IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene MPP3 Ensembl ENSG00000161647 Chromosome 17 Start 39233693 End 39266064
Description MAGUK p55 subfamily member 3 (Protein MPP3)(Discs large homolog 3) [Source:UniProtKB/Swiss-Prot;Acc:Q13368]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 7221
     Entrez Gene : 4356
     UCSC : uc002iei.3
     GeneCards : 7221
     RefSeq : NM_001932
     CCDS : CCDS42344.1
     Uniprot : Q13368
     Interpro : Q13368
     OMIM : 601114
     GeneTests : MPP3
     CGAP : MPP3
     PMID : 8824795

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  39684_at  -0.13  3.15e-1  4.20e-1  -0.03  8.56e-1  8.97e-1
 HG_U133A  206186_at  -0.29  6.36e-7  1.67e-6  -3.27  2.39e-63  6.83e-63
 HG_U133_Plus2  206186_at  0.16  2.90e-1  3.77e-1  0.87  5.44e-7  1.65e-6
 Stanford  11501  0.18  5.67e-1  7.33e-1  0.05  8.77e-1  9.45e-1
 Stanford  22529  0.73  1.91e-2  9.76e-2  0.76  2.95e-2  1.18e-1
 Agilent_HS_21.6K  21116  -0.08  4.09e-1  5.94e-1  -0.01  9.43e-1  9.67e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  206186_at  -0.11  5.17e-1  9.34e-1  0.11  4.27e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 39684_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 206186_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 206186_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 11501    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 22529    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 21116    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
dlg3 cancers Ten genes [macrophage inhibitory cytokine-1, CGD, fibronectin (FN), hypoxia-inducible factor 1, Fc-epsilon-receptor gamma-chain, lactate dehydrogenase A, HLA-DBP1, AH receptor, tissue inhibitor of metalloproteinase (TIMP-1), and glycyl-tRNA-synthetase] we 12538453 Human
mpp3 tumor Association of a lung tumor suppressor TSLC1 with MPP3, a human homologue of Drosophila tumor suppressor Dlg. 13679854 Human
mpp3 tumor Here, we report that TSLC1 directly associates with MPP3, one of the human homologues of a Drosophila tumor suppressor gene, Discs large (Dlg). 13679854 Human
mpp3 lung cancer These results suggest that TSLC1 and MPP3 are involved in the same cascade of cell-cell interaction, and that the disruption of this cascade might lead cells to malignant growth and tumor formation in lung cancer. 13679854 Human
mpp3 tumor These results suggest that TSLC1 and MPP3 are involved in the same cascade of cell-cell interaction, and that the disruption of this cascade might lead cells to malignant growth and tumor formation in lung cancer. 13679854 Human
mpp3 lung tumor Association of a lung tumor suppressor TSLC1 with MPP3, a human homologue of Drosophila tumor suppressor Dlg. 13679854 Human
mpp3 nsclc The MPP3 gene was expressed in normal lung as well as in many tissues examined except for peripheral blood lymphocytes but lost its expression in one of the nine NSCLC cell lines. 13679854 Human

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