IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene ETV4 Ensembl ENSG00000175832 Chromosome 17 Start 38960738 End 38979288
Description ETS translocation variant 4 (Adenovirus E1A enhancer-binding protein)(E1A-F) [Source:UniProtKB/Swiss-Prot;Acc:P43268]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 3493
     Entrez Gene : 2118
     UCSC : uc002idw.2
     GeneCards : 3493
     RefSeq : NM_001079675
     CCDS : CCDS11465.1
     Uniprot : P43268
     Interpro : P43268
     OMIM : 600711
     GeneTests : ETV4
     CGAP : ETV4
     PMID : 8530053

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  2084_s_at  2.08  2.27e-15  7.71e-14  1.76  5.58e-8  4.48e-7
 HG_U133A  211603_s_at  1.68  1.27e-22  1.20e-21  1.64  4.10e-33  7.16e-33
 HG_U133_Plus2  1554576_a_at  2.02  5.61e-22  1.61e-20  2.06  4.15e-16  3.70e-15
 HG_U133_Plus2  211603_s_at  2.40  1.93e-29  1.25e-27  2.26  3.83e-16  3.43e-15
 Stanford  5880  1.25  1.35e-2  7.80e-2  1.53  2.48e-2  1.16e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  211603_s_at  -0.64  2.28e-1  8.46e-1  -0.34  3.10e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 2084_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 211603_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 1554576_a_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 211603_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 5880    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
pea3 human breast carcinomas Moreover, there was a significant association of immunocytochemical staining for OPN and one of beta-catenin, Ets-1, Ets-2, PEA3, or c-Jun, in the 29 human breast carcinomas tested. 14990565 Human
pea3 human breast cancer Clinical significance of PEA3 in human breast cancer. 11821815 Human
pea3 breast cancer BACKGROUND: Recently, PEA3 has been reported to suppress HER-2/neu overexpression by promoter activity and thereby inhibit tumorigenesis of breast cancer both in vitro and in vivo. 11821815 Human
pea3 breast cancer METHODS: The expression of PEA3 and the clinicopathologic features of 89 patients with breast cancer were investigated. 11821815 Human
pea3 lymph-node metastasis RESULTS: The correlation between the expression of PEA3 and the clinicopathologic features were nil with regard to lymph node metastasis, hormone receptor, blood vessel invasion, and lymphatic vessel invasion. 11821815 Human
pea3 breast cancer CONCLUSIONS: The expression of PEA3 in breast cancer might therefore be a novel prognostic factor. 11821815 Human
pea3 breast cancer Cyclooxygenase-2 is overexpressed in HER-2/neu-positive breast cancer: evidence for involvement of AP-1 and PEA3. 11901151 Human
pea3 tumors The PEA3 subfamily of Ets transcription factors synergizes with beta-catenin-LEF-1 to activate matrilysin transcription in intestinal tumors. 11158322 Human
pea3 tumors Furthermore, all matrilysin-expressing benign intestinal tumors of the Min mouse expressed a member of the PEA3 subfamily, as did all human colon tumor cell lines examined. 11158322 Human
pea3 human colon tumor Furthermore, all matrilysin-expressing benign intestinal tumors of the Min mouse expressed a member of the PEA3 subfamily, as did all human colon tumor cell lines examined. 11158322 Human
pea3 tumors These data suggest that the expression of members of the PEA3 subfamily, in conjunction with the accumulation of beta-catenin in these tumors, leads to coordinate upregulation of matrilysin gene transcription, contributing to gastrointestinal tumorigenesi 11158322 Human
pea3 tumor Expression of E1AF/PEA3 (ETV4), an ets family transcriptional factor, has been implicated in tumor progression through induction of matrix metalloproteinase (MMP) expression. 14604892 Human
etv4 tumor Expression of E1AF/PEA3 (ETV4), an ets family transcriptional factor, has been implicated in tumor progression through induction of matrix metalloproteinase (MMP) expression. 14604892 Human
pea3 breast tumors To better obtain a molecular characterization of PEA3 expression in sporadic breast cancer, we quantified PEA3 mRNA by means of real-time reverse transcriptase-polymerase chain reaction assay in a large series of human primary breast tumors. 14633660 Human
pea3 sporadic breast cancer To better obtain a molecular characterization of PEA3 expression in sporadic breast cancer, we quantified PEA3 mRNA by means of real-time reverse transcriptase-polymerase chain reaction assay in a large series of human primary breast tumors. 14633660 Human
