IGDB.NSCLC Gene View
 
Gene Information        (help)
Gene ADAM11 Ensembl ENSG00000073670 Chromosome 17 Start 40192094 End 40214740
Description ADAM 11 Precursor (A disintegrin and metalloproteinase domain 11)(Metalloproteinase-like, disintegrin-like, and cysteine-rich protein)(MDC) [Source:UniProtKB/Swiss-Prot;Acc:O75078]
GENE RESOURCES :NUCLEOTIDE SEQUENCES :PROTEIN RESOURCES :CLINICAL RESOURCES :REFERENCES :
     HGNC : 189
     Entrez Gene : 4185
     UCSC : uc002ihh.2
     GeneCards : 189
     RefSeq : NM_002390
     CCDS : CCDS11486.1
     Uniprot : O75078
     Interpro : O75078
     OMIM : 155120
     GeneTests : ADAM11
     CGAP : ADAM11
     PMID : 8252040

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Microarray Gene Expression Fold Change Result        (help)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background : these probesets might have mapping problems. ref 1, ref 2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U95  33941_at  -0.00  9.91e-1  9.95e-1  0.52  1.54e-2  3.36e-2
 HG_U133A  207880_at  -0.78  3.38e-23  3.33e-22  4.05  4.56e-125  6.40e-124
 HG_U133_Plus2  207880_at  0.09  5.01e-1  5.88e-1  0.60  5.44e-5  1.26e-4
 HG_U133_Plus2  239837_at  0.49  2.73e-3  6.42e-3  1.27  4.30e-12  2.43e-11
 Stanford  2283  0.40  1.89e-1  3.76e-1  0.53  4.36e-2  1.55e-1
 Agilent_HS_21.6K  1881  0.07  1.92e-2  7.41e-2  0.07  8.67e-2  1.87e-1

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Adjuvant Cisplatin/vinorelbine Treatment vs Observation Result        (help) (Pubmed)
( red: up-regulation / green : down-regulation when p value < 0.01)
( gray background color : the mapping problems of probeset. ref_1, ref_2)
Chip Type Probeset Adenocarcinoma Squamous Cell Carcinoma
Fold Change p value q value Fold Change p value q value
 HG_U133A  207880_at  -0.04  8.65e-1  9.89e-1  0.08  5.06e-1  1.00e+0

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Microarray Sample Data        (help)
( The log2 value of tumor samples )
(Average : Average log2 value from Normal Samples.)
        HG_U95 - 33941_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133A - 207880_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 207880_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        HG_U133_Plus2 - 239837_at    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Stanford - 2283    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

        Agilent_HS_21.6K - 1881    (back)       Save as a PNG file. Save as a PDF file. Save as a PS file.
Gene expression figure

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Cancer Gene Index        (help)

If 0 entry was found, please remove the search key "lung cancer".
Keyword DiseaseData Statement PubMed Organism
mdc tumour The putative tumour suppressor gene MDC (ADAM11) is expressed at very low levels in all cells examined. 9199213 Human
mdc tumor A recently identified gene encoding a metalloprotease-like, disintegrin-like, cysteine-rich protein (MDC) represents a candidate tumor suppressor gene for human breast cancer based on its location within a minimal region of chromosome 17q21 previously def 7956356 Human
mdc human breast cancer A recently identified gene encoding a metalloprotease-like, disintegrin-like, cysteine-rich protein (MDC) represents a candidate tumor suppressor gene for human breast cancer based on its location within a minimal region of chromosome 17q21 previously def 7956356 Human
mdc tumours Rearrangements in both tumours involve multiple exons and disrupt the coding region of the new MDC. 8252040 Human
adam11 tumour The putative tumour suppressor gene MDC (ADAM11) is expressed at very low levels in all cells examined. 9199213 Human
adam11 gliomas METHODS: Specimens of low- and high-grade gliomas and normal brain were analyzed for ADAM11 and ADAM22 expression using Western blotting. 16385342 Human
adam11 glioma The effects of overexpression of ADAM11 and ADAM22 in glioma cells on growth were analyzed using bromodeoxyuridine incorporation linked to immunocytochemistry. 16385342 Human
adam11 gliomas RESULTS: ADAM22 is expressed in normal brain and some low-grade gliomas, but not in high-grade gliomas, whereas ADAM11 is expressed in all low- and high-grade gliomas. 16385342 Human
adam11 gliomas A related protein, ADAM11, has only a minor effect on cell growth, and its expression is unchanged in low- and high-grade gliomas. 16385342 Human
adam-11 recurrent breast cancer How ADAM-9 and ADAM-11 differentially from estrogen receptor predict response to tamoxifen treatment in patients with recurrent breast cancer: a retrospective study. 16243802 Human
adam-11 recurrent breast cancer PURPOSE: To evaluate the predictive value of the disintegrin and metalloproteinases, ADAM-9, ADAM-10, ADAM-11, and ADAM-12, and of the matrix metalloproteinases, MMP-2 and MMP-9, in patients with recurrent breast cancer treated with tamoxifen. 16243802 Human
adam-11 recurrent breast cancer CONCLUSIONS: Our results show that especially for primary tumors containing stromal elements, the assessment of mRNA expression levels of ADAM-9 and ADAM-11 could be useful to identify patients with recurrent breast cancer who are likely to benefit or fai 16243802 Human
adam-11 primary tumors CONCLUSIONS: Our results show that especially for primary tumors containing stromal elements, the assessment of mRNA expression levels of ADAM-9 and ADAM-11 could be useful to identify patients with recurrent breast cancer who are likely to benefit or fai 16243802 Human

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