IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene PSME3 Ensembl ENSG00000131467 Chromosome 17 Start 38238949 End 38249301
Description Proteasome activator complex subunit 3 (Proteasome activator 28 subunit gamma)(PA28gamma)(PA28g)(Activator of multicatalytic protease subunit 3)(11S regulator complex subunit gamma)(REG-gamma)(Ki nuclear autoantigen) [Source:UniProtKB/Swiss-Prot;Acc:P61289]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 9570
     Entrez Gene : 10197
     UCSC : uc002ibr.2
     GeneCards : 9570
     RefSeq : NM_005789
     CCDS : CCDS11442.1
     Uniprot : P61289
     Interpro : P61289
     OMIM : 605129
     GeneTests : PSME3
     CGAP : PSME3
     PMID : 7951316

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  39796_at  -0.09  4.21e-1  5.28e-1  0.14  2.91e-1  3.94e-1
 HG_U133A  200987_x_at  0.72  1.68e-29  2.53e-28  0.41  2.22e-11  2.84e-11
 HG_U133A  200988_s_at  -0.04  5.59e-1  6.10e-1  1.41  4.96e-71  1.65e-70
 HG_U133A  209852_x_at  0.25  3.68e-9  1.21e-8  -1.29  6.98e-17  9.69e-17
 HG_U133A  209853_s_at  0.53  4.28e-16  2.50e-15  0.60  3.08e-10  3.87e-10
 HG_U133_Plus2  200987_x_at  0.73  6.00e-11  4.91e-10  0.81  1.97e-15  1.62e-14
 HG_U133_Plus2  200988_s_at  0.09  2.57e-1  3.41e-1  0.25  8.94e-3  1.47e-2
 HG_U133_Plus2  209852_x_at  0.62  3.04e-17  5.32e-16  1.08  2.63e-21  4.24e-20
 HG_U133_Plus2  209853_s_at  0.63  9.12e-6  3.50e-5  0.61  3.88e-6  1.05e-5
 Stanford  2329  0.45  5.16e-2  1.59e-1  0.41  7.89e-2  2.32e-1
 Agilent_HS_21.6K  15026  0.05  8.36e-2  2.08e-1  0.10  5.10e-3  2.08e-2

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  200987_x_at  0.13  6.18e-1  9.54e-1  -0.16  2.41e-1  1.00e+0
 HG_U133A  200988_s_at  -0.24  3.41e-1  8.87e-1  0.18  5.35e-1  1.00e+0
 HG_U133A  209852_x_at  0.07  6.97e-1  9.68e-1  -0.02  8.95e-1  1.00e+0
 HG_U133A  209853_s_at  -0.15  5.54e-1  9.41e-1  -0.09  4.20e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 39796_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 200987_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 200988_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 209852_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 209853_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 200987_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 200988_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 209852_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 209853_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 2329    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 15026    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
pa28-gamma thyroid neoplasms In this paper, we show the abnormally high expression of PA28-gamma in various thyroid neoplasms. 12629132 Human
pa28-gamma cancer In all of the papillary adenocarcinoma samples, PA28-gamma was abnormally overexpressed, especially in cancer cells existing at the peripheral region of the cancer mass or in cancer cells invading the capsular region surrounding the cancer mass. 12629132 Human
pa28-gamma papillary adenocarcinoma In all of the papillary adenocarcinoma samples, PA28-gamma was abnormally overexpressed, especially in cancer cells existing at the peripheral region of the cancer mass or in cancer cells invading the capsular region surrounding the cancer mass. 12629132 Human
pa28-gamma cancer In cancer cells of these areas, PA28-gamma was predominantly distributed in nucleus rather than in the cytoplasm of cancer cells. 12629132 Human
pa28-gamma papillary adenocarcinoma In multinodular goiter, the expression of PA28-gamma was relatively low compared with papillary adenocarcinoma. 12629132 Human
pa28-gamma anaplastic carcinoma In anaplastic carcinoma, PA28-gamma was expressed at the highest level, especially in poorly differentiated regions such as squamous metaplasia of anaplastic cancer tissue. 12629132 Human
pa28-gamma metaplasia In anaplastic carcinoma, PA28-gamma was expressed at the highest level, especially in poorly differentiated regions such as squamous metaplasia of anaplastic cancer tissue. 12629132 Human
pa28-gamma anaplastic cancer In anaplastic carcinoma, PA28-gamma was expressed at the highest level, especially in poorly differentiated regions such as squamous metaplasia of anaplastic cancer tissue. 12629132 Human
pa28-gamma cancer Therefore, the PA28-gamma expression seems to be restricted to thyroid cancer cells, especially in the region where the growth rate of cancer cells is accelerated. 12629132 Human
pa28-gamma thyroid cancer Therefore, the PA28-gamma expression seems to be restricted to thyroid cancer cells, especially in the region where the growth rate of cancer cells is accelerated. 12629132 Human
pa28-gamma thyroid cancer These results demonstrate that PA28-gamma is overexpressed in thyroid cancer, especially in its growth-accelerated cells. 12629132 Human
ki antigen meningiomas The proliferating potential of these meningiomas was evaluated by the immunostaining of an antigen only present in proliferating cells (Ki antigen). 1595392 Human
proteasome thyroid neoplasm Abnormally high expression of proteasome activator-gamma in thyroid neoplasm. 12629132 Human

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