IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene SLC4A1 Ensembl ENSG00000004939 Chromosome 17 Start 39682566 End 39700993
Description Band 3 anion transport protein (Anion exchange protein 1)(Anion exchanger 1)(AE 1)(Solute carrier family 4 member 1)(CD233 antigen) [Source:UniProtKB/Swiss-Prot;Acc:P02730]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 11027
     Entrez Gene : 6521
     UCSC : uc002igf.3
     GeneCards : 11027
     RefSeq : NM_000342
     CCDS : CCDS11481.1
     Uniprot : P02730
     Interpro : P02730
     OMIM : 109270
     GeneTests : SLC4A1
     CGAP : SLC4A1
     PMID : 8434259

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  33336_at  -0.28  5.49e-2  9.98e-2  -0.21  3.61e-1  4.67e-1
 HG_U133A  205592_at  -0.41  8.41e-7  2.18e-6  2.77  7.62e-89  3.85e-88
 HG_U133_Plus2  1552713_a_at  0.10  5.58e-1  6.41e-1  0.69  2.34e-4  4.95e-4
 HG_U133_Plus2  205592_at  -0.58  5.05e-4  1.40e-3  -0.44  2.24e-2  3.43e-2
 Stanford  19666  0.55  2.26e-2  1.09e-1  0.16  6.29e-1  8.05e-1
 Agilent_HS_21.6K  1541  -0.25  5.70e-2  1.60e-1  -0.32  2.27e-2  6.78e-2
 Agilent_HS_21.6K  20552  -0.02  4.75e-1  6.54e-1  -0.00  9.36e-1  9.63e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  205592_at  -0.16  6.76e-1  9.66e-1  0.21  3.60e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 33336_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 205592_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 1552713_a_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 205592_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 19666    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 1541    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 20552    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
ae1 cysts Additional studies demonstrated that AE1 is expressed in ADPKD kidneys, and is located at the basolateral pole of CFTR-positive ADPKD cysts that do not express NKCC1. 12355171 Human
ae1 cysts AE1 might be an alternative basolateral pathway for Cl(-) in a minority of cysts. 12355171 Human
ae1 tumour Tumour cells expressed AE1 and CA19-9 (markers for cholangioepithelium) and CEA (for bile canaliculi). 10599313 Human
ae1 erythroleukemia Functional cell surface expression of band 3, the human red blood cell anion exchange protein (AE1), in K562 erythroleukemia cells: band 3 enhances the cell surface reactivity of Rh antigens. 9834250 Human
ae1 oncocytoma Anion exchanger 1 in human kidney and oncocytoma differs from erythroid AE1 in its NH2 terminus. 7506871 Human
ae1 renal oncocytoma Acid-secreting intercalated cells of the kidney collecting duct and tumor cells of renal oncocytoma express an anion exchanger that is immunologically related but not identical to the chloride-bicarbonate anion exchanger of erythrocytes (AE1). 7506871 Human
ae1 tumor Acid-secreting intercalated cells of the kidney collecting duct and tumor cells of renal oncocytoma express an anion exchanger that is immunologically related but not identical to the chloride-bicarbonate anion exchanger of erythrocytes (AE1). 7506871 Human
ae1 oncocytoma In this study, we have mapped the binding site of a monoclonal antibody against erythroid AE1 that does not react with either intercalated cells or oncocytoma. 7506871 Human
ae1 oncocytoma The epitope is located close to the NH2 terminus of AE1, indicating that AE1 in intercalated cells and oncocytoma differs in its NH2 terminus from erythroid AE1. 7506871 Human
ae1 oncocytoma This conclusion was supported by an antibody directed against residues 1-14 of erythroid AE1 that does not react with intercalated cells in oncocytoma. 7506871 Human
ae1 oncocytoma Altogether, the results indicate that AE1 in the human kidney is an amino-terminally truncated form of erythroid AE1 that is restricted to the basolateral membrane domain of the acid-secreting intercalated cells of the collecting duct and is also expresse 7506871 Human
ae1 malignancy We hypothesized that induction or up-regulation of AE1 occurs when lymphocytes are transformed as an initial event in the path to malignancy. 8960772 Human

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