IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene PYY Ensembl ENSG00000131096 Chromosome 17 Start 39385637 End 39437363
Description Peptide YY Precursor (PYY)(PYY-I)(Peptide tyrosine tyrosine) [Contains Peptide YY(3-36)(PYY-II)] [Source:UniProtKB/Swiss-Prot;Acc:P10082]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 9748
     Entrez Gene : 5697
     UCSC : uc002ieq.2
     GeneCards : 9748
     RefSeq : NM_004160
     CCDS : CCDS32662.1
     Uniprot : P10082
     Interpro : P10082
     OMIM : 600781
     GeneTests : PYY
     CGAP : PYY
     PMID : 7782089

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  36449_s_at  0.80  1.64e-6  1.02e-5  1.09  3.35e-6  1.88e-5
 HG_U95  36450_at  0.68  7.46e-4  2.42e-3  1.14  5.97e-5  2.51e-4
 HG_U133A  207080_s_at  -0.16  3.41e-1  3.96e-1  3.32  6.75e-60  1.82e-59
 HG_U133A  211253_x_at  0.08  5.25e-1  5.78e-1  -0.74  1.74e-7  2.09e-7
 HG_U133_Plus2  207080_s_at  0.44  3.42e-2  6.03e-2  -0.22  2.81e-1  3.38e-1
 HG_U133_Plus2  211253_x_at  0.45  2.99e-3  6.98e-3  1.17  1.61e-11  8.46e-11
 Agilent_HS_21.6K  12551  0.04  1.80e-1  3.49e-1  0.02  3.67e-1  5.28e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  207080_s_at  -0.58  1.66e-1  8.15e-1  -0.01  9.77e-1  1.00e+0
 HG_U133A  211253_x_at  0.81  2.27e-2  6.83e-1  0.16  4.84e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 36449_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 36450_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 207080_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 211253_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 207080_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 211253_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 12551    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
peptide yy cancer Peptide YY and cancer: current findings and potential clinical applications. 11825654 Human
pyy colon adenocarcinoma PYY has been identified in several carcinoid tumors and a decreased expression of PYY may be relevant to the development and progression of colon adenocarcinoma. 11825654 Human
pyy breast tumors Treatment with PYY decreases growth in pancreatic and breast tumors, most likely through a reduction in intracellular cAMP. 11825654 Human
pyy cancer In cancer patients, PYY may also improve malnutrition that results from iatrogenic causes or cachexia associated with advanced disease. 11825654 Human
pyy cancer PYY plays a significant role in multiple aspects of cancer from regulation of cell growth to potential therapeutic applications. 11825654 Human
pyy colorectal carcinoma PYY does not seem to be involved in colorectal carcinoma. 11825655 Human
peptide yy cancer The gastrointestinal hormone peptide YY (PYY) has growth inhibitory activity against multiple cancer cell lines and is synergistic with ATS against breast and pancreatic cancer growth. 12069504 Human
pyy cancer The gastrointestinal hormone peptide YY (PYY) has growth inhibitory activity against multiple cancer cell lines and is synergistic with ATS against breast and pancreatic cancer growth. 12069504 Human
peptide yy pancreatic cancer The gastrointestinal hormone peptide YY (PYY) has growth inhibitory activity against multiple cancer cell lines and is synergistic with ATS against breast and pancreatic cancer growth. 12069504 Human
pyy pancreatic cancer The gastrointestinal hormone peptide YY (PYY) has growth inhibitory activity against multiple cancer cell lines and is synergistic with ATS against breast and pancreatic cancer growth. 12069504 Human
pyy human prostate cancer METHODS: A hormone-refractory human prostate cancer cell line, PC-3, was treated with ATS alone at 10 pg/ml, PYY or BA-129 alone at doses of 75 and 500 pmol/ml, or a combination of the two agents. 12069504 Human
pyy hormone-refractory prostate cancer CONCLUSIONS: Both PYY and ATS inhibit growth in hormone-refractory prostate cancer, with augmentation when used in combination. 12069504 Human
pyy prostate cancer Our data suggest that PYY is involved in the regulation of VEGF production and prostate cancer growth. 12069504 Human
pyy strumal carcinoid tumor Strumal carcinoid tumor of the ovary: a case exhibiting severe constipation associated with PYY. 12468356 Human
pyy tumor The tumor cells were positive for PYY, a peptide hormone that has a strong inhibitory effect on intestinal motility, by immunohistochemical stain. 12468356 Human
pyy neuroendocrine tumor Biopsies from mesenterial lymph nodes showed, histologically, a well-differentiated neuroendocrine tumor (G1), with positive immunostaining for chromogranin A, GLP-1, GLP-2 and polypeptide YY (PYY). 11173902 Human
pyy tumor HPLC analysis combined with RIA of tumor and serum extracts revealed that the tumor was producing and releasing fasting levels of GLP-1 of 738+/-20.7 pg/ml (normal levels (nl) <100 pg/ml), GLP-2 of 3,150+/-9 pg/ml (nl <100 pg/ml) as well as PYY 550 pg/ml 11173902 Human
pyy neuroendocrine tumor This is the first case report demonstrating the overproduction of GLP-1, GLP-2 and PYY from an neuroendocrine tumor, in a patient with intestinal hypertrophy and delayed intestinal transit time. 11173902 Human
pyy pancreatic cancer Our purpose was to construct an optimal synthetic PYY analog that binds to pancreatic cancer cells that may be used for imaging and therapy. 11331476 Human
peptide yy tumour Further investigations identified a circumscribed central mass in the right lung which was surgically resected and histologically confirmed to be an endocrine tumour with strong immunopositivity for GHRH, synaptophysin and chromogranin; the lesion also ex 11453963 Human
peptide yy human pancreatic cancer Peptide YY augments gross inhibition by vitamin E succinate of human pancreatic cancer cell growth. 10644462 Human
pyy pancreatic cancer Peptide YY (PYY) also inhibits pancreatic cancer cell growth in vitro. 10644462 Human
peptide yy pancreatic cancer Peptide YY (PYY) also inhibits pancreatic cancer cell growth in vitro. 10644462 Human
pyy pancreatic ductal adenocarcinoma METHODS: Human pancreatic ductal adenocarcinoma Mia PaCa-2 cells were cultured and treated once with either 10 pg/ml of VES or 500 pmols of PYY or with both agents together. 10644462 Human
pyy pancreatic cancer RESULTS: Pancreatic cancer cell growth was reduced in all groups treated with PYY and VES. 10644462 Human
pyy pancreatic cancer CONCLUSION: PYY and vitamin E both inhibit growth of pancreatic cancer cells in vitro with a significant increase in effect when used in combination. 10644462 Human