pea3 tumor PEA3 expression showed wide variations in tumor tissues, being under-expressed in 30 of 130 (23.1%) and over-expressed in 18 of 130 (13.8%) compared with normal breast tissues. 14633660 Human
pea3 tumor High PEA3 mRNA levels correlated significantly with Scarff-Bloom-Richardson histopathological grade III (P = 0.018) but not with poor prognosis, suggesting that PEA3 is a marker of tumor aggressiveness rather than a prognostic factor in human breast cance 14633660 Human
pea3 human breast cancer High PEA3 mRNA levels correlated significantly with Scarff-Bloom-Richardson histopathological grade III (P = 0.018) but not with poor prognosis, suggesting that PEA3 is a marker of tumor aggressiveness rather than a prognostic factor in human breast cance 14633660 Human
pea3 tumors Our results do not support recent findings suggesting that PEA3 could be a tumor-suppressor gene that can act therapeutically in ERBB2 over-expressed tumors. 14633660 Human
pea3 breast cancer Our results also suggest major roles of the MMP2, NRG1 and CGB genes (which encode type I gelatinase, heregulin and human chorionic gonadotropin beta subunit, respectively) in the PEA3 pathway dysregulation observed in breast cancer. 14633660 Human
pea3 cancers The ets family paralogues Fli-1 and Elf-1 were also highly expressed in adenocarcinoma cells of the majority of cancers, while Erg 1,2 and Ets-2 were expressed in a minority of cancers and Elk-1, PEA3 and PU.1 were minimally expressed. 11334730 Human
pea3 adenocarcinoma The ets family paralogues Fli-1 and Elf-1 were also highly expressed in adenocarcinoma cells of the majority of cancers, while Erg 1,2 and Ets-2 were expressed in a minority of cancers and Elk-1, PEA3 and PU.1 were minimally expressed. 11334730 Human
pea3 tumors Consistent with this, PEA3 is up-regulated in Wnt1-expressing mouse mammary epithelial cells, and PEA3 factors are highly expressed in tumors from Wnt1 transgenic mice, in which Cox-2 is also up-regulated. 11274170 Mouse
pea3 colorectal cancer 275, 33951-33956), and PEA3 factors are highly expressed in colorectal cancer cell lines. 11274170 Human
pea3 breast tumors PEA3 is overexpressed in the vast majority of human breast tumors and in nearly all of the HER2-positive subclass of such tumors. 11467448 Human
pea3 tumors PEA3 is overexpressed in the vast majority of human breast tumors and in nearly all of the HER2-positive subclass of such tumors. 11467448 Human
pea3 human non-small-cell lung cancers Expression of E1AF/PEA3, an Ets-related transcription factor in human non-small-cell lung cancers: its relevance in cell motility and invasion. 11519038 Human
pea3 breast tumors BACKGROUND: The PEA3 Ets transcription factor is overexpressed in the vast majority of human breast tumors and in nearly all of those of the HER2/Neu-positive subclass. 11719215 Human
pea3 tumors Expression of a dominant-negative pea3 transgene under the control of the MMTV promoter in mammary epithelial cells of MMTV-neu transgenic mice dramatically delayed the onset of mammary tumors and reduced the number and size of such tumors in individual m 11719215 Mouse
pea3 tumors Those tumors that arose in bitransgenic mice expressed the MMTV-neu transgene, but not the MMTV-dominant-negative pea3 transgene. 11719215 Mouse
pea3 breast cancer Hence, agents that inhibit the expression or activity of the PEA3 subfamily proteins may prove efficacious in the treatment of breast cancer. 11719215 Mouse
pea3 cancer Expression of PEA3 resulted in preferential inhibition of cell growth and tumor development of HER-2/neu-overexpressing cancer cells. 10655108 Human
pea3 tumor Expression of PEA3 resulted in preferential inhibition of cell growth and tumor development of HER-2/neu-overexpressing cancer cells. 10655108 Human
pea3 cancer Our findings document the importance of both AP1 and PEA3 transcription factors in mediating basal and elevated expression of PEG-3 in H5ts125-transformed rat embryo cells displaying an aggressive and progressed cancer phenotype. 10918598 Human
pea3 mouse mammary tumors In fact, PEA3 group members are over-expressed in metastatic human breast cancer cells and mouse mammary tumors, a feature which suggests a function of these transcription factors in mammary oncogenesis. 10959416 Mouse
