IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene FZD2 Ensembl ENSG00000180340 Chromosome 17 Start 39990451 End 39992433
Description Frizzled-2 Precursor (Fz-2)(hFz2)(FzE2) [Source:UniProtKB/Swiss-Prot;Acc:Q14332]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 4040
     Entrez Gene : 2535
     UCSC : uc002igx.1
     GeneCards : 4040
     RefSeq : NM_001466
     CCDS : CCDS11484.1
     Uniprot : Q14332
     Interpro : Q14332
     OMIM : 600667
     GeneTests : FZD2
     CGAP : FZD2
     PMID : 7558010

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  36799_at  -0.20  1.31e-1  2.07e-1  -0.32  3.89e-2  7.41e-2
 HG_U95  628_at  0.01  9.57e-1  9.69e-1  -0.12  3.69e-1  4.75e-1
 HG_U133A  210220_at  -0.05  7.23e-1  7.62e-1  -2.32  1.85e-53  4.45e-53
 HG_U133_Plus2  210220_at  -0.07  6.93e-1  7.60e-1  -0.27  1.61e-1  2.06e-1
 Agilent_HS_21.6K  9867  -0.03  6.19e-1  7.66e-1  -0.05  4.76e-1  6.28e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  210220_at  -0.05  8.36e-1  9.86e-1  0.02  9.18e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 36799_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U95 - 628_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 210220_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 210220_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 9867    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
fzd2 neuroblastoma Whereas ET lines demonstrated increased expression of microtubule-associated protein tau (MAPT), protein phosphatase 1 regulatory subunit 1A (PPP1R1A), NIMA (never in mitosis gene a)-related kinase 2 (NEK2), and cyclin D1 (CCND1), neuroblastoma samples ex 11836553 Human
fzd2 primary gastric cancer Among 10 cases of primary gastric cancer, FZD9 was up-regulated in 2 cases, FZD2 and FZD8 were up-regulated in 4 cases. 11562753 Human
fzd2 human gastric cancer These results indicate that FZD2, FZD8, and FZD9 might play key roles in human gastric cancer. 11562753 Human
fzd2 oesophageal squamous cell carcinomas Interestingly, mRNA levels of human FzD2 are reported to be up-regulated in oesophageal squamous cell carcinomas. 10903145 Human
frizzled homolog 2 neuroblastoma Whereas ET lines demonstrated increased expression of microtubule-associated protein tau (MAPT), protein phosphatase 1 regulatory subunit 1A (PPP1R1A), NIMA (never in mitosis gene a)-related kinase 2 (NEK2), and cyclin D1 (CCND1), neuroblastoma samples ex 11836553 Human
frizzled-2 teratocarcinoma Activation of a frizzled-2/beta-adrenergic receptor chimera promotes Wnt signaling and differentiation of mouse F9 teratocarcinoma cells via Galphao and Galphat. 10588714 Mouse
frizzled-2 teratocarcinoma Because F9 embryonic teratocarcinoma cells form primitive endoderm after stable transfection of Frizzled-2 chimera and stimulation with ISO, they were subject to depletion of G protein subunits. 10588714 Mouse
frizzled-2 fibroid MAIN OUTCOME MEASURE(S): Expression of mRNA transcripts and protein in fibroid compared with myometrium.A more extensive microarray confirmed differential expression of Frizzled-2 and CD-24 but did not confirm Dlk overexpression. 12909487 Human
frizzled-2 fibroid RT-PCR and real-time PCR demonstrated equivalent Dlk mRNA expression between fibroid and myometrium (ratio, 1.02), a slight Frizzled-2 overexpression (ratio, 2.09), and robust CD-24 overexpression in fibroids (ratio, 12.35). 12909487 Human
frizzled-2 teratocarcinoma Gene profiling of Frizzled-1 and Frizzled-2 signaling: expression of G-protein-coupled receptor chimeras in mouse F9 teratocarcinoma embryonal cells. 14722236 Mouse
frizzled-2 tumors The majority of the remaining tumors demonstrated concurrent increases in Wnt-1 and frizzled-2 (positive regulators) and a decrease in Ser45/Thr41-phospho-beta-catenin. 16756720 Human

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