peptide yy breast cancer Peptide YY and vitamin E inhibit hormone-sensitive and -insensitive breast cancer cells. 10816343 Human
peptide yy pancreatic cancer We have shown that peptide YY, an endogenous gut hormone, and vitamin E succinate (VES) inhibit pancreatic cancer cell growth in vitro. 10816343 Human
pyy breast cancer We hypothesized that PYY and VES would inhibit breast cancer cell viability regardless of the hormone receptor status. 10816343 Human
pyy ductal carcinoma Human breast ZR-75 ductal carcinoma (estrogen receptor negative) and MCF-7 adenocarcinoma (estrogen receptor positive) cells were cultured and exposed to VES (10 pg/ml), PYY (500 pmol), or both agents together. 10816343 Human
pyy breast cancer We have shown that PYY and vitamin E inhibit in vitro growth of breast cancer cells with variable hormone receptor status. 10816343 Human
peptide yy colon cancer B-cell leukemia protein-2 and peptide YY chemotherapy resistance in colon cancer. 10612539 Human
pyy colon cancer It is our hypothesis that higher levels of bcl-2 expression will be seen in colon cancer cells resistant to PYY treatment. 10612539 Human
pyy colon cancer METHODS: Caco2 and HCT116 colon cancer cells were treated with 2 microM PYY for 24 hours. 10612539 Human
pyy colon cancer CONCLUSIONS: Increased expression of bcl-2 is seen in a population of colon cancer cells resistant to PYY. 10612539 Human
peptide yy tumors In this study, the presence of NPY receptors was evaluated in another group of gynecological tumors, namely ovarian tumors, using in vitro receptor autoradiography with (125)I-labeled peptide YY and receptor subtype selective analogs. 14631382 Human
peptide yy strumal carcinoid Ovarian strumal carcinoid with severe constipation: immunohistochemical and mRNA analyses of peptide YY. 10029457 Human
pyy ovarian carcinoid tumors Recently, strumal and trabecular ovarian carcinoid tumors are reported to cause severe constipation possibly because of tumor-producing peptide YY (PYY). 10029457 Human
peptide yy ovarian carcinoid tumors Recently, strumal and trabecular ovarian carcinoid tumors are reported to cause severe constipation possibly because of tumor-producing peptide YY (PYY). 10029457 Human
pyy tumor Immunohistochemically, many tumor cells were strongly positive for PYY. 10029457 Human
pyy strumal carcinoid From these findings, an ovarian strumal carcinoid is strongly suggested to express complete PYY mRNA and therefore complete PYY protein that results in severe constipation. 10029457 Human
peptide yy human breast cancer Peptide YY inhibits growth of human breast cancer in vitro and in vivo. 10090823 Human
pyy pancreatic adenocarcinoma Peptide YY (PYY) suppresses growth of, and levels of, intracellular cyclic adenosine monophosphate (cAMP) in pancreatic adenocarcinoma. 10090823 Human
peptide yy pancreatic adenocarcinoma Peptide YY (PYY) suppresses growth of, and levels of, intracellular cyclic adenosine monophosphate (cAMP) in pancreatic adenocarcinoma. 10090823 Human
pyy breast cancer We hypothesized that PYY would inhibit growth of breast cancer. 10090823 Human
pyy breast cancer CONCLUSIONS. PYY inhibits growth of breast cancer in vitro and in vivo and may be of benefit in the treatment of this malignancy. 10090823 Human
peptide yy colonic polyps Lack of peptide YY immunoreactivity in adenomatous colonic polyps: evidence in favor of an adenoma-carcinoma sequence. 3374119 Human
pyy adenomatous polyps PYY was therefore measured in colonic carcinomas and adenomatous polyps, as its absence would be evidence in favor of genetic alterations in epithelial stem cell maturation. 3374119 Human
pyy colonic carcinomas PYY was therefore measured in colonic carcinomas and adenomatous polyps, as its absence would be evidence in favor of genetic alterations in epithelial stem cell maturation. 3374119 Human
pyy colonic carcinomas PYY concentrations in extracts of surgically removed colonic carcinomas (n = 22) from all regions were very low compared with those of adjacent normal bowel. 3374119 Human
pyy polyps Similarly, PYY concentrations in extracts of polyps (n = 39) obtained during endoscopic polypectomy were also very low when compared with those of adjacent normal mucosa. 3374119 Human
pyy carcinomas Low PYY levels appeared to reflect the malignant potential of these lesions: highest in tubular polyps, lower in villous polyps, and lowest in carcinomas. 3374119 Human
pyy polyps Low PYY levels appeared to reflect the malignant potential of these lesions: highest in tubular polyps, lower in villous polyps, and lowest in carcinomas. 3374119 Human
pyy colonic cancer The very low concentrations of PYY in adenomatous polyps, like those of colonic cancer, are consistent with epithelial dysplasia and the incomplete formation of mucosal endocrine cells. 3374119 Human
pyy adenomatous polyps The very low concentrations of PYY in adenomatous polyps, like those of colonic cancer, are consistent with epithelial dysplasia and the incomplete formation of mucosal endocrine cells. 3374119 Human
peptide yy inflammatory bowel disease Peptide YY concentrations in normal ileum and colon and in idiopathic inflammatory bowel disease. 3168701 Human
peptide yy crohn's colitis In both the ascending and descending colon, there were significantly decreased mean concentrations of peptide YY in Crohn's colitis and ulcerative colitis, compared to mean concentrations in normal colon. 3168701 Human
peptide yy inflammatory bowel disease The decrease in concentrations of peptide YY in colon obtained from patients with inflammatory bowel disease did not appear related either to the duration of the clinical symptoms of the disease or to the severity of colonic inflammation. 3168701 Human
peptide yy inflammatory bowel disease Further studies of the physiological function of peptide YY in man are needed to determine whether these findings might be useful in understanding a component of the pathophysiology of idiopathic inflammatory bowel disease. 3168701 Human
peptide yy carcinomas The ileal carcinomas frequently and densely demonstrated somatostatin, peptide YY, neurotensin, glucagon, and glicentin cells in addition to serotonin cells. 3804322 Human
pyy rectal carcinoid tumors Glucagon, glicentin, proglucagon, PYY, PP and proPP-icosapeptide immunoreactivities of rectal carcinoid tumors and related non-tumor cells. 2882565 Human
pyy tumor Both PYY and PP/proPP-like peptide(s) were detected in rectal L cells and carcinoids, with prevalence of PYY in normal cells and PP/proPP-like peptides in tumor cells. 2882565 Human