pea3 metastatic human breast cancer In fact, PEA3 group members are over-expressed in metastatic human breast cancer cells and mouse mammary tumors, a feature which suggests a function of these transcription factors in mammary oncogenesis. 10959416 Human
pea3 carcinoma These results suggest that EGF plays also an important role in MMP-7 production of TE-9 cells and that there is a difference not only in EGF-intracellular signaling system but also in regulation mechanisms of MMP-7 transcription by beta-catenin-Tcf and/or 12851697 Human
pea3 hepatoma PEA3 and AP-1 are required for constitutive IL-8 gene expression in hepatoma cells. 11112434 Human
pea3 tumor It is possible PEA3 may have important roles in tumor progression and in angiogenesis in HCC. 11112434 Human
pea3 breast cancer In addition to previously described erbB2-regulating breast cancer Ets factors (PEA3, ESX/Elf-3), Elf-1 is now shown to be another endogenously expressed Ets candidate capable of binding to and upregulating the erbB2 promoter. 11175365 Human
pea3 breast tumors Indeed PEA3, ETS-1, PDEF, and ELF-3 transcripts have all been reported to be elevated in human breast tumors. 14635793 Human
pea3 mouse mammary tumors Notably, pea3, as well as its close paralogs er81 and erm, which comprise the pea3 subfamily of ets genes, are coordinately overexpressed in mouse mammary tumors. 14635793 Mouse
pea3 mouse mammary tumors Genetic analyses in mice reveal required roles for one or more of the PEA3 subfamily Ets proteins in the initiation and progression of mouse mammary tumors. 14635793 Mouse
pea3 embryonal carcinoma A PEA3 site flanked by SP1, SP4, and GATA sites positively regulates the differentiation-dependent expression of Brachyury in embryonal carcinoma P19 cells. 9920775 Human
pea3 cancer The region upstream of the human meprin beta' transcription start site contained elements with homology to the promoters of intestine-specific genes, interspersed with AP-1 and PEA3 elements; the latter were essential to meprin beta' promoter ac 10190276 Human
pea3 breast tumors We have reported that PEA3, an Ets family transcription factor, is overexpressed in HER2/Neu-induced breast tumors and their metastases. 9467955 Human
pea3 metastases We have reported that PEA3, an Ets family transcription factor, is overexpressed in HER2/Neu-induced breast tumors and their metastases. 9467955 Human
pea3 tumors To account for the increased levels of PEA3 in these tumors we have suggested that HER2/Neu enhances PEA3 transcriptional activity, which then acts to stimulate expression of the PEA3 gene. 9467955 Human
pea3 ovarian carcinoma PEA3 is the second Ets family transcription factor involved in tumor progression in ovarian carcinoma. 12684413 Human
pea3 tumor PEA3 is the second Ets family transcription factor involved in tumor progression in ovarian carcinoma. 12684413 Human
pea3 ovarian carcinomas PURPOSE: The purpose of this study was to analyze the possible correlation between PEA3 mRNA expression and survival in advanced-stage ovarian carcinomas, studying two patient groups with extremely different disease outcome. 12684413 Human
pea3 ovarian carcinoma EXPERIMENTAL DESIGN: Sections from 61 primary ovarian carcinomas and metastatic lesions from 36 patients diagnosed with advanced-stage ovarian carcinoma [International Federation of Gynecologists and Obstetricians (FIGO) stages III-IV] were evaluated for 12684413 Human
pea3 primary ovarian carcinomas EXPERIMENTAL DESIGN: Sections from 61 primary ovarian carcinomas and metastatic lesions from 36 patients diagnosed with advanced-stage ovarian carcinoma [International Federation of Gynecologists and Obstetricians (FIGO) stages III-IV] were evaluated for 12684413 Human
pea3 carcinoma Expression of PEA3 mRNA was detected in carcinoma cells and stromal cells in 56 of 61 lesions (92%) and 54 of 61 lesions (89%), respectively. 12684413 Human
pea3 carcinoma PEA3 expression in stromal cells showed a significant association with matrix metalloproteinase 2 mRNA expression in carcinoma cells (P = 0.022). 12684413 Human
pea3 carcinoma PEA3 expression in carcinoma cells showed an association with mRNA expression of the beta(1) integrin subunit in the same compartment (P = 0.039). 12684413 Human
pea3 carcinoma PEA3 mRNA was detected more often in both carcinoma and stromal cells in tumors of short-term survivors (P = 0.021 for stromal cells). 12684413 Human
