IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene AOC3 Ensembl ENSG00000131471 Chromosome 17 Start 38256727 End 38263664
Description Membrane primary amine oxidase (EC 1.4.3.21)(Copper amine oxidase)(Semicarbazide-sensitive amine oxidase)(SSAO)(Vascular adhesion protein 1)(VAP-1)(HPAO) [Source:UniProtKB/Swiss-Prot;Acc:Q16853]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 550
     Entrez Gene : 8639
     UCSC : uc002ibv.2
     GeneCards : 550
     RefSeq : NM_003734
     CCDS : CCDS11444.1
     Uniprot : Q16853
     Interpro : Q16853
     OMIM : 603735
     GeneTests : AOC3
     CGAP : AOC3
     PMID : 9653080

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  33756_at  -2.27  7.40e-28  1.44e-25  -3.04  1.62e-22  3.25e-20
 HG_U133A  204894_s_at  -2.54  6.64e-100  3.21e-97  -2.19  1.20e-73  4.18e-73
 HG_U133_Plus2  204894_s_at  -2.75  7.11e-51  5.55e-48  -3.14  4.38e-40  8.41e-38
 Stanford  18955  -1.57  4.99e-4  9.23e-3  -2.54  1.12e-5  5.77e-4
 Agilent_HS_21.6K  4716  -0.17  6.39e-7  1.67e-5  -0.18  3.66e-4  2.35e-3

