are at higher risk of b 11212283 Human
hsd17b1 breast cancer HSD17B1 gene polymorphisms and risk of endometrial and breast cancer. 14973105 Human
hsd17b1 breast cancer We hypothesized that genetic variations in HSD17B1 gene may alter endogenous estrogen levels and, thus, influence endometrial and breast cancer risk. 14973105 Human
hsd17b1 breast cancer We validated and genotyped polymorphisms in the HSD17B1 gene and assessed whether these single nucleotide polymorphisms (SNPs), or the imputed haplotypes, were associated with endometrial and breast cancer risk. 14973105 Human
hsd17b1 cancer We also assessed whether a priori risk factors modified the associations between HSD17B1 genotype and cancer risk, and whether HSD17B1 genotypes were associated with plasma estrogen levels among postmenopausal women not using hormone replacement therapy. 14973105 Human
hsd17b1 postmenopausal breast cancer These findings suggest that the HSD17B1 may be associated with circulating estradiol levels and interact with body mass index in postmenopausal breast cancer. 14973105 Human
hsd17b1 familial breast cancer TCFL4 (transcription factor like 4) is the HGMW-approved symbol for the gene of a widely expressed putative basic helix-loop-helix leucine-zipper (bHLH-zip) transcription factor which is located 3' to HSD17B1 (17-beta-hydroxysteroid dehydrogenase gen 8973301 Human
hsd17b1 primary breast cancer Amplification of HSD17B1 and ERBB2 in primary breast cancer. 12527905 Human
hsd17b1 breast cancer The aim of this study was to investigate if HSD17B1 shows an altered gene copy number in breast cancer. 12527905 Human
hsd17b1 breast tumors We used real-time PCR and examined 221 postmenopausal breast tumors for amplification of HSD17B1 and ERBB2. 12527905 Human
hsd17b1 tumors In all, 32 tumors (14.5%) showed amplification of HSD17B1 and 21% were amplified for ERBB2. 12527905 Human
hsd17b1 tumors Amplification of the two genes was correlated (P=0.00078) and in 14 tumors (44%) with amplification of HSD17B1, ERBB2 was co amplified. 12527905 Human
hsd17b1 breast cancer For estrogen receptor (ER)-positive patients who received adjuvant tamoxifen, amplification of HSD17B1 was related to decreased breast cancer survival (P=0.017), whereas amplification of ERRB2 was not. 12527905 Human
hsd17b1 breast cancer HSD17B1 and CYP17 polymorphisms and breast cancer risk among Chinese women in Singapore. 12584742 Human
hsd17b1 breast cancer We conducted a nested case-control study to investigate, within the Singapore Chinese Health Study Cohort, the relationships between polymorphisms in 2 genes involved in estrogen metabolism, CYP17 and HSD17B1, and the risk of breast cancer. 12584742 Human
hsd17b1 breast cancer In addition, the significant increased risk of breast cancer associated with nulliparity or late age at first live birth (age 31 years or older) was largely limited to women with the high-risk CYP17 A1A2/A2A2 or HSD17B1 AA genotypes (RR=2.41, 95% CI=1.56- 12584742 Human
edh17b2 tumors These tumors were examined for LOH using genetic markers flanking and within BRCA1, including THRA1, D17S856, EDH17B1, EDH17B2, and D17S183. 9816013 Human
edh17b2 sporadic breast cancer Human familial and sporadic breast cancer: analysis of the coding regions of the 17 beta-hydroxysteroid dehydrogenase 2 gene (EDH17B2) using a single-strand conformation polymorphism assay. 8125484 Human
edh17b2 familial breast cancer The gene encoding this enzyme, EDH17B2, has been mapped to chromosome 17, region q12-q21, in the vicinity of BRCA1, as as yet unidentified gene that appears to be involved in familial breast cancer and in familial ovarian cancer. 8125484 Human
edh17b2 familial ovarian cancer The gene encoding this enzyme, EDH17B2, has been mapped to chromosome 17, region q12-q21, in the vicinity of BRCA1, as as yet unidentified gene that appears to be involved in familial breast cancer and in familial ovarian cancer. 8125484 Human
edh17b2 hereditary breast cancer A point mutation in the putative TATA box, detected in nondiseased individuals and patients with hereditary breast cancer, decreases promoter activity of the 17 beta-hydroxysteroid dehydrogenase type 1 gene 2 (EDH17B2) in vitro. 7829082 Human
edh17b2 familial breast cancer EDH17B2, the gene encoding 17 beta-hydroxysteroid dehydrogenase type 1, has been suggested as a candidate for the familial breast cancer gene, BRCA1, located on 17q12-q21. 7829082 Human
edh17b2 familial breast cancer We analyzed the promoter region of EDH17B2 in DNA from 20 control individuals and 40 patients with familial breast cancer. 7829082 Human
edh17b2 hereditary breast-ovarian cancer The gene for hereditary breast-ovarian cancer, BRCA1, maps distal to EDH17B2 in chromosome region 17q12-q21. 7833928 Human
edh17b2 breast cancer Fifteen SNPs in the CYP17, CYP19, EDH17B2, SHBG, COMT, and CYP1B1 genes were genotyped in these postmenopausal women and in a breast cancer case-control study. 15199113 Human
edh17b2 breast-ovarian cancer syndrome Genetic mapping of the breast-ovarian cancer syndrome to a small interval on chromosome 17q12-21: exclusion of candidate genes EDH17B2 and RARA. 8401501 Human
edh17b2 breast-ovarian cancer We have typed 22 breast and breast-ovarian cancer families with eight polymorphisms from the chromosome 17q12-21 region, including two in the EDH17B2 gene. 8401501 Human