pea3 tumors PEA3 mRNA was detected more often in both carcinoma and stromal cells in tumors of short-term survivors (P = 0.021 for stromal cells). 12684413 Human
pea3 tumor In univariate survival analysis, PEA3 expression in stromal cells correlated with both shorter disease-free survival (P = 0.019) and overall survival (P = 0.029), whereas tumor cell expression predicted poor overall survival (P = 0.049). 12684413 Human
pea3 ovarian carcinoma PEA3 is thus a novel prognostic marker in advanced-stage ovarian carcinoma. 12684413 Human
pea3 ovarian carcinoma The association between PEA3 mRNA expression and the expression of the beta(1) integrin subunit, basic fibroblast growth factor, and EMMPRIN, first documented in our patient cohort, points to the central role of this transcription factor in tumor progress 12684413 Human
pea3 tumor The association between PEA3 mRNA expression and the expression of the beta(1) integrin subunit, basic fibroblast growth factor, and EMMPRIN, first documented in our patient cohort, points to the central role of this transcription factor in tumor progress 12684413 Human
etv4 tumors Long PCR and sequence analysis of genomic DNA revealed that either exon 8 or intron 7 of EWSR1 is fused to the same intron of ETV4 in both tumors. 9858836 Human
pea3 mammary adenocarcinomas Recently, transgenic mice bearing the c-erbB-2/neu oncogene have been shown to over-express PEA3 mRNA in mammary adenocarcinomas, suggesting a role for this gene family in mammary tumorigenesis. 9052761 Mouse
pea3 human breast cancer Although the target genes of the PEA3 group of transcription factors in breast-cancer cells have yet to be determined, these genes have a potential role in the regulation of growth and the progression of human breast cancer. 9052761 Human
pea3 ovarian carcinomas Fifty-five primary and metastatic FIGO stage III-IV ovarian carcinomas were analyzed for the expression of alpha v and beta1 integrin subunits, the matrix metalloproteinases MMP-2, MMP-9, and MT1-MMP, the MMP inhibitor TIMP-2, vascular endothelial growth 12716042 Human
pea3 carcinoma Alpha v integrin subunit mRNA expression in carcinoma cells showed significant association with that of MMP-2 and IL-8 in this cellular compartment, while the presence of beta1 integrin subunit mRNA showed similar association with that of PEA3, Ets-1, IL- 12716042 Human
pea3 carcinoma The presence of beta1 integrin subunit mRNA in carcinoma cells showed a significant association with that of Ets-1, IL-8 and bFGF in stromal cells, while the presence of beta1 integrin subunit mRNA in stromal cells was associated with tumor PEA3 mRNA expr 12716042 Human
pea3 tumor The presence of beta1 integrin subunit mRNA in carcinoma cells showed a significant association with that of Ets-1, IL-8 and bFGF in stromal cells, while the presence of beta1 integrin subunit mRNA in stromal cells was associated with tumor PEA3 mRNA expr 12716042 Human
pea3 ovarian carcinoma They also suggest the existence of a putative activation sequence of metastatic genes, involving the beta1 (and possibly alpha v) integrin subunits, IL-8, PEA3, Ets-1 and MMP in ovarian carcinoma. 12716042 Human
pea3 human breast cancer HER2/Neu and the Ets transcription activator PEA3 are coordinately upregulated in human breast cancer. 9380403 Human
pea3 breast tumor Here we report that transcripts of PEA3, an ETS transcription factor implicated in oncogenesis, were increased in 93% of HER2/Neu-overexpressing human breast tumor samples. 9380403 Human
pea3 breast tumors Analyses to uncover the molecular basis for elevated PEA3 transcripts in HER2/Neu-positive breast tumors revealed that the HER2/Neu receptor tyrosine kinase initiated an intracellular signaling cascade resulting in increased PEA3 transcriptional activity; 9380403 Human
pea3 tumor PEA3 also activates transcription of genes encoding matrix-degrading proteinases, enzymes required for tumor cell migration and invasion. 9380403 Human
pea3 breast cancer These findings implicate PEA3 in the initiation and progression of HER2/Neu positive breast cancer, and suggest that PEA3 and signaling proteins affecting its regulation are appropriate therapeutic targets. 9380403 Human
e1a-f ewing's sarcoma A novel chimera gene between EWS and E1A-F, encoding the adenovirus E1A enhancer-binding protein, in extraosseous Ewing's sarcoma. 8605035 Human