peptide yy inflammatory bowel diseases Abnormalities of fasting serum concentrations of peptide YY in the idiopathic inflammatory bowel diseases. 3565336 Human
peptide yy inflammatory bowel diseases Since our previous studies had shown decreased colonic concentrations of peptide YY in the idiopathic inflammatory bowel diseases, a specific radioimmunoassay was used to measure fasting serum concentrations of peptide YY in healthy controls and in patien 3565336 Human
peptide yy adenocarcinoma of the rectum Since our previous studies had shown decreased colonic concentrations of peptide YY in the idiopathic inflammatory bowel diseases, a specific radioimmunoassay was used to measure fasting serum concentrations of peptide YY in healthy controls and in patien 3565336 Human
peptide yy adenocarcinoma of the rectum In healthy controls and in patients with adenocarcinoma of the rectum, serum concentrations of peptide YY ranged from 50 to 260 pg/ml. 3565336 Human
pyy human neuroblastoma 3-(3-(Benzothiazol-6-yl)ureido)-1-N-(3-(N'-(3-isopropylureido++ +))benzyl )-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one (21), which was one of the most potent derivatives, competitively inhibited specific [(125)I]peptide YY (PYY) binding to Y1 receptors 10411482 Human
pyy human neuroblastoma Compound 1 competitively inhibited [125I]peptide YY (PYY) binding to Y1 receptors in human neuroblastoma SK-N-MC cells with Ki of 6.4 +/- 1.0 nM, while it had no effect on [125I]PYY binding to Y2 or Y5 receptors even at 1 microM. 9747900 Human
pyy insulinoma We show that insulin secretion in the insulinoma cell line RIN 5AH is inhibited by NPY. 125I-Peptide YY (PYY) saturation and competition-binding studies using NPY fragments and analogues on membranes prepared from this cell line show the presence of a sin 9867216 Human
pyy lung cancer These results seem to indicate that PP and PYY would be useful tumor markers for lung cancer in clinical management. 12792985 Human
pyy tumor These results seem to indicate that PP and PYY would be useful tumor markers for lung cancer in clinical management. 12792985 Human
peptide yy human pancreatic carcinoma Adjuvant hormonal treatment with peptide YY or its analog decreases human pancreatic carcinoma growth. 8554139 Human
pyy pancreatic cancer BACKGROUND: Recent studies have revealed decreased pancreatic cancer cell growth upon administration of peptide YY (PYY). 8554139 Human
peptide yy pancreatic cancer BACKGROUND: Recent studies have revealed decreased pancreatic cancer cell growth upon administration of peptide YY (PYY). 8554139 Human
pyy human pancreatic adenocarcinoma We examined whether adjuvant treatment with PYY or its synthetic analog, BIM-43004, would decrease human pancreatic adenocarcinoma growth. 8554139 Human
pyy pancreatic cancer Pancreatic cancer cells received 500 pmol of PYY or BIM-43004 for 24 hours prior to 5-fluorouracil (5-FU; 10 micrograms/mL) and leucovorin (40 micrograms/mL) administration. 8554139 Human
pyy human pancreatic cancer CONCLUSION: Human pancreatic cancer cell growth is further decreased when pretreated with PYY or its synthetic analog prior to chemotherapy. 8554139 Human
pyy gastrinoma In athymic-nude mice, implantation of a human gastrinoma resulted in an elevation of serum gastrin concentrations and a concomitant depression of colonic PYY mRNA levels. 8625912 Human
pyy tumours Colonic tumours expressed SV40Tag, proglucagon-derived peptides and peptide YY (PYY); scattered cells contained cholecystokinin or glycoprotein hormone alpha-subunit. 8605571 Mouse
peptide yy tumours Colonic tumours expressed SV40Tag, proglucagon-derived peptides and peptide YY (PYY); scattered cells contained cholecystokinin or glycoprotein hormone alpha-subunit. 8605571 Mouse
pyy tumour Some neoplastic pancreatic cells contained glucagon, PYY or vasoactive intestinal peptide immunopositivity, but most were negative for all peptides; they contained immunoreactivity for tyrosine hydroxylase and by electron microscopy, pancreatic tumour cel 8605571 Human
peptide yy endocrine tumors Characterization of colonic endocrine tumors in transgenic mice expressing simian virus 40 large T antigen under the control of the peptide YY gene 5' flanking region revealed tumor cells producing not only peptide YY and glucagon, but also neurotens 8620842 Human
peptide yy tumor Characterization of colonic endocrine tumors in transgenic mice expressing simian virus 40 large T antigen under the control of the peptide YY gene 5' flanking region revealed tumor cells producing not only peptide YY and glucagon, but also neurotens 8620842 Human
peptide yy cancer Furthermore, the following neuropeptides are dysregulated in both anorexia nervosa and cancer cachexia: vasoactive intestinal peptide, cholecystokinin, corticotropin-releasing factor, neuropeptide Y, peptide YY and beta-endorphin. 8961238 Human
peptide yy tumor We report a patient with primary trabecular carcinoid of the ovary with severe constipation probably due to peptide YY production by the tumor. 7896203 Human
peptide yy tumor Immunohistochemically, the tumor cells were strongly positive for peptide YY, which has a strong inhibitory action on intestinal motility. 7896203 Human
peptide yy carcinoid syndrome The present case supports previously reported findings that not typical carcinoid syndrome but rather severe constipation accompanies primary trabecular carcinoid of the ovary, and that peptide YY is presumably the cause of the constipation. 7896203 Human
peptide yy human pancreatic cancer Human pancreatic cancer growth is inhibited by peptide YY and BIM-43004-1. 7791350 Human
pyy pancreatic cancer We hypothesized that pancreatic cancer cell growth may be inhibited by PYY and a new synthetic analog, BIM-43004-1. 7791350 Human
pyy pancreatic cancer Pancreatic cancer cells received either PYY or BIM-43004-1 at various concentrations. 7791350 Human
pyy pancreatic cancer After incubation with the above peptides for 24 hr, MTT tetrazolium bromide was added to assay mitochondrial activity of pancreatic cancer cells in response to PYY and its analog. 7791350 Human
pyy pancreatic cancer MTT assay reveals a significant decrease in pancreatic cancer cell growth when PYY and BIM-43004-1 are added to the cell culture. 7791350 Human
pyy pancreatic cancer We investigated the effects of both PYY and BIM-43004-1 on pancreatic cancer growth in vivo. 7638738 Human
pyy tumor Tumor mass was decreased by 60.5% in BIM-43004-1 treated mice and 27.1% in PYY treated mice. 7638738 Mouse
