IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene GRN Ensembl ENSG00000030582 Chromosome 17 Start 39778017 End 39785996
Description Granulins Precursor (Proepithelin)(PEPI) [Contains Acrogranin;Paragranulin;Granulin-1(Granulin G);Granulin-2(Granulin F);Granulin-3(Granulin B);Granulin-4(Granulin A);Granulin-5(Granulin C);Granulin-6(Granulin D);Granulin-7(Granulin E)] [Source:UniProtKB/Swiss-Prot;Acc:P28799]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 4601
     Entrez Gene : 2896
     UCSC : uc002igp.1
     GeneCards : 4601
     RefSeq : NM_002087
     CCDS : CCDS11483.1
     Uniprot : Q9UCH0
     Interpro : Q9UCH0
     OMIM : 138945
     GeneTests : GRN
     CGAP : GRN
     PMID : 1417868

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  41198_at  -0.60  6.12e-12  1.14e-10  -0.83  1.62e-10  2.10e-9
 HG_U133A  200678_x_at  -0.60  1.35e-17  8.90e-17  -3.90  4.69e-112  4.47e-111
 HG_U133A  211284_s_at  -0.62  2.65e-16  1.58e-15  -5.98  8.23e-115  8.48e-114
 HG_U133A  216041_x_at  -0.66  2.28e-18  1.59e-17  -7.41  2.19e-156  9.63e-155
 HG_U133_Plus2  200678_x_at  -0.56  3.19e-9  2.08e-8  -0.48  1.62e-5  4.03e-5
 HG_U133_Plus2  211284_s_at  -0.70  2.92e-13  3.20e-12  -0.61  6.76e-8  2.30e-7
 HG_U133_Plus2  216041_x_at  -0.65  1.67e-12  1.67e-11  -0.66  5.87e-9  2.28e-8
 Stanford  16879  -0.46  2.00e-1  3.90e-1  -0.88  4.05e-3  3.69e-2
 Stanford  17253  -0.84  1.28e-2  7.55e-2  -1.59  4.15e-5  1.44e-3
 Stanford  23972  -1.06  8.91e-4  1.36e-2  -1.53  2.36e-4  5.01e-3
 Agilent_HS_21.6K  12720  -0.27  1.38e-5  2.27e-4  -0.36  1.01e-6  1.57e-5

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  200678_x_at  0.01  9.67e-1  9.98e-1  -0.22  1.13e-1  1.00e+0
 HG_U133A  211284_s_at  0.01  9.63e-1  9.98e-1  -0.28  9.93e-2  1.00e+0
 HG_U133A  216041_x_at  0.09  7.27e-1  9.72e-1  -0.25  7.41e-2  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 41198_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 200678_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 211284_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 216041_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 200678_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 211284_s_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 216041_x_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 16879    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 17253    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 23972    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 12720    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
granulin cancer Comparison of mRNA levels by semi-quantitative RT-PCR revealed a relative overexpression of three genes in cancer tissues, including growth factor granulin and Tbdn-1--an orthologue of the mouse acetyltransferase gene which is associated with blood vessel 12087473 Human
pcdgf human breast cancer Mediation of estrogen mitogenic effect in human breast cancer MCF-7 cells by PC-cell-derived growth factor (PCDGF/granulin precursor). 11134521 Human
granulin human breast cancer Mediation of estrogen mitogenic effect in human breast cancer MCF-7 cells by PC-cell-derived growth factor (PCDGF/granulin precursor). 11134521 Human
pcdgf human breast cancer We have reported that PCDGF was expressed in human breast cancer cells. 11134521 Human
pcdgf human breast cancer PC cell-derived growth factor, also known as progranulin, is an M(r) 88,000 growth factor (referred as PCDGF/GP88) overexpressed in human breast cancer. 14996734 Human
pcdgf tumor Antisense inhibition of PCDGF/GP88 expression in MDA-MB-468 cells inhibited tumor formation in nude mice. 14996734 Mouse
pcdgf invasive ductal carcinomas Pathologic studies indicated that PCDGF/GP88 was expressed in 80% of invasive ductal carcinomas in correlation with parameters of poor prognosis. 14996734 Human
pcdgf breast cancer These studies suggest that PCDGF/GP88 plays a critical role in breast cancer tumorigenesis and in the transition to estrogen independence and tamoxifen resistance, a hallmark of poor prognosis. 14996734 Human