e1a-f ewing's sarcoma Since E1A-F is known to activate matrix metalloproteinase genes, the chimera gene may possibly be involved in tumor progression and could be a novel tumor marker for Ewing's sarcoma/PNET. 8605035 Human
e1a-f tumor Since E1A-F is known to activate matrix metalloproteinase genes, the chimera gene may possibly be involved in tumor progression and could be a novel tumor marker for Ewing's sarcoma/PNET. 8605035 Human
pea3 tumor PEA3 transactivates the Muc4/sialomucin complex promoter in mammary epithelial and tumor cells. 12855694 Human
pea3 mammary adenocarcinoma Up-regulation of the Muc4/SMC gene in the 13762 sublines of the rat mammary adenocarcinoma correlates with the overexpression of transcription factor PEA3 and the receptor tyrosine kinase ErbB2. 12855694 Rat
e1a-f tumor E1A-F mRNA was demonstrated to be highly expressed in HSC 3 and SAS by Northern blotting, and in situ hybridization confirmed E1A-F mRNA expression at the invasion front of tumor cells seeded on collagen gel. 8774124 Human
e1a-f oral squamous-cell carcinoma These results suggest that the ets-related E1A-F participates in the regulation of invasion-associated MMP genes and is involved in presenting invasive activity in tumor cells of oral squamous cell carcinoma. 8774124 Human
e1a-f tumor These results suggest that the ets-related E1A-F participates in the regulation of invasion-associated MMP genes and is involved in presenting invasive activity in tumor cells of oral squamous cell carcinoma. 8774124 Human
pea3 tumor PEA3 transactivates vimentin promoter in mammary epithelial and tumor cells. 8895512 Mouse
pea3 mouse mammary tumor Since the promoters of human and mouse vimentin genes contain one PEA3 binding site we investigated the ability of PEA3 to transactivate the vimentin promoter in mouse mammary epithelial cell CLS1, mouse mammary tumor MMT and human mammary tumor cell line 8895512 Human
e1a-f metastasis These results suggest that E1A-F positively regulates transcriptions from matrix metalloproteinase genes that are associated with invasion and metastasis of tumor cells. 7731700 Human
e1a-f tumor These results suggest that E1A-F positively regulates transcriptions from matrix metalloproteinase genes that are associated with invasion and metastasis of tumor cells. 7731700 Human
pea3 cancer Expression of E1AF/PEA3 (ETV4), an ets family transcription factor, has been implicated in the invasive potential of several cancer cell lines through induction of matrix metalloproteinase (MMP) expression. 12898592 Human
etv4 cancer Expression of E1AF/PEA3 (ETV4), an ets family transcription factor, has been implicated in the invasive potential of several cancer cell lines through induction of matrix metalloproteinase (MMP) expression. 12898592 Human
pea3 breast cancer UV cross-linking and immunoprecipitation implicate a approximately 60-kDa ETS protein, and candidate ETS genes expressed in these breast cancer cells include GABP alpha, elk-1, elf-1, and PEA3. 7914192 Human
pea3 embryonic carcinoma Analysis of transcription factors binding to the duplicated PEA1 and PEA3 sites that are required for polyomavirus mutant expression in PCC4 embryonic carcinoma cells. 8388487 Human
pea3 tumors Both PEA3 factors and c-jun were highly expressed in tumors from Wnt1 transgenic mice and may therefore contribute to the increased Twist expression observed in these tumors. 12702582 Mouse
pea3 mammary adenocarcinomas PEA3 is overexpressed in mouse metastatic mammary adenocarcinomas. 7692372 Mouse
pea3 tumor We have investigated the expression of PEA3, a new member of the ets oncogene family of transcriptional regulatory factors, in neu-induced mammary tumors to learn whether PEA3 plays a role in tumor progression in this organ. 7692372 Human
pea3 tumors We observed high levels of PEA3 RNA in neu-induced tumors, but little, if any, PEA3 RNA in the surrounding mammary epithelium. 7692372 Mouse
pea3 metastasis These findings suggest that enhanced expression of PEA3 may be required to facilitate mammary tumor progression and metastasis. 7692372 Mouse
pea3 embryonal carcinoma Because many developmentally regulated cellular genes have PEA3 motifs near their promoter sequences, and because Ets family gene products activate the PEA3 motif, we have studied the expression of PEA3-binding proteins and Ets-related proteins during dif 1569949 Human