peptide yy moderately differentiated adenocarcinoma Peptide YY (PYY)-like immunoreactivity was detected in the mucosa and muscle layer of normal human colon and rectum and in well to moderately differentiated adenocarcinoma derived from the mucosa of the colon and rectum, using a sensitive and specific rad 3626157 Human
pyy moderately differentiated adenocarcinoma Peptide YY (PYY)-like immunoreactivity was detected in the mucosa and muscle layer of normal human colon and rectum and in well to moderately differentiated adenocarcinoma derived from the mucosa of the colon and rectum, using a sensitive and specific rad 3626157 Human
peptide yy endocrine tumors Immunohistochemical demonstration of peptide YY in gastrointestinal endocrine tumors. 2888260 Human
peptide yy endocrine tumors Fourteen cases of gastrointestinal endocrine tumors were examined immunohistochemically for peptide YY, pancreatic polypeptide, glucagon, and somatostatin. 2888260 Human
peptide yy tumors Peptide YY cells were present in seven tumors, pancreatic polypeptide cells in eight tumors, glucagon cells in six tumors, and somatostatin cells in nine tumors. 2888260 Human
peptide yy endocrine tumors All 7 rectal endocrine tumors examined were found to contain peptide YY, while in the tumors of the other sites peptide YY cells were not detected. 2888260 Human
peptide yy tumors All 7 rectal endocrine tumors examined were found to contain peptide YY, while in the tumors of the other sites peptide YY cells were not detected. 2888260 Human
peptide yy tumors Peptide YY cell population in the rectal tumors was small to moderate in comparison with pancreatic polypeptide and glucagon cell population. 2888260 Human
peptide yy endocrine tumors This study suggests that peptide YY cells may be a common constituent of rectal endocrine tumors together with pancreatic polypeptide and glucagon cells, and that the peptide YY spectrum of gastrointestinal endocrine tumors may be closely related to the l 2888260 Human
peptide yy tumors This study suggests that peptide YY cells may be a common constituent of rectal endocrine tumors together with pancreatic polypeptide and glucagon cells, and that the peptide YY spectrum of gastrointestinal endocrine tumors may be closely related to the l 2888260 Human
peptide yy endocrine tumors Moreover, it can also be said that peptide YY may be used as one of the markers of rectal endocrine tumors. 2888260 Human
pyy inflammatory bowel disease Moderately elevated plasma PYY concentrations were seen in patients with inflammatory bowel disease and patients recovering from acute infective diarrhea. 3753594 Human
peptide yy tumors Peptide YY immunoreactive cells in gastrointestinal carcinoids: immunohistochemical and ultrastructural studies of 60 tumors. 3753951 Human
pyy tumours The immunoreactive material in the tumours corresponded to human PP and not PYY or NPY on the basis of immunoreactivity and HPLC behaviour. 2872701 Human
pyy tumour Transplanted rats had significantly (P less than 0.05) elevated levels of PYY (44-165 pmol/l) and glucagon (67-162 pmol/l) in plasma as compared with sham-operated rats (PYY 28-40 pmol/l, glucagon 33-40 pmol/l), indicating that hormone secretion by tumour 2358971 Rat
peptide yy pancreatic carcinoma Neuropeptide Y and peptide YY stimulate the growth of exocrine pancreatic carcinoma cells. 2080016 Human
pyy pancreatic carcinoma This study was executed to evaluate the effects of PYY and NPY on cell growth and 3H-thymidine incorporation in human (MiaPaCa-2, Capan-2) and hamster (H2T) exocrine pancreatic carcinoma cells in vitro. 2080016 Human
pyy pancreatic carcinoma The results suggest that NPY and PYY may have a role in the regulation of growth of exocrine pancreatic carcinoma cells. 2080016 Human
peptide yy cancer Zacopride is thus a unique and potent antiemetic agent as it selectively inhibits the emetic response to cancer chemotherapy agents and peptide YY. 2568416 Human
peptide yy tumor Similarly, in tumor tissue, peptide YY (676 +/- 152 pmol/gm) and enteroglucagon (551 +/- 164 pmol/gm) were found in large quantities, whereas gastrin was undetectable. 2573958 Human
peptide yy insulinomas The pancreatic and intestinal hormone, peptide YY, has been previously identified in glucagon-producing cells in islets; however, transgenic mice expressing Simian Virus 40 large T antigen under the control of the peptide YY gene expressed the oncoprotein 8149907 Human
peptide yy human neuroblastoma In the human neuroblastoma cell line (SMS-KAN) which expresses and endogenous Y2-like neuropeptide Y receptor, N-acetyl [Leu28,Leu31]neuropeptide Y-(24-36) competes with peptide YY for binding sites with an IC50 of 0.5 +/- 0.1 nM. 8088364 Human
peptide yy human neuroblastoma In binding studies [Pro34]peptide YY had a similarly high affinity as peptide YY to human Y1-like receptors in SK-N-MC cells, a human neuroblastoma cell line of presumed neurogenic origin, and HEL cells, a human cell line derived from a patient with Hodgk 7851489 Human
pyy tumors Of CGA-positive tumors, 70% additionally produced neurohormones, mainly indigenous to normal colorectal epithelium: 55% showed immunoreactivity for glucagon-like substances, 20% for serotonin and 10% for somatostatin, PYY and HCG. 8100808 Human
pyy ewing's sarcoma These results demonstrate that conventional Ewing's sarcoma cells possess Gi-protein-coupled NPY receptors of the Y1 type, which upon interaction with NPY, PYY, and PP mediate inhibition of cyclic AMP generation. 1320624 Human
peptide-yy tumor Evidence for further heterogeneity of the receptors for neuropeptide-Y and peptide-YY in tumor cell lines derived from neural crest. 1330489 Human
pyy tumor The expression and structure of the receptors for neuropeptide-Y (NPY) and peptide-YY (PYY) were studied in 16 human and rodent tumor cell lines derived from the neural crest by ligand binding and cross-linking techniques using [125I]Bolton-Hunter-NPY, [1 1330489 Human
peptide-yy tumor The expression and structure of the receptors for neuropeptide-Y (NPY) and peptide-YY (PYY) were studied in 16 human and rodent tumor cell lines derived from the neural crest by ligand binding and cross-linking techniques using [125I]Bolton-Hunter-NPY, [1 1330489 Human
peptide yy tumors They are also rich in histidine decarboxylase activity and produce large amounts of histamine, although other hormones, such as peptide YY and enteroglucagon, have also been demonstrated in these tumors. 1341076 Human
pyy tumor The tumor cells revealed argyrophilia, and were positive for peptide tyrosine tyrosine (PYY) in the cytoplasm and for CEA in part of the luminal surface. 1867100 Human