pcdgf breast tumors On the basis of the in vivo studies, it is postulated that tamoxifen treatment of patients with estrogen receptor-positive breast tumors overexpressing PCDGF/GP88 could have adverse clinical consequences. 14996734 Human
granulin glial tumors The 2.1-kb granulin mRNA was expressed predominantly in glial tumors, with lower levels in spleen, kidney, and testes, whereas expression was not detected in non-tumor brain tissues. 10728698 Human
granulin glioblastoma Functional assays using [3H]thymidine incorporation indicated that granulin may be a glial mitogen, as addition of synthetic granulin peptide to primary rat astrocytes and three different early-passage human glioblastoma cultures increased cell proliferat 10728698 Human
granulin primary brain neoplasms The differential expression pattern, tissue distribution, and implication of this glioma-associated molecule in growth regulation suggest a potentially important role for granulin in the pathogenesis and/or malignant progression of primary brain neoplasms 10728698 Human
pcdgf human breast carcinoma Inhibition of PC cell-derived growth factor (PCDGF, epithelin/granulin precursor) expression by antisense PCDGF cDNA transfection inhibits tumorigenicity of the human breast carcinoma cell line MDA-MB-468. 10760271 Human
granulin human breast carcinoma Inhibition of PC cell-derived growth factor (PCDGF, epithelin/granulin precursor) expression by antisense PCDGF cDNA transfection inhibits tumorigenicity of the human breast carcinoma cell line MDA-MB-468. 10760271 Human
pcdgf teratoma PC-cell derived growth factor (PCDGF) is an 88-kDa growth factor originally purified from the highly tumorigenic teratoma PC cell line and corresponds to the epithelin/granulin precursor. 10760271 Human
granulin teratoma PC-cell derived growth factor (PCDGF) is an 88-kDa growth factor originally purified from the highly tumorigenic teratoma PC cell line and corresponds to the epithelin/granulin precursor. 10760271 Human
pcdgf teratoma In teratoma cells, PCDGF expression was shown to be essential for tumorigenicity. 10760271 Human
pcdgf breast carcinoma In this study, we have investigated PCDGF expression in human mammary epithelial cell lines ranging from immortalized nontumorigenic cells to ER(+) and ER(-) breast carcinoma cells. 10760271 Human
pcdgf human breast carcinomas Northern and Western blot analyses indicated that PCDGF mRNA and protein expression was low in nontumorigenic cells and increased in human breast carcinomas cell lines in a positive correlation with their tumorigenicity. 10760271 Human
pcdgf breast carcinoma Treatment of the ER(-) MDA-MB-468 cells with anti-PCDGF neutralizing antibody resulted in a dose-dependent inhibition of their proliferation, suggesting that secreted PCDGF acted as an autocrine growth factor for breast carcinoma cells. 10760271 Human
pcdgf breast carcinomas These results demonstrate the importance of PCDGF overexpression for the proliferation and tumorigenicity of ER(-) breast carcinomas and suggest that PCDGF overexpression may play an important role in human breast cancer. 10760271 Human
pcdgf human breast cancer These results demonstrate the importance of PCDGF overexpression for the proliferation and tumorigenicity of ER(-) breast carcinomas and suggest that PCDGF overexpression may play an important role in human breast cancer. 10760271 Human
granulin human breast cancer Stimulation of PC cell-derived growth factor (epithelin/granulin precursor) expression by estradiol in human breast cancer cells. 10066447 Human
pcdgf teratoma PC cell-derived growth factor (PCDGF) is an 88 kDa glycosylated protein isolated from a highly tumorigenic mouse teratoma derived cell line which is similar to the epithelin/granulin precursor. 10066447 Mouse
granulin teratoma PC cell-derived growth factor (PCDGF) is an 88 kDa glycosylated protein isolated from a highly tumorigenic mouse teratoma derived cell line which is similar to the epithelin/granulin precursor. 10066447 Mouse
pcdgf mcf-7 human breast cancer Using Northern blot and western blot analyses, we detect the expression of PCDGF mRNA and protein in MCF-7 human breast cancer cells. 10066447 Human
