IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene BECN1 Ensembl ENSG00000126581 Chromosome 17 Start 38215678 End 38229807
Description Beclin-1 (Coiled-coil myosin-like BCL2-interacting protein)(Protein GT197) [Source:UniProtKB/Swiss-Prot;Acc:Q14457]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 1034
     Entrez Gene : 8678
     UCSC : uc002ibn.2
     GeneCards : 1034
     RefSeq : NM_003766
     CCDS : CCDS11441.1
     Uniprot : Q14457
     Interpro : Q14457
     OMIM : 604378
     GeneTests : BECN1
     CGAP : BECN1
     PMID : 9765397

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  39378_at  0.23  2.49e-5  1.18e-4  0.14  5.13e-2  9.36e-2
 HG_U133A  208945_s_at  0.40  3.59e-12  1.55e-11  -3.90  1.84e-73  6.43e-73
 HG_U133A  208946_s_at  0.54  1.13e-25  1.31e-24  -5.32  3.73e-111  3.46e-110
 HG_U133_Plus2  1561652_at  0.24  2.28e-1  3.09e-1  0.10  6.58e-1  7.07e-1
 HG_U133_Plus2  208945_s_at  0.29  7.60e-4  2.02e-3  0.09  2.77e-1  3.34e-1
 HG_U133_Plus2  208946_s_at  0.14  1.10e-2  2.23e-2  -0.15  3.20e-2  4.75e-2
 Stanford  8350  0.23  2.53e-1  4.52e-1  -0.03  9.01e-1  9.57e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  208945_s_at  -0.18  3.77e-1  8.96e-1  -0.16  1.51e-1  1.00e+0
 HG_U133A  208946_s_at  -0.06  6.98e-1  9.68e-1  -0.01  9.53e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 39378_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 208945_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 208946_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 1561652_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 208945_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 208946_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 8350    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
beclin 1 tumor Now two reports demonstrate that the autophagic gene, Beclin 1, is a haploinsufficient tumor suppressor gene. 14706333 Human
beclin 1 cancer The recent implication of tumor suppressors like Beclin 1, DAP-kinase and PTEN in autophagic pathways indicates a causative role for autophagy deficiencies in cancer formation. 15077152 Human
beclin 1 tumor The recent implication of tumor suppressors like Beclin 1, DAP-kinase and PTEN in autophagic pathways indicates a causative role for autophagy deficiencies in cancer formation. 15077152 Human
beclin 1 primary hepatocellular carcinoma Genes encoding Pir51, Beclin 1, RbAp48 and aldolase b are up or down-regulated in human primary hepatocellular carcinoma. 14966907 Human
beclin 1 liver tumor We identified 4 genes, the expression of three (Beclin 1, RbAp48 and Pir51) were increased and one (aldolase b) was decreased in liver tumor tissues. 14966907 Human
beclin 1 tumor Beclin 1 contains a leucine-rich nuclear export signal that is required for its autophagy and tumor suppressor function. 11309306 Human
beclin 1 breast and ovarian cancers Beclin 1 encodes a Bcl-2-interacting coiled-coil protein with autophagy and tumor suppressor function and is monoallelically deleted in 40-75% of sporadic human breast and ovarian cancers. 11309306 Human
beclin 1 tumor Beclin 1 encodes a Bcl-2-interacting coiled-coil protein with autophagy and tumor suppressor function and is monoallelically deleted in 40-75% of sporadic human breast and ovarian cancers. 11309306 Human
beclin 1 tumor Beclin 1 contains a leucine-rich nuclear export signal motif raising the possibility that its autophagy and/or tumor suppressor function may require regulated, CRM1-dependent, nucleocytoplasmic transport. 11309306 Human
beclin 1 human breast carcinoma In this study, we show that wild-type Beclin 1 colocalizes with both intracytoplasmic organelles and nuclei in COS7 monkey kidney and MCF7 human breast carcinoma cells. 11309306 Human
beclin 1 tumor Thus, beclin 1 has a leptomycin B-sensitive leucine-rich nuclear export signal that is required for its autophagy and tumor suppressor function. 11309306 Human
beclin 1 human breast cancers The mammalian gene encoding Beclin 1, a novel Bcl-2-interacting, coiled-coil protein, has structural similarity to the yeast autophagy gene, apg6/vps30, and is mono-allelically deleted in 40-75% of sporadic human breast cancers and ovarian cancers. 10604474 Human
beclin 1 ovarian cancers The mammalian gene encoding Beclin 1, a novel Bcl-2-interacting, coiled-coil protein, has structural similarity to the yeast autophagy gene, apg6/vps30, and is mono-allelically deleted in 40-75% of sporadic human breast cancers and ovarian cancers. 10604474 Human
beclin 1 breast carcinoma Here we show, using gene-transfer techniques, that beclin 1 promotes autophagy in autophagy-defective yeast with a targeted disruption of agp6/vps30, and in human MCF7 breast carcinoma cells. 10604474 Human
beclin 1 carcinoma Furthermore, endogenous Beclin 1 protein expression is frequently low in human breast epithelial carcinoma cell lines and tissue, but is expressed ubiquitously at high levels in normal breast epithelia. 10604474 Human
beclin 1 human breast carcinoma Thus, beclin 1 is a mammalian autophagy gene that can inhibit tumorigenesis and is expressed at decreased levels in human breast carcinoma. 10604474 Human