pyy ovarian carcinoid tumors PYY may be a potential marker for determining the histogenesis of ovarian carcinoid tumors. 1867100 Human
pyy tumor PYY and enteroglucagon (EG) were significantly (P less than 0.001) elevated in both tumor tissue (676 +/- 152, 551 +/- 164 pmol/g) and plasma (620 +/- 160, 500 +/- 147 pmol/l) of tumor-bearing animals. 2326498 others
peptide yy carcinoid tumor Numerous peptide YY (PYY)-positive cells were detected, with PYY-positive cells representing more than 50% of all carcinoid tumor cells in each patient. 1617602 Human
peptide yy ovarian tumors In this study, the presence of NPY receptors was evaluated in another group of gynecological tumors, namely ovarian tumors, using in vitro receptor autoradiography with (125)I-labeled peptide YY and receptor subtype selective analogs. 14631382 Human
pyy necrosis In addition, pancreatic histologic findings were significantly improved in those rats receiving PYY (decreased vacuolization and necrosis). 7685154 Rat
pyy colonic tumours Colonic tumours expressed SV40Tag, proglucagon-derived peptides and peptide YY (PYY); scattered cells contained cholecystokinin or glycoprotein hormone alpha-subunit. 8605571 Mouse
pyy pancreatic tumour Some neoplastic pancreatic cells contained glucagon, PYY or vasoactive intestinal peptide immunopositivity, but most were negative for all peptides; they contained immunoreactivity for tyrosine hydroxylase and by electron microscopy, pancreatic tumour cel 8605571 Human
pyy malignancy CONCLUSIONS. PYY inhibits growth of breast cancer in vitro and in vivo and may be of benefit in the treatment of this malignancy. 10090823 Human
pyy carcinoid tumors PYY has been identified in several carcinoid tumors and a decreased expression of PYY may be relevant to the development and progression of colon adenocarcinoma. 11825654 Human
pyy ovarian tumor CONCLUSION: Our case provides the more convincing information to indicate that PYY protein, produced by ovarian tumor cells in the trabecular carcinoid component, may be associated with severe constipation. 12468356 Human
pyy carcinoid CONCLUSION: Our case provides the more convincing information to indicate that PYY protein, produced by ovarian tumor cells in the trabecular carcinoid component, may be associated with severe constipation. 12468356 Human
pyy cancers BACKGROUND: Peptide YY (PYY) is an endogenous gut hormone that inhibits the growth of certain cancers. 15546561 Human
pyy barrett's adenocarcinoma We hypothesized that treatment of Barrett's adenocarcinoma with PYY would result in decreased proliferation. 15546561 Human
pyy cancer METHODS: Barrett's cancer cell lines (BIC and SEG-1) were treated with PYY (3-36) at 500 pmol/mL. 15546561 Human
pyy carcinoma CONCLUSIONS: This is the first report of antiproliferative effects of PYY against Barrett's carcinoma in vitro. 15546561 Human
pyy barrett's adenocarcinoma Further investigation of PYY in the treatment of Barrett's adenocarcinoma is warranted. 15546561 Human
pyy ibd It can be speculated that, in inflammatory bowel disease (IBD), the production and secretion of GLP-2 and PYY could be affected as a part of a regulatory mechanism. 15674099 Human
pyy inflammatory bowel disease It can be speculated that, in inflammatory bowel disease (IBD), the production and secretion of GLP-2 and PYY could be affected as a part of a regulatory mechanism. 15674099 Human
pyy ibd Therefore, tissue levels and meal-stimulated secretion of GLP-2 and PYY were studied in IBD patients and compared to controls. 15674099 Human
pyy ibd In IBD patients with acute inflammation, the content of GLP-2 was similar to controls, whereas PYY was decreased to 72.1+/-17.7% (P=0.03, n=13) of control values. 15674099 Human
pyy ibd Neither the fasting plasma levels nor the meal responses of GLP-2 and PYY differed between controls and IBD patients. 15674099 Human
pyy ibd CONCLUSION: The similar responses of GLP-2 and PYY in patients and controls do not support the suggestion that L-cell secretion is altered in IBD. 15674099 Human
pyy renal-cell carcinomas (rccs) Since NPY can play a role in the kidney, NPY receptor expression and/or endogenous production of peptides of the NPY family (NPY, PYY, PP) were evaluated in 40 renal cell carcinomas (RCCs) and 18 nephroblastomas. 15704095 Human
pyy tumor In selected cases, NPY was observed in nerve fibers in close association with intratumoral blood vessels and in the vicinity of tumor cells, while no PYY or PP was detected immunohistochemically in these sites. 15704095 Human
pyy endocrine tumours Transgenic mice expressing a viral oncoprotein under the control of the PYY gene 5'-flanking region develop well-differentiated colonic endocrine tumours producing mainly PYY and enteroglucagon. 15898955 Mouse
pyy tumours CONCLUSIONS: In the present study, we demonstrate that the sustained inhibition of gastric secretion due to tumours producing PYY/enteroglucagon in transgenic mice is associated with an increase in AQP4 expression and a down-regulation of H(+)/K(+)-ATPase 15898955 Mouse
the pyy gene endocrine tumours Transgenic mice expressing a viral oncoprotein under the control of the PYY gene 5'-flanking region develop well-differentiated colonic endocrine tumours producing mainly PYY and enteroglucagon. 15898955 Mouse
peptide yy rectal tumors Peptide YY cell population in the rectal tumors was small to moderate in comparison with pancreatic polypeptide and glucagon cell population. 2888260 Human
peptide yy crohn's disease Concentrations of the candidate endocrine and paracrine peptide, peptide YY, were measured by specific radioimmunoassay in tissue extracts prepared from normal ileum, normal colon, Crohn's disease, and ulcerative colitis. 3168701 Human
peptide yy crohn's disease Since our previous studies had shown decreased colonic concentrations of peptide YY in the idiopathic inflammatory bowel diseases, a specific radioimmunoassay was used to measure fasting serum concentrations of peptide YY in healthy controls and in patien 3565336 Human
peptide yy crohn's disease In patients with Crohn's disease, serum concentrations of peptide YY were less than 50 pg/ml in three patients who had had a previous proctocolectomy, and were more than 260 pg/ml in 14 patients who had had previous resection of more than 48 cm of il 3565336 Human
peptide yy crohn's disease Hepatic cirrhosis, previous ileal resection, and symptomatic Crohn's disease were associated with elevation of fasting serum peptide YY. 3565336 Human