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  204894_s_at  0.33  4.03e-1  9.02e-1  -0.23  4.73e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 33756_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 204894_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 204894_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 18955    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 4716    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
vascular adhesion protein 1 inflammatory bowel disease Circulating soluble vascular adhesion protein 1 in patients with inflammatory bowel disease. 11943954 Human
vap-1 inflammatory bowel disease Since vascular adhesion protein 1 (VAP-1) is one of the adhesion molecules that mediates lymphocyte binding to endothelium, we investigated the levels of soluble VAP-1 (sVAP-1) in the sera of inflammatory bowel disease (IBD) patients compared with healthy 11943954 Human
vascular adhesion protein 1 inflammatory bowel disease Since vascular adhesion protein 1 (VAP-1) is one of the adhesion molecules that mediates lymphocyte binding to endothelium, we investigated the levels of soluble VAP-1 (sVAP-1) in the sera of inflammatory bowel disease (IBD) patients compared with healthy 11943954 Human
vascular adhesion protein 1 tumor Vascular adhesion protein 1 mediates binding of immunotherapeutic effector cells to tumor endothelium. 11359855 Human
vap-1 cancer Here, we studied whether VAP-1 is involved in binding of TIL, lymphokine-activated killer (LAK) cells, and NK cells to vasculature of the cancer tissue. 11359855 Human
vap-1 cancer We demonstrated that VAP-1 is expressed on the endothelium of cancer vasculature. 11359855 Human
vap-1 cancer Using an in vitro adhesion assay we showed that VAP-1 mediates adhesion of TIL, LAK, and NK cells to cancer vasculature. 11359855 Human
vap-1 tumor Thus, by up-regulating the expression of VAP-1 in tumor vasculature, it can be possible to improve the effectiveness of TIL therapy. 11359855 Human
vap-1 leiomyoma In tumors, VAP-1 is retained on all leiomyoma cells, whereas it is lost in half of leiomyosarcoma samples. 10595925 Human
vap-1 tumors In tumors, VAP-1 is retained on all leiomyoma cells, whereas it is lost in half of leiomyosarcoma samples. 10595925 Human
vap-1 leiomyosarcoma In tumors, VAP-1 is retained on all leiomyoma cells, whereas it is lost in half of leiomyosarcoma samples. 10595925 Human
vascular adhesion protein-1 human hepatocellular carcinoma Vascular adhesion protein-1 and ICAM-1 support the adhesion of tumor-infiltrating lymphocytes to tumor endothelium in human hepatocellular carcinoma. 9558106 Human
vascular adhesion protein-1 tumor Vascular adhesion protein-1 and ICAM-1 support the adhesion of tumor-infiltrating lymphocytes to tumor endothelium in human hepatocellular carcinoma. 9558106 Human
vap-1 tumor In HCC, an intense T cell infiltrate is observed within the tumor associated with strong expression of ICAM-1 and vascular adhesion protein-1 (VAP-1) on tumor endothelium. 9558106 Human
vascular adhesion protein-1 tumor In HCC, an intense T cell infiltrate is observed within the tumor associated with strong expression of ICAM-1 and vascular adhesion protein-1 (VAP-1) on tumor endothelium. 9558106 Human
vap-1 tumors In contrast, fewer T cells infiltrated CHM and these tumors have little ICAM-1 and no detectable VAP-1 or VCAM-1 on tumor endothelium. 9558106 Human
vap-1 tumor In contrast, fewer T cells infiltrated CHM and these tumors have little ICAM-1 and no detectable VAP-1 or VCAM-1 on tumor endothelium. 9558106 Human
vap-1 tumor In vitro tissue-binding studies demonstrated that T cells bound readily to tumor endothelium in HCC, and Abs to ICAM-1, VAP-1, and to a lesser extent VCAM-1 could inhibit this binding. 9558106 Human
vap-1 tumor The strong expression of VAP-1 on tumor endothelium distinguishes HCC from CHM and supports our previous hypothesis that VAP-1 is an important hepatic endothelial adhesion molecule. 9558106 Human
vascular adhesion protein-1 human hepatocellular carcinoma Vascular adhesion protein-1 and intercellular adhesion molecule-1 mediate T-cell binding to human hepatocellular carcinoma. 9191301 Human
vap-1 inflammatory bowel diseases At sites of inflammation, such as in inflammatory bowel diseases and chronic dermatoses, expression of VAP-1 is clearly increased. 8245796 Human
hpao tumor Importantly, hPAO demonstrates the ability to oxidize a subset of antitumor polyamine analogues, suggesting that this oxidase activity could have a significant effect on determining tumor sensitivity to these or similar agents. 15791459 Human
vap-1 hcc In HCC, an intense T cell infiltrate is observed within the tumor associated with strong expression of ICAM-1 and vascular adhesion protein-1 (VAP-1) on tumor endothelium. 9558106 Human
vap-1 hcc In vitro tissue-binding studies demonstrated that T cells bound readily to tumor endothelium in HCC, and Abs to ICAM-1, VAP-1, and to a lesser extent VCAM-1 could inhibit this binding. 9558106 Human
vap-1 hcc The strong expression of VAP-1 on tumor endothelium distinguishes HCC from CHM and supports our previous hypothesis that VAP-1 is an important hepatic endothelial adhesion molecule. 9558106 Human
vap-1 ibd Since vascular adhesion protein 1 (VAP-1) is one of the adhesion molecules that mediates lymphocyte binding to endothelium, we investigated the levels of soluble VAP-1 (sVAP-1) in the sera of inflammatory bowel disease (IBD) patients compared with healthy 11943954 Human
vap-1 skin melanoma In this study we analysed the expression of an adhesion molecule--vascular adhesion protein-1 (VAP-1)--in melanoma-associated blood vessels in 28 primary skin melanoma cases using immunocytochemistry and immunoelectron microscopy. 15057044 Human
vap-1 tumour We have found that VAP-1 protein expression is significantly decreased in intratumoral vessels compared with peritumoral ones; this difference was independent of the tumour thickness. 15057044 Human
vap-1 other cancer Unlike in other cancer types, the VAP-1 protein expression of intratumoral vessels did not correlate with the density of cytotoxic T-lymphocytes or dendritic cells. 15057044 Human
vap-1 melanoma On the other hand, the 5-year survival of melanoma patients with low VAP-1 protein expression in intratumoral blood vessels (< or =25%) was lower (26.3%) than in patients whose VAP-1 expression was higher (42.6%, P=0.0632). 15057044 Human
vap-1 neoplasms Here, current knowledge of the importance of VAP-1 in the pathogenesis of several diseases, including inflammatory bowel and liver diseases, skin diseases, some neoplasms, as well as the reaction of graft rejection is presented. 15928600 Human
vascular adhesion protein-1 hcc In HCC, an intense T cell infiltrate is observed within the tumor associated with strong expression of ICAM-1 and vascular adhesion protein-1 (VAP-1) on tumor endothelium. 9558106 Human
vascular adhesion protein-1 skin melanoma Loss of vascular adhesion protein-1 expression in intratumoral microvessels of human skin melanoma. 15057044 Human
vascular adhesion protein-1 skin melanoma In this study we analysed the expression of an adhesion molecule--vascular adhesion protein-1 (VAP-1)--in melanoma-associated blood vessels in 28 primary skin melanoma cases using immunocytochemistry and immunoelectron microscopy. 15057044 Human
vascular adhesion protein 1 ibd Since vascular adhesion protein 1 (VAP-1) is one of the adhesion molecules that mediates lymphocyte binding to endothelium, we investigated the levels of soluble VAP-1 (sVAP-1) in the sera of inflammatory bowel disease (IBD) patients compared with healthy 11943954 Human

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