IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene G6PC Ensembl ENSG00000131482 Chromosome 17 Start 38306341 End 38318912
Description Glucose-6-phosphatase (G-6-Pase)(G6Pase)(EC 3.1.3.9)(Glucose-6-phosphatase alpha)(G6Pase-alpha) [Source:UniProtKB/Swiss-Prot;Acc:P35575]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 4056
     Entrez Gene : 2538
     UCSC : uc002icb.1
     GeneCards : 4056
     RefSeq : NM_000151
     CCDS : CCDS11446.1
     Uniprot : P35575
     Interpro : P35575
     OMIM : 232200
     GeneTests : G6PC
     CGAP : G6PC
     PMID : 7774924

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  36241_r_at  0.05  8.37e-1  8.85e-1  -0.75  5.26e-2  9.56e-2
 HG_U133A  206952_at  -0.69  1.47e-4  2.99e-4  3.06  1.73e-44  3.59e-44
 HG_U133_Plus2  1555612_s_at  0.11  5.96e-1  6.75e-1  0.76  1.43e-3  2.68e-3
 HG_U133_Plus2  206952_at  -0.08  7.17e-1  7.80e-1  -0.19  4.44e-1  5.05e-1
 Stanford  21194  -0.89  2.51e-2  1.16e-1  -0.45  2.38e-1  4.72e-1
 Agilent_HS_21.6K  12379  0.00  8.86e-1  9.37e-1  0.01  8.23e-1  8.91e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  206952_at  -1.33  2.11e-2  6.83e-1  0.24  5.55e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 36241_r_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 206952_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 1555612_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 206952_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 21194    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 12379    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
g6pc hepatocellular carcinoma Some genotype-phenotype correlations exist, for example, homozygosity for one G6PC mutation, G188R, seems to be associated with a glycogen storage disease type I non-a phenotype and homozygosity for the 727G>T mutation may be associated with a milder phen 12373566 Human
gsd 1a hepatic adenomas We report on a 42-year-old female patient with glycogen storage disease type 1a (von Gierke disease, GSD 1a) who developed hepatic adenomas and finally a hepatocellular carcinoma 10 years after renal transplantation. 11477366 Human
gsd 1a hepatocellular carcinoma We report on a 42-year-old female patient with glycogen storage disease type 1a (von Gierke disease, GSD 1a) who developed hepatic adenomas and finally a hepatocellular carcinoma 10 years after renal transplantation. 11477366 Human
gsd1a liver neoplasms BACKGROUND AND AIMS: A few cases are reported of liver neoplasms observed in patients with glycogen storage disease type 1a (GSD1a). 11851840 Human
gsd1a hepatic tumors Genetic analysis was carried out in adult Japanese patients with GSD1a and their family members, and hepatic tumors were also investigated in these patients. 11851840 Human
gsd1a liver tumors This is the first study of liver tumors in a large group of adult GSD1a patients with the G727T mutation. 11851840 Human
gsd-1a hepatoblastoma Clinical and histologic details of the two siblings with type 1a glycogen storage disease (GSD-1a) who developed hepatoblastoma are presented. 3030527 Human
gsd1a hepatocellular carcinoma (hcc) A 40-year-old man with glycogen storage disease type 1a (von Gierke disease, GSD1a) developed hepatocellular carcinoma (HCC). 10385064 Human
gsd1a hcc Given the prevalence of HCC in GSD1a with various germline mutations, analysis is needed to confirm that the germline mutation in this case is really related to hepatocarcinogenesis. 10385064 Human
gsd 1a imt In different multivariate models, GSD 1a remained an independent predictor for a thinner IMT (R(2)=0.90; beta=-0.69; P=0.018). 12373574 Human

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