peptide yy crohn's disease The mechanism of increased fasting serum peptide YY in patients with Crohn's disease could be the loss of an ileal inhibitory factor or possibly an increased release of colonic peptide YY in response to fat malabsorption. 3565336 Human
peptide yy crohn's disease The effect of alteration of serum peptide YY concentrations on the pathophysiology of Crohn's disease is yet unknown. 3565336 Human
peptide yy colorectal adenocarcinomas An immunocytochemical study. Colorectal adenocarcinomas were induced in male Wistar rats, by weekly subcutaneous administration of 1,2-dimethylhydrazine, classified according to the degree of differentiation and submitted to immunocytochemistry for the pe 3779800 Human
peptide yy cancer In addition, argyrophilic cancer cells with immunoreactivities of neuron-specific enolase, chromagranin A and peptide YY were demonstrated. 1713733 Human
pyy colorectal adenocarcinomas An immunocytochemical study. Colorectal adenocarcinomas were induced in male Wistar rats, by weekly subcutaneous administration of 1,2-dimethylhydrazine, classified according to the degree of differentiation and submitted to immunocytochemistry for the pe 3779800 Human
pyy tumours Glucagon, PYY and 5-hydroxytryptamine immunoreactive cells were frequently observed within well- or moderately well-differentiated tumours and within such regions of tumours possessing a mixed morphological pattern. 3779800 Human
pyy tumor Most of the tumor cells showed a positive reaction for Grimelius stain and some immunoreactivities for GLI, PP, PYY, insulin and NSE by the PAP method. 3795507 Human
pyy cell hyperplasia Moreover, PYY cell hyperplasia was detected in the rectal mucosa, markedly in the areas surrounding the carcinoids. 3795507 Human
pyy tumour An immunocytochemical study. The frequency and distribution of polypeptide YY (PYY) and pancreatic polypeptide (PP) immunoreactive tumour cells of 14 small intestinal and of 27 rectal carcinoids were studied. 6412449 Human
pyy tumours Two rectal carcinoids with PYY and PP immunoreactivities, but not the rest of the tumours, reacted also with an antiserum specific to the C-terminus of PP. 6412449 Human
pyy carcinoid tumor Numerous peptide YY (PYY)-positive cells were detected, with PYY-positive cells representing more than 50% of all carcinoid tumor cells in each patient. 1617602 Human
pyy cancer The present paper reviews our current findings with PYY and examines the therapeutic implications of its utility in treating inflammation and cancer. 17194501 Human
pyy tumor PYY and the pancreas: inhibition of tumor growth and inflammation. 17194501 Human
peptide yy hodgkin's disease In binding studies [Pro34]peptide YY had a similarly high affinity as peptide YY to human Y1-like receptors in SK-N-MC cells, a human neuroblastoma cell line of presumed neurogenic origin, and HEL cells, a human cell line derived from a patient with Hodgk 7851489 Human
peptide yy carcinoid Ovarian carcinoid with severe constipation due to peptide YY production. 7896203 Human
peptide yy carcinoid We report a patient with primary trabecular carcinoid of the ovary with severe constipation probably due to peptide YY production by the tumor. 7896203 Human
peptide yy carcinoid The present case supports previously reported findings that not typical carcinoid syndrome but rather severe constipation accompanies primary trabecular carcinoid of the ovary, and that peptide YY is presumably the cause of the constipation. 7896203 Human
peptide yy colonic tumours Colonic tumours expressed SV40Tag, proglucagon-derived peptides and peptide YY (PYY); scattered cells contained cholecystokinin or glycoprotein hormone alpha-subunit. 8605571 Mouse
peptide yy human neuroblastoma Compound 1 competitively inhibited [125I]peptide YY (PYY) binding to Y1 receptors in human neuroblastoma SK-N-MC cells with Ki of 6.4 +/- 1.0 nM, while it had no effect on [125I]PYY binding to Y2 or Y5 receptors even at 1 microM. 9747900 Human
peptide yy endocrine tumour Further investigations identified a circumscribed central mass in the right lung which was surgically resected and histologically confirmed to be an endocrine tumour with strong immunopositivity for GHRH, synaptophysin and chromogranin; the lesion also ex 11453963 Human
peptide yy endocrine tumors PYY-Tag transgenic mice develop endocrine tumors in the colon that are composed mainly of peptide YY/enteroglucagon-producing L type cells. 12533685 Mouse
peptide yy esophageal adenocarcinoma Peptide YY inhibits the growth of Barrett's esophageal adenocarcinoma in vitro. 15546561 Human
peptide yy cancers BACKGROUND: Peptide YY (PYY) is an endogenous gut hormone that inhibits the growth of certain cancers. 15546561 Human
peptide yy colonic carcinoma In transfected colonic carcinoma epithelial layers, functional Y1 and Y1T361* peptide YY responses became more transient as the agonist concentration increased, whereas those mediated by the Y1S352* receptor remained sustained. 15576634 Human
peptide yy paragangliomas EXPERIMENTAL DESIGN: Fifteen adrenal cortical tumors, 20 paragangliomas, 23 pheochromocytomas, 20 neuroblastomas, and 8 normal adrenal glands were investigated by in vitro NPY receptor autoradiography using 125I-labeled peptide YY in competition experimen 15623622 Human
peptide yy pheochromocytomas EXPERIMENTAL DESIGN: Fifteen adrenal cortical tumors, 20 paragangliomas, 23 pheochromocytomas, 20 neuroblastomas, and 8 normal adrenal glands were investigated by in vitro NPY receptor autoradiography using 125I-labeled peptide YY in competition experimen 15623622 Human
peptide yy inflammatory bowel disease Tissue levels and post-prandial secretion of the intestinal growth factor, glucagon-like peptide-2, in controls and inflammatory bowel disease: comparison with peptide YY. 15674099 Human
peptide yy cancer The present review summarizes recent advances in this field including the characterization of peripheral metabolic signals to the brain such as leptin, insulin, peptide YY, ghrelin and lipid mediators as well as the vagus nerve; signalling of the metaboli 16164570 Human
pyy cancer RESULTS: Cancer cell growth was reduced in all groups receiving hormonal pretreatment (23% PYY/5-FU/leucovorin versus control; 27% BIM-43004/5-FU/leucovorin versus control) as compared with groups receiving 5-FU and leucovorin only (16% versus control). 8554139 Human
pyy pheochromocytoma To investigate whether the stimulatory influence of IGF-I is exerted at the level of gene transcription, rat PYY 5'-upstream sequences (-2800/+37 bp, -770/+37 bp, -127/+37 bp) fused to the firefly luciferase (luc) reporter gene were transfected into 14592960 Human
