IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene HDAC5 Ensembl ENSG00000108840 Chromosome 17 Start 39509647 End 39556540
Description Histone deacetylase 5 (HD5)(EC 3.5.1.98)(Antigen NY-CO-9) [Source:UniProtKB/Swiss-Prot;Acc:Q9UQL6]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 14068
     Entrez Gene : 10014
     UCSC : uc002iff.1
     GeneCards : 14068
     RefSeq : NM_001015053
     CCDS : CCDS32663.1
     Uniprot : Q9UQL6
     Interpro : Q9UQL6
     OMIM : 605315
     GeneTests : HDAC5
     CGAP : HDAC5
     PMID : 10220385

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  38810_at  -0.32  7.72e-7  5.22e-6  -0.42  6.57e-6  3.45e-5
 HG_U133A  202455_at  -0.54  2.75e-13  1.29e-12  0.74  5.33e-29  8.83e-29
 HG_U133_Plus2  202455_at  -0.47  1.90e-4  5.72e-4  -0.46  1.27e-3  2.40e-3
 HG_U133_Plus2  229408_at  -0.27  1.03e-1  1.57e-1  -0.09  6.56e-1  7.06e-1
 Agilent_HS_21.6K  16640  -0.20  7.44e-11  6.04e-9  -0.22  2.91e-10  1.44e-8

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  202455_at  -0.08  7.70e-1  9.77e-1  -0.12  3.02e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 38810_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 202455_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 202455_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 229408_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 16640    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
histone deacetylase 5 tumor Histone deacetylase 5 is not a p53 target gene, but its overexpression inhibits tumor cell growth and induces apoptosis. p53 tumor suppressor is activated by phosphorylation and acetylation on DNA damage. 12019172 Human
hdac5 tumor We next studied the effect of HDAC5 on tumor cell growth and apoptosis. 12019172 Human
hdac5 multiple tumor Transfection of HDAC5 inhibited growth of multiple tumor cell lines including U2OS osteogenic sarcoma cells, SY5Y neuroblastoma cells, and MCF breast carcinoma cells. 12019172 Human
hdac5 breast carcinoma Transfection of HDAC5 inhibited growth of multiple tumor cell lines including U2OS osteogenic sarcoma cells, SY5Y neuroblastoma cells, and MCF breast carcinoma cells. 12019172 Human
hdac5 osteogenic sarcoma Transfection of HDAC5 inhibited growth of multiple tumor cell lines including U2OS osteogenic sarcoma cells, SY5Y neuroblastoma cells, and MCF breast carcinoma cells. 12019172 Human
hdac5 neuroblastoma Transfection of HDAC5 inhibited growth of multiple tumor cell lines including U2OS osteogenic sarcoma cells, SY5Y neuroblastoma cells, and MCF breast carcinoma cells. 12019172 Human
hdac5 colon cancer The following 13 antigens reacted exclusively with sera from the colon cancer patients and not with sera from normal blood donors: p53, MAGEA3, SSX2, NY-ESO-1, HDAC5, MBD2, TRIP4, NY-CO-45, KNSL6, HIP1R, Seb4D, KIAA1416, and LMNA. 12124339 Human
hdac5 colon cancer Quantitative real-time reverse transcription-PCR showed that the mRNA expression levels of 2 antigens, HDAC5 and Seb4B, were down-regulated in colon cancer, 2 other antigens, KNSL6 and KIAA1416, were up-regulated, and another antigen, NY-CO-45, showed a v 12124339 Human
hdac5 cancer Fluorescence in situ hybridization analysis localized the human HDAC5 gene to chromosome 17q21, a region which is characterized by frequent gains and losses of chromosomal material in several types of cancer. 11018260 Human
hdac5 murine erythroleukemia Our results demonstrated that GATA-1 and HDAC5 colocalized to the nucleus of murine erythroleukemia (MEL) cells. 14668799 Mouse

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