pcdgf human breast cancer The results presented here provide evidence of a novel estradiol responsive gene product in human breast cancer cell lines and give information about the hormonal control of epithelin/granulin (PCDGF) expression in these cells. 10066447 Human
granulin human breast cancer The results presented here provide evidence of a novel estradiol responsive gene product in human breast cancer cell lines and give information about the hormonal control of epithelin/granulin (PCDGF) expression in these cells. 10066447 Human
pcdgf human breast cancer PC-cell-derived growth factor (PCDGF, progranulin) is a novel autocrine growth factor that is overexpressed in human breast cancer cell lines. 14652816 Human
pcdgf breast carcinoma PCDGF staining was observed in breast carcinoma, whereas it was almost always negative in benign breast epithelium. 14652816 Human
pcdgf invasive lobular carcinoma PCDGF expression was more common in invasive ductal carcinoma (80% cases positive) than in invasive lobular carcinoma (53% positive). 14652816 Human
pcdgf invasive ductal carcinoma PCDGF expression was more common in invasive ductal carcinoma (80% cases positive) than in invasive lobular carcinoma (53% positive). 14652816 Human
pcdgf lobular carcinoma in situ PCDGF staining was almost never observed in lobular carcinoma in situ. 14652816 Human
pcdgf ductal carcinoma in situ Ductal carcinoma in situ expressed PCDGF in 66% of the cases, and this expression correlated strongly with nuclear grade. 14652816 Human
pcdgf invasive ductal carcinoma Similar correlation was observed between PCDGF expression and histologic grade of invasive ductal carcinoma. 14652816 Human
pcdgf tumors A larger percentage of tumors that expressed PCDGF with a staining intensity of 2+ or 3+ were p53 positive (44%) than were PCDGF-negative tumors (25%), P=0.02. 14652816 Human
pcdgf tumor Our study provides the first evidence of high incidence of PCDGF expression in human breast cancer in which it correlates with clinicopathological variables such as tumor grade, proliferation index, and p53 expression. 14652816 Human
pcdgf human breast cancer Our study provides the first evidence of high incidence of PCDGF expression in human breast cancer in which it correlates with clinicopathological variables such as tumor grade, proliferation index, and p53 expression. 14652816 Human
pcdgf breast cancer These characteristics, as well as the virtual absence of expression in benign breast tissue, suggest an important role of PCDGF in breast cancer pathogenesis and make it a potential novel target for the treatment of breast cancer. 14652816 Human
granulin multiple myeloma PC cell-derived growth factor (granulin precursor) expression and action in human multiple myeloma. 12796389 Human
pcdgf myeloma Immunohistochemical analysis of bone marrow smears obtained from MM patients indicated that PCDGF expression was associated with myeloma cells from MM patients and correlated with the presence of MM disease. 12796389 Human
pcdgf teratoma Inhibition of tumorigenicity of the teratoma PC cell line by transfection with antisense cDNA for PC cell-derived growth factor (PCDGF, epithelin/granulin precursor). 9826678 Human
granulin teratoma Inhibition of tumorigenicity of the teratoma PC cell line by transfection with antisense cDNA for PC cell-derived growth factor (PCDGF, epithelin/granulin precursor). 9826678 Human
pcdgf tumor These data demonstrate the importance in tumor formation of overexpression of the novel growth factor PCDGF. 9826678 Human
granulin epithelial ovarian cancer Differential granulin expression in tumor samples and the antiproliferative effects of its antisense down-regulation suggest that GEP may be a new autocrine growth factor and molecular target for epithelial ovarian cancer. 12538450 Human
granulin tumor Differential granulin expression in tumor samples and the antiproliferative effects of its antisense down-regulation suggest that GEP may be a new autocrine growth factor and molecular target for epithelial ovarian cancer. 12538450 Human
pcdgf cancer These studies suggest that PCDGF is a suitable therapeutic and diagnostic target for the development of novel cancer therapy and diagnosis. 12914763 Human

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