edh17b2 hereditary breast-ovarian cancer syndrome Mutations in the EDH17B2 gene, therefore do not appear to be responsible for the hereditary breast-ovarian cancer syndrome. 8401501 Human
hsd 17 choriocarcinoma [Regulation of human 17 beta-hydroxysteroid dehydrogenase type 1 expression by cyclic adenosine 3',5'-monophosphate in choriocarcinoma cells] Human 17 beta-hydroxysteroid dehydrogenase type 1 (17 HSD type 1), encoded by HSD 17 B 1 gene, is a ste 10684114 Human
hsd 17 choriocarcinoma The data provide the first evidence that HSD 17 B 1 gene transcription is activated by cAMP in choriocarcinoma cells. 10684114 Human
hsd17b1 breast cancer The genes included in the breast cancer model are the 17beta-hydroxysteroid dehydrogenase 1 (HSD17B1) gene, the cytochrome P459c17alpha (CYP17) gene, the aromatase (CYP19) gene, and the estrogen receptor alpha (ER) gene. 10688862 Human
hsd17b1 breast cancer When we evaluated breast cancer risk in relation to the joint stratification of CYP17 and HSD17B1 genotypes and according to the combined number of putative high-risk alleles (range, 0-4), we observed an elevated joint effect of the CYP17 and HSD17B1 gene 12584742 Human
hsd17b1 breast cancer Risk of breast cancer was similar among women possessing the other genotypes (i.e., less than 4 putative high-risk alleles in the joint CYP17/HSD17B1 genotypes). 12584742 Human
hsd17b1 prostate cancer Genetic Variation in the HSD17B1 Gene and Risk of Prostate Cancer. 16311626 Human
hsd17b1 prostate cancer Here we report on the results of a comprehensive study of the association between HSD17B1 and prostate cancer by the Breast and Prostate Cancer Cohort Consortium, a large collaborative study. 16311626 Human
hsd17b1 prostate cancer The Breast and Prostate Cancer Cohort Consortium researchers systematically characterized variation in HSD17B1 by targeted resequencing and dense genotyping; selected haplotype-tagging single nucleotide polymorphisms (htSNPs) that efficiently predict comm 16311626 Human
hsd17b1 prostate cancer We found no evidence that HSD17B1 htSNPs (including the nonsynonymous coding SNP S312G) or htSNP haplotypes were associated with risk of prostate cancer or tumor stage in the pooled multiethnic sample or in U.S. and European whites. 16311626 Human
hsd17b1 tumor We found no evidence that HSD17B1 htSNPs (including the nonsynonymous coding SNP S312G) or htSNP haplotypes were associated with risk of prostate cancer or tumor stage in the pooled multiethnic sample or in U.S. and European whites. 16311626 Human
hsd17b1 prostate cancer Analyses stratified by age, body mass index, and family history of disease found no subgroup-specific associations between these HSD17B1 htSNPs and prostate cancer. 16311626 Human
hsd17b1 prostate cancer We found significant evidence of heterogeneity in associations between HSD17B1 haplotypes and prostate cancer across ethnicity: one haplotype had a significant (p < 0.002) inverse association with risk of prostate cancer in Latinos and Japanese Americans 16311626 Human
hsd17b1 prostate cancer These results suggest that the germline variants in HSD17B1 characterized by these htSNPs do not substantially influence the risk of prostate cancer in U.S. and European whites. 16311626 Human
hsd17b1 breast cancer Haplotype Analysis of the HSD17B1 Gene and Risk of Breast Cancer: A Comprehensive Approach to Multicenter Analyses of Prospective Cohort Studies. 16489054 Human
hsd17b1 breast cancer Despite the important role of HSD17B1 in hormone metabolism, few epidemiologic studies of HSD17B1 and breast cancer have been conducted. 16489054 Human
hsd17b1 breast cancer We found no evidence of association between common HSD17B1 haplotypes or htSNPs and overall risk of breast cancer. 16489054 Human
hsd17b1 breast cancer HSD17B1 variants that are common in Caucasians are not associated with overall risk of breast cancer; however, there was an association among the subset of ER-negative tumors. 16489054 Human
hsd17b1 tumors HSD17B1 variants that are common in Caucasians are not associated with overall risk of breast cancer; however, there was an association among the subset of ER-negative tumors. 16489054 Human
edh17b2 breast and ovarian cancer We have typed 22 breast and breast-ovarian cancer families with eight polymorphisms from the chromosome 17q12-21 region, including two in the EDH17B2 gene. 8401501 Human
hsd17b1 mcf-7 human breast cancer In the present study, estrogen-dependent MCF-7 human breast cancer cells were stably transfected with an expression plasmid for human HSD17B1. 16916945 Human
hsd17b1 tumors The HSD17B1-expressing cells also formed estrogen-dependent tumors in immunodeficient nude mice. 16916945 Human
hsd17b1 tumor After treating the mice with an appropriate dose of the substrate (E1, 0.1 micromol/kg x d), a marked difference in tumor growth was observed between nontransfected and HSD17B1-transfected MCF-7 cells, mean tumor weights at the end of E1 treatment being 2 16916945 Human
hsd17b1 tumor After a 4-wk treatment, the tumor size was reduced by 59.8% as compared with the nontreated tumors, whereas the uterine growth of the mice was not affected by the HSD17B1 inhibitor used. 16916945 Human
hsd17b1 tumors After a 4-wk treatment, the tumor size was reduced by 59.8% as compared with the nontreated tumors, whereas the uterine growth of the mice was not affected by the HSD17B1 inhibitor used. 16916945 Human

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