pea3 hepatoma Both the PEA3--AP-1 element, the AP-1 site and the COM are required for efficient phorbol ester induction of transcription from the uPA promoter in the HepG2 hepatoma cell line. 1330539 Human
e1a-f extraosseous ewing's sarcoma A novel chimera gene between EWS and E1A-F, encoding the adenovirus E1A enhancer-binding protein, in extraosseous Ewing's sarcoma. 8605035 Human
e1a-f pnet Since E1A-F is known to activate matrix metalloproteinase genes, the chimera gene may possibly be involved in tumor progression and could be a novel tumor marker for Ewing's sarcoma/PNET. 8605035 Human
e1a-f ca On the other hand, KB and Ca 9.22 have little potential for invasion, and MMP-1 and MMP-9 protein and E1A-F mRNA could not be detected. 8774124 Human
e1a-f neoplasia E1A-F is overexpressed early in human colorectal neoplasia and associated with cyclooxygenase-2 and matrix metalloproteinase-7. 15800927 Human
e1a-f colorectal cancer (crc) However, the role of E1A-F, the human homolog of murine PEA3, in colorectal cancer (CRC) development has not been elucidated. 15800927 Human
e1a-f carcinomas In this study, we used real-time reverse transcription (RT)-polymerase chain reaction (PCR) to measure the levels of E1A-F, COX-2, and MMP-7 in matched normal mucosa, adenomas, and/or carcinomas from 128 patients. 15800927 Human
e1a-f adenomas In this study, we used real-time reverse transcription (RT)-polymerase chain reaction (PCR) to measure the levels of E1A-F, COX-2, and MMP-7 in matched normal mucosa, adenomas, and/or carcinomas from 128 patients. 15800927 Human
e1a-f carcinomas Our results demonstrate significant overexpression of E1A-F and MMP-7 in adenomas and E1A-F, COX-2, and MMP-7 in carcinomas. 15800927 Human
e1a-f adenomas Our results demonstrate significant overexpression of E1A-F and MMP-7 in adenomas and E1A-F, COX-2, and MMP-7 in carcinomas. 15800927 Human
e1a-f carcinomas In carcinomas, E1A-F expression was significantly associated with both COX-2 and MMP-7 overexpression. 15800927 Human
pea-3 glioma Using human uPA promoter chloramphenicol acetyl transferase (CAT) constructs with mutations of the AP-1 element at -1967 or the PEA-3 cis element at -1973, the activity of the uPA promoter was decreased 4-fold to 10-fold in all three human glioma cell lin 11115541 Human
pea-3 glioblastoma The region spanning -144 to -123 bp of the human uPAR promoter that contains the Sp-1 site and a PEA-3 element and an AP-1 site at -184 plays major roles in uPAR promoter activity in glioblastoma cells. 11234878 Human
pea3 mammary tumors We have investigated the expression of PEA3, a new member of the ets oncogene family of transcriptional regulatory factors, in neu-induced mammary tumors to learn whether PEA3 plays a role in tumor progression in this organ. 7692372 Human
pea3 mammary tumors Moreover, mammary tumors that had metastasized to the lung also overexpressed the PEA3 gene, whereas normal lung tissue did not. 7692372 Mouse
pea3 mammary tumor These findings suggest that enhanced expression of PEA3 may be required to facilitate mammary tumor progression and metastasis. 7692372 Mouse
pea3 mammary cancer [Transcription factors of the PEA3 group in mammary cancer] Prognosis factors such as mutated or amplified oncogenes are used in the treatment of breast cancer. 8597501 Human
pea3 tumors We have recently shown that the members of the PEA3 group (ER81, ERM and PEA3) from the transcription factor family of the ets genes are overexpressed in breast cancer tumors arising from MMTV-neu transgenic animals. 8597501 Mouse
pea3 breast cancer We have recently shown that the members of the PEA3 group (ER81, ERM and PEA3) from the transcription factor family of the ets genes are overexpressed in breast cancer tumors arising from MMTV-neu transgenic animals. 8597501 Mouse
pea3 mammary cancer Moreover, we have shown that ER81, and in a lesser extent ERM and PEA3, are not expressed in the estrogen and/or progesterone receptor-positive mammary cancer cell lines, whereas they are expressed in the receptor negative ones. 8597501 Human
pea3 mammary tumor Since the promoters of human and mouse vimentin genes contain one PEA3 binding site we investigated the ability of PEA3 to transactivate the vimentin promoter in mouse mammary epithelial cell CLS1, mouse mammary tumor MMT and human mammary tumor cell line 8895512 Human
