IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene RAMP2 Ensembl ENSG00000131477 Chromosome 17 Start 38166731 End 38168585
Description Receptor activity-modifying protein 2 Precursor (Calcitonin-receptor-like receptor activity-modifying protein 2)(CRLR activity-modifying protein 2) [Source:UniProtKB/Swiss-Prot;Acc:O60895]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :
     HGNC : 9844
     Entrez Gene : 10266
     UCSC : uc002ibg.2
     GeneCards : 9844
     RefSeq : NM_005854
     CCDS : CCDS11437.1
     Uniprot : O60895
     Interpro : O60895
     OMIM : 605154
     GeneTests : RAMP2
     CGAP : RAMP2

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  38177_at  -2.35  9.33e-34  4.71e-31  -2.21  1.53e-26  1.13e-23
 HG_U133A  205779_at  -3.73  6.43e-98  2.75e-95  -2.24  1.04e-29  1.73e-29
 HG_U133_Plus2  205779_at  -2.01  4.54e-33  4.43e-31  -2.11  6.34e-20  8.69e-19
 Stanford  9486  -1.18  4.24e-4  8.35e-3  -1.64  5.41e-5  1.75e-3
 Agilent_HS_21.6K  17710  -0.30  1.92e-17  6.16e-15  -0.30  2.18e-15  5.37e-13

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  205779_at  0.79  1.36e-1  7.99e-1  0.09  7.83e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 38177_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 205779_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 205779_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 9486    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 17710    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
ramp2 glioblastoma In the present study we also demonstrate the presence of mRNA encoding the putative AM receptors, calcitonin receptor-like receptor/receptor activity-modifying protein-2 and -3 (CRLR/RAMP2; CRLR/RAMP3) in both glioma tissues and glioblastoma cell lines an 11943713 Human
ramp2 glioma In the present study we also demonstrate the presence of mRNA encoding the putative AM receptors, calcitonin receptor-like receptor/receptor activity-modifying protein-2 and -3 (CRLR/RAMP2; CRLR/RAMP3) in both glioma tissues and glioblastoma cell lines an 11943713 Human
ramp2 human neuroblastoma To explore possible pathophysiological roles of adrenomedullin and its receptor component RAMP2 in hypoxic tissues, we studied effects of hypoxia on expression of adrenomedullin and RAMP2 in two human neuroblastoma cell lines, IMR-32 and NB69, by radioimm 11754965 Human
ramp2 neuroblastoma These findings indicate that adrenomedullin expression is induced during hypoxia in IMR-32 and NB69 neuroblastoma cells, but RAMP2 expression is rather suppressed under the same conditions. 11754965 Human
ramp2 pheochromocytoma [Expression of adrenomedullin and its receptor mRNA in the tissues of normal adrenal medulla and pheochromocytoma] OBJECTIVE: To investigate the expression of human adrenomedullin (ADM) and its receptor-receptor activity modifying protein 2/calcitonin rec 16178438 Human
ramp2 pheochromocytoma RESULTS: Expressions of ADM and its receptor- RAMP2/CRLR mRNA were detected in normal adrenal medulla and pheochromocytoma tissues. 16178438 Human
ramp2 pheochromocytomas ADM/GAPDH were 0.48+/-0.09 and 0.75+/-0.24, RAMP2/ GAPDH 0.79+/-0.12 and 1.29+/-0.30, CRLR/GAPDH 0.40+/-0.08 and 0.87+/-0.22 in normal adrenal medulla and pheochromocytomas, respectively (P < 0.05). 16178438 Human
ramp2 pheochromocytoma This study investigates the expression of human adrenomedullin (ADM) and its receptor-receptor activity modifying protein 2/calcitonin receptor-like receptor (RAMP2/CRLR) mRNA in pheochromocytoma by reverse transcriptase polymerase chain reaction (RT-PCR) 17102095 Human
ramp2 pheochromocytoma The mRNA expression of ADM and its receptor RAMP2/CRLR was present in normal adrenal medulla and pheochromocytoma tissues. 17102095 Human
ramp2 pheochromocytomas The mRNA expression of ADM, RAMP2, and CRLR is markedly higher in pheochromocytomas than in normal medulla. 17102095 Human
receptor activity modifying protein 2 pheochromocytoma [Expression of adrenomedullin and its receptor mRNA in the tissues of normal adrenal medulla and pheochromocytoma] OBJECTIVE: To investigate the expression of human adrenomedullin (ADM) and its receptor-receptor activity modifying protein 2/calcitonin rec 16178438 Human
receptor activity modifying protein 2 pheochromocytoma This study investigates the expression of human adrenomedullin (ADM) and its receptor-receptor activity modifying protein 2/calcitonin receptor-like receptor (RAMP2/CRLR) mRNA in pheochromocytoma by reverse transcriptase polymerase chain reaction (RT-PCR) 17102095 Human
ramp2 pancreatic cancer By immunohistochemistry, ADM, CRLR, RAMP1 and RAMP2, but not RAMP3, were expressed in pancreatic cancer cells. 17290391 Human
ramp2 pancreatic cancer All 5 evaluated pancreatic cancer cells lines expressed ADM, CRLR, RAMP1 and RAMP2, whereas RAMP3 was expressed in only 1/5 pancreatic cancer cell lines. 17290391 Human
ramp2 lung cancer Frequent inactivation of RAMP2, EFEMP1 and Dutt1 in lung cancer by promoter hypermethylation. 17671114 Human
ramp2 lung cancer Pathologic and functional analyses were done to study the role of one candidate gene, receptor activity-modifying protein 2 (RAMP2), in suppressing lung cancer cell growth. 17671114 Human
ramp2 primary lung tumors Promoter hypermethylation of RAMP2, epidermal growth factor-containing fibulin-like extracellular matrix protein 1, and deleted in U Twenty Twenty cells was detected in 36% to 77% of 22 lung cancer cell lines and in 38% to 50% of 32 primary lung tumors, w 17671114 Human
ramp2 lung cancer Promoter hypermethylation of RAMP2, epidermal growth factor-containing fibulin-like extracellular matrix protein 1, and deleted in U Twenty Twenty cells was detected in 36% to 77% of 22 lung cancer cell lines and in 38% to 50% of 32 primary lung tumors, w 17671114 Human
ramp2 lung tumors Immunohistochemistry showed that RAMP2 was down-regulated in a majority of lung tumors, and RAMP2 down-regulation was correlated with high tumor grade. 17671114 Human
ramp2 tumor Immunohistochemistry showed that RAMP2 was down-regulated in a majority of lung tumors, and RAMP2 down-regulation was correlated with high tumor grade. 17671114 Human
ramp2 lung cancer Ectopic expression of RAMP2 inhibited lung cancer cell growth and caused apoptotic cell death. 17671114 Human
ramp2 adrenal tumors RT-PCR showed expression of AM2/IMD, CRLR, and RAMP1, RAMP2, and RAMP3 mRNA in tissues of adrenal tumors and attached adrenal glands. 18460550 Human

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