pyy renal cell carcinomas (rccs) Since NPY can play a role in the kidney, NPY receptor expression and/or endogenous production of peptides of the NPY family (NPY, PYY, PP) were evaluated in 40 renal cell carcinomas (RCCs) and 18 nephroblastomas. 15704095 Human
pyy lymph node metastases Seventy-seven primary breast cancers and 15 breast cancer lymph node metastases were investigated in vitro for their expression of somatostatin, VPAC(1), GRP and NPY(Y(1)) receptors using in vitro receptor autoradiography on successive tissue sections wit 12111125 Human
peptide yy adrenal cortical tumors EXPERIMENTAL DESIGN: Fifteen adrenal cortical tumors, 20 paragangliomas, 23 pheochromocytomas, 20 neuroblastomas, and 8 normal adrenal glands were investigated by in vitro NPY receptor autoradiography using 125I-labeled peptide YY in competition experimen 15623622 Human
pyy ductal pancreatic cancer Our results reveal a significant reduction in human ductal pancreatic cancer growth when treated with either PYY or its analog, BIM-43004-1. 7791350 Human
pyy infiltrative ductal carcinoma MATERIALS AND METHODS. MCF-7 human breast infiltrative ductal carcinoma cells in 96-well plates were treated with PYY at 1.25 pmol/mcl. 10090823 Human
peptide yy colorectal cancer [Plasma peptide YY-like immunoreactivity in ulcerative colitis, colorectal cancer, and colectomy] 3450882 Human
peptide yy adenocarcinoma Peptide YY-like immunoreactivity in normal colon mucosa, muscle layer and adenocarcinoma. 3626157 Human
peptide yy neuroblastoma Using guanine nucleotides, pertussis toxin, and specific antisera against the COOH-terminals of the alpha-subunits of Gi1/2, Gi3, and G(o), the binding and biological response of the Y2 receptor (Y2R) for peptide YY (PYY) was probed in SMS-KAN neuroblasto 7830057 Human
peptide yy oncoprotein The pancreatic and intestinal hormone, peptide YY, has been previously identified in glucagon-producing cells in islets; however, transgenic mice expressing Simian Virus 40 large T antigen under the control of the peptide YY gene expressed the oncoprotein 8149907 Human
peptide yy adenocarcinoma 1. Confluent epithelial layers of a human adenocarcinoma cell line called Colony-6 have been shown to respond to nanomolar concentrations of vasoactive intestinal polypeptide (VIP), peptide YY (PYY), neuropeptide Y (NPY) and somatostatin (Som). 8590988 Human
peptide yy human neuroblastoma 1229U91 displaced [125I]peptide YY (PYY) binding to membranes of human neuroblastoma-derived SK-N-MC cells that predominantly express Y1 receptors with a K1 value 0.10 nM and inhibited the NPY-induced increase in intracellular calcium levels(IC50 = 0.27 n 8754736 Human
peptide yy tumor Reduction of gut hypoplasia and cachexia in tumor-bearing rats maintained on total parenteral nutrition and treated with peptide YY and clenbuterol. 9646290 Rat
pyy adenocarcinomas This study revealed the presence of PYY-like immunoreactivity not only in normal tissue of the colon and rectum but also in adenocarcinomas with the same elution pattern, and the mucosal concentrations of PYY-like immunoreactivity were found to be increas 3626157 Human
pyy neuroblastoma Using guanine nucleotides, pertussis toxin, and specific antisera against the COOH-terminals of the alpha-subunits of Gi1/2, Gi3, and G(o), the binding and biological response of the Y2 receptor (Y2R) for peptide YY (PYY) was probed in SMS-KAN neuroblasto 7830057 Human
pyy adenocarcinoma 1. Confluent epithelial layers of a human adenocarcinoma cell line called Colony-6 have been shown to respond to nanomolar concentrations of vasoactive intestinal polypeptide (VIP), peptide YY (PYY), neuropeptide Y (NPY) and somatostatin (Som). 8590988 Human
pyy human neuroblastoma 1229U91 displaced [125I]peptide YY (PYY) binding to membranes of human neuroblastoma-derived SK-N-MC cells that predominantly express Y1 receptors with a K1 value 0.10 nM and inhibited the NPY-induced increase in intracellular calcium levels(IC50 = 0.27 n 8754736 Human
pyy human neuroblastoma In contrast, the K1 values for [125I]PYY binding to Y2 receptors in membranes of human neuroblastoma-derived SK-N-BE2 cells and rat hypothalamus were 700 nM and more than 1 microM, respectively. 8754736 Human
pyy adenocarcinoma The same concentration of antagonist abolished responses to PYY and [Leu31,Pro34]NPY but had no effect upon human pancreatic polypeptide (hPP) in monolayer cultures of the human adenocarcinoma cell line, Colony-6. 8880067 Human
pyy adenocarcinoma 1. The human adenocarcinoma cell line, HT-29, has been stably transfected with the cDNA sequence for the rat neuropeptide Y (NPY) Y1 receptor, and three Y1 clones (Y1-4, Y1-7 and Y1-16) have been isolated which express high levels of specific [125I]-PYY b 8886416 Human
peptide yy tumor Recently, strumal and trabecular ovarian carcinoid tumors are reported to cause severe constipation possibly because of tumor-producing peptide YY (PYY). 10029457 Human
peptide yy neuroblastomas EXPERIMENTAL DESIGN: Fifteen adrenal cortical tumors, 20 paragangliomas, 23 pheochromocytomas, 20 neuroblastomas, and 8 normal adrenal glands were investigated by in vitro NPY receptor autoradiography using 125I-labeled peptide YY in competition experimen 15623622 Human
peptide yy cancer Although total ghrelin levels are increased in energy-negative states, levels of the biologically active octanoylated ghrelin and the anorexigenic peptide YY (PYY) have not been reported in patients with cancer-induced cachexia. 15713718 Human
pyy tumor Recently, strumal and trabecular ovarian carcinoid tumors are reported to cause severe constipation possibly because of tumor-producing peptide YY (PYY). 10029457 Human
pyy tumors Tumors from control mice weighed twice as much as those from PYY-treated mice (P < 0.006); volume of PYY-exposed tumors was one-third that of controls (P < 0.005). 10090823 Mouse
pyy adenocarcinoma Human breast ZR-75 ductal carcinoma (estrogen receptor negative) and MCF-7 adenocarcinoma (estrogen receptor positive) cells were cultured and exposed to VES (10 pg/ml), PYY (500 pmol), or both agents together. 10816343 Human
pyy neuroendocrine carcinoma Intestinal proliferation and delayed intestinal transit in a patient with a GLP-1-, GLP-2- and PYY-producing neuroendocrine carcinoma. 11173902 Human
pyy lymphoid hyperplasia The density of PYY-immunoreactive cells increased significantly in rats with dysplasia and lymphoid hyperplasia and in rats with colon carcinoma. 11510974 Rat