pea3 mammary tumors In metastatic mammary tumors derived from mice carrying the polyoma middle T or neu transgene, PEA3 is overexpressed and vimentin has been shown to play a key role in the motility of cells. 8895512 Mouse
pea3 mammary tumors Our results suggest that one of the roles of PEA3 in mammary tumor is to participate the activation of vimentin gene whose gene product in turn contributes to the metastatic potential of mammary tumors. 8895512 Human
pea3 mammary tumor Our results suggest that one of the roles of PEA3 in mammary tumor is to participate the activation of vimentin gene whose gene product in turn contributes to the metastatic potential of mammary tumors. 8895512 Human
pea3 tumor cell migration PEA3 also activates transcription of genes encoding matrix-degrading proteinases, enzymes required for tumor cell migration and invasion. 9380403 Human
pea3 mammary tumour Transcription factor PEA3, encoded by a member of the ets oncogene family, activates the vimentin promoter in mammary tumour cells. 9769935 Human
pea3 hcc Moreover, PEA3 and IL-8 proteins coexisted in HCC tissues, but not in uninvolved liver tissues. 11112434 Human
pea3 hcc It is possible PEA3 may have important roles in tumor progression and in angiogenesis in HCC. 11112434 Human
pea3 tumor In a preclinical gene therapy setting, in which the PEA3 gene tumor delivery was facilitated by a cationic liposome DC-Chol, blocked HER-2/neu overexpression by PEA3 resulted in prolonged survival of treated animals. 12845342 Human
pea3 intestinal tumors The PEA3 subfamily of Ets transcription factors synergizes with beta-catenin-LEF-1 to activate matrilysin transcription in intestinal tumors. 11158322 Human
pea3 benign intestinal tumors Furthermore, all matrilysin-expressing benign intestinal tumors of the Min mouse expressed a member of the PEA3 subfamily, as did all human colon tumor cell lines examined. 11158322 Mouse
pea3 malignancy PEA3 is similarly overexpressed in transgenic mouse models of this malignancy. 11467448 Mouse
pea3 mammary tumors Expression of dominant-negative PEA3 in the mouse mammary gland of MMTV-HER2 transgenic mice dramatically delays the onset and reduces the incidence of mammary tumors. 11467448 Mouse
pea3 mammary tumors RESULTS: Here, we report that each of the three highly related ets genes of the pea3 subfamily (pea3, er81, and erm) were coordinately overexpressed in mammary tumors of MMTV-neu transgenic mice. 11719215 Mouse
pea3 mammary tumors Expression of a dominant-negative pea3 transgene under the control of the MMTV promoter in mammary epithelial cells of MMTV-neu transgenic mice dramatically delayed the onset of mammary tumors and reduced the number and size of such tumors in individual m 11719215 Mouse
pea3 mammary tumors The PEA3 group members PEA3, ER81 and ERM, which are highly conserved transcription factors from the Ets family, are over-expressed in metastatic mammary tumors. 12054346 Human
pea3 malignancy CONCLUSIONS: To the best of our knowledge, this is the first evidence associating PEA3 mRNA expression and poor survival in human epithelial malignancy. 12684413 Human
pea3 mammary tumors These data suggest that expression of PEA3 in mammary tumors leads to up-regulation of Muc4/SMC transcription, the gene product of which may contribute to the metastatic potential of mammary tumors. 12855694 Human
pea3 mammary tumors Comparison of Ets factor expression in normal mammary tissue and mammary tumors identified significantly elevated expression of Pse/PDEF, Ese2/Elf5, Ese3/Ehf, TEL/Etv6, and Elf2/NERF in mammary tumors and confirmed previously reported alterations in expre 14662758 Human
pea3 breast carcinoma The clinical role of the PEA3 transcription factor in ovarian and breast carcinoma in effusions. 15387369 Human
pea3 breast carcinoma The objective of this study was to investigate the role of PEA3 in tumor progression of ovarian and breast carcinoma metastatic to effusions, and to evaluate the expression of Ets-2 and Erg in ovarian carcinoma. 15387369 Human
pea3 tumor The objective of this study was to investigate the role of PEA3 in tumor progression of ovarian and breast carcinoma metastatic to effusions, and to evaluate the expression of Ets-2 and Erg in ovarian carcinoma. 15387369 Human
