IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene UBTF Ensembl ENSG00000108312 Chromosome 17 Start 39637928 End 39653776
Description Nucleolar transcription factor 1 (Upstream-binding factor 1)(UBF-1)(Autoantigen NOR-90) [Source:UniProtKB/Swiss-Prot;Acc:P17480]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 12511
     Entrez Gene : 7343
     UCSC : uc002igb.2
     GeneCards : 12511
     RefSeq : NM_001076683
     CCDS : CCDS11480.1
     Uniprot : P17480
     Interpro : P17480
     OMIM : 600673
     GeneTests : UBTF
     CGAP : UBTF
     PMID : 9126496

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  38794_at  -0.13  1.58e-1  2.41e-1  0.00  9.76e-1  9.85e-1
 HG_U95  38795_s_at  0.08  4.41e-1  5.47e-1  0.76  5.09e-9  4.90e-8
 HG_U133A  202692_s_at  0.00  9.81e-1  9.84e-1  0.98  6.85e-32  1.18e-31
 HG_U133A  214881_s_at  0.28  2.80e-4  5.49e-4  -2.34  3.41e-44  7.06e-44
 HG_U133_Plus2  1558215_s_at  0.25  1.60e-2  3.10e-2  0.49  5.63e-5  1.30e-4
 HG_U133_Plus2  202692_s_at  0.14  1.03e-1  1.58e-1  0.59  9.95e-10  4.25e-9
 HG_U133_Plus2  214881_s_at  -0.02  8.67e-1  9.01e-1  0.12  3.74e-1  4.35e-1
 HG_U133_Plus2  225982_at  0.51  1.56e-9  1.06e-8  0.97  1.25e-17  1.33e-16
 HG_U133_Plus2  239920_at  -0.05  7.15e-1  7.78e-1  -0.24  7.68e-2  1.06e-1
 Stanford  15882  0.92  7.62e-4  1.22e-2  0.78  1.22e-2  7.90e-2
 Agilent_HS_21.6K  5039  -0.01  7.65e-1  8.65e-1  0.00  9.32e-1  9.61e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  202692_s_at  0.18  3.23e-1  8.82e-1  0.01  9.11e-1  1.00e+0
 HG_U133A  214881_s_at  0.13  5.19e-1  9.34e-1  0.36  1.28e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 38794_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 38795_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 202692_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 214881_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 1558215_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 202692_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 214881_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 225982_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 239920_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 15882    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 5039    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
ubf hepatocellular carcinoma By representational difference analysis, Northern blot, and cDNA array analysis, up-regulation of UBF was detected in 12 of 17 clinical hepatocellular carcinoma samples comparing to the paired normal liver tissues. 11874979 Human
ubf hepatoma Introduction of UBF in human lung fibroblast cells that do not express UBF resulted in an accelerated rate of cell growth; on the other hand, antisense oligodeoxynucleotides (ODNs) treatment of UBF-expressing hepatoma cell lines reduced the level of UBF p 11874979 Human
ubf hodgkin's disease Immunohistochemical detection of ribosomal transcription factor UBF and AgNOR staining identify apoptotic events in neoplastic cells of Hodgkin's disease and in other lymphoid cells. 11036095 Human
ubf hodgkin's disease Here we studied the expression of UBF in several cases of Hodgkin's disease (HD) by immunostaining and found it to be absent or clearly diminished in a high proportion of Reed-Sternberg cells and Hodgkin cells compared to small reactive lymphocytes. 11036095 Human
ubf necrosis On the contrary, the fluorescent pattern characteristic for other nuclear proteins (C23/nucleolin, UBF, fibrillarin, RNA polymerase I) did not change during necrosis. 11455567 Human

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