pyy colon carcinoma The density of PYY-immunoreactive cells increased significantly in rats with dysplasia and lymphoid hyperplasia and in rats with colon carcinoma. 11510974 Rat
pyy breast cancer Seventy-seven primary breast cancers and 15 breast cancer lymph node metastases were investigated in vitro for their expression of somatostatin, VPAC(1), GRP and NPY(Y(1)) receptors using in vitro receptor autoradiography on successive tissue sections wit 12111125 Human
pyy primary breast cancers Seventy-seven primary breast cancers and 15 breast cancer lymph node metastases were investigated in vitro for their expression of somatostatin, VPAC(1), GRP and NPY(Y(1)) receptors using in vitro receptor autoradiography on successive tissue sections wit 12111125 Human
pyy endocrine tumors PYY-Tag transgenic mice develop endocrine tumors in the colon that are composed mainly of peptide YY/enteroglucagon-producing L type cells. 12533685 Mouse
pyy tumors Therefore we studied the functional activity of such tumors and the gastric functions of PYY-Tag mice. 12533685 Human
pyy adenocarcinoma (5) In stably transfected adenocarcinoma cells expressing Y(1) or Y(1)(C337S) receptors, PYY inhibited anion secretion stimulated by vasoactive intestinal peptide (VIP; measured as short-circuit current, I(SC)) with similar potency (EC(50): 26-53 nM). 12788810 Human
pyy cancer Although total ghrelin levels are increased in energy-negative states, levels of the biologically active octanoylated ghrelin and the anorexigenic peptide YY (PYY) have not been reported in patients with cancer-induced cachexia. 15713718 Human
pyy cancer We hypothesized that abnormal ghrelin and/or PYY levels contribute to cancer-induced cachexia. 15713718 Human
pyy cancer PYY is unlikely to play an important role in cancer-induced cachexia. 15713718 Human
pyy large bowel cancer METHODS: Fasting plasma levels of ghrelin and PYY were determined in 20 super-obese patients (BMI> or =50) who underwent BPD-RYGBP and in 13 patients who underwent colectomy for large bowel cancer. 16756737 Human
pyy gross tumor RESULTS: Compared with the negative control group, the high- and low-dose PYY groups showed reduced gross tumor volume, lowered serum AFP, tumor weight, and cAMP content in the tumor tissue (P<0.05). 18753082 Mouse
peptide yy strumal carcinoid Peptide YY producing strumal carcinoid of the ovary as the cause of severe constipation with contralateral epithelial ovarian cancer. 17578375 Human
peptide yy epithelial ovarian cancer Peptide YY producing strumal carcinoid of the ovary as the cause of severe constipation with contralateral epithelial ovarian cancer. 17578375 Human
peptide yy carcinoid The tumor cells were positive for peptide YY (PYY) in the carcinoid component, but not in any other components. 17578375 Human
pyy carcinoid The tumor cells were positive for peptide YY (PYY) in the carcinoid component, but not in any other components. 17578375 Human
pyy epithelial ovarian cancer Interestingly, the constipation caused by PYY also helped in discovering epithelial ovarian cancer. 17578375 Human
peptide yy carcinoid tumor Pathological examination revealed that many carcinoid tumor cells were immunohistochemically positive for peptide YY, which inhibits intestinal motility and many peripheral steroid cells. 12608902 Human
peptide yy polycystic ovary syndrome Postprandial ghrelin, cholecystokinin, peptide YY, and appetite before and after weight loss in overweight women with and without polycystic ovary syndrome. 18065576 Human
peptide yy human hepatoma [Effect of peptide YY on subcutaneous transplantation tumor of human hepatoma in nude mice.] OBJECTIVE:To investigate the effects of peptide YY (PYY) on subcutaneous transplantation tumor of human hepatoma in nude mice and preliminarily explore the mechan 18753082 Human
peptide yy tumor [Effect of peptide YY on subcutaneous transplantation tumor of human hepatoma in nude mice.] OBJECTIVE:To investigate the effects of peptide YY (PYY) on subcutaneous transplantation tumor of human hepatoma in nude mice and preliminarily explore the mechan 18753082 Human
pyy cancer In addition to NPY, PYY is also able to affect cancer cell growth in a dose-dependent manner and through Y-Rs. 17979777 Human
pyy human hepatoma [Effect of peptide YY on subcutaneous transplantation tumor of human hepatoma in nude mice.] OBJECTIVE:To investigate the effects of peptide YY (PYY) on subcutaneous transplantation tumor of human hepatoma in nude mice and preliminarily explore the mechan 18753082 Human
pyy tumor [Effect of peptide YY on subcutaneous transplantation tumor of human hepatoma in nude mice.] OBJECTIVE:To investigate the effects of peptide YY (PYY) on subcutaneous transplantation tumor of human hepatoma in nude mice and preliminarily explore the mechan 18753082 Human
pyy tumor RESULTS: Compared with the negative control group, the high- and low-dose PYY groups showed reduced gross tumor volume, lowered serum AFP, tumor weight, and cAMP content in the tumor tissue (P<0.05). 18753082 Mouse
pyy hepatoma CONCLUSION: PYY can inhibit the growth of subcutaneous hepatoma in nude mice, which might be associated with the reduction of cAMP content in the tumors following PYY treatment. 18753082 Mouse
pyy tumors CONCLUSION: PYY can inhibit the growth of subcutaneous hepatoma in nude mice, which might be associated with the reduction of cAMP content in the tumors following PYY treatment. 18753082 Mouse
pyy polycystic ovary syndrome Postprandial response of ghrelin and PYY and indices of low-grade chronic inflammation in lean young women with polycystic ovary syndrome. 18812636 Human
pyy polycystic ovary syndrome (pcos) The aim of the study were to answer the question 1.) Whether circulating pro-inflammatory markers of endothelial dysfunction and due to chronic low-grade inflammation of obesity, are altered in untreated lean, young relatively healthy polycystic ovary syn 18812636 Human
pyy renal cell carcinomas Since NPY can play a role in the kidney, NPY receptor expression and/or endogenous production of peptides of the NPY family (NPY, PYY, PP) were evaluated in 40 renal cell carcinomas (RCCs) and 18 nephroblastomas. 15704095 Human
pyy polycystic ovary syndrome The aim of the study were to answer the question 1.) Whether circulating pro-inflammatory markers of endothelial dysfunction and due to chronic low-grade inflammation of obesity, are altered in untreated lean, young relatively healthy polycystic ovary syn 18812636 Human

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