beclin 1 tumor Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21. 10395800 Human
beclin 1 prostate cancer Previous studies indicate that beclin 1 maps to a region approximately 150 kb centromeric to BRCA1 on chromosome 17q21 that is commonly deleted in breast, ovarian, and prostate cancer. 10395800 Human
beclin 1 human breast carcinoma FISH analysis of human breast carcinoma cell lines using PAC 452O8 as probe identified allelic beclin 1 deletions in 9 of 22 cell lines. 10395800 Human
beclin 1 human breast carcinoma These results indicate that human breast carcinoma cell lines frequently contain allelic deletions of beclin 1, but not beclin 1 coding mutations. 10395800 Human
beclin 1 tumor Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. 14657337 Mouse
beclin 1 tumors These tumors continue to express wild-type beclin 1 mRNA and protein, establishing that beclin 1 is a haploinsufficient tumor suppressor gene. 14657337 Mouse
beclin 1 tumor These tumors continue to express wild-type beclin 1 mRNA and protein, establishing that beclin 1 is a haploinsufficient tumor suppressor gene. 14657337 Mouse
beclin 1 tumor These results demonstrate that beclin 1 is a critical component of mammalian autophagy and establish a role for autophagy in tumor suppression. 14657337 Mouse
beclin 1 cancer They both provide a biological explanation for recent evidence implicating beclin 1 in human cancer and suggest that mutations in other genes operating in this pathway may contribute to tumor formation through deregulation of autophagy. 14657337 Mouse
beclin 1 tumor They both provide a biological explanation for recent evidence implicating beclin 1 in human cancer and suggest that mutations in other genes operating in this pathway may contribute to tumor formation through deregulation of autophagy. 14657337 Mouse
beclin 1 prostate cancer The beclin 1 autophagy gene is monoallelically deleted in 40-75% of cases of human sporadic breast, ovarian, and prostate cancer. 14638851 Human
beclin 1 tumors Molecular analyses of tumors in beclin 1 heterozygous mice show that the remaining wild-type allele is neither mutated nor silenced. 14638851 Mouse
beclin 1 tumor These findings demonstrate that beclin 1 is a haplo-insufficient tumor-suppressor gene and provide genetic evidence that autophagy is a novel mechanism of cell-growth control and tumor suppression. 14638851 Mouse
beclin 1 cancers Thus, mutation of beclin 1 or other autophagy genes may contribute to the pathogenesis of human cancers. 14638851 Human
beclin 1 epithelial carcinoma Furthermore, endogenous Beclin 1 protein expression is frequently low in human breast epithelial carcinoma cell lines and tissue, but is expressed ubiquitously at high levels in normal breast epithelia. 10604474 Human
beclin 1 tumor [Analysis of cell cycle inhibition by novel tumor suppressor gene Beclin 1 in human colon cancer cells] 14574891 Human
beclin 1 human colon cancer [Analysis of cell cycle inhibition by novel tumor suppressor gene Beclin 1 in human colon cancer cells] 14574891 Human
beclin 1 human gastric cancer Here, we show that overexpression of Beclin 1 in MKN28 human gastric cancer cells augmented cis-diamminedichloroplatinum (CDDP)-induced apoptosis. 15922724 Human
beclin 1 tumour Beclin 1, an autophagic protein, has been found to be a tumour suppressor. 16001423 Human
beclin 1 tumor Furthermore, restoration of normal levels of beclin 1, an autophagy-inducing tumor suppressor gene that is monoallelically deleted in MCF-7 cells, greatly enhanced the EB1089-induced nuclear changes and cell death. 15905882 Human
beclin 1 tumor Surprisingly, tumor cells depleted for Beclin 1 failed to proliferate suggesting that even though the monoallelic depletion of beclin 1 in human cancer cells suppresses EB1089-induced autophagic death, one intact beclin 1 allele is essential for tumor cel 15905882 Human
beclin 1 cancer Surprisingly, tumor cells depleted for Beclin 1 failed to proliferate suggesting that even though the monoallelic depletion of beclin 1 in human cancer cells suppresses EB1089-induced autophagic death, one intact beclin 1 allele is essential for tumor cel 15905882 Human
vps30 human breast cancers The mammalian gene encoding Beclin 1, a novel Bcl-2-interacting, coiled-coil protein, has structural similarity to the yeast autophagy gene, apg6/vps30, and is mono-allelically deleted in 40-75% of sporadic human breast cancers and ovarian cancers. 10604474 Human
vps30 ovarian cancers The mammalian gene encoding Beclin 1, a novel Bcl-2-interacting, coiled-coil protein, has structural similarity to the yeast autophagy gene, apg6/vps30, and is mono-allelically deleted in 40-75% of sporadic human breast cancers and ovarian cancers. 10604474 Human
vps30 breast carcinoma Here we show, using gene-transfer techniques, that beclin 1 promotes autophagy in autophagy-defective yeast with a targeted disruption of agp6/vps30, and in human MCF7 breast carcinoma cells. 10604474 Human

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