pea3 ovarian carcinoma The objective of this study was to investigate the role of PEA3 in tumor progression of ovarian and breast carcinoma metastatic to effusions, and to evaluate the expression of Ets-2 and Erg in ovarian carcinoma. 15387369 Human
pea3 carcinomas Ovarian (83 malignant effusions, 102 corresponding solid lesions) and breast (33 malignant effusions, 40 corresponding solid lesions) carcinomas were evaluated for expression of PEA3 using mRNA in situ Hybridization (ISH). 15387369 Human
pea3 ovarian carcinoma PEA3 mRNA expression was comparable at all sites in ovarian carcinoma (44 out of 83; 53% of effusions, 48 out of 102; 47% of solid tumors). 15387369 Human
pea3 solid tumors PEA3 mRNA expression was comparable at all sites in ovarian carcinoma (44 out of 83; 53% of effusions, 48 out of 102; 47% of solid tumors). 15387369 Human
pea3 breast carcinoma In breast carcinoma, PEA3 expression was seen in 19/40 (48%) of solid lesions, with a significant upregulation in corresponding effusions compared to primary tumors (24 out of 33; 73%, P = 0.038). 15387369 Human
pea3 primary tumors In breast carcinoma, PEA3 expression was seen in 19/40 (48%) of solid lesions, with a significant upregulation in corresponding effusions compared to primary tumors (24 out of 33; 73%, P = 0.038). 15387369 Human
pea3 serous ovarian cancer In conclusion, PEA3 is expressed at all anatomic sites in serous ovarian cancer and co-localizes with Erg, Ets-2 and several metastasis-associated molecules. 15387369 Human
pea3 breast carcinoma PEA3 mRNA expression is a novel marker for tumor progression to malignant effusion in breast carcinoma, and predicts poor outcome in effusions sampled prior to therapeutic intervention in ovarian carcinoma. 15387369 Human
pea3 tumor PEA3 mRNA expression is a novel marker for tumor progression to malignant effusion in breast carcinoma, and predicts poor outcome in effusions sampled prior to therapeutic intervention in ovarian carcinoma. 15387369 Human
pea3 ovarian carcinoma PEA3 mRNA expression is a novel marker for tumor progression to malignant effusion in breast carcinoma, and predicts poor outcome in effusions sampled prior to therapeutic intervention in ovarian carcinoma. 15387369 Human
pea3 resistant breast cancer Expression of SRC-1, AIB1, and PEA3 in HER2 mediated endocrine resistant breast cancer; a predictive role for SRC-1. 15452162 Human
pea3 breast cancer AIM: To determine whether insensitivity to endocrine treatment in HER2 positive patients is associated with enhanced expression of coactivator proteins, expression of the HER2 transcriptional regulator, PEA3, and coregulatory proteins, AIB1 and SRC-1, was 15452162 Human
pea3 breast tumours METHODS: PEA3, AIB1, and SRC-1 protein expression in 70 primary breast tumours of known HER2 status (HER2 positive, n = 35) and six reduction mammoplasties was assessed using immunohistochemistry. 15452162 Human
pea3 breast tumours RESULTS: In primary breast tumours expression of PEA3, AIB1, and SRC-1 was associated with HER2 status (p = 0.0486, p = 0.0444, and p = 0.0012, respectively). 15452162 Human
pea3 pancreatic cancer The antagonistic regulation of human MUC4 and ErbB-2 genes by the Ets protein PEA3 in pancreatic cancer cells: implications for the proliferation/differentiation balance in the cells. 15461591 Human
pea3 pancreatic cancer Our aim was to investigate in parallel the role of the Ets factor PEA3 in MUC4 and ErbB-2 transcriptional regulation in pancreatic cancer cells. 15461591 Human
pea3 pancreatic cancer These results suggest that MUC4 is a new target gene of the Ets factor PEA3 in pancreatic cancer cells. 15461591 Human
pea3 pancreatic cancer Thus, PEA3, by its capacity to up-regulate the epithelial marker MUC4 and to down-regulate the ErbB-2 oncogene, appears as a key regulator of the differentiation/proliferation balance in pancreatic cancer cells. 15461591 Human
pea3 breast cancer By transfecting a PEA3 expression vector into breast cancer cell lines MDA-MB-415 and MCF-7, we determined that exogenous PEA3 was able to drive transcription. 15754128 Human
pea3 tumor These three factors belong to the PEA3 subfamily and are known to mediate diverse functions ranging from neuronal development to tumor progression. 15855628 Human
pea3 colorectal cancer (crc) However, the role of E1A-F, the human homolog of murine PEA3, in colorectal cancer (CRC) development has not been elucidated. 15800927 Human

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